Incidental Mutation 'T0970:Gm11232'
ID 67256
Institutional Source Beutler Lab
Gene Symbol Gm11232
Ensembl Gene ENSMUSG00000066141
Gene Name predicted gene 11232
Synonyms
Accession Numbers
Essential gene? Probably non essential (E-score: 0.048) question?
Stock # T0970 (G3) of strain 713
Quality Score 204
Status Validated
Chromosome 4
Chromosomal Location 71673983-71676197 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 71674740 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Phenylalanine at position 254 (Y254F)
Ref Sequence ENSEMBL: ENSMUSP00000081532 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000084489]
AlphaFold Q5SPI8
Predicted Effect possibly damaging
Transcript: ENSMUST00000084489
AA Change: Y254F

PolyPhen 2 Score 0.659 (Sensitivity: 0.86; Specificity: 0.91)
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.5%
  • 3x: 98.9%
  • 10x: 97.3%
  • 20x: 94.7%
Validation Efficiency 100% (25/25)
Allele List at MGI
Other mutations in this stock
Total: 23 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ano4 A T 10: 88,817,052 (GRCm39) L591* probably null Het
Aqp4 A G 18: 15,532,940 (GRCm39) L51P probably damaging Het
Cemip A T 7: 83,632,354 (GRCm39) C403S probably damaging Het
Cfap74 G T 4: 155,547,574 (GRCm39) probably null Het
Glis3 G A 19: 28,508,332 (GRCm39) R551W probably damaging Het
Map3k14 G T 11: 103,115,124 (GRCm39) C837* probably null Het
Mrc2 A C 11: 105,238,453 (GRCm39) E1200A probably benign Het
Nfix T C 8: 85,453,112 (GRCm39) N314S possibly damaging Het
Nphp4 T C 4: 152,640,836 (GRCm39) S1068P probably damaging Het
Nup98 A C 7: 101,835,959 (GRCm39) probably benign Het
Or13p8 A G 4: 118,583,464 (GRCm39) R7G probably benign Het
Pcdhac2 T C 18: 37,278,388 (GRCm39) V456A possibly damaging Het
Pcdhb1 G T 18: 37,399,026 (GRCm39) G326C probably damaging Het
Prss38 A G 11: 59,263,974 (GRCm39) V246A possibly damaging Het
Rnf26 C G 9: 44,023,369 (GRCm39) R172P probably damaging Het
Septin4 A T 11: 87,458,558 (GRCm39) T311S probably damaging Het
Serinc3 TATCATC TATC 2: 163,469,835 (GRCm39) probably benign Het
Spire1 C A 18: 67,634,133 (GRCm39) probably null Het
Tex2 T A 11: 106,437,772 (GRCm39) I633F unknown Het
Tle2 A G 10: 81,416,119 (GRCm39) D108G possibly damaging Het
Txnrd2 T C 16: 18,260,523 (GRCm39) V185A probably damaging Het
Unc45b C A 11: 82,813,714 (GRCm39) H374N probably benign Het
Wtap T C 17: 13,188,277 (GRCm39) probably benign Het
Other mutations in Gm11232
AlleleSourceChrCoordTypePredicted EffectPPH Score
hint UTSW 4 71,675,450 (GRCm39) nonsense probably null
suggestion UTSW 4 71,675,138 (GRCm39) missense possibly damaging 0.82
R0062:Gm11232 UTSW 4 71,675,112 (GRCm39) missense possibly damaging 0.46
R0062:Gm11232 UTSW 4 71,675,112 (GRCm39) missense possibly damaging 0.46
R1457:Gm11232 UTSW 4 71,675,156 (GRCm39) critical splice acceptor site probably null
R1458:Gm11232 UTSW 4 71,675,450 (GRCm39) nonsense probably null
R1594:Gm11232 UTSW 4 71,675,572 (GRCm39) missense possibly damaging 0.82
R2566:Gm11232 UTSW 4 71,676,022 (GRCm39) missense probably benign 0.00
R4983:Gm11232 UTSW 4 71,675,138 (GRCm39) missense possibly damaging 0.82
R6020:Gm11232 UTSW 4 71,674,905 (GRCm39) missense possibly damaging 0.66
R6977:Gm11232 UTSW 4 71,676,178 (GRCm39) start gained probably benign
R7375:Gm11232 UTSW 4 71,675,583 (GRCm39) nonsense probably null
R7772:Gm11232 UTSW 4 71,674,818 (GRCm39) missense possibly damaging 0.52
R8523:Gm11232 UTSW 4 71,675,465 (GRCm39) missense probably benign 0.27
R9080:Gm11232 UTSW 4 71,676,070 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- GGTTTGATGCTCACTGGACACAAGG -3'
(R):5'- CAGAGTCTTCACCAATCTGAGTGCC -3'

Sequencing Primer
(F):5'- GCCTGCATCCTGGTCTCTATG -3'
(R):5'- TGACCCTGGATGACCTACAG -3'
Posted On 2013-09-03