Incidental Mutation 'T0970:Or13p8'
ID 67257
Institutional Source Beutler Lab
Gene Symbol Or13p8
Ensembl Gene ENSMUSG00000070821
Gene Name olfactory receptor family 13 subfamily P member 8
Synonyms MOR258-6, Olfr1340, GA_x6K02T2QD9B-18823451-18822504
Accession Numbers
Essential gene? Probably non essential (E-score: 0.083) question?
Stock # T0970 (G3) of strain 713
Quality Score 197
Status Validated
Chromosome 4
Chromosomal Location 118582919-118584393 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 118583464 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Glycine at position 7 (R7G)
Ref Sequence ENSEMBL: ENSMUSP00000149563 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000094834] [ENSMUST00000213436] [ENSMUST00000216242] [ENSMUST00000217334]
AlphaFold Q3KPC7
Predicted Effect probably benign
Transcript: ENSMUST00000094834
AA Change: R7G

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000092430
Gene: ENSMUSG00000070821
AA Change: R7G

DomainStartEndE-ValueType
Pfam:7tm_4 34 310 4.4e-57 PFAM
Pfam:7tm_1 44 293 1.3e-24 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213436
AA Change: R7G

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Predicted Effect probably benign
Transcript: ENSMUST00000216242
AA Change: R7G

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Predicted Effect probably benign
Transcript: ENSMUST00000217334
AA Change: R7G

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.5%
  • 3x: 98.9%
  • 10x: 97.3%
  • 20x: 94.7%
Validation Efficiency 100% (25/25)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 23 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ano4 A T 10: 88,817,052 (GRCm39) L591* probably null Het
Aqp4 A G 18: 15,532,940 (GRCm39) L51P probably damaging Het
Cemip A T 7: 83,632,354 (GRCm39) C403S probably damaging Het
Cfap74 G T 4: 155,547,574 (GRCm39) probably null Het
Glis3 G A 19: 28,508,332 (GRCm39) R551W probably damaging Het
Gm11232 T A 4: 71,674,740 (GRCm39) Y254F possibly damaging Het
Map3k14 G T 11: 103,115,124 (GRCm39) C837* probably null Het
Mrc2 A C 11: 105,238,453 (GRCm39) E1200A probably benign Het
Nfix T C 8: 85,453,112 (GRCm39) N314S possibly damaging Het
Nphp4 T C 4: 152,640,836 (GRCm39) S1068P probably damaging Het
Nup98 A C 7: 101,835,959 (GRCm39) probably benign Het
Pcdhac2 T C 18: 37,278,388 (GRCm39) V456A possibly damaging Het
Pcdhb1 G T 18: 37,399,026 (GRCm39) G326C probably damaging Het
Prss38 A G 11: 59,263,974 (GRCm39) V246A possibly damaging Het
Rnf26 C G 9: 44,023,369 (GRCm39) R172P probably damaging Het
Septin4 A T 11: 87,458,558 (GRCm39) T311S probably damaging Het
Serinc3 TATCATC TATC 2: 163,469,835 (GRCm39) probably benign Het
Spire1 C A 18: 67,634,133 (GRCm39) probably null Het
Tex2 T A 11: 106,437,772 (GRCm39) I633F unknown Het
Tle2 A G 10: 81,416,119 (GRCm39) D108G possibly damaging Het
Txnrd2 T C 16: 18,260,523 (GRCm39) V185A probably damaging Het
Unc45b C A 11: 82,813,714 (GRCm39) H374N probably benign Het
Wtap T C 17: 13,188,277 (GRCm39) probably benign Het
Other mutations in Or13p8
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0153:Or13p8 UTSW 4 118,583,530 (GRCm39) missense possibly damaging 0.86
R0335:Or13p8 UTSW 4 118,584,367 (GRCm39) missense probably null
R0517:Or13p8 UTSW 4 118,583,831 (GRCm39) missense probably damaging 1.00
R4463:Or13p8 UTSW 4 118,583,855 (GRCm39) missense probably benign 0.32
R6240:Or13p8 UTSW 4 118,583,668 (GRCm39) missense probably benign 0.00
R6481:Or13p8 UTSW 4 118,583,930 (GRCm39) missense probably damaging 1.00
R6930:Or13p8 UTSW 4 118,584,338 (GRCm39) missense probably damaging 1.00
R7662:Or13p8 UTSW 4 118,583,504 (GRCm39) missense probably damaging 0.99
R7681:Or13p8 UTSW 4 118,583,761 (GRCm39) missense probably benign 0.00
R7782:Or13p8 UTSW 4 118,584,106 (GRCm39) missense probably damaging 1.00
R7845:Or13p8 UTSW 4 118,584,158 (GRCm39) missense probably benign 0.00
R8498:Or13p8 UTSW 4 118,583,822 (GRCm39) missense possibly damaging 0.78
R8529:Or13p8 UTSW 4 118,583,770 (GRCm39) missense probably benign 0.18
R8990:Or13p8 UTSW 4 118,584,224 (GRCm39) missense probably benign 0.01
R9017:Or13p8 UTSW 4 118,583,565 (GRCm39) missense probably benign
R9176:Or13p8 UTSW 4 118,583,850 (GRCm39) nonsense probably null
R9797:Or13p8 UTSW 4 118,584,079 (GRCm39) missense probably benign 0.27
Z1176:Or13p8 UTSW 4 118,584,338 (GRCm39) missense probably damaging 1.00
Z1177:Or13p8 UTSW 4 118,584,261 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- GGAAACAACAGGCATTCCTTTCGAC -3'
(R):5'- GGTGTGTGGAGACGAGCATCTATTC -3'

Sequencing Primer
(F):5'- TCGACTTGTTTAAGAtgtgtgtg -3'
(R):5'- GACGAGCATCTATTCTAATCAGGG -3'
Posted On 2013-09-03