Incidental Mutation 'R0730:Erbb4'
| ID |
67433 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Erbb4
|
| Ensembl Gene |
ENSMUSG00000062209 |
| Gene Name |
erb-b2 receptor tyrosine kinase 4 |
| Synonyms |
Her4, ErbB4 |
| MMRRC Submission |
038911-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R0730 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
1 |
| Chromosomal Location |
68071345-69147218 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 68298449 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Alanine
at position 647
(V647A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000115373
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000119142]
[ENSMUST00000121473]
[ENSMUST00000153432]
|
| AlphaFold |
Q61527 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000119142
AA Change: V657A
PolyPhen 2
Score 0.243 (Sensitivity: 0.91; Specificity: 0.88)
|
| SMART Domains |
Protein: ENSMUSP00000112713
Gene: ENSMUSG00000062209
AA Change: V657A
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
25 |
N/A |
INTRINSIC |
|
Pfam:Recep_L_domain
|
55 |
167 |
5e-34 |
PFAM |
|
FU
|
183 |
223 |
2.07e1 |
SMART |
|
FU
|
226 |
268 |
5.78e-10 |
SMART |
|
Pfam:Recep_L_domain
|
358 |
478 |
1e-29 |
PFAM |
|
FU
|
493 |
544 |
6.45e-8 |
SMART |
|
FU
|
549 |
599 |
3.51e-9 |
SMART |
|
FU
|
611 |
659 |
2.32e0 |
SMART |
|
TyrKc
|
718 |
974 |
7.53e-133 |
SMART |
|
low complexity region
|
1007 |
1023 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000121473
AA Change: V657A
PolyPhen 2
Score 0.243 (Sensitivity: 0.91; Specificity: 0.88)
|
| SMART Domains |
Protein: ENSMUSP00000114123
Gene: ENSMUSG00000062209
AA Change: V657A
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
25 |
N/A |
INTRINSIC |
|
Pfam:Recep_L_domain
|
55 |
167 |
1.6e-34 |
PFAM |
|
FU
|
183 |
223 |
2.07e1 |
SMART |
|
FU
|
226 |
268 |
5.78e-10 |
SMART |
|
Pfam:Recep_L_domain
|
358 |
478 |
5.5e-29 |
PFAM |
|
FU
|
493 |
544 |
6.45e-8 |
SMART |
|
FU
|
549 |
599 |
3.51e-9 |
SMART |
|
FU
|
611 |
659 |
2.32e0 |
SMART |
|
TyrKc
|
718 |
974 |
7.53e-133 |
SMART |
|
low complexity region
|
1007 |
1023 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000153432
AA Change: V647A
PolyPhen 2
Score 0.977 (Sensitivity: 0.76; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000115373
Gene: ENSMUSG00000062209
AA Change: V647A
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
25 |
N/A |
INTRINSIC |
|
Pfam:Recep_L_domain
|
55 |
167 |
1.7e-34 |
PFAM |
|
FU
|
183 |
223 |
2.07e1 |
SMART |
|
FU
|
226 |
268 |
5.78e-10 |
SMART |
|
Pfam:Recep_L_domain
|
358 |
478 |
5.7e-29 |
PFAM |
|
FU
|
493 |
544 |
6.45e-8 |
SMART |
|
FU
|
549 |
599 |
3.51e-9 |
SMART |
|
FU
|
611 |
649 |
2.98e0 |
SMART |
|
PDB:2R4B|B
|
680 |
732 |
1e-25 |
PDB |
|
| Meta Mutation Damage Score |
0.1303 |
| Coding Region Coverage |
- 1x: 99.4%
- 3x: 98.9%
- 10x: 97.8%
- 20x: 96.1%
|
| Validation Efficiency |
99% (99/100) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygotes for a targeted null mutation exhibit cardiac defects, alterations in hindbrain development, and midgestational lethality. Heterozygotes show schizophrenia-like behavior. Genetically rescued females show mammary defects. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(7) : Targeted(6) Gene trapped(1)
|
| Other mutations in this stock |
Total: 99 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adam9 |
A |
T |
8: 25,486,774 (GRCm39) |
I168N |
probably benign |
Het |
| Adamts20 |
G |
A |
15: 94,245,571 (GRCm39) |
A577V |
probably benign |
Het |
| Agtr1a |
A |
T |
13: 30,565,279 (GRCm39) |
S115C |
probably damaging |
Het |
| Ankrd11 |
T |
C |
8: 123,618,692 (GRCm39) |
Y1720C |
probably damaging |
Het |
| Ano6 |
A |
T |
15: 95,818,252 (GRCm39) |
T353S |
probably damaging |
Het |
| App |
A |
G |
16: 84,876,840 (GRCm39) |
F184L |
probably damaging |
Het |
| Arhgef38 |
T |
A |
3: 132,843,232 (GRCm39) |
Y446F |
probably benign |
Het |
| Aspg |
T |
A |
12: 112,078,693 (GRCm39) |
Y57* |
probably null |
Het |
| Atp1a4 |
G |
A |
1: 172,067,774 (GRCm39) |
|
probably benign |
Het |
| Bdp1 |
G |
A |
13: 100,195,459 (GRCm39) |
|
probably benign |
Het |
| Bicd2 |
T |
A |
13: 49,531,717 (GRCm39) |
S246T |
possibly damaging |
Het |
| Brd10 |
T |
A |
19: 29,695,381 (GRCm39) |
I1438F |
probably benign |
Het |
| Bsn |
T |
A |
9: 107,984,011 (GRCm39) |
M3348L |
unknown |
Het |
| Cacna1c |
C |
T |
6: 118,589,586 (GRCm39) |
R1446H |
probably damaging |
Het |
| Cacna2d3 |
T |
C |
14: 28,704,322 (GRCm39) |
I820V |
probably benign |
Het |
| Cdc40 |
A |
G |
10: 40,720,952 (GRCm39) |
|
probably benign |
Het |
| Cdh23 |
T |
C |
10: 60,159,493 (GRCm39) |
E2094G |
probably damaging |
Het |
| Celsr2 |
T |
A |
3: 108,305,922 (GRCm39) |
N2061Y |
probably damaging |
Het |
| Cfap206 |
G |
A |
4: 34,711,391 (GRCm39) |
A502V |
probably benign |
Het |
| Cfap54 |
T |
C |
10: 92,870,599 (GRCm39) |
T29A |
probably benign |
Het |
| Cfap57 |
T |
C |
4: 118,470,117 (GRCm39) |
|
probably null |
Het |
| Chd5 |
A |
G |
4: 152,432,441 (GRCm39) |
E43G |
possibly damaging |
Het |
| Clk1 |
G |
A |
1: 58,453,558 (GRCm39) |
H343Y |
probably benign |
Het |
| Cntn4 |
A |
C |
6: 106,527,447 (GRCm39) |
K443T |
probably damaging |
Het |
| Csn2 |
G |
A |
5: 87,842,811 (GRCm39) |
A72V |
possibly damaging |
Het |
| Ctdp1 |
T |
A |
18: 80,493,457 (GRCm39) |
H346L |
probably benign |
Het |
| Ctif |
A |
T |
18: 75,698,083 (GRCm39) |
N192K |
probably damaging |
Het |
| Ddr2 |
G |
A |
1: 169,823,135 (GRCm39) |
A383V |
probably benign |
Het |
| Derl3 |
C |
T |
10: 75,731,076 (GRCm39) |
|
probably benign |
Het |
| Dgkh |
T |
C |
14: 78,821,919 (GRCm39) |
I865V |
probably damaging |
Het |
| Dip2b |
C |
T |
15: 100,069,532 (GRCm39) |
A619V |
probably damaging |
Het |
| Elapor1 |
T |
A |
3: 108,376,851 (GRCm39) |
H509L |
probably benign |
Het |
| Eml1 |
A |
G |
12: 108,496,585 (GRCm39) |
T614A |
possibly damaging |
Het |
| Eogt |
G |
C |
6: 97,092,970 (GRCm39) |
Y402* |
probably null |
Het |
| Esm1 |
G |
T |
13: 113,350,036 (GRCm39) |
|
probably null |
Het |
| Fbxo31 |
A |
G |
8: 122,282,103 (GRCm39) |
|
probably benign |
Het |
| Fbxw5 |
T |
A |
2: 25,394,630 (GRCm39) |
D201E |
possibly damaging |
Het |
| Fgfr1 |
G |
A |
8: 26,045,760 (GRCm39) |
D123N |
probably benign |
Het |
| G530012D18Rik |
A |
C |
1: 85,504,757 (GRCm39) |
|
probably benign |
Het |
| Gnat1 |
G |
A |
9: 107,556,662 (GRCm39) |
T29I |
probably damaging |
Het |
| Gtf2ird2 |
A |
T |
5: 134,221,597 (GRCm39) |
R67* |
probably null |
Het |
| Il22b |
A |
T |
10: 118,130,142 (GRCm39) |
D87E |
probably benign |
Het |
| Kcnq3 |
T |
C |
15: 65,867,457 (GRCm39) |
T729A |
probably benign |
Het |
| Klrc2 |
A |
T |
6: 129,635,659 (GRCm39) |
S156R |
probably damaging |
Het |
| Krt76 |
A |
T |
15: 101,795,784 (GRCm39) |
L462Q |
probably damaging |
Het |
| Lama3 |
C |
A |
18: 12,589,907 (GRCm39) |
|
probably benign |
Het |
| Lin28a |
A |
T |
4: 133,735,319 (GRCm39) |
S56T |
probably damaging |
Het |
| Macf1 |
A |
G |
4: 123,276,323 (GRCm39) |
|
probably benign |
Het |
| Macrod2 |
C |
T |
2: 142,059,594 (GRCm39) |
|
probably benign |
Het |
| Mansc1 |
C |
T |
6: 134,594,424 (GRCm39) |
|
probably benign |
Het |
| Map1b |
G |
T |
13: 99,566,274 (GRCm39) |
S2149* |
probably null |
Het |
| Mgst1 |
A |
T |
6: 138,124,667 (GRCm39) |
T34S |
probably benign |
Het |
| Mlf2 |
C |
T |
6: 124,911,354 (GRCm39) |
T123M |
probably damaging |
Het |
| Mospd2 |
C |
T |
X: 163,731,253 (GRCm39) |
|
probably benign |
Het |
| Mrpl15 |
A |
T |
1: 4,847,834 (GRCm39) |
V155E |
probably damaging |
Het |
| Mstn |
A |
T |
1: 53,100,953 (GRCm39) |
Y10F |
possibly damaging |
Het |
| Myo1g |
C |
T |
11: 6,470,794 (GRCm39) |
V21M |
probably damaging |
Het |
| Myom2 |
T |
C |
8: 15,149,326 (GRCm39) |
I599T |
probably benign |
Het |
| Ndc80 |
A |
T |
17: 71,803,241 (GRCm39) |
N633K |
probably benign |
Het |
| Nhs |
C |
A |
X: 160,620,296 (GRCm39) |
V1487L |
possibly damaging |
Het |
| Npc1 |
T |
C |
18: 12,352,382 (GRCm39) |
T106A |
probably benign |
Het |
| Nup133 |
C |
T |
8: 124,675,747 (GRCm39) |
V57M |
probably benign |
Het |
| Nup98 |
T |
A |
7: 101,809,923 (GRCm39) |
T536S |
probably damaging |
Het |
| Oprm1 |
T |
C |
10: 6,782,652 (GRCm39) |
|
probably benign |
Het |
| Or5j1 |
T |
C |
2: 86,879,492 (GRCm39) |
I29M |
probably benign |
Het |
| Or6c219 |
T |
A |
10: 129,780,980 (GRCm39) |
H317L |
probably benign |
Het |
| Or8j3 |
A |
G |
2: 86,029,069 (GRCm39) |
V9A |
probably benign |
Het |
| Ostf1 |
C |
T |
19: 18,581,571 (GRCm39) |
V14I |
unknown |
Het |
| Pcdhb14 |
C |
A |
18: 37,581,921 (GRCm39) |
D342E |
probably damaging |
Het |
| Pdia3 |
G |
A |
2: 121,262,858 (GRCm39) |
G275S |
probably damaging |
Het |
| Pdpr |
T |
C |
8: 111,852,387 (GRCm39) |
|
probably null |
Het |
| Plce1 |
G |
A |
19: 38,705,135 (GRCm39) |
V847M |
probably damaging |
Het |
| Pon3 |
A |
G |
6: 5,230,444 (GRCm39) |
M288T |
probably benign |
Het |
| Psd2 |
A |
T |
18: 36,111,627 (GRCm39) |
D84V |
possibly damaging |
Het |
| Ptpro |
T |
A |
6: 137,420,592 (GRCm39) |
V1007D |
probably damaging |
Het |
| Ralgapa1 |
T |
C |
12: 55,712,448 (GRCm39) |
K1808E |
probably damaging |
Het |
| Ramp3 |
T |
C |
11: 6,626,476 (GRCm39) |
|
probably benign |
Het |
| Rasgrf1 |
T |
A |
9: 89,833,062 (GRCm39) |
|
probably benign |
Het |
| Rictor |
A |
G |
15: 6,803,467 (GRCm39) |
|
probably benign |
Het |
| Rptor |
A |
T |
11: 119,775,780 (GRCm39) |
I984F |
probably benign |
Het |
| Slc1a6 |
C |
T |
10: 78,631,842 (GRCm39) |
P223S |
probably benign |
Het |
| Taar8b |
A |
C |
10: 23,967,924 (GRCm39) |
V90G |
probably damaging |
Het |
| Tbc1d21 |
A |
G |
9: 58,267,160 (GRCm39) |
V327A |
probably benign |
Het |
| Tex21 |
T |
C |
12: 76,250,940 (GRCm39) |
T499A |
probably benign |
Het |
| Tg |
A |
T |
15: 66,550,638 (GRCm39) |
D256V |
probably damaging |
Het |
| Tmf1 |
A |
G |
6: 97,153,453 (GRCm39) |
S207P |
probably benign |
Het |
| Tpr |
A |
G |
1: 150,269,158 (GRCm39) |
|
probably benign |
Het |
| Ufd1 |
A |
G |
16: 18,633,637 (GRCm39) |
T21A |
probably damaging |
Het |
| Unc13a |
T |
C |
8: 72,108,929 (GRCm39) |
D115G |
possibly damaging |
Het |
| Usb1 |
T |
A |
8: 96,070,669 (GRCm39) |
F198L |
probably damaging |
Het |
| Utrn |
A |
T |
10: 12,573,902 (GRCm39) |
|
probably benign |
Het |
| Vars1 |
A |
G |
17: 35,233,276 (GRCm39) |
N954S |
probably damaging |
Het |
| Wdr17 |
C |
T |
8: 55,146,131 (GRCm39) |
A90T |
possibly damaging |
Het |
| Wdr33 |
C |
T |
18: 31,968,429 (GRCm39) |
|
probably benign |
Het |
| Zfp236 |
A |
G |
18: 82,658,369 (GRCm39) |
|
probably benign |
Het |
| Zfp445 |
A |
T |
9: 122,690,823 (GRCm39) |
V124E |
probably damaging |
Het |
| Zfp616 |
A |
T |
11: 73,975,648 (GRCm39) |
H639L |
probably damaging |
Het |
| Zfyve16 |
C |
A |
13: 92,657,985 (GRCm39) |
S642I |
probably damaging |
Het |
| Zswim5 |
C |
T |
4: 116,842,943 (GRCm39) |
T896I |
possibly damaging |
Het |
|
| Other mutations in Erbb4 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00965:Erbb4
|
APN |
1 |
68,110,789 (GRCm39) |
nonsense |
probably null |
|
|
IGL01020:Erbb4
|
APN |
1 |
68,337,608 (GRCm39) |
splice site |
probably benign |
|
|
IGL01349:Erbb4
|
APN |
1 |
68,385,752 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01386:Erbb4
|
APN |
1 |
68,383,090 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01516:Erbb4
|
APN |
1 |
68,367,404 (GRCm39) |
nonsense |
probably null |
|
|
IGL01536:Erbb4
|
APN |
1 |
68,329,441 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01721:Erbb4
|
APN |
1 |
68,293,722 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
IGL01832:Erbb4
|
APN |
1 |
68,293,725 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
IGL02002:Erbb4
|
APN |
1 |
68,119,885 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02040:Erbb4
|
APN |
1 |
68,081,694 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02371:Erbb4
|
APN |
1 |
68,329,453 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02399:Erbb4
|
APN |
1 |
68,081,596 (GRCm39) |
splice site |
probably benign |
|
|
IGL02553:Erbb4
|
APN |
1 |
68,345,023 (GRCm39) |
missense |
probably benign |
0.17 |
|
IGL03118:Erbb4
|
APN |
1 |
68,081,878 (GRCm39) |
missense |
probably benign |
0.11 |
|
IGL03329:Erbb4
|
APN |
1 |
68,367,281 (GRCm39) |
missense |
probably benign |
0.30 |
|
IGL03405:Erbb4
|
APN |
1 |
68,369,397 (GRCm39) |
missense |
probably benign |
0.02 |
|
earthworm
|
UTSW |
1 |
68,289,739 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
excrescence
|
UTSW |
1 |
68,369,405 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Mole
|
UTSW |
1 |
68,599,735 (GRCm39) |
missense |
probably damaging |
1.00 |
|
P0018:Erbb4
|
UTSW |
1 |
68,110,835 (GRCm39) |
missense |
probably benign |
0.05 |
|
PIT4480001:Erbb4
|
UTSW |
1 |
68,114,702 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0193:Erbb4
|
UTSW |
1 |
68,083,119 (GRCm39) |
intron |
probably benign |
|
|
R0329:Erbb4
|
UTSW |
1 |
68,337,439 (GRCm39) |
splice site |
probably benign |
|
|
R0335:Erbb4
|
UTSW |
1 |
68,298,418 (GRCm39) |
missense |
probably benign |
|
|
R0362:Erbb4
|
UTSW |
1 |
68,369,429 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0579:Erbb4
|
UTSW |
1 |
68,081,621 (GRCm39) |
missense |
probably benign |
0.17 |
|
R1029:Erbb4
|
UTSW |
1 |
68,348,773 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R1444:Erbb4
|
UTSW |
1 |
68,293,759 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1469:Erbb4
|
UTSW |
1 |
68,599,841 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1469:Erbb4
|
UTSW |
1 |
68,599,841 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1503:Erbb4
|
UTSW |
1 |
68,385,705 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1523:Erbb4
|
UTSW |
1 |
68,435,411 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1528:Erbb4
|
UTSW |
1 |
68,117,741 (GRCm39) |
nonsense |
probably null |
|
|
R1604:Erbb4
|
UTSW |
1 |
68,385,728 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R1611:Erbb4
|
UTSW |
1 |
68,079,547 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1642:Erbb4
|
UTSW |
1 |
68,370,393 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1905:Erbb4
|
UTSW |
1 |
68,114,569 (GRCm39) |
splice site |
probably benign |
|
|
R1929:Erbb4
|
UTSW |
1 |
68,238,047 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2046:Erbb4
|
UTSW |
1 |
68,337,482 (GRCm39) |
missense |
probably benign |
0.02 |
|
R2139:Erbb4
|
UTSW |
1 |
68,385,788 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R2271:Erbb4
|
UTSW |
1 |
68,238,047 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2298:Erbb4
|
UTSW |
1 |
68,081,690 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2356:Erbb4
|
UTSW |
1 |
68,117,755 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3821:Erbb4
|
UTSW |
1 |
68,345,072 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4007:Erbb4
|
UTSW |
1 |
68,779,560 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4012:Erbb4
|
UTSW |
1 |
68,599,735 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4077:Erbb4
|
UTSW |
1 |
68,079,496 (GRCm39) |
missense |
probably benign |
0.07 |
|
R4196:Erbb4
|
UTSW |
1 |
68,383,014 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R4536:Erbb4
|
UTSW |
1 |
68,385,781 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4561:Erbb4
|
UTSW |
1 |
68,383,080 (GRCm39) |
nonsense |
probably null |
|
|
R4642:Erbb4
|
UTSW |
1 |
68,289,791 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4737:Erbb4
|
UTSW |
1 |
68,383,059 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4739:Erbb4
|
UTSW |
1 |
68,383,059 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4780:Erbb4
|
UTSW |
1 |
68,337,473 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4801:Erbb4
|
UTSW |
1 |
68,369,405 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4802:Erbb4
|
UTSW |
1 |
68,369,405 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4811:Erbb4
|
UTSW |
1 |
68,293,703 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4832:Erbb4
|
UTSW |
1 |
68,369,397 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5068:Erbb4
|
UTSW |
1 |
68,083,061 (GRCm39) |
splice site |
probably null |
|
|
R5546:Erbb4
|
UTSW |
1 |
68,337,452 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5755:Erbb4
|
UTSW |
1 |
68,599,678 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R6189:Erbb4
|
UTSW |
1 |
68,083,075 (GRCm39) |
missense |
probably benign |
|
|
R6257:Erbb4
|
UTSW |
1 |
68,435,432 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6276:Erbb4
|
UTSW |
1 |
68,599,735 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6521:Erbb4
|
UTSW |
1 |
68,081,689 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6602:Erbb4
|
UTSW |
1 |
68,409,662 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6808:Erbb4
|
UTSW |
1 |
68,079,462 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7087:Erbb4
|
UTSW |
1 |
68,779,650 (GRCm39) |
missense |
probably null |
1.00 |
|
R7215:Erbb4
|
UTSW |
1 |
68,378,619 (GRCm39) |
missense |
probably benign |
|
|
R7356:Erbb4
|
UTSW |
1 |
68,378,514 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7509:Erbb4
|
UTSW |
1 |
68,289,739 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R7593:Erbb4
|
UTSW |
1 |
68,293,758 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7743:Erbb4
|
UTSW |
1 |
68,367,278 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7784:Erbb4
|
UTSW |
1 |
68,114,658 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7815:Erbb4
|
UTSW |
1 |
68,081,885 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7923:Erbb4
|
UTSW |
1 |
68,298,368 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8071:Erbb4
|
UTSW |
1 |
68,435,470 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8288:Erbb4
|
UTSW |
1 |
68,337,509 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8356:Erbb4
|
UTSW |
1 |
68,110,789 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8456:Erbb4
|
UTSW |
1 |
68,110,789 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8464:Erbb4
|
UTSW |
1 |
68,348,785 (GRCm39) |
missense |
probably benign |
|
|
R8783:Erbb4
|
UTSW |
1 |
68,079,331 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8830:Erbb4
|
UTSW |
1 |
68,114,627 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8881:Erbb4
|
UTSW |
1 |
68,382,997 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9053:Erbb4
|
UTSW |
1 |
68,289,779 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R9142:Erbb4
|
UTSW |
1 |
68,388,552 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9237:Erbb4
|
UTSW |
1 |
68,081,601 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R9350:Erbb4
|
UTSW |
1 |
68,329,638 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9374:Erbb4
|
UTSW |
1 |
68,779,642 (GRCm39) |
nonsense |
probably null |
|
|
R9434:Erbb4
|
UTSW |
1 |
68,081,773 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R9499:Erbb4
|
UTSW |
1 |
68,779,642 (GRCm39) |
nonsense |
probably null |
|
|
R9551:Erbb4
|
UTSW |
1 |
68,779,642 (GRCm39) |
nonsense |
probably null |
|
|
R9753:Erbb4
|
UTSW |
1 |
68,238,062 (GRCm39) |
missense |
probably benign |
0.00 |
|
X0019:Erbb4
|
UTSW |
1 |
68,112,304 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1176:Erbb4
|
UTSW |
1 |
68,367,418 (GRCm39) |
nonsense |
probably null |
|
|
Z1176:Erbb4
|
UTSW |
1 |
68,337,561 (GRCm39) |
frame shift |
probably null |
|
|
Z1177:Erbb4
|
UTSW |
1 |
68,348,802 (GRCm39) |
missense |
probably benign |
0.06 |
|
Z1177:Erbb4
|
UTSW |
1 |
68,329,635 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Erbb4
|
UTSW |
1 |
68,298,342 (GRCm39) |
frame shift |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- TCCTTAGACACATGCTGGCTCTACA -3'
(R):5'- GCTTTATTACAGCCCTGGTGGCTTT -3'
Sequencing Primer
(F):5'- gaagtgggagtggttggg -3'
(R):5'- CAGCCCTGGTGGCTTTTTATTTG -3'
|
| Posted On |
2013-09-03 |
Incidental Mutation