Incidental Mutation 'R0730:Wdr17'
| ID |
67467 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Wdr17
|
| Ensembl Gene |
ENSMUSG00000039375 |
| Gene Name |
WD repeat domain 17 |
| Synonyms |
B230207L18Rik, 3010002I12Rik |
| MMRRC Submission |
038911-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R0730 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
8 |
| Chromosomal Location |
55082316-55180014 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to T
at 55146131 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Alanine to Threonine
at position 90
(A90T)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000135805
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000127511]
[ENSMUST00000129132]
[ENSMUST00000144482]
[ENSMUST00000144711]
[ENSMUST00000148408]
[ENSMUST00000175915]
[ENSMUST00000150488]
[ENSMUST00000176866]
|
| AlphaFold |
E9Q271 |
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000126316
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000127511
AA Change: A114T
PolyPhen 2
Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
|
| SMART Domains |
Protein: ENSMUSP00000115550
Gene: ENSMUSG00000039375
AA Change: A114T
| Domain | Start | End | E-Value | Type |
|---|
|
WD40
|
72 |
112 |
8.55e-8 |
SMART |
|
WD40
|
162 |
202 |
1.58e2 |
SMART |
|
WD40
|
205 |
252 |
4.26e1 |
SMART |
|
WD40
|
255 |
298 |
1.15e0 |
SMART |
|
WD40
|
383 |
422 |
1.59e-7 |
SMART |
|
WD40
|
425 |
465 |
2.39e0 |
SMART |
|
WD40
|
468 |
509 |
5.52e-2 |
SMART |
|
WD40
|
511 |
550 |
4.14e-6 |
SMART |
|
WD40
|
555 |
595 |
5.14e-11 |
SMART |
|
WD40
|
598 |
638 |
6.58e-9 |
SMART |
|
WD40
|
641 |
681 |
6.28e-6 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000129132
AA Change: A90T
PolyPhen 2
Score 0.015 (Sensitivity: 0.96; Specificity: 0.79)
|
| SMART Domains |
Protein: ENSMUSP00000134935
Gene: ENSMUSG00000039375
AA Change: A90T
| Domain | Start | End | E-Value | Type |
|---|
|
WD40
|
48 |
88 |
8.55e-8 |
SMART |
|
Blast:WD40
|
91 |
131 |
1e-12 |
BLAST |
|
WD40
|
138 |
178 |
1.58e2 |
SMART |
|
WD40
|
181 |
228 |
4.26e1 |
SMART |
|
WD40
|
231 |
271 |
9.86e1 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000144482
|
| SMART Domains |
Protein: ENSMUSP00000134950
Gene: ENSMUSG00000039375
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:WD40
|
16 |
65 |
2e-24 |
BLAST |
|
WD40
|
70 |
109 |
1.59e-7 |
SMART |
|
WD40
|
112 |
152 |
2.39e0 |
SMART |
|
WD40
|
155 |
196 |
5.52e-2 |
SMART |
|
WD40
|
198 |
237 |
4.14e-6 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000144711
AA Change: A114T
PolyPhen 2
Score 0.010 (Sensitivity: 0.96; Specificity: 0.77)
|
| SMART Domains |
Protein: ENSMUSP00000117710
Gene: ENSMUSG00000039375
AA Change: A114T
| Domain | Start | End | E-Value | Type |
|---|
|
WD40
|
72 |
112 |
8.55e-8 |
SMART |
|
WD40
|
194 |
235 |
7.64e1 |
SMART |
|
WD40
|
238 |
281 |
1.15e0 |
SMART |
|
WD40
|
366 |
405 |
1.59e-7 |
SMART |
|
WD40
|
408 |
448 |
2.39e0 |
SMART |
|
WD40
|
451 |
492 |
5.52e-2 |
SMART |
|
WD40
|
494 |
533 |
4.14e-6 |
SMART |
|
WD40
|
538 |
578 |
5.14e-11 |
SMART |
|
WD40
|
581 |
621 |
6.58e-9 |
SMART |
|
WD40
|
624 |
664 |
6.28e-6 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000148408
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000148806
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000175915
AA Change: A90T
PolyPhen 2
Score 0.845 (Sensitivity: 0.83; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000135805
Gene: ENSMUSG00000039375
AA Change: A90T
| Domain | Start | End | E-Value | Type |
|---|
|
WD40
|
48 |
88 |
8.55e-8 |
SMART |
|
WD40
|
138 |
178 |
1.58e2 |
SMART |
|
WD40
|
181 |
228 |
4.26e1 |
SMART |
|
WD40
|
231 |
274 |
1.15e0 |
SMART |
|
WD40
|
359 |
398 |
1.59e-7 |
SMART |
|
WD40
|
401 |
441 |
2.39e0 |
SMART |
|
WD40
|
444 |
485 |
5.52e-2 |
SMART |
|
WD40
|
487 |
526 |
4.14e-6 |
SMART |
|
WD40
|
531 |
571 |
5.14e-11 |
SMART |
|
WD40
|
574 |
614 |
6.58e-9 |
SMART |
|
WD40
|
617 |
657 |
6.28e-6 |
SMART |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000150488
AA Change: A90T
PolyPhen 2
Score 0.740 (Sensitivity: 0.85; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000122326
Gene: ENSMUSG00000039375
AA Change: A90T
| Domain | Start | End | E-Value | Type |
|---|
|
WD40
|
48 |
88 |
8.55e-8 |
SMART |
|
WD40
|
138 |
178 |
1.58e2 |
SMART |
|
WD40
|
181 |
228 |
4.26e1 |
SMART |
|
WD40
|
231 |
274 |
1.15e0 |
SMART |
|
WD40
|
359 |
398 |
1.59e-7 |
SMART |
|
WD40
|
401 |
441 |
2.39e0 |
SMART |
|
WD40
|
444 |
485 |
5.52e-2 |
SMART |
|
WD40
|
487 |
526 |
4.14e-6 |
SMART |
|
WD40
|
531 |
571 |
5.14e-11 |
SMART |
|
WD40
|
574 |
614 |
6.58e-9 |
SMART |
|
WD40
|
617 |
657 |
6.28e-6 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000176866
|
| Meta Mutation Damage Score |
0.0614 |
| Coding Region Coverage |
- 1x: 99.4%
- 3x: 98.9%
- 10x: 97.8%
- 20x: 96.1%
|
| Validation Efficiency |
99% (99/100) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a WD repeat-containing protein. It is abundantly expressed in retina and testis, and is thought to be a candidate gene for retinal disease. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2009]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 99 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adam9 |
A |
T |
8: 25,486,774 (GRCm39) |
I168N |
probably benign |
Het |
| Adamts20 |
G |
A |
15: 94,245,571 (GRCm39) |
A577V |
probably benign |
Het |
| Agtr1a |
A |
T |
13: 30,565,279 (GRCm39) |
S115C |
probably damaging |
Het |
| Ankrd11 |
T |
C |
8: 123,618,692 (GRCm39) |
Y1720C |
probably damaging |
Het |
| Ano6 |
A |
T |
15: 95,818,252 (GRCm39) |
T353S |
probably damaging |
Het |
| App |
A |
G |
16: 84,876,840 (GRCm39) |
F184L |
probably damaging |
Het |
| Arhgef38 |
T |
A |
3: 132,843,232 (GRCm39) |
Y446F |
probably benign |
Het |
| Aspg |
T |
A |
12: 112,078,693 (GRCm39) |
Y57* |
probably null |
Het |
| Atp1a4 |
G |
A |
1: 172,067,774 (GRCm39) |
|
probably benign |
Het |
| Bdp1 |
G |
A |
13: 100,195,459 (GRCm39) |
|
probably benign |
Het |
| Bicd2 |
T |
A |
13: 49,531,717 (GRCm39) |
S246T |
possibly damaging |
Het |
| Brd10 |
T |
A |
19: 29,695,381 (GRCm39) |
I1438F |
probably benign |
Het |
| Bsn |
T |
A |
9: 107,984,011 (GRCm39) |
M3348L |
unknown |
Het |
| Cacna1c |
C |
T |
6: 118,589,586 (GRCm39) |
R1446H |
probably damaging |
Het |
| Cacna2d3 |
T |
C |
14: 28,704,322 (GRCm39) |
I820V |
probably benign |
Het |
| Cdc40 |
A |
G |
10: 40,720,952 (GRCm39) |
|
probably benign |
Het |
| Cdh23 |
T |
C |
10: 60,159,493 (GRCm39) |
E2094G |
probably damaging |
Het |
| Celsr2 |
T |
A |
3: 108,305,922 (GRCm39) |
N2061Y |
probably damaging |
Het |
| Cfap206 |
G |
A |
4: 34,711,391 (GRCm39) |
A502V |
probably benign |
Het |
| Cfap54 |
T |
C |
10: 92,870,599 (GRCm39) |
T29A |
probably benign |
Het |
| Cfap57 |
T |
C |
4: 118,470,117 (GRCm39) |
|
probably null |
Het |
| Chd5 |
A |
G |
4: 152,432,441 (GRCm39) |
E43G |
possibly damaging |
Het |
| Clk1 |
G |
A |
1: 58,453,558 (GRCm39) |
H343Y |
probably benign |
Het |
| Cntn4 |
A |
C |
6: 106,527,447 (GRCm39) |
K443T |
probably damaging |
Het |
| Csn2 |
G |
A |
5: 87,842,811 (GRCm39) |
A72V |
possibly damaging |
Het |
| Ctdp1 |
T |
A |
18: 80,493,457 (GRCm39) |
H346L |
probably benign |
Het |
| Ctif |
A |
T |
18: 75,698,083 (GRCm39) |
N192K |
probably damaging |
Het |
| Ddr2 |
G |
A |
1: 169,823,135 (GRCm39) |
A383V |
probably benign |
Het |
| Derl3 |
C |
T |
10: 75,731,076 (GRCm39) |
|
probably benign |
Het |
| Dgkh |
T |
C |
14: 78,821,919 (GRCm39) |
I865V |
probably damaging |
Het |
| Dip2b |
C |
T |
15: 100,069,532 (GRCm39) |
A619V |
probably damaging |
Het |
| Elapor1 |
T |
A |
3: 108,376,851 (GRCm39) |
H509L |
probably benign |
Het |
| Eml1 |
A |
G |
12: 108,496,585 (GRCm39) |
T614A |
possibly damaging |
Het |
| Eogt |
G |
C |
6: 97,092,970 (GRCm39) |
Y402* |
probably null |
Het |
| Erbb4 |
A |
G |
1: 68,298,449 (GRCm39) |
V647A |
probably damaging |
Het |
| Esm1 |
G |
T |
13: 113,350,036 (GRCm39) |
|
probably null |
Het |
| Fbxo31 |
A |
G |
8: 122,282,103 (GRCm39) |
|
probably benign |
Het |
| Fbxw5 |
T |
A |
2: 25,394,630 (GRCm39) |
D201E |
possibly damaging |
Het |
| Fgfr1 |
G |
A |
8: 26,045,760 (GRCm39) |
D123N |
probably benign |
Het |
| G530012D18Rik |
A |
C |
1: 85,504,757 (GRCm39) |
|
probably benign |
Het |
| Gnat1 |
G |
A |
9: 107,556,662 (GRCm39) |
T29I |
probably damaging |
Het |
| Gtf2ird2 |
A |
T |
5: 134,221,597 (GRCm39) |
R67* |
probably null |
Het |
| Il22b |
A |
T |
10: 118,130,142 (GRCm39) |
D87E |
probably benign |
Het |
| Kcnq3 |
T |
C |
15: 65,867,457 (GRCm39) |
T729A |
probably benign |
Het |
| Klrc2 |
A |
T |
6: 129,635,659 (GRCm39) |
S156R |
probably damaging |
Het |
| Krt76 |
A |
T |
15: 101,795,784 (GRCm39) |
L462Q |
probably damaging |
Het |
| Lama3 |
C |
A |
18: 12,589,907 (GRCm39) |
|
probably benign |
Het |
| Lin28a |
A |
T |
4: 133,735,319 (GRCm39) |
S56T |
probably damaging |
Het |
| Macf1 |
A |
G |
4: 123,276,323 (GRCm39) |
|
probably benign |
Het |
| Macrod2 |
C |
T |
2: 142,059,594 (GRCm39) |
|
probably benign |
Het |
| Mansc1 |
C |
T |
6: 134,594,424 (GRCm39) |
|
probably benign |
Het |
| Map1b |
G |
T |
13: 99,566,274 (GRCm39) |
S2149* |
probably null |
Het |
| Mgst1 |
A |
T |
6: 138,124,667 (GRCm39) |
T34S |
probably benign |
Het |
| Mlf2 |
C |
T |
6: 124,911,354 (GRCm39) |
T123M |
probably damaging |
Het |
| Mospd2 |
C |
T |
X: 163,731,253 (GRCm39) |
|
probably benign |
Het |
| Mrpl15 |
A |
T |
1: 4,847,834 (GRCm39) |
V155E |
probably damaging |
Het |
| Mstn |
A |
T |
1: 53,100,953 (GRCm39) |
Y10F |
possibly damaging |
Het |
| Myo1g |
C |
T |
11: 6,470,794 (GRCm39) |
V21M |
probably damaging |
Het |
| Myom2 |
T |
C |
8: 15,149,326 (GRCm39) |
I599T |
probably benign |
Het |
| Ndc80 |
A |
T |
17: 71,803,241 (GRCm39) |
N633K |
probably benign |
Het |
| Nhs |
C |
A |
X: 160,620,296 (GRCm39) |
V1487L |
possibly damaging |
Het |
| Npc1 |
T |
C |
18: 12,352,382 (GRCm39) |
T106A |
probably benign |
Het |
| Nup133 |
C |
T |
8: 124,675,747 (GRCm39) |
V57M |
probably benign |
Het |
| Nup98 |
T |
A |
7: 101,809,923 (GRCm39) |
T536S |
probably damaging |
Het |
| Oprm1 |
T |
C |
10: 6,782,652 (GRCm39) |
|
probably benign |
Het |
| Or5j1 |
T |
C |
2: 86,879,492 (GRCm39) |
I29M |
probably benign |
Het |
| Or6c219 |
T |
A |
10: 129,780,980 (GRCm39) |
H317L |
probably benign |
Het |
| Or8j3 |
A |
G |
2: 86,029,069 (GRCm39) |
V9A |
probably benign |
Het |
| Ostf1 |
C |
T |
19: 18,581,571 (GRCm39) |
V14I |
unknown |
Het |
| Pcdhb14 |
C |
A |
18: 37,581,921 (GRCm39) |
D342E |
probably damaging |
Het |
| Pdia3 |
G |
A |
2: 121,262,858 (GRCm39) |
G275S |
probably damaging |
Het |
| Pdpr |
T |
C |
8: 111,852,387 (GRCm39) |
|
probably null |
Het |
| Plce1 |
G |
A |
19: 38,705,135 (GRCm39) |
V847M |
probably damaging |
Het |
| Pon3 |
A |
G |
6: 5,230,444 (GRCm39) |
M288T |
probably benign |
Het |
| Psd2 |
A |
T |
18: 36,111,627 (GRCm39) |
D84V |
possibly damaging |
Het |
| Ptpro |
T |
A |
6: 137,420,592 (GRCm39) |
V1007D |
probably damaging |
Het |
| Ralgapa1 |
T |
C |
12: 55,712,448 (GRCm39) |
K1808E |
probably damaging |
Het |
| Ramp3 |
T |
C |
11: 6,626,476 (GRCm39) |
|
probably benign |
Het |
| Rasgrf1 |
T |
A |
9: 89,833,062 (GRCm39) |
|
probably benign |
Het |
| Rictor |
A |
G |
15: 6,803,467 (GRCm39) |
|
probably benign |
Het |
| Rptor |
A |
T |
11: 119,775,780 (GRCm39) |
I984F |
probably benign |
Het |
| Slc1a6 |
C |
T |
10: 78,631,842 (GRCm39) |
P223S |
probably benign |
Het |
| Taar8b |
A |
C |
10: 23,967,924 (GRCm39) |
V90G |
probably damaging |
Het |
| Tbc1d21 |
A |
G |
9: 58,267,160 (GRCm39) |
V327A |
probably benign |
Het |
| Tex21 |
T |
C |
12: 76,250,940 (GRCm39) |
T499A |
probably benign |
Het |
| Tg |
A |
T |
15: 66,550,638 (GRCm39) |
D256V |
probably damaging |
Het |
| Tmf1 |
A |
G |
6: 97,153,453 (GRCm39) |
S207P |
probably benign |
Het |
| Tpr |
A |
G |
1: 150,269,158 (GRCm39) |
|
probably benign |
Het |
| Ufd1 |
A |
G |
16: 18,633,637 (GRCm39) |
T21A |
probably damaging |
Het |
| Unc13a |
T |
C |
8: 72,108,929 (GRCm39) |
D115G |
possibly damaging |
Het |
| Usb1 |
T |
A |
8: 96,070,669 (GRCm39) |
F198L |
probably damaging |
Het |
| Utrn |
A |
T |
10: 12,573,902 (GRCm39) |
|
probably benign |
Het |
| Vars1 |
A |
G |
17: 35,233,276 (GRCm39) |
N954S |
probably damaging |
Het |
| Wdr33 |
C |
T |
18: 31,968,429 (GRCm39) |
|
probably benign |
Het |
| Zfp236 |
A |
G |
18: 82,658,369 (GRCm39) |
|
probably benign |
Het |
| Zfp445 |
A |
T |
9: 122,690,823 (GRCm39) |
V124E |
probably damaging |
Het |
| Zfp616 |
A |
T |
11: 73,975,648 (GRCm39) |
H639L |
probably damaging |
Het |
| Zfyve16 |
C |
A |
13: 92,657,985 (GRCm39) |
S642I |
probably damaging |
Het |
| Zswim5 |
C |
T |
4: 116,842,943 (GRCm39) |
T896I |
possibly damaging |
Het |
|
| Other mutations in Wdr17 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00309:Wdr17
|
APN |
8 |
55,140,746 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00496:Wdr17
|
APN |
8 |
55,112,614 (GRCm39) |
splice site |
probably benign |
|
|
IGL01318:Wdr17
|
APN |
8 |
55,125,585 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01347:Wdr17
|
APN |
8 |
55,104,380 (GRCm39) |
missense |
probably benign |
|
|
IGL01654:Wdr17
|
APN |
8 |
55,115,914 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02010:Wdr17
|
APN |
8 |
55,112,738 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02085:Wdr17
|
APN |
8 |
55,140,771 (GRCm39) |
nonsense |
probably null |
|
|
IGL02205:Wdr17
|
APN |
8 |
55,149,335 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02375:Wdr17
|
APN |
8 |
55,149,423 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL02705:Wdr17
|
APN |
8 |
55,101,250 (GRCm39) |
splice site |
probably null |
|
|
IGL02719:Wdr17
|
APN |
8 |
55,146,089 (GRCm39) |
splice site |
probably null |
|
|
IGL03051:Wdr17
|
APN |
8 |
55,104,349 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03131:Wdr17
|
APN |
8 |
55,149,302 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL03172:Wdr17
|
APN |
8 |
55,114,515 (GRCm39) |
missense |
probably damaging |
0.96 |
|
enthralled
|
UTSW |
8 |
55,112,716 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
riveted
|
UTSW |
8 |
55,085,522 (GRCm39) |
missense |
probably benign |
0.00 |
|
thrilled
|
UTSW |
8 |
55,149,303 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL03138:Wdr17
|
UTSW |
8 |
55,102,178 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4458001:Wdr17
|
UTSW |
8 |
55,126,614 (GRCm39) |
nonsense |
probably null |
|
|
R0011:Wdr17
|
UTSW |
8 |
55,125,536 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R0011:Wdr17
|
UTSW |
8 |
55,125,536 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R0124:Wdr17
|
UTSW |
8 |
55,088,526 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0226:Wdr17
|
UTSW |
8 |
55,116,043 (GRCm39) |
missense |
probably benign |
0.08 |
|
R0270:Wdr17
|
UTSW |
8 |
55,146,131 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R0271:Wdr17
|
UTSW |
8 |
55,146,131 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R0288:Wdr17
|
UTSW |
8 |
55,146,131 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R0321:Wdr17
|
UTSW |
8 |
55,149,303 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0464:Wdr17
|
UTSW |
8 |
55,123,427 (GRCm39) |
splice site |
probably benign |
|
|
R0479:Wdr17
|
UTSW |
8 |
55,104,456 (GRCm39) |
splice site |
probably null |
|
|
R0488:Wdr17
|
UTSW |
8 |
55,146,087 (GRCm39) |
unclassified |
probably benign |
|
|
R0552:Wdr17
|
UTSW |
8 |
55,146,131 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R0553:Wdr17
|
UTSW |
8 |
55,146,131 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R0600:Wdr17
|
UTSW |
8 |
55,114,530 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0621:Wdr17
|
UTSW |
8 |
55,096,226 (GRCm39) |
missense |
probably benign |
0.18 |
|
R0655:Wdr17
|
UTSW |
8 |
55,102,233 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0789:Wdr17
|
UTSW |
8 |
55,112,607 (GRCm39) |
splice site |
probably benign |
|
|
R0854:Wdr17
|
UTSW |
8 |
55,156,916 (GRCm39) |
missense |
probably benign |
|
|
R0879:Wdr17
|
UTSW |
8 |
55,114,516 (GRCm39) |
missense |
probably benign |
0.08 |
|
R1462:Wdr17
|
UTSW |
8 |
55,123,363 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1462:Wdr17
|
UTSW |
8 |
55,123,363 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1497:Wdr17
|
UTSW |
8 |
55,125,536 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R1589:Wdr17
|
UTSW |
8 |
55,156,942 (GRCm39) |
intron |
probably benign |
|
|
R1618:Wdr17
|
UTSW |
8 |
55,092,930 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1768:Wdr17
|
UTSW |
8 |
55,126,689 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R1778:Wdr17
|
UTSW |
8 |
55,143,249 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1819:Wdr17
|
UTSW |
8 |
55,143,159 (GRCm39) |
missense |
probably benign |
0.18 |
|
R1913:Wdr17
|
UTSW |
8 |
55,140,761 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2129:Wdr17
|
UTSW |
8 |
55,085,416 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2132:Wdr17
|
UTSW |
8 |
55,125,541 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2309:Wdr17
|
UTSW |
8 |
55,096,283 (GRCm39) |
missense |
probably benign |
|
|
R3882:Wdr17
|
UTSW |
8 |
55,092,536 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R4097:Wdr17
|
UTSW |
8 |
55,088,504 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4372:Wdr17
|
UTSW |
8 |
55,092,930 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4380:Wdr17
|
UTSW |
8 |
55,101,442 (GRCm39) |
intron |
probably benign |
|
|
R4480:Wdr17
|
UTSW |
8 |
55,117,999 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4654:Wdr17
|
UTSW |
8 |
55,134,434 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4656:Wdr17
|
UTSW |
8 |
55,134,434 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4669:Wdr17
|
UTSW |
8 |
55,143,083 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R4719:Wdr17
|
UTSW |
8 |
55,092,911 (GRCm39) |
missense |
probably benign |
0.33 |
|
R4912:Wdr17
|
UTSW |
8 |
55,082,896 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5000:Wdr17
|
UTSW |
8 |
55,118,161 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R5073:Wdr17
|
UTSW |
8 |
55,143,271 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R5176:Wdr17
|
UTSW |
8 |
55,106,913 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5194:Wdr17
|
UTSW |
8 |
55,140,639 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5270:Wdr17
|
UTSW |
8 |
55,096,221 (GRCm39) |
missense |
probably benign |
0.20 |
|
R5300:Wdr17
|
UTSW |
8 |
55,134,434 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5325:Wdr17
|
UTSW |
8 |
55,112,716 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R5336:Wdr17
|
UTSW |
8 |
55,085,353 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5394:Wdr17
|
UTSW |
8 |
55,092,524 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R5424:Wdr17
|
UTSW |
8 |
55,134,434 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5425:Wdr17
|
UTSW |
8 |
55,134,434 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5426:Wdr17
|
UTSW |
8 |
55,134,434 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5548:Wdr17
|
UTSW |
8 |
55,156,886 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5681:Wdr17
|
UTSW |
8 |
55,115,904 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5722:Wdr17
|
UTSW |
8 |
55,113,806 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5894:Wdr17
|
UTSW |
8 |
55,149,335 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5906:Wdr17
|
UTSW |
8 |
55,092,503 (GRCm39) |
missense |
probably benign |
0.33 |
|
R6038:Wdr17
|
UTSW |
8 |
55,085,346 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6038:Wdr17
|
UTSW |
8 |
55,085,346 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6391:Wdr17
|
UTSW |
8 |
55,114,495 (GRCm39) |
missense |
probably benign |
0.04 |
|
R6605:Wdr17
|
UTSW |
8 |
55,134,559 (GRCm39) |
missense |
probably benign |
0.16 |
|
R6892:Wdr17
|
UTSW |
8 |
55,126,631 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7019:Wdr17
|
UTSW |
8 |
55,134,488 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7257:Wdr17
|
UTSW |
8 |
55,085,522 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7481:Wdr17
|
UTSW |
8 |
55,114,371 (GRCm39) |
missense |
probably benign |
|
|
R7868:Wdr17
|
UTSW |
8 |
55,149,302 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7939:Wdr17
|
UTSW |
8 |
55,140,677 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7962:Wdr17
|
UTSW |
8 |
55,113,806 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8017:Wdr17
|
UTSW |
8 |
55,091,403 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R8122:Wdr17
|
UTSW |
8 |
55,118,011 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8226:Wdr17
|
UTSW |
8 |
55,146,155 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R8251:Wdr17
|
UTSW |
8 |
55,110,267 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8413:Wdr17
|
UTSW |
8 |
55,115,953 (GRCm39) |
missense |
probably benign |
0.08 |
|
R8534:Wdr17
|
UTSW |
8 |
55,101,265 (GRCm39) |
missense |
probably benign |
0.08 |
|
R8708:Wdr17
|
UTSW |
8 |
55,093,127 (GRCm39) |
intron |
probably benign |
|
|
R9116:Wdr17
|
UTSW |
8 |
55,114,605 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9258:Wdr17
|
UTSW |
8 |
55,112,654 (GRCm39) |
nonsense |
probably null |
|
|
R9351:Wdr17
|
UTSW |
8 |
55,143,057 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9475:Wdr17
|
UTSW |
8 |
55,088,512 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9546:Wdr17
|
UTSW |
8 |
55,112,735 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9547:Wdr17
|
UTSW |
8 |
55,112,735 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9635:Wdr17
|
UTSW |
8 |
55,101,375 (GRCm39) |
missense |
probably damaging |
0.98 |
|
V5088:Wdr17
|
UTSW |
8 |
55,146,131 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
V5622:Wdr17
|
UTSW |
8 |
55,146,131 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
V5622:Wdr17
|
UTSW |
8 |
55,146,131 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
X0022:Wdr17
|
UTSW |
8 |
55,092,529 (GRCm39) |
missense |
probably benign |
0.04 |
|
X0066:Wdr17
|
UTSW |
8 |
55,126,595 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Wdr17
|
UTSW |
8 |
55,123,414 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Wdr17
|
UTSW |
8 |
55,096,220 (GRCm39) |
missense |
probably benign |
0.03 |
|
| Predicted Primers |
PCR Primer
(F):5'- GGCTAATAgtaatggcatacctttaatcccag -3'
(R):5'- GGTTGAATGAAAACCAAGGCATAACATGA -3'
Sequencing Primer
(F):5'- agaacacataaatgaacaggcaag -3'
(R):5'- GGTTGCTAACTGAGAGCATATTACG -3'
|
| Posted On |
2013-09-03 |
Incidental Mutation