Incidental Mutation 'R0734:Olfr1426'
ID68190
Institutional Source Beutler Lab
Gene Symbol Olfr1426
Ensembl Gene ENSMUSG00000044994
Gene Nameolfactory receptor 1426
SynonymsGA_x6K02T2RE5P-2447610-2446675, MOR239-1
MMRRC Submission 038915-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.072) question?
Stock #R0734 (G1)
Quality Score225
Status Validated
Chromosome19
Chromosomal Location12086746-12092013 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 12088119 bp
ZygosityHeterozygous
Amino Acid Change Arginine to Serine at position 224 (R224S)
Ref Sequence ENSEMBL: ENSMUSP00000151988 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000112952] [ENSMUST00000208703] [ENSMUST00000217952] [ENSMUST00000219005] [ENSMUST00000219155] [ENSMUST00000219996] [ENSMUST00000220005]
Predicted Effect probably benign
Transcript: ENSMUST00000112952
AA Change: R224S

PolyPhen 2 Score 0.116 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000108575
Gene: ENSMUSG00000044994
AA Change: R224S

DomainStartEndE-ValueType
Pfam:7tm_4 29 302 2.1e-49 PFAM
Pfam:7tm_1 39 300 1.1e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000208703
AA Change: R224S

PolyPhen 2 Score 0.116 (Sensitivity: 0.93; Specificity: 0.86)
Predicted Effect probably benign
Transcript: ENSMUST00000217952
AA Change: R224S

PolyPhen 2 Score 0.116 (Sensitivity: 0.93; Specificity: 0.86)
Predicted Effect probably benign
Transcript: ENSMUST00000219005
AA Change: R224S

PolyPhen 2 Score 0.116 (Sensitivity: 0.93; Specificity: 0.86)
Predicted Effect probably benign
Transcript: ENSMUST00000219155
AA Change: R224S

PolyPhen 2 Score 0.116 (Sensitivity: 0.93; Specificity: 0.86)
Predicted Effect probably benign
Transcript: ENSMUST00000219996
AA Change: R224S

PolyPhen 2 Score 0.116 (Sensitivity: 0.93; Specificity: 0.86)
Predicted Effect probably benign
Transcript: ENSMUST00000220005
AA Change: R224S

PolyPhen 2 Score 0.116 (Sensitivity: 0.93; Specificity: 0.86)
Meta Mutation Damage Score 0.1216 question?
Coding Region Coverage
  • 1x: 99.5%
  • 3x: 98.8%
  • 10x: 97.0%
  • 20x: 93.3%
Validation Efficiency 99% (80/81)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 75 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930562C15Rik T A 16: 4,850,334 S530T probably benign Het
Acer2 G T 4: 86,917,559 K223N probably benign Het
Adam19 T G 11: 46,127,403 C431G probably damaging Het
Adamts16 T G 13: 70,738,481 probably benign Het
Aox2 A T 1: 58,305,341 E531V probably benign Het
Apaf1 A T 10: 91,037,021 N720K probably benign Het
Atrnl1 T A 19: 57,654,861 W394R probably damaging Het
Bcl6 T C 16: 23,968,139 E634G probably damaging Het
Cfap65 T A 1: 74,918,887 Y954F probably damaging Het
Cobl A G 11: 12,375,971 V168A probably damaging Het
Cped1 C T 6: 22,085,041 P210S probably damaging Het
Crb1 C T 1: 139,337,084 V199M probably benign Het
Cyp2j6 A T 4: 96,523,844 probably benign Het
Dhrs3 C G 4: 144,927,176 S289W probably damaging Het
Dido1 T G 2: 180,660,042 Q2023P probably benign Het
Dlg4 G A 11: 70,042,705 G550R probably damaging Het
Dnah12 C A 14: 26,800,013 H1928N probably benign Het
Dthd1 A C 5: 62,839,410 probably benign Het
Erg C A 16: 95,370,025 G269C possibly damaging Het
Erich6 G A 3: 58,629,388 probably benign Het
F5 G C 1: 164,198,917 R1686P probably damaging Het
Fancc T C 13: 63,331,842 R300G probably damaging Het
Fcer1g T A 1: 171,231,179 K47* probably null Het
Flt4 A G 11: 49,626,717 T289A possibly damaging Het
Gcnt2 T A 13: 40,860,521 F56Y probably benign Het
Gpatch8 G T 11: 102,481,400 S437R unknown Het
Grin2a T A 16: 9,579,611 I871F possibly damaging Het
Hsd17b4 T C 18: 50,170,777 V439A possibly damaging Het
Hykk A T 9: 54,946,432 K346M possibly damaging Het
Ifi208 T C 1: 173,683,335 L352S probably damaging Het
Ikzf1 T C 11: 11,758,195 V110A probably damaging Het
Irak3 A T 10: 120,145,637 probably benign Het
Lamp5 T A 2: 136,059,030 V50E probably damaging Het
Lgr6 C T 1: 134,994,010 A199T probably damaging Het
Lrch3 C T 16: 32,997,483 R570* probably null Het
Map1lc3a T C 2: 155,276,976 V20A possibly damaging Het
Map3k14 C A 11: 103,227,000 K655N probably benign Het
Mark2 A G 19: 7,285,981 probably benign Het
Mbtd1 G A 11: 93,923,146 G205D probably damaging Het
Med13 T C 11: 86,301,237 T861A probably benign Het
Meltf T A 16: 31,881,958 Y99N probably damaging Het
Mex3d G A 10: 80,381,532 T617I possibly damaging Het
Muc13 G A 16: 33,803,082 V249I probably damaging Het
Myo18a C A 11: 77,847,404 P1688Q probably damaging Het
Naaladl1 A T 19: 6,112,874 probably null Het
Ncoa3 T A 2: 166,069,191 probably benign Het
Nf2 T C 11: 4,820,409 T67A probably benign Het
Nin A G 12: 70,030,113 V1056A probably benign Het
Olfr1458 G A 19: 13,103,278 R3C possibly damaging Het
Olfr59 A T 11: 74,288,946 Q100L probably damaging Het
P3h1 T C 4: 119,238,688 L331P probably damaging Het
Pabpc4l T C 3: 46,446,973 K79E possibly damaging Het
Pam T A 1: 97,864,362 R445* probably null Het
Pcdhb6 T C 18: 37,335,334 I436T probably damaging Het
Piezo2 A G 18: 63,041,723 Y1987H probably damaging Het
Plch2 G A 4: 154,996,283 T477I probably damaging Het
Postn G A 3: 54,362,715 G72R probably damaging Het
Proca1 G A 11: 78,201,802 probably benign Het
Psip1 T A 4: 83,463,588 probably benign Het
Ptprd G A 4: 76,140,597 P153L probably damaging Het
Rgl1 T C 1: 152,554,300 D242G probably damaging Het
Ric1 T A 19: 29,594,818 I671K possibly damaging Het
Rxrg T A 1: 167,627,444 C199S probably damaging Het
Sec24c A C 14: 20,693,745 D1006A probably damaging Het
Sec63 A G 10: 42,796,208 T173A probably benign Het
Sfxn5 T C 6: 85,267,865 probably benign Het
Spam1 A G 6: 24,796,949 I300V probably benign Het
Spem1 A G 11: 69,821,271 L189P probably damaging Het
Sptbn2 A T 19: 4,748,123 R1959* probably null Het
Timeless C T 10: 128,250,060 R935W probably damaging Het
Tnfrsf21 C T 17: 43,038,213 H239Y probably benign Het
Trim24 T C 6: 37,919,465 Y286H possibly damaging Het
Ttyh2 A G 11: 114,710,193 probably benign Het
Zbtb21 C T 16: 97,952,627 C180Y probably damaging Het
Zfp746 T C 6: 48,064,899 T298A probably damaging Het
Other mutations in Olfr1426
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00092:Olfr1426 APN 19 12087993 missense probably benign 0.28
IGL01549:Olfr1426 APN 19 12087965 missense probably benign 0.20
IGL02479:Olfr1426 APN 19 12087905 missense probably benign 0.01
IGL03065:Olfr1426 APN 19 12088611 missense possibly damaging 0.91
IGL03092:Olfr1426 APN 19 12087866 nonsense probably null
IGL03046:Olfr1426 UTSW 19 12088027 missense probably damaging 0.98
R1190:Olfr1426 UTSW 19 12088687 missense possibly damaging 0.82
R1990:Olfr1426 UTSW 19 12088256 missense probably damaging 0.98
R2331:Olfr1426 UTSW 19 12088158 missense probably benign 0.00
R3500:Olfr1426 UTSW 19 12088057 missense possibly damaging 0.58
R3768:Olfr1426 UTSW 19 12087940 missense probably damaging 1.00
R3825:Olfr1426 UTSW 19 12088027 missense probably damaging 0.98
R4589:Olfr1426 UTSW 19 12087941 missense possibly damaging 0.61
R5175:Olfr1426 UTSW 19 12088562 missense probably damaging 1.00
R6436:Olfr1426 UTSW 19 12087935 missense probably benign 0.24
R6729:Olfr1426 UTSW 19 12088496 missense probably benign 0.04
R6965:Olfr1426 UTSW 19 12088756 missense possibly damaging 0.95
R7099:Olfr1426 UTSW 19 12088166 missense possibly damaging 0.78
R7393:Olfr1426 UTSW 19 12088628 missense probably benign 0.13
Predicted Primers PCR Primer
(F):5'- GACAGGGTCGAGCTATTGCTCTTC -3'
(R):5'- TTGCCCACTCCATAGTGCAGATTTC -3'

Sequencing Primer
(F):5'- CCTGGTTCCTCAGTGTATAGATCAAG -3'
(R):5'- TGACACTTCCATTCTGTGGAC -3'
Posted On2013-09-03