Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00480:Selenot'

6894

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Selenot

Ensembl Gene

ENSMUSG00000075700

Gene Name

selenoprotein T

Synonyms

5730408P04Rik, SelT, 2810407C02Rik, Selt

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.296) question?

Stock #

IGL00480

Quality Score

Status

Chromosome

Chromosomal Location

58484057-58500554 bp(+) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

T to A at 58493503 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000103557 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000107924]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000107924

SMART Domains

Protein: ENSMUSP00000103557
Gene: ENSMUSG00000075700

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
Pfam:Rdx	40	179	1.9e-18	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000125815

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a conditional allele activated in beta cells exhibit impaired glucose tolerance, increased circulating glucose levels, decreased circulating insulin levels, decreased insulin secretion and an increase in smaller islets. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 18 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acvr1c	A	T	2: 58,205,867 (GRCm39)	V31E	probably damaging	Het
Cdc6	T	C	11: 98,799,597 (GRCm39)	V68A	probably benign	Het
Ceacam23	T	A	7: 17,644,622 (GRCm39)	S580T	probably benign	Het
Cfap46	C	T	7: 139,240,605 (GRCm39)	S56N	probably damaging	Het
Gtf3c1	C	T	7: 125,243,430 (GRCm39)	V1821I	probably benign	Het
Haus3	T	C	5: 34,325,272 (GRCm39)	E129G	probably benign	Het
Ogfr	T	C	2: 180,235,355 (GRCm39)		probably benign	Het
Pabpc1l	G	A	2: 163,884,237 (GRCm39)	V325M	probably damaging	Het
Pou6f1	A	G	15: 100,477,928 (GRCm39)		probably benign	Het
Ppp1r9a	A	T	6: 5,158,195 (GRCm39)	D1201V	possibly damaging	Het
Ppp6r2	A	G	15: 89,149,452 (GRCm39)		probably benign	Het
Scn5a	G	T	9: 119,346,604 (GRCm39)	P1016Q	possibly damaging	Het
Smyd2	C	T	1: 189,632,043 (GRCm39)	R107Q	probably damaging	Het
Tgoln1	T	C	6: 72,593,073 (GRCm39)	K136E	probably benign	Het
Trio	T	C	15: 27,912,829 (GRCm39)		probably benign	Het
Usp24	T	C	4: 106,225,303 (GRCm39)	I645T	probably damaging	Het
Uts2r	T	A	11: 121,051,172 (GRCm39)	M12K	probably benign	Het
Zfp772	T	C	7: 7,207,115 (GRCm39)	N192S	probably benign	Het

Other mutations in Selenot

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R4335:Selenot	UTSW	3	58,492,722 (GRCm39)	missense	possibly damaging	0.87
R5023:Selenot	UTSW	3	58,495,874 (GRCm39)	frame shift	probably null
R5078:Selenot	UTSW	3	58,492,692 (GRCm39)	missense	probably damaging	1.00
R5353:Selenot	UTSW	3	58,493,387 (GRCm39)	missense	possibly damaging	0.78
R5554:Selenot	UTSW	3	58,484,296 (GRCm39)	critical splice donor site	probably null
R5691:Selenot	UTSW	3	58,493,447 (GRCm39)	missense	probably benign	0.38
R6137:Selenot	UTSW	3	58,492,705 (GRCm39)	missense	probably damaging	1.00
R7532:Selenot	UTSW	3	58,492,653 (GRCm39)	missense	probably benign	0.01
R8482:Selenot	UTSW	3	58,495,889 (GRCm39)	missense	probably damaging	1.00
R8504:Selenot	UTSW	3	58,492,698 (GRCm39)	missense	probably benign	0.36

Posted On

2012-04-20