Incidental Mutation 'V7580:Or10j7'
ID 69395
Institutional Source Beutler Lab
Gene Symbol Or10j7
Ensembl Gene ENSMUSG00000058981
Gene Name olfactory receptor family 10 subfamily J member 7
Synonyms GA_x6K02T2R7CC-664297-665229, MOR267-5, Olfr1406
Accession Numbers
Essential gene? Probably non essential (E-score: 0.081) question?
Stock # V7580 () of strain stinger
Quality Score 225
Status Not validated
Chromosome 1
Chromosomal Location 173011009-173012071 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 173011531 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Isoleucine at position 157 (L157I)
Ref Sequence ENSEMBL: ENSMUSP00000151023 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000072395] [ENSMUST00000201132] [ENSMUST00000215878]
AlphaFold E9Q8X1
Predicted Effect probably benign
Transcript: ENSMUST00000072395
AA Change: L157I

PolyPhen 2 Score 0.045 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000072231
Gene: ENSMUSG00000058981
AA Change: L157I

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 3.9e-55 PFAM
Pfam:7tm_1 41 289 2.7e-17 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000201132
AA Change: L157I

PolyPhen 2 Score 0.045 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000144530
Gene: ENSMUSG00000058981
AA Change: L157I

DomainStartEndE-ValueType
Pfam:7tm_4 31 88 5.4e-11 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000215878
AA Change: L157I

PolyPhen 2 Score 0.045 (Sensitivity: 0.94; Specificity: 0.83)
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.5%
  • 3x: 99.0%
  • 10x: 97.8%
  • 20x: 96.0%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb5 T A 12: 118,849,914 (GRCm39) M950L probably benign Het
Atp6v1h A G 1: 5,194,666 (GRCm39) T282A possibly damaging Het
Casp8ap2 C T 4: 32,639,944 (GRCm39) H333Y probably benign Het
Cd36 ACTGTCTGT ACTGT 5: 18,025,526 (GRCm39) probably null Het
Cfi T A 3: 129,648,641 (GRCm39) I175K possibly damaging Het
D630003M21Rik T C 2: 158,042,931 (GRCm39) T870A probably benign Het
Dnah12 T A 14: 26,495,050 (GRCm39) N1369K possibly damaging Het
Dnajc22 T A 15: 98,999,363 (GRCm39) Y183N probably damaging Het
Erv3 T C 2: 131,697,846 (GRCm39) H171R possibly damaging Het
Fam221b T C 4: 43,665,865 (GRCm39) T249A probably benign Het
Gm10770 T A 2: 150,021,404 (GRCm39) K38* probably null Het
Gm4787 G A 12: 81,424,341 (GRCm39) Q606* probably null Het
Izumo4 A T 10: 80,539,725 (GRCm39) T155S probably benign Het
Kcnb2 A G 1: 15,780,315 (GRCm39) I396V probably benign Het
Klc1 A T 12: 111,741,006 (GRCm39) I161F probably benign Het
Lpar5 C A 6: 125,058,690 (GRCm39) A137E possibly damaging Het
Lrp4 C T 2: 91,318,863 (GRCm39) S900L possibly damaging Het
Lrrc37a T G 11: 103,346,338 (GRCm39) N3176T possibly damaging Het
Med20 G A 17: 47,929,757 (GRCm39) V65M probably damaging Het
Mylk G T 16: 34,815,574 (GRCm39) probably null Het
Numbl T C 7: 26,979,027 (GRCm39) S379P probably benign Het
Or5an6 G A 19: 12,371,914 (GRCm39) V96I probably benign Het
Otop3 T A 11: 115,235,664 (GRCm39) L432Q probably damaging Het
Papln C T 12: 83,825,608 (GRCm39) R608C possibly damaging Het
Pelp1 T A 11: 70,288,976 (GRCm39) T257S probably damaging Het
Pigx T C 16: 31,906,240 (GRCm39) D129G probably damaging Het
Pik3cd A C 4: 149,741,776 (GRCm39) L390R probably damaging Het
Plekhb1 T C 7: 100,303,825 (GRCm39) T112A probably benign Het
Ppwd1 A G 13: 104,356,745 (GRCm39) Y257H probably damaging Het
Recql4 T C 15: 76,590,369 (GRCm39) D705G possibly damaging Het
Ror1 A G 4: 100,298,130 (GRCm39) Q501R probably damaging Het
Slc30a4 T A 2: 122,531,458 (GRCm39) M136L probably benign Het
Spaca1 T C 4: 34,039,311 (GRCm39) E192G probably damaging Het
Spata31 C A 13: 65,069,462 (GRCm39) P537T probably benign Het
Sptbn2 C T 19: 4,800,660 (GRCm39) R2292C probably damaging Het
Tnrc6c G A 11: 117,614,152 (GRCm39) R770H probably damaging Het
Trps1 T C 15: 50,694,973 (GRCm39) K150E probably damaging Het
Tspyl3 A G 2: 153,066,980 (GRCm39) V86A probably benign Het
Zfp292 C T 4: 34,806,783 (GRCm39) C2087Y possibly damaging Het
Zmynd8 G A 2: 165,654,314 (GRCm39) R724* probably null Het
Other mutations in Or10j7
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00946:Or10j7 APN 1 173,011,190 (GRCm39) missense probably benign 0.45
IGL01609:Or10j7 APN 1 173,011,843 (GRCm39) missense probably benign 0.00
IGL01996:Or10j7 APN 1 173,011,294 (GRCm39) missense probably benign 0.00
F5770:Or10j7 UTSW 1 173,011,531 (GRCm39) missense probably benign 0.05
PIT4378001:Or10j7 UTSW 1 173,011,381 (GRCm39) missense probably benign 0.00
R0053:Or10j7 UTSW 1 173,011,845 (GRCm39) missense probably benign 0.35
R0800:Or10j7 UTSW 1 173,011,627 (GRCm39) missense probably damaging 1.00
R1793:Or10j7 UTSW 1 173,011,976 (GRCm39) missense probably benign
R2230:Or10j7 UTSW 1 173,011,182 (GRCm39) missense probably benign 0.04
R2232:Or10j7 UTSW 1 173,011,182 (GRCm39) missense probably benign 0.04
R5395:Or10j7 UTSW 1 173,011,247 (GRCm39) nonsense probably null
R5455:Or10j7 UTSW 1 173,011,818 (GRCm39) missense probably damaging 1.00
R5457:Or10j7 UTSW 1 173,011,180 (GRCm39) missense probably damaging 1.00
R5558:Or10j7 UTSW 1 173,011,585 (GRCm39) missense probably benign 0.01
R5760:Or10j7 UTSW 1 173,011,318 (GRCm39) missense probably benign 0.05
R6285:Or10j7 UTSW 1 173,011,477 (GRCm39) missense probably damaging 1.00
R7159:Or10j7 UTSW 1 173,011,890 (GRCm39) missense possibly damaging 0.95
R7676:Or10j7 UTSW 1 173,011,120 (GRCm39) nonsense probably null
R8700:Or10j7 UTSW 1 173,011,429 (GRCm39) missense probably benign
R8829:Or10j7 UTSW 1 173,011,458 (GRCm39) missense probably benign 0.06
R9721:Or10j7 UTSW 1 173,011,915 (GRCm39) missense probably benign 0.07
R9785:Or10j7 UTSW 1 173,011,458 (GRCm39) missense probably benign 0.06
R9788:Or10j7 UTSW 1 173,011,458 (GRCm39) missense probably benign 0.06
R9789:Or10j7 UTSW 1 173,011,458 (GRCm39) missense probably benign 0.06
V7581:Or10j7 UTSW 1 173,011,531 (GRCm39) missense probably benign 0.05
V7582:Or10j7 UTSW 1 173,011,531 (GRCm39) missense probably benign 0.05
Predicted Primers PCR Primer
(F):5'- GGGCTGTGATGACCATAAGGCTAAG -3'
(R):5'- TGACCATTATCCGCATTGACCACC -3'

Sequencing Primer
(F):5'- TGACCATAAGGCTAAGAGCTAAC -3'
(R):5'- TTGTAGGTCTGAGCCAAACC -3'
Posted On 2013-09-04