Incidental Mutation 'V7580:Gm10770'
ID69399
Institutional Source Beutler Lab
Gene Symbol Gm10770
Ensembl Gene ENSMUSG00000074837
Gene Namepredicted gene 10770
Synonyms
Accession Numbers
Is this an essential gene? Possibly non essential (E-score: 0.292) question?
Stock #V7580 () of strain stinger
Quality Score225
Status Not validated
Chromosome2
Chromosomal Location150178882-150179679 bp(-) (GRCm38)
Type of Mutationnonsense
DNA Base Change (assembly) T to A at 150179484 bp
ZygosityHeterozygous
Amino Acid Change Lysine to Stop codon at position 38 (K38*)
Ref Sequence ENSEMBL: ENSMUSP00000097015 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099418] [ENSMUST00000109926]
Predicted Effect probably null
Transcript: ENSMUST00000099418
AA Change: K38*
SMART Domains Protein: ENSMUSP00000097015
Gene: ENSMUSG00000074837
AA Change: K38*

DomainStartEndE-ValueType
ZnF_C2H2 12 34 8.09e0 SMART
ZnF_C2H2 40 62 8.4e1 SMART
ZnF_C2H2 68 90 1.12e-3 SMART
ZnF_C2H2 96 118 3.47e1 SMART
ZnF_C2H2 124 146 1.09e2 SMART
ZnF_C2H2 152 174 3.58e-2 SMART
ZnF_C2H2 180 202 6.23e-2 SMART
ZnF_C2H2 208 230 2.49e-1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000109926
SMART Domains Protein: ENSMUSP00000105552
Gene: ENSMUSG00000079009

DomainStartEndE-ValueType
Blast:KRAB 1 34 7e-15 BLAST
ZnF_C2H2 71 93 8.6e-5 SMART
ZnF_C2H2 99 121 1.76e-1 SMART
ZnF_C2H2 127 149 3.02e0 SMART
ZnF_C2H2 183 205 6.08e-5 SMART
ZnF_C2H2 211 233 1.04e-3 SMART
ZnF_C2H2 239 261 2.57e-3 SMART
ZnF_C2H2 267 289 1.06e-4 SMART
ZnF_C2H2 295 317 2.2e-2 SMART
ZnF_C2H2 323 345 4.47e-3 SMART
ZnF_C2H2 351 373 7.37e-4 SMART
ZnF_C2H2 379 401 4.24e-4 SMART
ZnF_C2H2 407 429 1.2e-3 SMART
ZnF_C2H2 435 457 2.61e-4 SMART
Meta Mutation Damage Score 0.706 question?
Coding Region Coverage
  • 1x: 99.5%
  • 3x: 99.0%
  • 10x: 97.8%
  • 20x: 96.0%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb5 T A 12: 118,886,179 M950L probably benign Het
Atp6v1h A G 1: 5,124,443 T282A possibly damaging Het
Casp8ap2 C T 4: 32,639,944 H333Y probably benign Het
Cd36 ACTGTCTGT ACTGT 5: 17,820,528 probably null Het
Cfi T A 3: 129,854,992 I175K possibly damaging Het
D630003M21Rik T C 2: 158,201,011 T870A probably benign Het
Dnah12 T A 14: 26,773,093 N1369K possibly damaging Het
Dnajc22 T A 15: 99,101,482 Y183N probably damaging Het
Erv3 T C 2: 131,855,926 H171R possibly damaging Het
Fam221b T C 4: 43,665,865 T249A probably benign Het
Gm4787 G A 12: 81,377,567 Q606* probably null Het
Izumo4 A T 10: 80,703,891 T155S probably benign Het
Kcnb2 A G 1: 15,710,091 I396V probably benign Het
Klc1 A T 12: 111,774,572 I161F probably benign Het
Lpar5 C A 6: 125,081,727 A137E possibly damaging Het
Lrp4 C T 2: 91,488,518 S900L possibly damaging Het
Lrrc37a T G 11: 103,455,512 N3176T possibly damaging Het
Med20 G A 17: 47,618,832 V65M probably damaging Het
Mylk G T 16: 34,995,204 probably null Het
Numbl T C 7: 27,279,602 S379P probably benign Het
Olfr1406 G T 1: 173,183,964 L157I probably benign Het
Olfr1440 G A 19: 12,394,550 V96I probably benign Het
Otop3 T A 11: 115,344,838 L432Q probably damaging Het
Papln C T 12: 83,778,834 R608C possibly damaging Het
Pelp1 T A 11: 70,398,150 T257S probably damaging Het
Pigx T C 16: 32,087,422 D129G probably damaging Het
Pik3cd A C 4: 149,657,319 L390R probably damaging Het
Plekhb1 T C 7: 100,654,618 T112A probably benign Het
Ppwd1 A G 13: 104,220,237 Y257H probably damaging Het
Recql4 T C 15: 76,706,169 D705G possibly damaging Het
Ror1 A G 4: 100,440,933 Q501R probably damaging Het
Slc30a4 T A 2: 122,689,538 M136L probably benign Het
Spaca1 T C 4: 34,039,311 E192G probably damaging Het
Spata31 C A 13: 64,921,648 P537T probably benign Het
Sptbn2 C T 19: 4,750,632 R2292C probably damaging Het
Tnrc6c G A 11: 117,723,326 R770H probably damaging Het
Trps1 T C 15: 50,831,577 K150E probably damaging Het
Tspyl3 A G 2: 153,225,060 V86A probably benign Het
Zfp292 C T 4: 34,806,783 C2087Y possibly damaging Het
Zmynd8 G A 2: 165,812,394 R724* probably null Het
Other mutations in Gm10770
AlleleSourceChrCoordTypePredicted EffectPPH Score
F5770:Gm10770 UTSW 2 150179484 nonsense probably null
R1765:Gm10770 UTSW 2 150179338 missense probably damaging 1.00
R1842:Gm10770 UTSW 2 150179156 missense probably damaging 1.00
R3438:Gm10770 UTSW 2 150179549 unclassified probably null
R4564:Gm10770 UTSW 2 150178911 missense probably benign 0.00
R4863:Gm10770 UTSW 2 150178896 nonsense probably null
R5134:Gm10770 UTSW 2 150179560 splice site probably null
R5424:Gm10770 UTSW 2 150179028 missense probably benign 0.01
R5429:Gm10770 UTSW 2 150179423 missense probably benign 0.00
R5976:Gm10770 UTSW 2 150179400 nonsense probably null
R6436:Gm10770 UTSW 2 150178910 missense probably benign 0.07
R6679:Gm10770 UTSW 2 150179649 missense probably damaging 1.00
V7581:Gm10770 UTSW 2 150179484 nonsense probably null
V7583:Gm10770 UTSW 2 150179484 nonsense probably null
Predicted Primers
Posted On2013-09-04