Incidental Mutation 'V7580:Lpar5'
ID 69411
Institutional Source Beutler Lab
Gene Symbol Lpar5
Ensembl Gene ENSMUSG00000067714
Gene Name lysophosphatidic acid receptor 5
Synonyms Gpr92, LOC381810, GPR93, LPA5
Accession Numbers
Essential gene? Probably non essential (E-score: 0.074) question?
Stock # V7580 () of strain stinger
Quality Score 128
Status Not validated
Chromosome 6
Chromosomal Location 125044883-125059435 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 125058690 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Alanine to Glutamic Acid at position 137 (A137E)
Ref Sequence ENSEMBL: ENSMUSP00000119904 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000088292] [ENSMUST00000140346] [ENSMUST00000171989]
AlphaFold no structure available at present
Predicted Effect possibly damaging
Transcript: ENSMUST00000088292
AA Change: A137E

PolyPhen 2 Score 0.502 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000085630
Gene: ENSMUSG00000067714
AA Change: A137E

DomainStartEndE-ValueType
low complexity region 15 27 N/A INTRINSIC
Pfam:7tm_1 55 313 7.4e-40 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000140346
AA Change: A137E

PolyPhen 2 Score 0.883 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000119904
Gene: ENSMUSG00000067714
AA Change: A137E

DomainStartEndE-ValueType
low complexity region 15 27 N/A INTRINSIC
Pfam:7tm_1 55 164 1.5e-30 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000171989
AA Change: A137E

PolyPhen 2 Score 0.502 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000132511
Gene: ENSMUSG00000067714
AA Change: A137E

DomainStartEndE-ValueType
low complexity region 15 27 N/A INTRINSIC
Pfam:7tm_1 55 313 1.1e-48 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000203956
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.5%
  • 3x: 99.0%
  • 10x: 97.8%
  • 20x: 96.0%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the rhodopsin class of G protein-coupled transmembrane receptors. This protein transmits extracellular signals from lysophosphatidic acid to cells through heterotrimeric G proteins and mediates numerous cellular processes. Many G protein receptors serve as targets for pharmaceutical drugs. Transcript variants of this gene have been described.[provided by RefSeq, Dec 2008]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit resistance to neuropathic pain and myelin sheath alterations. Mice homozygous for a different targeted allele exhibit decreased nociception sensitivity, decreased anxiety-related response and enhanced coordination and spatial learning. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb5 T A 12: 118,849,914 (GRCm39) M950L probably benign Het
Atp6v1h A G 1: 5,194,666 (GRCm39) T282A possibly damaging Het
Casp8ap2 C T 4: 32,639,944 (GRCm39) H333Y probably benign Het
Cd36 ACTGTCTGT ACTGT 5: 18,025,526 (GRCm39) probably null Het
Cfi T A 3: 129,648,641 (GRCm39) I175K possibly damaging Het
D630003M21Rik T C 2: 158,042,931 (GRCm39) T870A probably benign Het
Dnah12 T A 14: 26,495,050 (GRCm39) N1369K possibly damaging Het
Dnajc22 T A 15: 98,999,363 (GRCm39) Y183N probably damaging Het
Erv3 T C 2: 131,697,846 (GRCm39) H171R possibly damaging Het
Fam221b T C 4: 43,665,865 (GRCm39) T249A probably benign Het
Gm10770 T A 2: 150,021,404 (GRCm39) K38* probably null Het
Gm4787 G A 12: 81,424,341 (GRCm39) Q606* probably null Het
Izumo4 A T 10: 80,539,725 (GRCm39) T155S probably benign Het
Kcnb2 A G 1: 15,780,315 (GRCm39) I396V probably benign Het
Klc1 A T 12: 111,741,006 (GRCm39) I161F probably benign Het
Lrp4 C T 2: 91,318,863 (GRCm39) S900L possibly damaging Het
Lrrc37a T G 11: 103,346,338 (GRCm39) N3176T possibly damaging Het
Med20 G A 17: 47,929,757 (GRCm39) V65M probably damaging Het
Mylk G T 16: 34,815,574 (GRCm39) probably null Het
Numbl T C 7: 26,979,027 (GRCm39) S379P probably benign Het
Or10j7 G T 1: 173,011,531 (GRCm39) L157I probably benign Het
Or5an6 G A 19: 12,371,914 (GRCm39) V96I probably benign Het
Otop3 T A 11: 115,235,664 (GRCm39) L432Q probably damaging Het
Papln C T 12: 83,825,608 (GRCm39) R608C possibly damaging Het
Pelp1 T A 11: 70,288,976 (GRCm39) T257S probably damaging Het
Pigx T C 16: 31,906,240 (GRCm39) D129G probably damaging Het
Pik3cd A C 4: 149,741,776 (GRCm39) L390R probably damaging Het
Plekhb1 T C 7: 100,303,825 (GRCm39) T112A probably benign Het
Ppwd1 A G 13: 104,356,745 (GRCm39) Y257H probably damaging Het
Recql4 T C 15: 76,590,369 (GRCm39) D705G possibly damaging Het
Ror1 A G 4: 100,298,130 (GRCm39) Q501R probably damaging Het
Slc30a4 T A 2: 122,531,458 (GRCm39) M136L probably benign Het
Spaca1 T C 4: 34,039,311 (GRCm39) E192G probably damaging Het
Spata31 C A 13: 65,069,462 (GRCm39) P537T probably benign Het
Sptbn2 C T 19: 4,800,660 (GRCm39) R2292C probably damaging Het
Tnrc6c G A 11: 117,614,152 (GRCm39) R770H probably damaging Het
Trps1 T C 15: 50,694,973 (GRCm39) K150E probably damaging Het
Tspyl3 A G 2: 153,066,980 (GRCm39) V86A probably benign Het
Zfp292 C T 4: 34,806,783 (GRCm39) C2087Y possibly damaging Het
Zmynd8 G A 2: 165,654,314 (GRCm39) R724* probably null Het
Other mutations in Lpar5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01719:Lpar5 APN 6 125,058,969 (GRCm39) missense possibly damaging 0.94
IGL01830:Lpar5 APN 6 125,058,785 (GRCm39) missense probably benign 0.01
IGL01975:Lpar5 APN 6 125,058,750 (GRCm39) missense probably damaging 0.99
IGL02021:Lpar5 APN 6 125,058,955 (GRCm39) nonsense probably null
IGL02718:Lpar5 APN 6 125,059,207 (GRCm39) missense probably damaging 1.00
IGL03027:Lpar5 APN 6 125,059,203 (GRCm39) missense probably damaging 1.00
IGL03300:Lpar5 APN 6 125,059,203 (GRCm39) missense probably damaging 1.00
F5770:Lpar5 UTSW 6 125,058,690 (GRCm39) missense possibly damaging 0.88
R0633:Lpar5 UTSW 6 125,058,954 (GRCm39) missense probably benign 0.25
R1639:Lpar5 UTSW 6 125,058,564 (GRCm39) missense probably damaging 1.00
R1822:Lpar5 UTSW 6 125,058,378 (GRCm39) missense possibly damaging 0.76
R2227:Lpar5 UTSW 6 125,058,098 (GRCm39) critical splice acceptor site probably null
R4019:Lpar5 UTSW 6 125,058,638 (GRCm39) missense probably damaging 1.00
R4288:Lpar5 UTSW 6 125,058,827 (GRCm39) missense probably benign 0.00
R4705:Lpar5 UTSW 6 125,059,170 (GRCm39) missense possibly damaging 0.64
R4787:Lpar5 UTSW 6 125,059,461 (GRCm39) splice site probably null
R5027:Lpar5 UTSW 6 125,059,110 (GRCm39) missense possibly damaging 0.69
R6114:Lpar5 UTSW 6 125,058,639 (GRCm39) missense probably damaging 1.00
R7197:Lpar5 UTSW 6 125,059,347 (GRCm39) missense probably benign 0.00
R7779:Lpar5 UTSW 6 125,059,207 (GRCm39) missense probably damaging 1.00
R8193:Lpar5 UTSW 6 125,058,302 (GRCm39) missense probably benign
R8264:Lpar5 UTSW 6 125,058,465 (GRCm39) missense probably damaging 1.00
R9460:Lpar5 UTSW 6 125,058,234 (GRCm39) start gained probably benign
R9628:Lpar5 UTSW 6 125,058,948 (GRCm39) missense probably damaging 0.96
V7581:Lpar5 UTSW 6 125,058,690 (GRCm39) missense possibly damaging 0.88
V7582:Lpar5 UTSW 6 125,058,690 (GRCm39) missense possibly damaging 0.88
Z1176:Lpar5 UTSW 6 125,059,035 (GRCm39) missense probably damaging 1.00
Z1176:Lpar5 UTSW 6 125,058,342 (GRCm39) missense possibly damaging 0.92
Z1177:Lpar5 UTSW 6 125,058,981 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TTGCCAATTCTTCAGCCAACACGAC -3'
(R):5'- AAGCACAGGCGCACAGTGATGTTC -3'

Sequencing Primer
(F):5'- GTGCCCTGACTATCGAGATAC -3'
(R):5'- CACAGCGAACAGCAGGAT -3'
Posted On 2013-09-04