Incidental Mutation 'R0761:Or11g27'
ID 70104
Institutional Source Beutler Lab
Gene Symbol Or11g27
Ensembl Gene ENSMUSG00000094285
Gene Name olfactory receptor family 11 subfamily G member 27
Synonyms GA_x6K02T2PMLR-6243196-6244132, MOR106-8P, Olfr264, Olfr743, Olfr743-ps1, Olfr265, GA_x6K02T2N6FY-2320-2039, GA_x6K02T2N6FY-3870-3385, MOR106-14
MMRRC Submission 038941-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.093) question?
Stock # R0761 (G1)
Quality Score 225
Status Validated
Chromosome 14
Chromosomal Location 50770871-50771806 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 50771159 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 97 (S97P)
Ref Sequence ENSEMBL: ENSMUSP00000150946 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071294] [ENSMUST00000215793]
AlphaFold L7N1Y2
Predicted Effect possibly damaging
Transcript: ENSMUST00000071294
AA Change: S97P

PolyPhen 2 Score 0.780 (Sensitivity: 0.85; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000071263
Gene: ENSMUSG00000094285
AA Change: S97P

DomainStartEndE-ValueType
Pfam:7tm_4 35 311 1.6e-56 PFAM
Pfam:7tm_1 45 294 1e-21 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000215793
AA Change: S97P

PolyPhen 2 Score 0.780 (Sensitivity: 0.85; Specificity: 0.93)
Meta Mutation Damage Score 0.1199 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.3%
  • 20x: 94.7%
Validation Efficiency 100% (51/51)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2610008E11Rik T C 10: 78,903,833 (GRCm39) Y133C probably benign Het
Adcy5 G A 16: 35,091,195 (GRCm39) probably benign Het
Asb17 A G 3: 153,550,052 (GRCm39) K28R probably damaging Het
Bbs10 G T 10: 111,135,244 (GRCm39) C119F probably damaging Het
Camk2g G A 14: 20,816,280 (GRCm39) Q119* probably null Het
Cdh18 A T 15: 23,226,838 (GRCm39) I46L possibly damaging Het
Cimip2a T C 2: 25,110,135 (GRCm39) probably benign Het
Clmn T A 12: 104,747,817 (GRCm39) N577Y probably damaging Het
Col1a2 G A 6: 4,518,822 (GRCm39) probably benign Het
Crocc T C 4: 140,774,387 (GRCm39) E63G probably benign Het
Crocc T C 4: 140,757,087 (GRCm39) T965A probably benign Het
Cryzl2 A G 1: 157,293,294 (GRCm39) I132V probably benign Het
Csgalnact2 T C 6: 118,103,073 (GRCm39) probably benign Het
Ctr9 T C 7: 110,645,479 (GRCm39) S569P probably damaging Het
Cul3 A G 1: 80,255,203 (GRCm39) probably benign Het
Dcp2 G A 18: 44,543,300 (GRCm39) S286N probably benign Het
Dgkz C T 2: 91,775,696 (GRCm39) R189H probably benign Het
Dst A G 1: 34,221,848 (GRCm39) T2551A probably benign Het
Kcna4 T A 2: 107,126,417 (GRCm39) S384T probably benign Het
Klhl17 T C 4: 156,317,204 (GRCm39) probably null Het
Kmt2e C A 5: 23,708,032 (GRCm39) S1865* probably null Het
L3mbtl1 G A 2: 162,807,967 (GRCm39) R534H probably damaging Het
Lmnb2 A T 10: 80,742,088 (GRCm39) M1K probably null Het
Lrp1b T C 2: 41,075,947 (GRCm39) D1784G probably damaging Het
Lrrc34 A G 3: 30,685,425 (GRCm39) probably null Het
Megf10 C A 18: 57,421,048 (GRCm39) Y895* probably null Het
Mesd G T 7: 83,544,951 (GRCm39) A143S probably damaging Het
Mfap3l G T 8: 61,124,615 (GRCm39) V286L possibly damaging Het
Mroh2a G A 1: 88,171,672 (GRCm39) R770Q probably damaging Het
Nek1 T A 8: 61,542,489 (GRCm39) D717E probably benign Het
Nudt12 A T 17: 59,318,064 (GRCm39) D60E probably benign Het
Nup205 C T 6: 35,173,363 (GRCm39) probably benign Het
Or2j3 A T 17: 38,616,282 (GRCm39) H23Q probably benign Het
Or4a75 T C 2: 89,448,179 (GRCm39) D119G probably damaging Het
Or5w19 C T 2: 87,698,880 (GRCm39) P182S possibly damaging Het
Pacs2 T A 12: 113,023,688 (GRCm39) probably benign Het
Pcdha9 T A 18: 37,133,016 (GRCm39) L695* probably null Het
Pira12 A T 7: 3,896,978 (GRCm39) probably null Het
Pkd1l1 A G 11: 8,804,375 (GRCm39) S1739P probably damaging Het
Polr1e C A 4: 45,027,392 (GRCm39) D207E probably damaging Het
Polr3f T A 2: 144,376,327 (GRCm39) V142E probably damaging Het
Psma6 T A 12: 55,459,127 (GRCm39) W170R possibly damaging Het
Rev3l T C 10: 39,750,191 (GRCm39) Y3114H probably benign Het
Rps6ka5 C T 12: 100,537,141 (GRCm39) A530T probably damaging Het
Simc1 T C 13: 54,674,387 (GRCm39) Y912H probably damaging Het
Tnfrsf1b T C 4: 144,942,670 (GRCm39) D371G possibly damaging Het
Trank1 T C 9: 111,195,681 (GRCm39) V1235A probably damaging Het
Ttn T C 2: 76,577,102 (GRCm39) E24597G probably damaging Het
Ubr2 G A 17: 47,294,242 (GRCm39) P297L probably damaging Het
Unc5d A T 8: 29,186,560 (GRCm39) probably null Het
Xpo4 A G 14: 57,850,840 (GRCm39) F355L probably damaging Het
Other mutations in Or11g27
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01128:Or11g27 APN 14 50,771,406 (GRCm39) missense probably damaging 1.00
IGL01551:Or11g27 APN 14 50,771,618 (GRCm39) missense probably benign
IGL02024:Or11g27 APN 14 50,771,307 (GRCm39) missense probably benign 0.00
IGL02867:Or11g27 APN 14 50,770,970 (GRCm39) missense probably benign
IGL02889:Or11g27 APN 14 50,770,970 (GRCm39) missense probably benign
IGL03195:Or11g27 APN 14 50,770,877 (GRCm39) missense probably benign
IGL03296:Or11g27 APN 14 50,771,402 (GRCm39) missense possibly damaging 0.90
R0049:Or11g27 UTSW 14 50,771,151 (GRCm39) missense probably damaging 1.00
R0049:Or11g27 UTSW 14 50,771,151 (GRCm39) missense probably damaging 1.00
R0102:Or11g27 UTSW 14 50,771,088 (GRCm39) missense probably damaging 1.00
R0556:Or11g27 UTSW 14 50,771,381 (GRCm39) missense probably benign 0.01
R0626:Or11g27 UTSW 14 50,771,159 (GRCm39) missense possibly damaging 0.78
R0661:Or11g27 UTSW 14 50,771,552 (GRCm39) missense probably benign
R0759:Or11g27 UTSW 14 50,771,159 (GRCm39) missense possibly damaging 0.78
R0894:Or11g27 UTSW 14 50,771,159 (GRCm39) missense possibly damaging 0.78
R1109:Or11g27 UTSW 14 50,771,159 (GRCm39) missense possibly damaging 0.78
R1110:Or11g27 UTSW 14 50,771,159 (GRCm39) missense possibly damaging 0.78
R1312:Or11g27 UTSW 14 50,771,652 (GRCm39) missense probably benign
R1446:Or11g27 UTSW 14 50,771,159 (GRCm39) missense possibly damaging 0.78
R1470:Or11g27 UTSW 14 50,771,159 (GRCm39) missense possibly damaging 0.78
R1470:Or11g27 UTSW 14 50,771,159 (GRCm39) missense possibly damaging 0.78
R1502:Or11g27 UTSW 14 50,771,234 (GRCm39) missense possibly damaging 0.47
R1518:Or11g27 UTSW 14 50,771,622 (GRCm39) missense probably damaging 1.00
R1529:Or11g27 UTSW 14 50,771,159 (GRCm39) missense possibly damaging 0.78
R1624:Or11g27 UTSW 14 50,771,100 (GRCm39) missense probably damaging 1.00
R1646:Or11g27 UTSW 14 50,771,040 (GRCm39) missense probably benign 0.01
R1687:Or11g27 UTSW 14 50,771,159 (GRCm39) missense possibly damaging 0.78
R1795:Or11g27 UTSW 14 50,771,159 (GRCm39) missense possibly damaging 0.78
R2011:Or11g27 UTSW 14 50,771,141 (GRCm39) missense probably damaging 1.00
R2120:Or11g27 UTSW 14 50,771,403 (GRCm39) missense probably damaging 1.00
R2697:Or11g27 UTSW 14 50,771,238 (GRCm39) missense probably damaging 1.00
R2857:Or11g27 UTSW 14 50,770,897 (GRCm39) missense probably benign 0.19
R2858:Or11g27 UTSW 14 50,770,897 (GRCm39) missense probably benign 0.19
R3906:Or11g27 UTSW 14 50,771,211 (GRCm39) missense probably benign 0.03
R4327:Or11g27 UTSW 14 50,770,971 (GRCm39) missense probably benign 0.05
R4355:Or11g27 UTSW 14 50,771,216 (GRCm39) missense possibly damaging 0.94
R4663:Or11g27 UTSW 14 50,771,061 (GRCm39) missense probably damaging 1.00
R5214:Or11g27 UTSW 14 50,771,804 (GRCm39) makesense probably null
R5964:Or11g27 UTSW 14 50,771,655 (GRCm39) missense probably damaging 0.99
R6148:Or11g27 UTSW 14 50,771,778 (GRCm39) missense probably benign 0.00
R6167:Or11g27 UTSW 14 50,771,612 (GRCm39) missense probably damaging 1.00
R6301:Or11g27 UTSW 14 50,771,711 (GRCm39) missense probably benign 0.02
R6616:Or11g27 UTSW 14 50,771,364 (GRCm39) missense probably benign 0.43
R6910:Or11g27 UTSW 14 50,771,330 (GRCm39) missense probably benign 0.31
R7076:Or11g27 UTSW 14 50,771,278 (GRCm39) nonsense probably null
R7483:Or11g27 UTSW 14 50,771,472 (GRCm39) missense probably benign 0.06
R7574:Or11g27 UTSW 14 50,771,770 (GRCm39) missense probably benign 0.01
R7731:Or11g27 UTSW 14 50,771,141 (GRCm39) missense probably damaging 0.99
R8691:Or11g27 UTSW 14 50,770,910 (GRCm39) missense probably benign 0.01
R9072:Or11g27 UTSW 14 50,771,211 (GRCm39) missense probably benign 0.03
R9073:Or11g27 UTSW 14 50,771,211 (GRCm39) missense probably benign 0.03
R9321:Or11g27 UTSW 14 50,771,471 (GRCm39) missense probably benign 0.01
R9478:Or11g27 UTSW 14 50,771,051 (GRCm39) missense probably benign 0.01
R9557:Or11g27 UTSW 14 50,771,552 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- TGGTGCTTTCACAGAACACAGACAG -3'
(R):5'- ACTGATCACAAGGATGTTGCAGAGG -3'

Sequencing Primer
(F):5'- ACAGGCTTCATCCTTTTGGG -3'
(R):5'- GCGCCTAGTCATGAGAGAAG -3'
Posted On 2013-09-30