Incidental Mutation 'R0749:Mcpt2'
ID 70264
Institutional Source Beutler Lab
Gene Symbol Mcpt2
Ensembl Gene ENSMUSG00000022226
Gene Name mast cell protease 2
Synonyms Mcp-2, MMCP-2, MMCP-2
MMRRC Submission 038929-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.052) question?
Stock # R0749 (G1)
Quality Score 225
Status Not validated
Chromosome 14
Chromosomal Location 56279498-56282099 bp(+) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) A to G at 56281136 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000015576 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000015576]
AlphaFold P15119
Predicted Effect probably null
Transcript: ENSMUST00000015576
SMART Domains Protein: ENSMUSP00000015576
Gene: ENSMUSG00000022226

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Tryp_SPc 20 237 2.09e-86 SMART
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.3%
  • 20x: 94.5%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 27 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aprt A T 8: 123,302,149 (GRCm39) Y105N probably damaging Het
Atxn2l A T 7: 126,100,009 (GRCm39) S109T possibly damaging Het
Bbs9 T C 9: 22,486,497 (GRCm39) probably null Het
Bmp4 T C 14: 46,622,070 (GRCm39) E158G probably damaging Het
Btn2a2 T C 13: 23,662,568 (GRCm39) *418W probably null Het
Cpt1c A G 7: 44,612,250 (GRCm39) Y494H probably damaging Het
Cyp3a16 T A 5: 145,392,987 (GRCm39) probably null Het
Dpy19l1 T A 9: 24,373,880 (GRCm39) H270L probably benign Het
Fdxr A G 11: 115,167,671 (GRCm39) S15P probably benign Het
Gm8688 T G 8: 100,391,152 (GRCm39) noncoding transcript Het
Golph3l G A 3: 95,515,260 (GRCm39) R134Q probably damaging Het
Hmgxb4 A G 8: 75,727,565 (GRCm39) T183A probably damaging Het
Krt1c T G 15: 101,726,098 (GRCm39) S147R unknown Het
Lipn T C 19: 34,054,379 (GRCm39) S206P probably damaging Het
Metap2 T C 10: 93,715,429 (GRCm39) E133G probably benign Het
Nuak1 T C 10: 84,210,648 (GRCm39) Y480C probably damaging Het
Oma1 C T 4: 103,182,496 (GRCm39) Q300* probably null Het
Pcnt T C 10: 76,217,198 (GRCm39) E2161G probably damaging Het
Pkdrej G T 15: 85,702,275 (GRCm39) D1220E probably benign Het
Ptdss1 T A 13: 67,135,914 (GRCm39) C390* probably null Het
Sars1 A C 3: 108,335,582 (GRCm39) F389V possibly damaging Het
Sec31b C T 19: 44,512,945 (GRCm39) V515M probably damaging Het
Syt3 A G 7: 44,048,571 (GRCm39) E587G probably benign Het
Tjp2 T C 19: 24,099,636 (GRCm39) E417G possibly damaging Het
Tmem63b A G 17: 45,977,041 (GRCm39) F442S possibly damaging Het
Togaram1 A G 12: 65,029,472 (GRCm39) D965G possibly damaging Het
Zmynd10 T C 9: 107,425,882 (GRCm39) V72A probably damaging Het
Other mutations in Mcpt2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03289:Mcpt2 APN 14 56,281,794 (GRCm39) missense probably damaging 1.00
R1186:Mcpt2 UTSW 14 56,281,402 (GRCm39) splice site probably benign
R1856:Mcpt2 UTSW 14 56,281,156 (GRCm39) missense probably benign 0.32
R2179:Mcpt2 UTSW 14 56,279,573 (GRCm39) utr 5 prime probably benign
R5327:Mcpt2 UTSW 14 56,280,833 (GRCm39) missense probably damaging 0.98
R8116:Mcpt2 UTSW 14 56,279,663 (GRCm39) missense probably damaging 1.00
R8342:Mcpt2 UTSW 14 56,280,250 (GRCm39) missense probably damaging 1.00
R8460:Mcpt2 UTSW 14 56,281,201 (GRCm39) missense possibly damaging 0.71
Predicted Primers PCR Primer
(F):5'- TCATGCTGCACTGGGACAGAAC -3'
(R):5'- TGCCTTGGAGAGCTGTTTGACAC -3'

Sequencing Primer
(F):5'- GAAATCAGTGTCATCCTTGGAGC -3'
(R):5'- GAGAGCTGTTTGACACACTTC -3'
Posted On 2013-09-30