Incidental Mutation 'R0751:Dcbld2'
ID 70362
Institutional Source Beutler Lab
Gene Symbol Dcbld2
Ensembl Gene ENSMUSG00000035107
Gene Name discoidin, CUB and LCCL domain containing 2
Synonyms CLCP1, 1700055P21Rik, Esdn
MMRRC Submission 038931-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R0751 (G1)
Quality Score 225
Status Validated
Chromosome 16
Chromosomal Location 58228806-58290090 bp(+) (GRCm39)
Type of Mutation critical splice donor site (2 bp from exon)
DNA Base Change (assembly) T to A at 58270204 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000039915 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000046663]
AlphaFold Q91ZV3
Predicted Effect probably null
Transcript: ENSMUST00000046663
SMART Domains Protein: ENSMUSP00000039915
Gene: ENSMUSG00000035107

DomainStartEndE-ValueType
low complexity region 2 34 N/A INTRINSIC
CUB 69 184 4.26e-37 SMART
LCCL 188 273 4.74e-37 SMART
FA58C 288 446 4.08e-28 SMART
transmembrane domain 522 544 N/A INTRINSIC
Meta Mutation Damage Score 0.9502 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.2%
  • 20x: 94.4%
Validation Efficiency 99% (73/74)
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit reduced postnatal angiogenesis and impaired recovery from femoral artery ligation with impaired blood flow and decreased capillary density. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 75 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ahdc1 T A 4: 132,792,707 (GRCm39) M1316K probably benign Het
Alox12 T C 11: 70,137,776 (GRCm39) I455V probably benign Het
Ankrd28 A G 14: 31,486,225 (GRCm39) L89P probably damaging Het
Aqp9 A T 9: 71,045,487 (GRCm39) C41S probably damaging Het
Arhgap17 T C 7: 122,913,913 (GRCm39) Y199C probably damaging Het
Aspm A T 1: 139,384,636 (GRCm39) probably benign Het
Cacfd1 T C 2: 26,908,993 (GRCm39) probably null Het
Cd33 T C 7: 43,181,545 (GRCm39) D205G probably damaging Het
Chadl T C 15: 81,577,258 (GRCm39) S198G probably benign Het
Chtf8 A G 8: 107,613,109 (GRCm39) probably null Het
Clec4a4 G T 6: 122,989,671 (GRCm39) W104L probably benign Het
Clock A T 5: 76,377,208 (GRCm39) I696K possibly damaging Het
Crtc2 T A 3: 90,169,940 (GRCm39) Y445* probably null Het
Dapk1 A T 13: 60,844,112 (GRCm39) I44F probably damaging Het
Derl2 T C 11: 70,905,373 (GRCm39) probably null Het
Dnah7c A G 1: 46,505,065 (GRCm39) T154A probably benign Het
Dnmt3b T A 2: 153,516,762 (GRCm39) probably null Het
Dusp3 A T 11: 101,872,554 (GRCm39) S106T probably benign Het
Eftud2 A G 11: 102,730,079 (GRCm39) V897A probably damaging Het
Eif3l T A 15: 78,959,966 (GRCm39) probably null Het
Fbxo33 A C 12: 59,265,878 (GRCm39) F130V probably damaging Het
Ffar3 T A 7: 30,554,529 (GRCm39) N264Y probably damaging Het
Fig4 T C 10: 41,148,978 (GRCm39) D158G probably damaging Het
Fyco1 A G 9: 123,648,218 (GRCm39) F1239L probably damaging Het
Gabra2 A G 5: 71,249,442 (GRCm39) probably benign Het
Gabra6 C A 11: 42,205,844 (GRCm39) R336S probably benign Het
Hkdc1 T C 10: 62,234,452 (GRCm39) D581G probably damaging Het
Ift70a2 C T 2: 75,808,375 (GRCm39) A46T probably damaging Het
Iqgap1 A G 7: 80,375,321 (GRCm39) probably benign Het
Larp4b T C 13: 9,216,345 (GRCm39) probably benign Het
Lcp1 A T 14: 75,436,827 (GRCm39) M58L probably benign Het
Lrrc8a T C 2: 30,146,362 (GRCm39) V392A possibly damaging Het
Mavs A T 2: 131,088,684 (GRCm39) Y496F probably damaging Het
Mpi A T 9: 57,457,897 (GRCm39) S102T probably damaging Het
Mroh9 G A 1: 162,893,693 (GRCm39) R161W possibly damaging Het
Myo1h A T 5: 114,458,747 (GRCm39) S161C probably damaging Het
Napg T G 18: 63,127,409 (GRCm39) H204Q probably benign Het
Nelfcd C A 2: 174,264,807 (GRCm39) A182D probably benign Het
Ntsr2 G T 12: 16,704,031 (GRCm39) K91N probably damaging Het
Obscn A G 11: 58,972,645 (GRCm39) S2134P probably damaging Het
Ogfod2 G A 5: 124,251,539 (GRCm39) probably benign Het
Or13a19 G A 7: 139,903,238 (GRCm39) V209I probably benign Het
Or1e26 G T 11: 73,479,970 (GRCm39) T198K probably benign Het
Pcdha8 T C 18: 37,127,123 (GRCm39) V535A probably damaging Het
Pdlim2 C T 14: 70,402,228 (GRCm39) R296H probably damaging Het
Pik3r1 T C 13: 101,822,866 (GRCm39) probably null Het
Pimreg C A 11: 71,933,939 (GRCm39) Q22K probably benign Het
Pld5 A G 1: 175,872,462 (GRCm39) I225T probably damaging Het
Plxnc1 T C 10: 94,667,195 (GRCm39) probably benign Het
Ppip5k2 A T 1: 97,677,377 (GRCm39) C306* probably null Het
Ptprc A G 1: 138,020,668 (GRCm39) Y588H probably damaging Het
Rac2 T G 15: 78,450,145 (GRCm39) D65A possibly damaging Het
Rgl3 A G 9: 21,888,676 (GRCm39) probably null Het
Serpinb1a T C 13: 33,027,199 (GRCm39) K248E probably benign Het
Serpinb9e A C 13: 33,443,757 (GRCm39) E259A probably benign Het
Slc12a4 A T 8: 106,678,532 (GRCm39) V266E probably damaging Het
Slc8b1 A G 5: 120,662,260 (GRCm39) probably benign Het
Spink6 T C 18: 44,204,605 (GRCm39) probably benign Het
Spta1 G A 1: 174,012,256 (GRCm39) R354H probably damaging Het
Ssb T A 2: 69,700,909 (GRCm39) S330T probably benign Het
Stard9 G T 2: 120,527,966 (GRCm39) V1408F probably benign Het
Sumf2 A T 5: 129,878,846 (GRCm39) T61S probably benign Het
Sypl2 T C 3: 108,124,072 (GRCm39) T157A probably damaging Het
Tgfbr3 A T 5: 107,287,749 (GRCm39) D483E probably damaging Het
Tnrc6a A G 7: 122,769,563 (GRCm39) N451S possibly damaging Het
Tradd T C 8: 105,986,403 (GRCm39) E123G probably damaging Het
Trim36 T C 18: 46,329,318 (GRCm39) T41A probably damaging Het
Ttll7 C T 3: 146,645,746 (GRCm39) P535S probably damaging Het
Ubr4 C T 4: 139,164,509 (GRCm39) probably benign Het
Uqcc5 G T 14: 30,810,953 (GRCm39) probably benign Het
Vmn1r195 A G 13: 22,463,181 (GRCm39) Y217C probably damaging Het
Vmn2r63 A C 7: 42,577,459 (GRCm39) F360V probably damaging Het
Vmn2r78 G A 7: 86,603,588 (GRCm39) V589M possibly damaging Het
Vmn2r-ps158 A G 7: 42,696,833 (GRCm39) Y630C probably damaging Het
Vrk2 A G 11: 26,433,331 (GRCm39) probably benign Het
Other mutations in Dcbld2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01456:Dcbld2 APN 16 58,229,236 (GRCm39) missense possibly damaging 0.75
IGL01978:Dcbld2 APN 16 58,284,682 (GRCm39) missense probably benign 0.00
IGL02143:Dcbld2 APN 16 58,268,889 (GRCm39) critical splice donor site probably null
IGL02953:Dcbld2 APN 16 58,272,100 (GRCm39) missense probably benign 0.29
IGL03109:Dcbld2 APN 16 58,276,765 (GRCm39) missense probably benign 0.06
IGL03131:Dcbld2 APN 16 58,272,051 (GRCm39) missense probably benign 0.00
R0183:Dcbld2 UTSW 16 58,265,722 (GRCm39) missense possibly damaging 0.70
R0305:Dcbld2 UTSW 16 58,269,302 (GRCm39) missense probably damaging 1.00
R0316:Dcbld2 UTSW 16 58,253,808 (GRCm39) missense probably damaging 1.00
R0371:Dcbld2 UTSW 16 58,271,186 (GRCm39) missense probably benign 0.09
R0548:Dcbld2 UTSW 16 58,275,508 (GRCm39) missense probably damaging 0.98
R0906:Dcbld2 UTSW 16 58,275,610 (GRCm39) missense probably damaging 1.00
R1184:Dcbld2 UTSW 16 58,270,204 (GRCm39) critical splice donor site probably null
R1557:Dcbld2 UTSW 16 58,285,713 (GRCm39) missense possibly damaging 0.49
R1995:Dcbld2 UTSW 16 58,276,695 (GRCm39) missense probably benign
R3930:Dcbld2 UTSW 16 58,285,701 (GRCm39) missense probably damaging 1.00
R3931:Dcbld2 UTSW 16 58,285,701 (GRCm39) missense probably damaging 1.00
R4080:Dcbld2 UTSW 16 58,285,736 (GRCm39) missense probably damaging 1.00
R4385:Dcbld2 UTSW 16 58,283,429 (GRCm39) missense probably damaging 0.96
R4615:Dcbld2 UTSW 16 58,276,457 (GRCm39) missense probably benign 0.03
R4739:Dcbld2 UTSW 16 58,281,339 (GRCm39) missense probably damaging 1.00
R4963:Dcbld2 UTSW 16 58,286,145 (GRCm39) missense probably benign
R4968:Dcbld2 UTSW 16 58,245,074 (GRCm39) missense probably damaging 1.00
R5419:Dcbld2 UTSW 16 58,275,621 (GRCm39) missense probably damaging 0.99
R5684:Dcbld2 UTSW 16 58,270,172 (GRCm39) missense possibly damaging 0.90
R5737:Dcbld2 UTSW 16 58,281,348 (GRCm39) missense probably damaging 1.00
R6277:Dcbld2 UTSW 16 58,285,866 (GRCm39) missense probably damaging 1.00
R6277:Dcbld2 UTSW 16 58,272,119 (GRCm39) missense probably damaging 0.97
R6468:Dcbld2 UTSW 16 58,253,736 (GRCm39) nonsense probably null
R6753:Dcbld2 UTSW 16 58,276,493 (GRCm39) missense possibly damaging 0.94
R7213:Dcbld2 UTSW 16 58,271,126 (GRCm39) missense probably benign 0.02
R7360:Dcbld2 UTSW 16 58,285,683 (GRCm39) splice site probably null
R7555:Dcbld2 UTSW 16 58,269,081 (GRCm39) splice site probably null
R7570:Dcbld2 UTSW 16 58,244,932 (GRCm39) missense possibly damaging 0.86
R7593:Dcbld2 UTSW 16 58,244,941 (GRCm39) missense possibly damaging 0.82
R8072:Dcbld2 UTSW 16 58,283,460 (GRCm39) nonsense probably null
R8175:Dcbld2 UTSW 16 58,253,710 (GRCm39) missense possibly damaging 0.63
R8193:Dcbld2 UTSW 16 58,284,373 (GRCm39) splice site probably null
R8323:Dcbld2 UTSW 16 58,283,473 (GRCm39) critical splice donor site probably null
R8804:Dcbld2 UTSW 16 58,281,412 (GRCm39) critical splice donor site probably benign
R8887:Dcbld2 UTSW 16 58,229,270 (GRCm39) missense probably damaging 1.00
R8955:Dcbld2 UTSW 16 58,271,125 (GRCm39) missense
R8971:Dcbld2 UTSW 16 58,276,715 (GRCm39) missense probably benign
R9335:Dcbld2 UTSW 16 58,272,141 (GRCm39) missense probably benign 0.01
R9384:Dcbld2 UTSW 16 58,285,926 (GRCm39) missense probably damaging 1.00
R9496:Dcbld2 UTSW 16 58,271,164 (GRCm39) missense probably benign 0.00
R9517:Dcbld2 UTSW 16 58,253,819 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- ACCTCGTTCTCTGAAAACACACGTC -3'
(R):5'- AGCCATCCCTGTCTGACTTCAAGC -3'

Sequencing Primer
(F):5'- CTGAAAACACACGTCTTCATGTTC -3'
(R):5'- TCCCCAGTGAATAGTGAACTTC -3'
Posted On 2013-09-30