Incidental Mutation 'R0741:Or10a3m'
ID 70688
Institutional Source Beutler Lab
Gene Symbol Or10a3m
Ensembl Gene ENSMUSG00000056946
Gene Name olfactory receptor family 10 subfamily A member 3M
Synonyms Olfr512, MOR268-3, GA_x6K02T2PBJ9-11043421-11044365
MMRRC Submission 038922-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.115) question?
Stock # R0741 (G1)
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 108312562-108313542 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 108312811 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Serine at position 84 (C84S)
Ref Sequence ENSEMBL: ENSMUSP00000074291 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000074730] [ENSMUST00000209620]
AlphaFold Q8VFZ4
Predicted Effect probably benign
Transcript: ENSMUST00000074730
AA Change: C84S

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000074291
Gene: ENSMUSG00000056946
AA Change: C84S

DomainStartEndE-ValueType
Pfam:7tm_4 43 320 7.8e-62 PFAM
Pfam:7TM_GPCR_Srsx 47 317 2.5e-6 PFAM
Pfam:7tm_1 53 302 2.3e-25 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000209620
AA Change: C72S

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.8%
  • 10x: 97.5%
  • 20x: 95.1%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ano7 T A 1: 93,329,309 (GRCm39) I701N probably damaging Het
Asb7 A T 7: 66,309,882 (GRCm39) N111K probably benign Het
Atp10a T A 7: 58,478,337 (GRCm39) L1460Q possibly damaging Het
Auh T C 13: 53,083,638 (GRCm39) T14A possibly damaging Het
Caskin2 A G 11: 115,695,626 (GRCm39) V245A probably damaging Het
Cryba4 G A 5: 112,394,554 (GRCm39) R192C probably damaging Het
Ctsq T A 13: 61,184,019 (GRCm39) D301V probably damaging Het
Dpyd A G 3: 118,468,154 (GRCm39) E56G possibly damaging Het
Dtd2 T C 12: 52,046,455 (GRCm39) K128R probably benign Het
Eps8l3 A G 3: 107,790,141 (GRCm39) T141A probably benign Het
Evc A T 5: 37,483,739 (GRCm39) I187N possibly damaging Het
Fam120a A G 13: 49,045,416 (GRCm39) S807P possibly damaging Het
Fbxw22 G A 9: 109,211,287 (GRCm39) S338L probably benign Het
Gcnt4 G T 13: 97,082,940 (GRCm39) E79* probably null Het
Get4 G A 5: 139,249,384 (GRCm39) probably benign Het
Hipk1 A G 3: 103,654,128 (GRCm39) V954A probably benign Het
Ifi206 C T 1: 173,301,315 (GRCm39) V788M probably benign Het
Iqgap1 A G 7: 80,370,735 (GRCm39) S1545P probably benign Het
Kif21b A G 1: 136,087,482 (GRCm39) T933A probably damaging Het
Lgr6 C T 1: 134,921,748 (GRCm39) A199T probably damaging Het
Magee2 A G X: 103,899,472 (GRCm39) L393P probably damaging Het
Mtrr T C 13: 68,727,658 (GRCm39) probably null Het
Nes A G 3: 87,886,274 (GRCm39) E1467G probably damaging Het
Nol3 C G 8: 106,005,756 (GRCm39) A50G probably damaging Het
Nr2f2 G A 7: 70,007,745 (GRCm39) R113C probably damaging Het
Obscn CCACACACACACAC CCACACACACAC 11: 58,954,279 (GRCm39) probably null Het
Pnkd T A 1: 74,391,018 (GRCm39) S337R possibly damaging Het
Ptprh A G 7: 4,557,172 (GRCm39) probably null Het
Ralgapa1 A C 12: 55,723,366 (GRCm39) V1767G probably damaging Het
Sema6a G A 18: 47,423,112 (GRCm39) probably null Het
Skap1 A C 11: 96,383,759 (GRCm39) probably benign Het
Trip12 A G 1: 84,722,902 (GRCm39) S1250P probably benign Het
Txndc5 T C 13: 38,712,236 (GRCm39) H50R possibly damaging Het
Usp25 C A 16: 76,868,596 (GRCm39) D332E possibly damaging Het
Vgll1 A T X: 56,141,644 (GRCm39) probably benign Het
Other mutations in Or10a3m
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01889:Or10a3m APN 7 108,313,089 (GRCm39) missense probably benign 0.02
IGL01912:Or10a3m APN 7 108,313,465 (GRCm39) missense possibly damaging 0.60
IGL02182:Or10a3m APN 7 108,313,075 (GRCm39) missense probably benign 0.02
IGL02409:Or10a3m APN 7 108,313,366 (GRCm39) missense probably benign 0.00
IGL02554:Or10a3m APN 7 108,312,949 (GRCm39) missense possibly damaging 0.94
IGL03210:Or10a3m APN 7 108,312,775 (GRCm39) missense probably damaging 1.00
IGL03373:Or10a3m APN 7 108,313,339 (GRCm39) missense probably damaging 1.00
IGL03400:Or10a3m APN 7 108,312,733 (GRCm39) missense probably benign 0.28
R0092:Or10a3m UTSW 7 108,313,031 (GRCm39) missense probably benign
R1515:Or10a3m UTSW 7 108,313,148 (GRCm39) missense possibly damaging 0.94
R1982:Or10a3m UTSW 7 108,312,902 (GRCm39) missense probably damaging 1.00
R2176:Or10a3m UTSW 7 108,313,339 (GRCm39) missense probably damaging 1.00
R3967:Or10a3m UTSW 7 108,313,060 (GRCm39) missense probably benign
R4009:Or10a3m UTSW 7 108,313,366 (GRCm39) missense probably benign 0.00
R4010:Or10a3m UTSW 7 108,313,366 (GRCm39) missense probably benign 0.00
R4011:Or10a3m UTSW 7 108,313,366 (GRCm39) missense probably benign 0.00
R5095:Or10a3m UTSW 7 108,313,019 (GRCm39) missense probably damaging 1.00
R5271:Or10a3m UTSW 7 108,313,424 (GRCm39) missense probably damaging 1.00
R5864:Or10a3m UTSW 7 108,312,671 (GRCm39) missense probably benign
R5926:Or10a3m UTSW 7 108,312,794 (GRCm39) missense probably damaging 1.00
R6295:Or10a3m UTSW 7 108,312,845 (GRCm39) missense probably damaging 0.98
R6528:Or10a3m UTSW 7 108,312,638 (GRCm39) missense probably damaging 1.00
R6624:Or10a3m UTSW 7 108,312,743 (GRCm39) missense possibly damaging 0.50
R8029:Or10a3m UTSW 7 108,313,037 (GRCm39) missense possibly damaging 0.70
R8443:Or10a3m UTSW 7 108,313,418 (GRCm39) missense possibly damaging 0.79
R8737:Or10a3m UTSW 7 108,312,964 (GRCm39) missense probably damaging 1.00
R9415:Or10a3m UTSW 7 108,313,042 (GRCm39) missense probably damaging 1.00
R9622:Or10a3m UTSW 7 108,312,677 (GRCm39) missense probably benign 0.30
X0023:Or10a3m UTSW 7 108,313,217 (GRCm39) missense possibly damaging 0.79
Z1088:Or10a3m UTSW 7 108,312,745 (GRCm39) missense probably benign 0.06
Predicted Primers PCR Primer
(F):5'- GTCCCTAAGACAAACACAGGGTTCC -3'
(R):5'- TCTGCACATGCCAGTTCTAGCAC -3'

Sequencing Primer
(F):5'- GGAGGCAAAATCACAGCTCTAC -3'
(R):5'- TCTAGCACAGGAGGAGTCTCAC -3'
Posted On 2013-09-30