Incidental Mutation 'R0741:Vgll1'
ID 70706
Institutional Source Beutler Lab
Gene Symbol Vgll1
Ensembl Gene ENSMUSG00000031131
Gene Name vestigial like family member 1
Synonyms Tondu
MMRRC Submission 038922-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.147) question?
Stock # R0741 (G1)
Quality Score 222
Status Not validated
Chromosome X
Chromosomal Location 56133466-56151900 bp(+) (GRCm39)
Type of Mutation unclassified
DNA Base Change (assembly) A to T at 56141644 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000114308 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000033465] [ENSMUST00000114745] [ENSMUST00000114746] [ENSMUST00000141936]
AlphaFold Q99NC0
Predicted Effect unknown
Transcript: ENSMUST00000033465
AA Change: D79V
SMART Domains Protein: ENSMUSP00000033465
Gene: ENSMUSG00000031131
AA Change: D79V

DomainStartEndE-ValueType
Pfam:Vg_Tdu 21 51 4.5e-21 PFAM
internal_repeat_1 180 198 3.9e-5 PROSPERO
internal_repeat_1 206 224 3.9e-5 PROSPERO
Predicted Effect unknown
Transcript: ENSMUST00000114745
AA Change: D79V
SMART Domains Protein: ENSMUSP00000110393
Gene: ENSMUSG00000031131
AA Change: D79V

DomainStartEndE-ValueType
Pfam:Vg_Tdu 21 53 9.6e-26 PFAM
internal_repeat_1 180 198 3.9e-5 PROSPERO
internal_repeat_1 206 224 3.9e-5 PROSPERO
Predicted Effect unknown
Transcript: ENSMUST00000114746
AA Change: D79V
SMART Domains Protein: ENSMUSP00000110394
Gene: ENSMUSG00000031131
AA Change: D79V

DomainStartEndE-ValueType
Pfam:Vg_Tdu 21 53 9.6e-26 PFAM
internal_repeat_1 180 198 3.9e-5 PROSPERO
internal_repeat_1 206 224 3.9e-5 PROSPERO
Predicted Effect probably benign
Transcript: ENSMUST00000141936
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.8%
  • 10x: 97.5%
  • 20x: 95.1%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene binds proteins of the TEA domain family of transcription factors (TEFs) through the Vg (vestigial) homology region found in its N-terminus. It may thus function as a specific coactivator for the mammalian TEFs. [provided by RefSeq, Sep 2009]
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ano7 T A 1: 93,329,309 (GRCm39) I701N probably damaging Het
Asb7 A T 7: 66,309,882 (GRCm39) N111K probably benign Het
Atp10a T A 7: 58,478,337 (GRCm39) L1460Q possibly damaging Het
Auh T C 13: 53,083,638 (GRCm39) T14A possibly damaging Het
Caskin2 A G 11: 115,695,626 (GRCm39) V245A probably damaging Het
Cryba4 G A 5: 112,394,554 (GRCm39) R192C probably damaging Het
Ctsq T A 13: 61,184,019 (GRCm39) D301V probably damaging Het
Dpyd A G 3: 118,468,154 (GRCm39) E56G possibly damaging Het
Dtd2 T C 12: 52,046,455 (GRCm39) K128R probably benign Het
Eps8l3 A G 3: 107,790,141 (GRCm39) T141A probably benign Het
Evc A T 5: 37,483,739 (GRCm39) I187N possibly damaging Het
Fam120a A G 13: 49,045,416 (GRCm39) S807P possibly damaging Het
Fbxw22 G A 9: 109,211,287 (GRCm39) S338L probably benign Het
Gcnt4 G T 13: 97,082,940 (GRCm39) E79* probably null Het
Get4 G A 5: 139,249,384 (GRCm39) probably benign Het
Hipk1 A G 3: 103,654,128 (GRCm39) V954A probably benign Het
Ifi206 C T 1: 173,301,315 (GRCm39) V788M probably benign Het
Iqgap1 A G 7: 80,370,735 (GRCm39) S1545P probably benign Het
Kif21b A G 1: 136,087,482 (GRCm39) T933A probably damaging Het
Lgr6 C T 1: 134,921,748 (GRCm39) A199T probably damaging Het
Magee2 A G X: 103,899,472 (GRCm39) L393P probably damaging Het
Mtrr T C 13: 68,727,658 (GRCm39) probably null Het
Nes A G 3: 87,886,274 (GRCm39) E1467G probably damaging Het
Nol3 C G 8: 106,005,756 (GRCm39) A50G probably damaging Het
Nr2f2 G A 7: 70,007,745 (GRCm39) R113C probably damaging Het
Obscn CCACACACACACAC CCACACACACAC 11: 58,954,279 (GRCm39) probably null Het
Or10a3m T A 7: 108,312,811 (GRCm39) C84S probably benign Het
Pnkd T A 1: 74,391,018 (GRCm39) S337R possibly damaging Het
Ptprh A G 7: 4,557,172 (GRCm39) probably null Het
Ralgapa1 A C 12: 55,723,366 (GRCm39) V1767G probably damaging Het
Sema6a G A 18: 47,423,112 (GRCm39) probably null Het
Skap1 A C 11: 96,383,759 (GRCm39) probably benign Het
Trip12 A G 1: 84,722,902 (GRCm39) S1250P probably benign Het
Txndc5 T C 13: 38,712,236 (GRCm39) H50R possibly damaging Het
Usp25 C A 16: 76,868,596 (GRCm39) D332E possibly damaging Het
Other mutations in Vgll1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02063:Vgll1 APN X 56,144,569 (GRCm39) unclassified probably benign
R2114:Vgll1 UTSW X 56,137,790 (GRCm39) missense probably damaging 0.96
R2115:Vgll1 UTSW X 56,137,790 (GRCm39) missense probably damaging 0.96
R2117:Vgll1 UTSW X 56,137,790 (GRCm39) missense probably damaging 0.96
R4665:Vgll1 UTSW X 56,137,792 (GRCm39) missense possibly damaging 0.93
Predicted Primers PCR Primer
(F):5'- TGTCAGCCATTCAACTGAAGACACC -3'
(R):5'- CCCATACAGCAAGGCACTTCCTTT -3'

Sequencing Primer
(F):5'- TCTAGCAAACAGACTAGGTGC -3'
(R):5'- TTGAAGcacacacacacacac -3'
Posted On 2013-09-30