Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01285:Olfml1'

72699

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Olfml1

Ensembl Gene

ENSMUSG00000051041

Gene Name

olfactomedin-like 1

Synonyms

mONT2, ONT2, MVAL564

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.081) question?

Stock #

IGL01285

Quality Score

Status

Chromosome

Chromosomal Location

107166653-107190301 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 107189364 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Serine at position 143 (N143S)

Ref Sequence

ENSEMBL: ENSMUSP00000114029 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000120990]

AlphaFold

Q8BSH2

Predicted Effect

possibly damaging
Transcript: ENSMUST00000120990
AA Change: N143S

PolyPhen 2 Score 0.804 (Sensitivity: 0.84; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000114029
Gene: ENSMUSG00000051041
AA Change: N143S

Domain	Start	End	E-Value	Type
signal peptide	1	26	N/A	INTRINSIC
coiled coil region	78	105	N/A	INTRINSIC
low complexity region	115	132	N/A	INTRINSIC
Pfam:OLF	145	233	5.5e-19	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000207374

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 47 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adam5	T	C	8: 25,271,610 (GRCm39)	N599S	probably benign	Het
Adam6a	A	T	12: 113,509,893 (GRCm39)	*755Y	probably null	Het
Adgrb3	G	T	1: 25,132,868 (GRCm39)	T1166K	probably benign	Het
Ano1	T	C	7: 144,198,479 (GRCm39)	Y345C	probably benign	Het
Ano1	A	G	7: 144,149,275 (GRCm39)	V862A	probably damaging	Het
Asap2	C	T	12: 21,279,264 (GRCm39)	A382V	probably damaging	Het
Asb18	A	G	1: 89,923,963 (GRCm39)	V100A	probably benign	Het
Bdnf	G	A	2: 109,553,931 (GRCm39)	A102T	probably benign	Het
Ccser2	G	A	14: 36,660,626 (GRCm39)	T509M	probably damaging	Het
Cfap47	A	G	X: 78,532,764 (GRCm39)	I767T	possibly damaging	Het
Des	G	A	1: 75,339,227 (GRCm39)	A251T	probably benign	Het
Dmd	C	T	X: 84,153,590 (GRCm39)	Q3224*	probably null	Het
Endog	G	T	2: 30,061,975 (GRCm39)		probably null	Het
Ggt7	A	G	2: 155,342,691 (GRCm39)	V269A	probably damaging	Het
Gucy2c	A	G	6: 136,686,739 (GRCm39)	F808S	probably damaging	Het
Hira	A	G	16: 18,730,930 (GRCm39)	T210A	probably benign	Het
Ifitm5	C	A	7: 140,530,076 (GRCm39)	R16L	probably benign	Het
Igdcc4	T	C	9: 65,031,273 (GRCm39)	C404R	probably damaging	Het
Ints7	G	A	1: 191,347,890 (GRCm39)	R754H	probably benign	Het
Irf9	A	G	14: 55,845,058 (GRCm39)	E258G	probably damaging	Het
Megf11	T	C	9: 64,567,728 (GRCm39)	C406R	probably damaging	Het
Or4m1	A	G	14: 50,557,713 (GRCm39)	F193S	possibly damaging	Het
Or6c66b	T	A	10: 129,376,711 (GRCm39)	F102I	probably benign	Het
Or7g30	A	G	9: 19,352,266 (GRCm39)	D19G	probably benign	Het
Otof	G	T	5: 30,562,527 (GRCm39)	Q254K	probably damaging	Het
Pate7	A	T	9: 35,688,044 (GRCm39)	N65K	possibly damaging	Het
Plcd3	A	G	11: 102,968,696 (GRCm39)	F332L	probably benign	Het
Plxnc1	T	C	10: 94,635,230 (GRCm39)	D1332G	probably damaging	Het
Rnasel	A	T	1: 153,634,130 (GRCm39)	D521V	probably benign	Het
Sema5a	T	A	15: 32,575,143 (GRCm39)	V417D	possibly damaging	Het
Senp6	G	A	9: 80,044,000 (GRCm39)	R877Q	probably benign	Het
Shroom2	A	T	X: 151,442,353 (GRCm39)	D937E	probably damaging	Het
Slc35a3	A	G	3: 116,488,262 (GRCm39)	S142P	probably damaging	Het
Srpx	A	T	X: 9,905,298 (GRCm39)	V398E	probably damaging	Het
Stk10	A	T	11: 32,560,653 (GRCm39)	K669N	possibly damaging	Het
Sumf2	A	G	5: 129,878,811 (GRCm39)	D49G	probably damaging	Het
Syde1	T	A	10: 78,424,721 (GRCm39)	E370D	probably damaging	Het
Tas2r115	G	T	6: 132,714,641 (GRCm39)	S103R	probably damaging	Het
Top2a	G	A	11: 98,896,985 (GRCm39)		probably benign	Het
Ttn	T	A	2: 76,550,842 (GRCm39)	T23190S	probably damaging	Het
Ttyh3	C	A	5: 140,615,167 (GRCm39)	C407F	probably damaging	Het
Vmn2r27	G	T	6: 124,169,370 (GRCm39)	H587N	possibly damaging	Het
Vmn2r74	A	G	7: 85,606,692 (GRCm39)	I218T	possibly damaging	Het
Vsig10	A	G	5: 117,462,954 (GRCm39)	N60S	probably benign	Het
Zc3h7a	A	G	16: 10,956,979 (GRCm39)	S877P	probably damaging	Het
Zfp979	G	T	4: 147,699,853 (GRCm39)	T29N	probably damaging	Het
Znfx1	G	A	2: 166,880,615 (GRCm39)	R390C	possibly damaging	Het

Other mutations in Olfml1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02355:Olfml1	APN	7	107,167,010 (GRCm39)	missense	probably benign	0.00
IGL02362:Olfml1	APN	7	107,167,010 (GRCm39)	missense	probably benign	0.00
IGL03218:Olfml1	APN	7	107,170,476 (GRCm39)	missense	possibly damaging	0.87
IGL03291:Olfml1	APN	7	107,189,436 (GRCm39)	missense	probably damaging	1.00
R0041:Olfml1	UTSW	7	107,189,393 (GRCm39)	missense	possibly damaging	0.81
R0041:Olfml1	UTSW	7	107,189,393 (GRCm39)	missense	possibly damaging	0.81
R0081:Olfml1	UTSW	7	107,170,506 (GRCm39)	missense	probably benign	0.08
R0524:Olfml1	UTSW	7	107,189,384 (GRCm39)	missense	probably damaging	1.00
R1311:Olfml1	UTSW	7	107,167,103 (GRCm39)	critical splice donor site	probably null
R1548:Olfml1	UTSW	7	107,189,582 (GRCm39)	missense	possibly damaging	0.88
R1564:Olfml1	UTSW	7	107,170,346 (GRCm39)	missense	possibly damaging	0.89
R4347:Olfml1	UTSW	7	107,167,040 (GRCm39)	missense	probably benign	0.00
R4997:Olfml1	UTSW	7	107,170,413 (GRCm39)	missense	probably damaging	1.00
R6788:Olfml1	UTSW	7	107,167,075 (GRCm39)	missense	probably damaging	1.00
R7282:Olfml1	UTSW	7	107,189,530 (GRCm39)	missense	possibly damaging	0.85
R7703:Olfml1	UTSW	7	107,170,392 (GRCm39)	missense	probably damaging	1.00
R7922:Olfml1	UTSW	7	107,170,356 (GRCm39)	missense	probably damaging	1.00
R8324:Olfml1	UTSW	7	107,189,570 (GRCm39)	missense	probably benign	0.04
R8441:Olfml1	UTSW	7	107,166,977 (GRCm39)	missense	probably benign	0.00
R9002:Olfml1	UTSW	7	107,189,423 (GRCm39)	missense	probably damaging	1.00
R9261:Olfml1	UTSW	7	107,167,007 (GRCm39)	missense	possibly damaging	0.88
R9797:Olfml1	UTSW	7	107,167,069 (GRCm39)	missense	probably benign	0.25

Posted On

2013-10-07