Incidental Mutation 'IGL01293:Obp2b'
ID72979
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Obp2b
Ensembl Gene ENSMUSG00000079539
Gene Nameodorant binding protein 2B
SynonymsLcn14, OTTMUSG00000012631
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.060) question?
Stock #IGL01293
Quality Score
Status
Chromosome2
Chromosomal Location25737009-25740097 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 25737707 bp
ZygosityHeterozygous
Amino Acid Change Histidine to Arginine at position 45 (H45R)
Ref Sequence ENSEMBL: ENSMUSP00000109830 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000114192]
Predicted Effect probably benign
Transcript: ENSMUST00000114192
AA Change: H45R

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
SMART Domains Protein: ENSMUSP00000109830
Gene: ENSMUSG00000079539
AA Change: H45R

DomainStartEndE-ValueType
low complexity region 4 17 N/A INTRINSIC
Pfam:Lipocalin 31 169 5.6e-32 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a small extracellular protein belonging to the lipocalin superfamily. The protein is thought to transport small, hydrophobic, volatile molecules or odorants through the nasal mucus to olfactory receptors, and may also function as a scavenger of highly concentrated or toxic odors. The protein is expressed as a monomer in the nasal mucus, and can bind diverse types of odorants with a higher affinity for aldehydes and fatty acids. This gene and a highly similar family member are located in a cluster of lipocalin genes on chromosome 9. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aadacl3 A G 4: 144,463,656 V25A probably benign Het
Aagab T C 9: 63,636,469 V235A probably benign Het
Ash1l T C 3: 88,983,529 V905A probably benign Het
Atrx A G X: 105,876,195 S641P probably benign Het
Bnc1 T C 7: 81,974,489 E330G probably damaging Het
Cenpq A T 17: 40,933,176 S4T possibly damaging Het
Clvs1 T A 4: 9,281,559 M1K probably null Het
Cul2 A G 18: 3,419,426 K196E probably damaging Het
Cyp2d10 A T 15: 82,403,009 V471E possibly damaging Het
Efhc2 T A X: 17,207,695 I469L probably benign Het
Fhod3 C T 18: 25,020,652 probably benign Het
Gm1968 A G 16: 29,958,814 noncoding transcript Het
Gm438 G T 4: 144,777,589 H331N probably benign Het
Hpdl T A 4: 116,820,944 T107S possibly damaging Het
Il1rl1 G A 1: 40,446,216 G276D possibly damaging Het
Irgq A G 7: 24,533,724 D330G probably damaging Het
Kdm4b A G 17: 56,353,019 D62G probably benign Het
Lama2 T C 10: 27,231,636 T793A probably benign Het
Lrrk2 T C 15: 91,726,137 F691L probably benign Het
Macf1 C T 4: 123,471,311 G1654E probably benign Het
Mgat4c A T 10: 102,388,225 Y100F probably benign Het
Ncapg A G 5: 45,681,854 N532S probably benign Het
Nfkb1 T C 3: 135,590,839 D782G probably damaging Het
Nthl1 G T 17: 24,638,709 C294F probably damaging Het
Olfm1 A G 2: 28,214,703 E156G probably damaging Het
Olfr113 A G 17: 37,575,417 I2T probably benign Het
Olfr847 C A 9: 19,375,336 A182S probably benign Het
Otud6b A G 4: 14,822,682 probably benign Het
Patl2 T C 2: 122,123,810 T427A probably benign Het
Pdzd8 T A 19: 59,299,786 R1061W probably damaging Het
Plk3 A T 4: 117,132,997 L137* probably null Het
Rps6ka6 T C X: 111,450,362 probably benign Het
Shank1 T C 7: 44,354,236 V1784A possibly damaging Het
Smc1b A T 15: 85,131,898 S14T probably damaging Het
Sox4 C A 13: 28,952,681 R114L probably damaging Het
Speg C T 1: 75,388,102 R221W probably damaging Het
Tram1l1 T C 3: 124,322,139 V316A probably benign Het
Virma G T 4: 11,521,114 K840N probably damaging Het
Vmn1r49 A T 6: 90,072,412 S203T probably damaging Het
Wdr1 T C 5: 38,529,543 T293A probably benign Het
Xirp2 C T 2: 67,515,184 P2590S possibly damaging Het
Zfp106 T C 2: 120,535,035 Y297C possibly damaging Het
Zfp128 A G 7: 12,891,424 *573W probably null Het
Zfp575 G A 7: 24,585,757 P153L probably damaging Het
Other mutations in Obp2b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00556:Obp2b APN 2 25738581 missense probably damaging 1.00
IGL01731:Obp2b APN 2 25739281 missense possibly damaging 0.74
IGL01751:Obp2b APN 2 25737748 missense possibly damaging 0.89
IGL02631:Obp2b APN 2 25739243 missense probably damaging 0.96
R0035:Obp2b UTSW 2 25738633 missense probably damaging 1.00
R0035:Obp2b UTSW 2 25738633 missense probably damaging 1.00
R1753:Obp2b UTSW 2 25738640 critical splice donor site probably null
R1955:Obp2b UTSW 2 25738551 missense probably benign 0.12
R4956:Obp2b UTSW 2 25737075 missense probably damaging 0.96
R5253:Obp2b UTSW 2 25737143 missense probably benign 0.08
R6434:Obp2b UTSW 2 25738587 missense probably damaging 1.00
R7176:Obp2b UTSW 2 25737748 missense possibly damaging 0.89
Posted On2013-10-07