Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01296:Trmo'

73132

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Trmo

Ensembl Gene

ENSMUSG00000028331

Gene Name

tRNA methyltransferase O

Synonyms

5830415F09Rik

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL01296

Quality Score

Status

Chromosome

Chromosomal Location

46376505-46389437 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 46387589 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Proline at position 84 (L84P)

Ref Sequence

ENSEMBL: ENSMUSP00000119785 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000030015] [ENSMUST00000086563] [ENSMUST00000151903]

AlphaFold

Q562D6

Predicted Effect

probably damaging
Transcript: ENSMUST00000030015
AA Change: L77P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000030015
Gene: ENSMUSG00000028331
AA Change: L77P

Domain	Start	End	E-Value	Type
Pfam:UPF0066	42	165	2.3e-45	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000086563
AA Change: L77P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000083752
Gene: ENSMUSG00000028331
AA Change: L77P

Domain	Start	End	E-Value	Type
Pfam:UPF0066	44	164	1.2e-46	PFAM
low complexity region	431	442	N/A	INTRINSIC
low complexity region	443	456	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000151903
AA Change: L84P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000119785
Gene: ENSMUSG00000028331
AA Change: L84P

Domain	Start	End	E-Value	Type
Pfam:UPF0066	49	172	4.1e-45	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 49 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acadl	A	G	1: 66,880,864 (GRCm39)	S301P	probably damaging	Het
Adam34	A	G	8: 44,104,178 (GRCm39)	V489A	possibly damaging	Het
Adcy8	G	A	15: 64,655,628 (GRCm39)	T617I	probably damaging	Het
Aggf1	T	C	13: 95,490,479 (GRCm39)	D605G	probably damaging	Het
Atp10a	T	A	7: 58,463,373 (GRCm39)	F969I	probably benign	Het
Becn1	A	T	11: 101,182,277 (GRCm39)	N97K	probably damaging	Het
Cd4	G	A	6: 124,856,341 (GRCm39)	T50I	probably benign	Het
Crtac1	A	T	19: 42,272,652 (GRCm39)	C578S	probably damaging	Het
Dcp1b	A	G	6: 119,192,319 (GRCm39)	K412E	probably damaging	Het
Dlg2	T	A	7: 91,589,267 (GRCm39)	I327N	probably damaging	Het
Ehf	T	A	2: 103,098,500 (GRCm39)		probably null	Het
Elavl4	T	C	4: 110,063,809 (GRCm39)	N264S	probably benign	Het
Enpp2	A	T	15: 54,739,065 (GRCm39)	I406N	probably damaging	Het
F10	A	T	8: 13,105,383 (GRCm39)	Y316F	possibly damaging	Het
Fam20a	A	G	11: 109,576,177 (GRCm39)	I194T	possibly damaging	Het
Fcgbp	T	C	7: 27,789,072 (GRCm39)	V546A	probably benign	Het
Fras1	A	T	5: 96,821,557 (GRCm39)	Q1438L	probably null	Het
Gm43638	T	C	5: 87,608,451 (GRCm39)	I463V	probably benign	Het
H2-T10	T	C	17: 36,431,602 (GRCm39)	D84G	probably benign	Het
Itpr1	T	C	6: 108,376,322 (GRCm39)	F1262L	probably damaging	Het
Lama1	A	G	17: 68,052,046 (GRCm39)	N335D	probably benign	Het
Lasp1	T	C	11: 97,727,016 (GRCm39)	V246A	probably damaging	Het
Lrrk2	A	T	15: 91,567,345 (GRCm39)	I135L	probably benign	Het
Malrd1	G	A	2: 16,106,768 (GRCm39)		probably null	Het
Mctp2	T	C	7: 71,878,274 (GRCm39)	K268R	probably benign	Het
Nbea	A	T	3: 55,938,957 (GRCm39)	H710Q	probably benign	Het
Notch3	G	A	17: 32,385,731 (GRCm39)	R13C	unknown	Het
Ogfod1	A	T	8: 94,782,299 (GRCm39)		probably benign	Het
Or1j11	A	G	2: 36,311,716 (GRCm39)	Y102C	probably benign	Het
Or5b111	A	G	19: 13,291,490 (GRCm39)	L53P	probably damaging	Het
Or8d2	T	C	9: 38,759,548 (GRCm39)	I46T	probably damaging	Het
Pgm3	A	G	9: 86,443,932 (GRCm39)	V324A	probably damaging	Het
Ppfia2	A	T	10: 106,694,068 (GRCm39)	I681F	probably damaging	Het
Prss23	T	C	7: 89,159,095 (GRCm39)	K325E	possibly damaging	Het
Psmd7	T	A	8: 108,313,249 (GRCm39)		probably benign	Het
Rfx2	T	A	17: 57,115,317 (GRCm39)	M1L	possibly damaging	Het
Rpa1	T	C	11: 75,203,141 (GRCm39)	Y418C	probably damaging	Het
Rps6kc1	C	T	1: 190,505,875 (GRCm39)	R1029H	probably damaging	Het
Septin10	A	G	10: 59,002,422 (GRCm39)	V391A	probably benign	Het
Skint6	A	G	4: 113,093,637 (GRCm39)	F169L	probably benign	Het
Slc44a4	C	T	17: 35,140,674 (GRCm39)	T289I	probably benign	Het
Spata31e5	T	C	1: 28,816,137 (GRCm39)	I632V	probably benign	Het
Srl	T	C	16: 4,315,546 (GRCm39)	D32G	probably damaging	Het
Stxbp3-ps	T	A	19: 9,535,256 (GRCm39)		noncoding transcript	Het
Sult1b1	T	C	5: 87,662,815 (GRCm39)	D295G	probably benign	Het
Tmprss7	A	G	16: 45,504,937 (GRCm39)	V151A	probably damaging	Het
Vmn2r98	T	A	17: 19,285,447 (GRCm39)	I89N	probably damaging	Het
Zcwpw1	G	A	5: 137,795,061 (GRCm39)	A86T	probably benign	Het
Zkscan16	A	G	4: 58,956,690 (GRCm39)	H324R	possibly damaging	Het

Other mutations in Trmo

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00593:Trmo	APN	4	46,382,490 (GRCm39)	missense	probably benign
IGL01308:Trmo	APN	4	46,377,053 (GRCm39)	utr 3 prime	probably benign
IGL01544:Trmo	APN	4	46,386,169 (GRCm39)	missense	probably damaging	1.00
IGL01545:Trmo	APN	4	46,386,169 (GRCm39)	missense	probably damaging	1.00
IGL01722:Trmo	APN	4	46,386,092 (GRCm39)	critical splice donor site	probably null
IGL02085:Trmo	APN	4	46,380,217 (GRCm39)	missense	probably damaging	1.00
IGL02927:Trmo	APN	4	46,387,602 (GRCm39)	missense	probably damaging	1.00
R0645:Trmo	UTSW	4	46,377,083 (GRCm39)	utr 3 prime	probably benign
R0745:Trmo	UTSW	4	46,382,104 (GRCm39)	missense	probably damaging	1.00
R1365:Trmo	UTSW	4	46,380,278 (GRCm39)	missense	probably damaging	1.00
R1835:Trmo	UTSW	4	46,380,158 (GRCm39)	missense	probably damaging	1.00
R3928:Trmo	UTSW	4	46,382,647 (GRCm39)	missense	probably damaging	1.00
R3929:Trmo	UTSW	4	46,382,647 (GRCm39)	missense	probably damaging	1.00
R4497:Trmo	UTSW	4	46,382,140 (GRCm39)	missense	probably damaging	1.00
R4938:Trmo	UTSW	4	46,382,388 (GRCm39)	missense	probably benign	0.00
R4980:Trmo	UTSW	4	46,389,364 (GRCm39)	nonsense	probably null
R5209:Trmo	UTSW	4	46,387,740 (GRCm39)	missense	probably damaging	0.99
R5639:Trmo	UTSW	4	46,382,073 (GRCm39)	missense	probably benign	0.00
R5855:Trmo	UTSW	4	46,382,568 (GRCm39)	missense	probably benign	0.43
R6151:Trmo	UTSW	4	46,389,390 (GRCm39)	missense	probably damaging	1.00
R7351:Trmo	UTSW	4	46,387,716 (GRCm39)	missense	possibly damaging	0.78
R8684:Trmo	UTSW	4	46,386,253 (GRCm39)	critical splice acceptor site	probably null
R8684:Trmo	UTSW	4	46,386,251 (GRCm39)	nonsense	probably null
R8823:Trmo	UTSW	4	46,382,604 (GRCm39)	missense	probably damaging	1.00
R8856:Trmo	UTSW	4	46,387,625 (GRCm39)	missense	probably benign	0.01
R9039:Trmo	UTSW	4	46,382,322 (GRCm39)	missense	probably benign	0.00
R9331:Trmo	UTSW	4	46,387,642 (GRCm39)	missense	possibly damaging	0.50

Posted On

2013-10-07