Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00334:Or10j5'

7320

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or10j5

Ensembl Gene

ENSMUSG00000037924

Gene Name

olfactory receptor family 10 subfamily J member 5

Synonyms

Olfr16, MOR267-13, GA_x6K02T2R7CC-893157-892228, MOR23

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.131) question?

Stock #

IGL00334

Quality Score

Status

Chromosome

Chromosomal Location

172784335-172785384 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to G at 172785158 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Arginine at position 265 (S265R)

Ref Sequence

ENSEMBL: ENSMUSP00000149249 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000038432] [ENSMUST00000215254]

AlphaFold

Q62007

Predicted Effect

possibly damaging
Transcript: ENSMUST00000038432
AA Change: S265R

PolyPhen 2 Score 0.658 (Sensitivity: 0.87; Specificity: 0.91)

SMART Domains

Protein: ENSMUSP00000041524
Gene: ENSMUSG00000037924
AA Change: S265R

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	307	7.5e-51	PFAM
Pfam:7tm_1	41	289	3.4e-22	PFAM

Predicted Effect

possibly damaging
Transcript: ENSMUST00000215254
AA Change: S265R

PolyPhen 2 Score 0.658 (Sensitivity: 0.87; Specificity: 0.91)

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 47 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Arsb	T	G	13: 94,075,787 (GRCm39)	H423Q	probably benign	Het
Bltp2	T	A	11: 78,160,400 (GRCm39)	L620I	possibly damaging	Het
Ces1f	T	C	8: 93,994,620 (GRCm39)	T264A	probably benign	Het
Clcn6	C	A	4: 148,102,359 (GRCm39)		probably null	Het
Cyb5r3	C	A	15: 83,044,605 (GRCm39)	A138S	probably benign	Het
Cyp3a57	A	T	5: 145,307,834 (GRCm39)	N197Y	probably damaging	Het
Dctn2	A	G	10: 127,113,559 (GRCm39)		probably benign	Het
Dnmt1	C	T	9: 20,821,566 (GRCm39)	A1197T	possibly damaging	Het
Dock2	T	C	11: 34,595,488 (GRCm39)	D436G	probably damaging	Het
Drd4	A	G	7: 140,872,096 (GRCm39)	N49S	probably damaging	Het
Dst	T	A	1: 34,205,373 (GRCm39)	V521D	probably damaging	Het
Eif5b	T	C	1: 38,080,800 (GRCm39)	S714P	probably damaging	Het
Glis3	A	G	19: 28,517,664 (GRCm39)	I178T	probably damaging	Het
Gm11565	T	A	11: 99,806,021 (GRCm39)	C138S	possibly damaging	Het
H1f8	T	A	6: 115,924,588 (GRCm39)		probably benign	Het
Hdx	T	A	X: 110,492,578 (GRCm39)	I623F	probably benign	Het
Huwe1	T	G	X: 150,668,623 (GRCm39)	L843V	probably damaging	Het
Hyal2	T	C	9: 107,447,604 (GRCm39)	Y86H	probably damaging	Het
Irf7	A	T	7: 140,844,553 (GRCm39)	S157T	probably benign	Het
Jmjd4	T	A	11: 59,346,140 (GRCm39)	M331K	probably damaging	Het
Kdm2a	A	T	19: 4,406,926 (GRCm39)	D112E	possibly damaging	Het
Mamdc2	A	C	19: 23,356,138 (GRCm39)	Y103*	probably null	Het
Map2k3	T	C	11: 60,834,041 (GRCm39)	V77A	possibly damaging	Het
Mideas	G	A	12: 84,219,629 (GRCm39)	R442*	probably null	Het
Mprip	T	A	11: 59,639,417 (GRCm39)	D403E	probably benign	Het
Mutyh	T	A	4: 116,676,516 (GRCm39)	V496D	possibly damaging	Het
Nbeal1	T	C	1: 60,321,042 (GRCm39)	V2051A	probably damaging	Het
Nbeal1	T	C	1: 60,367,262 (GRCm39)	L2575P	probably damaging	Het
Or51a6	T	C	7: 102,604,311 (GRCm39)	K173E	probably benign	Het
Pcdhb6	T	A	18: 37,467,277 (GRCm39)	I66N	probably damaging	Het
Pck2	T	C	14: 55,780,098 (GRCm39)	Y89H	probably benign	Het
Poglut3	T	A	9: 53,309,330 (GRCm39)		probably benign	Het
Poglut3	C	A	9: 53,309,328 (GRCm39)		probably benign	Het
Polr3e	C	T	7: 120,540,034 (GRCm39)	Q594*	probably null	Het
Ptpro	T	G	6: 137,371,907 (GRCm39)		probably null	Het
Rfx4	A	G	10: 84,615,917 (GRCm39)	K28E	possibly damaging	Het
Shox2	T	C	3: 66,888,774 (GRCm39)	E39G	possibly damaging	Het
Slc22a16	A	T	10: 40,449,930 (GRCm39)	D122V	probably benign	Het
Smr3a	A	C	5: 88,155,919 (GRCm39)		probably benign	Het
Spmip8	G	A	8: 96,039,676 (GRCm39)	R31H	probably damaging	Het
Taf4	G	T	2: 179,618,418 (GRCm39)	L8M	unknown	Het
Tbkbp1	T	A	11: 97,028,474 (GRCm39)		probably benign	Het
Tmem120b	G	T	5: 123,253,230 (GRCm39)	E210D	probably damaging	Het
Tmem120b	A	T	5: 123,253,229 (GRCm39)		probably null	Het
Trim21	C	T	7: 102,208,805 (GRCm39)	V305M	probably damaging	Het
Ube4a	A	T	9: 44,859,439 (GRCm39)	L353Q	probably damaging	Het
Zfyve1	A	T	12: 83,621,572 (GRCm39)	N274K	probably benign	Het

Other mutations in Or10j5

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00336:Or10j5	APN	1	172,785,045 (GRCm39)	missense	probably benign	0.30
IGL01155:Or10j5	APN	1	172,784,491 (GRCm39)	missense	probably benign	0.43
IGL01549:Or10j5	APN	1	172,784,541 (GRCm39)	missense	probably damaging	1.00
IGL02679:Or10j5	APN	1	172,784,743 (GRCm39)	missense	probably damaging	1.00
IGL03071:Or10j5	APN	1	172,784,502 (GRCm39)	missense	probably benign	0.01
IGL03352:Or10j5	APN	1	172,784,850 (GRCm39)	missense	probably benign	0.00
R0449:Or10j5	UTSW	1	172,784,965 (GRCm39)	missense	probably damaging	1.00
R1725:Or10j5	UTSW	1	172,784,908 (GRCm39)	missense	possibly damaging	0.90
R1726:Or10j5	UTSW	1	172,784,658 (GRCm39)	missense	probably benign	0.00
R1735:Or10j5	UTSW	1	172,784,374 (GRCm39)	missense	probably benign
R1928:Or10j5	UTSW	1	172,784,881 (GRCm39)	missense	probably damaging	0.98
R4258:Or10j5	UTSW	1	172,785,205 (GRCm39)	missense	possibly damaging	0.88
R4359:Or10j5	UTSW	1	172,784,647 (GRCm39)	missense	probably benign
R4434:Or10j5	UTSW	1	172,785,111 (GRCm39)	missense	probably damaging	1.00
R4666:Or10j5	UTSW	1	172,785,157 (GRCm39)	missense	probably benign
R4874:Or10j5	UTSW	1	172,785,166 (GRCm39)	missense	probably benign	0.00
R5063:Or10j5	UTSW	1	172,785,009 (GRCm39)	missense	possibly damaging	0.48
R5988:Or10j5	UTSW	1	172,784,723 (GRCm39)	nonsense	probably null
R6074:Or10j5	UTSW	1	172,784,945 (GRCm39)	missense	probably benign	0.10
R7021:Or10j5	UTSW	1	172,784,494 (GRCm39)	missense	probably benign	0.01
R7234:Or10j5	UTSW	1	172,784,673 (GRCm39)	missense	probably damaging	0.96
R7527:Or10j5	UTSW	1	172,784,511 (GRCm39)	missense	probably benign	0.00
R8271:Or10j5	UTSW	1	172,784,744 (GRCm39)	nonsense	probably null
R8890:Or10j5	UTSW	1	172,785,045 (GRCm39)	missense	probably benign	0.30
R8906:Or10j5	UTSW	1	172,784,186 (GRCm39)	start gained	probably benign
R9048:Or10j5	UTSW	1	172,784,929 (GRCm39)	missense	probably benign
R9583:Or10j5	UTSW	1	172,784,893 (GRCm39)	missense	probably damaging	1.00
Z1088:Or10j5	UTSW	1	172,784,891 (GRCm39)	missense	probably damaging	1.00

Posted On

2012-04-20