Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01301:Zfp213'

73230

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp213

Ensembl Gene

ENSMUSG00000071256

Gene Name

zinc finger protein 213

Synonyms

D17Ertd197e

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.065) question?

Stock #

IGL01301

Quality Score

Status

Chromosome

Chromosomal Location

23775741-23783200 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to T at 23780391 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Alanine to Aspartic acid at position 43 (A43D)

Ref Sequence

ENSEMBL: ENSMUSP00000093266 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000095606]

AlphaFold

E9QAW0

Predicted Effect

probably benign
Transcript: ENSMUST00000095606
AA Change: A43D

PolyPhen 2 Score 0.176 (Sensitivity: 0.92; Specificity: 0.87)

SMART Domains

Protein: ENSMUSP00000093266
Gene: ENSMUSG00000071256
AA Change: A43D

Domain	Start	End	E-Value	Type
SCAN	41	145	3.11e-56	SMART
KRAB	213	278	3.21e-4	SMART
ZnF_C2H2	326	348	3.89e-3	SMART
ZnF_C2H2	354	376	9.88e-5	SMART
ZnF_C2H2	382	404	6.42e-4	SMART
ZnF_C2H2	410	432	1.95e-3	SMART
ZnF_C2H2	438	460	4.4e-2	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000180920

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] C2H2 zinc finger proteins, such as ZNF213, have bipartite structures in which one domain binds DNA or RNA and the other modulates target gene expression.[supplied by OMIM, Apr 2004]

Allele List at MGI

Other mutations in this stock

Total: 44 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1600012H06Rik	C	T	17: 15,164,181 (GRCm39)		probably null	Het
Acacb	A	T	5: 114,384,559 (GRCm39)	I2238L	probably benign	Het
Aldh1l2	T	C	10: 83,358,710 (GRCm39)	Y95C	probably damaging	Het
Asxl2	A	G	12: 3,551,425 (GRCm39)	T1056A	probably damaging	Het
B4galnt1	A	G	10: 127,005,648 (GRCm39)	T250A	possibly damaging	Het
Cela3b	A	T	4: 137,151,154 (GRCm39)		probably null	Het
Chst3	T	C	10: 60,021,654 (GRCm39)	T398A	probably damaging	Het
Cngb3	A	G	4: 19,425,625 (GRCm39)	T478A	probably damaging	Het
Cyp4a10	T	C	4: 115,375,652 (GRCm39)	L45P	probably damaging	Het
Defb21	A	G	2: 152,416,671 (GRCm39)	E49G	possibly damaging	Het
Dnajc1	T	C	2: 18,313,645 (GRCm39)	T159A	probably damaging	Het
Dnmbp	A	G	19: 43,890,793 (GRCm39)	S325P	probably benign	Het
Fam91a1	T	C	15: 58,314,720 (GRCm39)	F534L	probably damaging	Het
Fermt2	T	C	14: 45,702,320 (GRCm39)	E488G	probably damaging	Het
Filip1	T	C	9: 79,726,462 (GRCm39)	D719G	possibly damaging	Het
Gad1-ps	A	G	10: 99,281,013 (GRCm39)		noncoding transcript	Het
Glra3	C	A	8: 56,393,997 (GRCm39)	A36E	probably benign	Het
Gm9884	T	A	1: 25,869,729 (GRCm39)		probably benign	Het
Hectd2	T	C	19: 36,546,770 (GRCm39)		probably benign	Het
Hnrnpm	C	T	17: 33,888,142 (GRCm39)		probably null	Het
Lrrk2	T	A	15: 91,651,542 (GRCm39)	Y1733N	probably damaging	Het
Mindy1	T	C	3: 95,195,701 (GRCm39)	L148P	probably damaging	Het
Mkrn2	C	A	6: 115,588,750 (GRCm39)	Y164*	probably null	Het
Msra	T	C	14: 64,447,884 (GRCm39)	Y135C	probably damaging	Het
Ndst3	C	T	3: 123,342,565 (GRCm39)	A749T	probably damaging	Het
Ngdn	G	T	14: 55,254,571 (GRCm39)	A41S	probably benign	Het
Nlrp12	A	T	7: 3,288,722 (GRCm39)	S597T	probably damaging	Het
Or5b99	A	T	19: 12,976,781 (GRCm39)	I144F	probably damaging	Het
Pabpc6	A	G	17: 9,886,899 (GRCm39)	S551P	probably benign	Het
Plekhg5	C	T	4: 152,197,010 (GRCm39)	A752V	probably benign	Het
Prpf4b	T	C	13: 35,068,274 (GRCm39)	S368P	probably benign	Het
Pus7	A	G	5: 23,951,422 (GRCm39)		probably null	Het
Rad23b	T	C	4: 55,366,774 (GRCm39)		probably benign	Het
Rgs13	T	C	1: 144,047,152 (GRCm39)		probably benign	Het
Sfpq	T	C	4: 126,920,553 (GRCm39)		probably benign	Het
Slc9a9	T	A	9: 94,937,512 (GRCm39)	S455T	probably benign	Het
Slco1a1	A	G	6: 141,878,256 (GRCm39)		probably benign	Het
Tmem26	A	T	10: 68,614,436 (GRCm39)	N284Y	probably damaging	Het
Tmem87a	T	C	2: 120,211,250 (GRCm39)	I232V	probably benign	Het
Trpm2	A	G	10: 77,759,818 (GRCm39)	L1106P	probably damaging	Het
Vmn1r18	T	C	6: 57,366,652 (GRCm39)		probably benign	Het
Zfp365	A	G	10: 67,745,184 (GRCm39)	V198A	probably damaging	Het
Zfp395	T	A	14: 65,632,200 (GRCm39)		probably null	Het
Zfp618	G	A	4: 63,051,063 (GRCm39)	V615M	probably damaging	Het

Other mutations in Zfp213

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02302:Zfp213	APN	17	23,776,945 (GRCm39)	missense	possibly damaging	0.88
ANU18:Zfp213	UTSW	17	23,780,391 (GRCm39)	missense	probably benign	0.18
R2137:Zfp213	UTSW	17	23,778,481 (GRCm39)	splice site	probably null
R4010:Zfp213	UTSW	17	23,777,064 (GRCm39)	missense	possibly damaging	0.93
R5149:Zfp213	UTSW	17	23,780,373 (GRCm39)	missense	probably damaging	0.97
R5595:Zfp213	UTSW	17	23,780,160 (GRCm39)	missense	possibly damaging	0.92
R5979:Zfp213	UTSW	17	23,776,885 (GRCm39)	nonsense	probably null
R6227:Zfp213	UTSW	17	23,776,996 (GRCm39)	missense	probably benign	0.16
R6711:Zfp213	UTSW	17	23,778,485 (GRCm39)	missense	probably benign
R7105:Zfp213	UTSW	17	23,777,178 (GRCm39)	missense	probably benign	0.40
R7409:Zfp213	UTSW	17	23,778,603 (GRCm39)	splice site	probably null

Posted On

2013-10-07