Incidental Mutation 'IGL01301:Slco1a1'
ID 73256
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Slco1a1
Ensembl Gene ENSMUSG00000041698
Gene Name solute carrier organic anion transporter family, member 1a1
Synonyms Slc21a1, Oatp1a1, Oatp1
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.270) question?
Stock # IGL01301
Quality Score
Status
Chromosome 6
Chromosomal Location 141853008-141892688 bp(-) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) A to G at 141878256 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000132386 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000042119] [ENSMUST00000168119]
AlphaFold Q9QXZ6
Predicted Effect probably benign
Transcript: ENSMUST00000042119
SMART Domains Protein: ENSMUSP00000037022
Gene: ENSMUSG00000041698

DomainStartEndE-ValueType
Pfam:OATP 21 597 6e-168 PFAM
Pfam:MFS_1 22 410 4.7e-28 PFAM
Pfam:Kazal_2 445 486 1.2e-10 PFAM
transmembrane domain 600 622 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000168119
SMART Domains Protein: ENSMUSP00000132386
Gene: ENSMUSG00000041698

DomainStartEndE-ValueType
Pfam:OATP 21 597 1.6e-168 PFAM
Pfam:MFS_1 22 410 1e-27 PFAM
Pfam:Kazal_2 445 486 4.6e-11 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000171651
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired organic anion transporter activity and urinary metabolomic profiles. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1600012H06Rik C T 17: 15,164,181 (GRCm39) probably null Het
Acacb A T 5: 114,384,559 (GRCm39) I2238L probably benign Het
Aldh1l2 T C 10: 83,358,710 (GRCm39) Y95C probably damaging Het
Asxl2 A G 12: 3,551,425 (GRCm39) T1056A probably damaging Het
B4galnt1 A G 10: 127,005,648 (GRCm39) T250A possibly damaging Het
Cela3b A T 4: 137,151,154 (GRCm39) probably null Het
Chst3 T C 10: 60,021,654 (GRCm39) T398A probably damaging Het
Cngb3 A G 4: 19,425,625 (GRCm39) T478A probably damaging Het
Cyp4a10 T C 4: 115,375,652 (GRCm39) L45P probably damaging Het
Defb21 A G 2: 152,416,671 (GRCm39) E49G possibly damaging Het
Dnajc1 T C 2: 18,313,645 (GRCm39) T159A probably damaging Het
Dnmbp A G 19: 43,890,793 (GRCm39) S325P probably benign Het
Fam91a1 T C 15: 58,314,720 (GRCm39) F534L probably damaging Het
Fermt2 T C 14: 45,702,320 (GRCm39) E488G probably damaging Het
Filip1 T C 9: 79,726,462 (GRCm39) D719G possibly damaging Het
Gad1-ps A G 10: 99,281,013 (GRCm39) noncoding transcript Het
Glra3 C A 8: 56,393,997 (GRCm39) A36E probably benign Het
Gm9884 T A 1: 25,869,729 (GRCm39) probably benign Het
Hectd2 T C 19: 36,546,770 (GRCm39) probably benign Het
Hnrnpm C T 17: 33,888,142 (GRCm39) probably null Het
Lrrk2 T A 15: 91,651,542 (GRCm39) Y1733N probably damaging Het
Mindy1 T C 3: 95,195,701 (GRCm39) L148P probably damaging Het
Mkrn2 C A 6: 115,588,750 (GRCm39) Y164* probably null Het
Msra T C 14: 64,447,884 (GRCm39) Y135C probably damaging Het
Ndst3 C T 3: 123,342,565 (GRCm39) A749T probably damaging Het
Ngdn G T 14: 55,254,571 (GRCm39) A41S probably benign Het
Nlrp12 A T 7: 3,288,722 (GRCm39) S597T probably damaging Het
Or5b99 A T 19: 12,976,781 (GRCm39) I144F probably damaging Het
Pabpc6 A G 17: 9,886,899 (GRCm39) S551P probably benign Het
Plekhg5 C T 4: 152,197,010 (GRCm39) A752V probably benign Het
Prpf4b T C 13: 35,068,274 (GRCm39) S368P probably benign Het
Pus7 A G 5: 23,951,422 (GRCm39) probably null Het
Rad23b T C 4: 55,366,774 (GRCm39) probably benign Het
Rgs13 T C 1: 144,047,152 (GRCm39) probably benign Het
Sfpq T C 4: 126,920,553 (GRCm39) probably benign Het
Slc9a9 T A 9: 94,937,512 (GRCm39) S455T probably benign Het
Tmem26 A T 10: 68,614,436 (GRCm39) N284Y probably damaging Het
Tmem87a T C 2: 120,211,250 (GRCm39) I232V probably benign Het
Trpm2 A G 10: 77,759,818 (GRCm39) L1106P probably damaging Het
Vmn1r18 T C 6: 57,366,652 (GRCm39) probably benign Het
Zfp213 G T 17: 23,780,391 (GRCm39) A43D probably benign Het
Zfp365 A G 10: 67,745,184 (GRCm39) V198A probably damaging Het
Zfp395 T A 14: 65,632,200 (GRCm39) probably null Het
Zfp618 G A 4: 63,051,063 (GRCm39) V615M probably damaging Het
Other mutations in Slco1a1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00327:Slco1a1 APN 6 141,854,851 (GRCm39) missense probably damaging 0.98
IGL00942:Slco1a1 APN 6 141,892,354 (GRCm39) missense probably benign 0.00
IGL01306:Slco1a1 APN 6 141,892,313 (GRCm39) nonsense probably null
IGL01774:Slco1a1 APN 6 141,871,339 (GRCm39) nonsense probably null
IGL02097:Slco1a1 APN 6 141,885,765 (GRCm39) missense possibly damaging 0.94
IGL02183:Slco1a1 APN 6 141,867,669 (GRCm39) splice site probably benign
IGL02376:Slco1a1 APN 6 141,870,060 (GRCm39) critical splice donor site probably null
IGL02550:Slco1a1 APN 6 141,889,191 (GRCm39) missense probably benign 0.24
IGL02559:Slco1a1 APN 6 141,867,514 (GRCm39) missense probably benign 0.01
IGL02825:Slco1a1 APN 6 141,864,343 (GRCm39) missense probably damaging 1.00
IGL03352:Slco1a1 APN 6 141,857,611 (GRCm39) missense probably benign 0.00
ANU23:Slco1a1 UTSW 6 141,892,313 (GRCm39) nonsense probably null
R0041:Slco1a1 UTSW 6 141,864,185 (GRCm39) splice site probably benign
R0153:Slco1a1 UTSW 6 141,856,427 (GRCm39) splice site probably benign
R0610:Slco1a1 UTSW 6 141,864,187 (GRCm39) critical splice donor site probably null
R0646:Slco1a1 UTSW 6 141,871,480 (GRCm39) splice site probably benign
R0828:Slco1a1 UTSW 6 141,867,565 (GRCm39) missense possibly damaging 0.89
R1674:Slco1a1 UTSW 6 141,881,661 (GRCm39) missense probably damaging 0.99
R1848:Slco1a1 UTSW 6 141,868,837 (GRCm39) missense probably benign 0.29
R3834:Slco1a1 UTSW 6 141,889,163 (GRCm39) missense possibly damaging 0.94
R3953:Slco1a1 UTSW 6 141,868,833 (GRCm39) missense probably damaging 1.00
R3974:Slco1a1 UTSW 6 141,854,819 (GRCm39) missense probably benign 0.01
R4081:Slco1a1 UTSW 6 141,881,688 (GRCm39) missense probably damaging 0.99
R4729:Slco1a1 UTSW 6 141,854,695 (GRCm39) missense probably benign 0.00
R4752:Slco1a1 UTSW 6 141,892,340 (GRCm39) missense possibly damaging 0.80
R4806:Slco1a1 UTSW 6 141,854,735 (GRCm39) missense possibly damaging 0.76
R4812:Slco1a1 UTSW 6 141,864,319 (GRCm39) missense probably damaging 1.00
R4963:Slco1a1 UTSW 6 141,868,825 (GRCm39) missense probably benign 0.26
R5641:Slco1a1 UTSW 6 141,885,695 (GRCm39) missense probably damaging 1.00
R6044:Slco1a1 UTSW 6 141,885,743 (GRCm39) missense probably benign 0.01
R6211:Slco1a1 UTSW 6 141,854,775 (GRCm39) missense probably benign 0.20
R6225:Slco1a1 UTSW 6 141,870,215 (GRCm39) missense possibly damaging 0.70
R6328:Slco1a1 UTSW 6 141,878,176 (GRCm39) missense probably damaging 1.00
R6428:Slco1a1 UTSW 6 141,871,416 (GRCm39) missense probably damaging 1.00
R6787:Slco1a1 UTSW 6 141,882,213 (GRCm39) missense probably benign 0.00
R7182:Slco1a1 UTSW 6 141,857,565 (GRCm39) missense probably damaging 1.00
R7305:Slco1a1 UTSW 6 141,870,223 (GRCm39) missense probably damaging 1.00
R7328:Slco1a1 UTSW 6 141,882,134 (GRCm39) missense possibly damaging 0.94
R7723:Slco1a1 UTSW 6 141,854,795 (GRCm39) missense probably damaging 0.97
R7784:Slco1a1 UTSW 6 141,889,114 (GRCm39) missense probably damaging 0.99
R8348:Slco1a1 UTSW 6 141,885,787 (GRCm39) missense possibly damaging 0.79
R8448:Slco1a1 UTSW 6 141,885,787 (GRCm39) missense possibly damaging 0.79
R8856:Slco1a1 UTSW 6 141,857,624 (GRCm39) missense probably damaging 1.00
R9121:Slco1a1 UTSW 6 141,892,542 (GRCm39) unclassified probably benign
R9484:Slco1a1 UTSW 6 141,854,672 (GRCm39) missense probably benign 0.00
Z1177:Slco1a1 UTSW 6 141,885,744 (GRCm39) missense probably benign 0.01
Posted On 2013-10-07