Incidental Mutation 'IGL01302:Olfr672'
ID73286
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr672
Ensembl Gene ENSMUSG00000051172
Gene Nameolfactory receptor 672
SynonymsMOR32-4, GA_x6K02T2PBJ9-7625746-7624808
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.072) question?
Stock #IGL01302
Quality Score
Status
Chromosome7
Chromosomal Location104995760-105002029 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 104996721 bp
ZygosityHeterozygous
Amino Acid Change Methionine to Lysine at position 61 (M61K)
Ref Sequence ENSEMBL: ENSMUSP00000149704 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000050599] [ENSMUST00000213942]
Predicted Effect probably damaging
Transcript: ENSMUST00000050599
AA Change: M61K

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000054607
Gene: ENSMUSG00000051172
AA Change: M61K

DomainStartEndE-ValueType
Pfam:7tm_4 33 311 9.1e-111 PFAM
Pfam:7TM_GPCR_Srsx 37 304 4.8e-7 PFAM
Pfam:7tm_1 43 293 5.8e-16 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000211761
AA Change: M61K
Predicted Effect probably damaging
Transcript: ENSMUST00000213942
AA Change: M61K

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca13 T A 11: 9,399,470 probably benign Het
Abcb5 T A 12: 118,918,200 D598V probably damaging Het
Adssl1 T C 12: 112,634,736 probably benign Het
Akap9 T A 5: 3,970,711 S1141T probably benign Het
Avil T C 10: 127,017,034 probably null Het
Avl9 C A 6: 56,725,090 H77N probably damaging Het
Cacna1e A G 1: 154,443,907 V1349A probably damaging Het
Cdc23 A C 18: 34,634,644 S483A probably benign Het
Cep192 C T 18: 67,858,903 P1951S probably benign Het
Cp A G 3: 19,966,367 T175A probably damaging Het
Dubr A C 16: 50,732,635 noncoding transcript Het
Eif4g2 G T 7: 111,074,713 Q695K possibly damaging Het
Endod1 A T 9: 14,357,239 S317T possibly damaging Het
Ep400 T C 5: 110,742,048 T450A probably benign Het
Erc1 A C 6: 119,722,303 V790G probably damaging Het
Fam222a T A 5: 114,594,453 L23Q possibly damaging Het
Fam35a C T 14: 34,259,727 V485I probably benign Het
Fancf A G 7: 51,861,287 V323A probably benign Het
Grik2 T A 10: 49,244,330 Q621L probably damaging Het
Gsk3b G T 16: 38,220,018 R319L probably benign Het
Ikzf1 A G 11: 11,768,923 Y297C probably damaging Het
Katnal2 T C 18: 77,047,167 probably benign Het
Lrba G T 3: 86,295,400 C289F probably damaging Het
Mos T C 4: 3,871,815 probably benign Het
Mycn T C 12: 12,937,586 D270G possibly damaging Het
Olfr777 T A 10: 129,268,523 I267F probably benign Het
Pclo A G 5: 14,675,999 probably benign Het
Pgm2 A G 4: 99,929,606 D14G probably damaging Het
Pramel7 T A 2: 87,491,373 D106V possibly damaging Het
Prdm9 G T 17: 15,553,346 H263N probably benign Het
Psd4 T A 2: 24,396,787 probably null Het
Ptprc G A 1: 138,099,631 T493I possibly damaging Het
Rbbp8 T A 18: 11,721,979 S420R probably benign Het
Sap30bp A G 11: 115,962,547 T219A probably damaging Het
Slc2a7 T A 4: 150,157,564 L200Q probably damaging Het
Slc38a6 T A 12: 73,288,525 probably null Het
Tatdn2 T A 6: 113,704,024 probably benign Het
Thrb A G 14: 18,011,056 probably benign Het
Timp4 T C 6: 115,246,308 Y218C possibly damaging Het
Tlr5 A G 1: 182,974,748 D525G probably benign Het
Usp32 G T 11: 84,988,482 T1467N probably benign Het
Vmn2r78 A G 7: 86,915,361 I5V unknown Het
Zbtb43 T C 2: 33,454,091 H374R probably benign Het
Zfhx4 C A 3: 5,243,568 T618K probably damaging Het
Other mutations in Olfr672
AlleleSourceChrCoordTypePredicted EffectPPH Score
PIT4151001:Olfr672 UTSW 7 104996217 missense probably damaging 1.00
R0396:Olfr672 UTSW 7 104996706 missense probably damaging 0.99
R0632:Olfr672 UTSW 7 104996703 missense probably benign 0.00
R1490:Olfr672 UTSW 7 104996493 missense possibly damaging 0.95
R1781:Olfr672 UTSW 7 104996108 missense possibly damaging 0.80
R2251:Olfr672 UTSW 7 104996595 missense probably damaging 1.00
R3419:Olfr672 UTSW 7 104996520 missense probably damaging 1.00
R3625:Olfr672 UTSW 7 104995984 missense probably benign 0.17
R4093:Olfr672 UTSW 7 104996635 missense probably benign 0.01
R4620:Olfr672 UTSW 7 104996623 missense probably damaging 1.00
R4890:Olfr672 UTSW 7 104996104 missense probably benign 0.15
R5338:Olfr672 UTSW 7 104996307 missense possibly damaging 0.61
R5934:Olfr672 UTSW 7 104996178 missense probably damaging 1.00
R6712:Olfr672 UTSW 7 104996418 missense possibly damaging 0.92
Z1088:Olfr672 UTSW 7 104996454 missense probably benign 0.00
Posted On2013-10-07