Incidental Mutation 'IGL01307:Fez2'
ID73510
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Fez2
Ensembl Gene ENSMUSG00000056121
Gene Namefasciculation and elongation protein zeta 2 (zygin II)
Synonymszygin 2, D17Ertd315e
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.220) question?
Stock #IGL01307
Quality Score
Status
Chromosome17
Chromosomal Location78377885-78418131 bp(-) (GRCm38)
Type of Mutationsplice site
DNA Base Change (assembly) C to T at 78381600 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000108106 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000070039] [ENSMUST00000112487]
Predicted Effect probably benign
Transcript: ENSMUST00000070039
SMART Domains Protein: ENSMUSP00000068987
Gene: ENSMUSG00000056121

DomainStartEndE-ValueType
Pfam:FEZ 42 284 7.2e-106 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000112487
SMART Domains Protein: ENSMUSP00000108106
Gene: ENSMUSG00000056121

DomainStartEndE-ValueType
Pfam:FEZ 42 281 2.2e-96 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is an ortholog of the C. elegans unc-76 gene, which is necessary for normal axonal bundling and elongation within axon bundles. Other orthologs include the rat gene that encodes zygin II, which can bind to synaptotagmin. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca13 T A 11: 9,297,159 M2302K possibly damaging Het
Actl9 A G 17: 33,434,178 E404G probably damaging Het
Adamts12 A T 15: 11,237,546 I314L possibly damaging Het
Card6 C A 15: 5,100,002 M637I possibly damaging Het
Ccdc122 G A 14: 77,092,076 probably benign Het
Cdh10 A G 15: 18,899,800 D71G probably benign Het
Cdk15 A T 1: 59,287,796 Y214F probably benign Het
Cdon A G 9: 35,457,564 K365E probably benign Het
Cyp2c37 T C 19: 39,992,579 V47A probably benign Het
Ddc T A 11: 11,839,462 D271V probably damaging Het
Dnah6 G A 6: 73,065,725 A3290V probably damaging Het
Dtl A T 1: 191,570,699 S20T possibly damaging Het
Egf A C 3: 129,739,993 I66S probably damaging Het
Eif4a3 T C 11: 119,293,561 K268E probably damaging Het
Fam205a1 G T 4: 42,850,963 L398I probably benign Het
Fbxl16 A T 17: 25,819,364 probably benign Het
Fras1 C A 5: 96,781,692 T3985K probably benign Het
Gbp4 T C 5: 105,137,021 M1V probably null Het
Gpnmb A G 6: 49,045,365 D143G probably benign Het
Grm5 A T 7: 88,075,012 T837S probably damaging Het
Hmcn1 T C 1: 150,745,001 T1153A possibly damaging Het
Hp C T 8: 109,575,783 V178I probably benign Het
Macf1 A T 4: 123,383,129 V4061E probably damaging Het
Msto1 C A 3: 88,913,686 R34L probably benign Het
Mtf2 C T 5: 108,106,890 T519M probably damaging Het
Myo3a T A 2: 22,558,289 N25K probably damaging Het
Ncapd2 A G 6: 125,168,619 V1355A possibly damaging Het
Nhlrc2 C A 19: 56,551,799 Y73* probably null Het
Nwd2 A T 5: 63,808,283 S1737C possibly damaging Het
Olfr59 T A 11: 74,289,428 C261S possibly damaging Het
Osmr A G 15: 6,844,427 V163A probably damaging Het
Palm3 T C 8: 84,029,445 S529P possibly damaging Het
Pcnt A G 10: 76,411,588 Y1037H probably damaging Het
Pkhd1l1 T C 15: 44,530,029 I1920T possibly damaging Het
Plekha7 A G 7: 116,145,244 probably benign Het
Psd C T 19: 46,314,658 G762R probably damaging Het
Psmb8 A G 17: 34,199,236 T51A probably benign Het
Rbm12 A C 2: 156,095,382 probably benign Het
Rictor T A 15: 6,774,604 probably null Het
Slc24a5 G A 2: 125,080,880 G158S probably damaging Het
Stag1 A G 9: 100,951,788 probably benign Het
Tln2 A G 9: 67,395,467 M74T probably benign Het
Trim24 C A 6: 37,965,635 D957E possibly damaging Het
Trpa1 A T 1: 14,896,547 M531K probably benign Het
Ttn A G 2: 76,906,293 Y4376H possibly damaging Het
Twsg1 T C 17: 65,948,651 probably benign Het
Usp34 T A 11: 23,417,676 V1671E probably damaging Het
Vwa5b2 A G 16: 20,604,270 D1006G probably benign Het
Other mutations in Fez2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01633:Fez2 APN 17 78404718 splice site probably benign
IGL02043:Fez2 APN 17 78381622 missense probably damaging 1.00
IGL02898:Fez2 APN 17 78384755 missense probably benign 0.03
R0433:Fez2 UTSW 17 78418047 missense probably damaging 1.00
R0472:Fez2 UTSW 17 78384832 splice site probably benign
R0753:Fez2 UTSW 17 78400686 small deletion probably benign
R4629:Fez2 UTSW 17 78402754 missense probably benign 0.00
R4646:Fez2 UTSW 17 78412928 missense probably damaging 1.00
R5955:Fez2 UTSW 17 78387043 missense probably damaging 1.00
Posted On2013-10-07