Incidental Mutation 'IGL01308:Or6c5'
ID 73520
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or6c5
Ensembl Gene ENSMUSG00000096229
Gene Name olfactory receptor family 6 subfamily C member 5
Synonyms Olfr774, MOR111-2, GA_x6K02T2PULF-10924432-10925370, MOR111-11
Accession Numbers
Essential gene? Probably non essential (E-score: 0.064) question?
Stock # IGL01308
Quality Score
Status
Chromosome 10
Chromosomal Location 129074020-129074958 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 129074476 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Serine at position 153 (T153S)
Ref Sequence ENSEMBL: ENSMUSP00000145042 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000097164] [ENSMUST00000203248]
AlphaFold Q7TRI5
Predicted Effect probably benign
Transcript: ENSMUST00000097164
AA Change: T153S

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000131609
Gene: ENSMUSG00000096229
AA Change: T153S

DomainStartEndE-ValueType
Pfam:7tm_4 28 307 6e-49 PFAM
Pfam:7tm_1 39 288 2.2e-18 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000203248
AA Change: T153S

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000145042
Gene: ENSMUSG00000096229
AA Change: T153S

DomainStartEndE-ValueType
Pfam:7tm_4 28 307 6e-49 PFAM
Pfam:7tm_1 39 288 2.2e-18 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acan A G 7: 78,748,997 (GRCm39) D1256G probably damaging Het
Acot7 A T 4: 152,345,353 (GRCm39) M308L probably benign Het
Adarb2 A G 13: 8,253,329 (GRCm39) R25G possibly damaging Het
Ano1 C A 7: 144,149,235 (GRCm39) Q875H probably damaging Het
Ano6 G A 15: 95,811,542 (GRCm39) probably null Het
Defa40 C T 8: 21,740,434 (GRCm39) T80I probably damaging Het
Efcab3 A T 11: 104,611,523 (GRCm39) D455V probably benign Het
Ehbp1 G A 11: 22,088,022 (GRCm39) P354L probably damaging Het
Eml5 T C 12: 98,768,572 (GRCm39) H1454R probably damaging Het
Esyt1 T A 10: 128,355,660 (GRCm39) N421Y possibly damaging Het
Gen1 T C 12: 11,306,871 (GRCm39) T100A probably damaging Het
Jak3 A T 8: 72,137,810 (GRCm39) D780V probably damaging Het
Klrb1a A G 6: 128,595,008 (GRCm39) probably benign Het
Lrp8 A G 4: 107,721,273 (GRCm39) I826M probably benign Het
Mcmbp G A 7: 128,316,209 (GRCm39) Q214* probably null Het
Mtmr7 A T 8: 41,050,388 (GRCm39) Y136N probably damaging Het
Ndor1 A G 2: 25,140,151 (GRCm39) Y88H probably benign Het
Nkx2-4 A G 2: 146,926,260 (GRCm39) Y201H possibly damaging Het
Or3a1d A G 11: 74,237,486 (GRCm39) L308P probably damaging Het
Or52n4b T A 7: 108,143,933 (GRCm39) L65* probably null Het
Pigg T C 5: 108,484,343 (GRCm39) L663P probably damaging Het
Pik3cd A G 4: 149,741,917 (GRCm39) V343A probably damaging Het
Plekha4 A G 7: 45,187,659 (GRCm39) S244G probably damaging Het
Prkce T A 17: 86,932,890 (GRCm39) D623E probably damaging Het
Rasgrf2 A G 13: 92,159,425 (GRCm39) probably benign Het
Rexo5 T C 7: 119,433,499 (GRCm39) W419R probably damaging Het
Rnaseh2b A G 14: 62,602,706 (GRCm39) probably null Het
Rras A G 7: 44,670,709 (GRCm39) Y193C possibly damaging Het
Sall4 T C 2: 168,592,164 (GRCm39) I997V probably damaging Het
Sec31b A G 19: 44,512,122 (GRCm39) F591L probably benign Het
Skic2 A G 17: 35,059,610 (GRCm39) L232P probably benign Het
Slc13a3 A T 2: 165,248,700 (GRCm39) I526N probably damaging Het
Slc6a11 C T 6: 114,111,626 (GRCm39) T103M probably damaging Het
Snrnp25 A G 11: 32,158,745 (GRCm39) probably benign Het
Tex264 T C 9: 106,539,607 (GRCm39) K201E possibly damaging Het
Tgfb1 G T 7: 25,387,442 (GRCm39) R50L probably damaging Het
Tle4 A G 19: 14,445,625 (GRCm39) V207A probably benign Het
Tmed1 A T 9: 21,421,338 (GRCm39) C45* probably null Het
Tmem260 A G 14: 48,749,415 (GRCm39) N638S probably damaging Het
Traf3ip3 T C 1: 192,867,199 (GRCm39) E274G probably damaging Het
Trak1 T C 9: 121,272,802 (GRCm39) probably null Het
Trim3 A T 7: 105,266,676 (GRCm39) V502E probably damaging Het
Trmo C T 4: 46,377,053 (GRCm39) probably benign Het
Xab2 C T 8: 3,666,332 (GRCm39) R192Q probably benign Het
Other mutations in Or6c5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01627:Or6c5 APN 10 129,074,138 (GRCm39) missense probably damaging 1.00
IGL01678:Or6c5 APN 10 129,074,537 (GRCm39) missense possibly damaging 0.94
IGL01759:Or6c5 APN 10 129,074,941 (GRCm39) missense probably benign 0.13
IGL03261:Or6c5 APN 10 129,074,272 (GRCm39) missense possibly damaging 0.72
R1996:Or6c5 UTSW 10 129,074,298 (GRCm39) missense possibly damaging 0.89
R2103:Or6c5 UTSW 10 129,074,368 (GRCm39) missense probably damaging 0.99
R2104:Or6c5 UTSW 10 129,074,368 (GRCm39) missense probably damaging 0.99
R2330:Or6c5 UTSW 10 129,074,908 (GRCm39) nonsense probably null
R3977:Or6c5 UTSW 10 129,074,377 (GRCm39) missense probably damaging 1.00
R4544:Or6c5 UTSW 10 129,074,027 (GRCm39) missense probably damaging 0.96
R6058:Or6c5 UTSW 10 129,074,329 (GRCm39) missense probably damaging 0.97
R8176:Or6c5 UTSW 10 129,074,747 (GRCm39) missense probably benign 0.39
R8708:Or6c5 UTSW 10 129,074,678 (GRCm39) missense possibly damaging 0.92
R9476:Or6c5 UTSW 10 129,074,656 (GRCm39) missense probably damaging 1.00
Posted On 2013-10-07