Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01310:Or10ag60'

73620

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or10ag60

Ensembl Gene

ENSMUSG00000059205

Gene Name

olfactory receptor family 10 subfamily AG member 60

Synonyms

GA_x6K02T2Q125-49112575-49113519, Olfr1130, MOR264-4

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.176) question?

Stock #

IGL01310

Quality Score

Status

Chromosome

Chromosomal Location

87436556-87438678 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 87437852 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Asparagine at position 40 (I40N)

Ref Sequence

ENSEMBL: ENSMUSP00000078649 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000079711] [ENSMUST00000213103] [ENSMUST00000216580]

AlphaFold

A0A1L1SQT2

Predicted Effect

possibly damaging
Transcript: ENSMUST00000079711
AA Change: I40N

PolyPhen 2 Score 0.683 (Sensitivity: 0.86; Specificity: 0.92)

SMART Domains

Protein: ENSMUSP00000078649
Gene: ENSMUSG00000068814
AA Change: I40N

Domain	Start	End	E-Value	Type
Pfam:7tm_4	37	314	3.4e-52	PFAM
Pfam:7tm_1	47	296	1.3e-19	PFAM

Predicted Effect

possibly damaging
Transcript: ENSMUST00000213103
AA Change: I40N

PolyPhen 2 Score 0.632 (Sensitivity: 0.87; Specificity: 0.91)

Predicted Effect

possibly damaging
Transcript: ENSMUST00000216580
AA Change: I40N

PolyPhen 2 Score 0.632 (Sensitivity: 0.87; Specificity: 0.91)

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 50 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930431F12Rik	A	T	5: 45,125,156 (GRCm39)		noncoding transcript	Het
Abca12	A	T	1: 71,323,315 (GRCm39)	I1589N	probably benign	Het
Abca8a	T	G	11: 109,950,801 (GRCm39)	D888A	probably benign	Het
Adam5	C	T	8: 25,232,150 (GRCm39)		probably benign	Het
Amer1	A	T	X: 94,470,716 (GRCm39)	N467K	probably benign	Het
Atp6v0a2	A	G	5: 124,783,968 (GRCm39)	D272G	probably damaging	Het
Cacna1b	A	T	2: 24,575,794 (GRCm39)	N751K	probably damaging	Het
Cfi	T	A	3: 129,652,080 (GRCm39)	N250K	probably damaging	Het
Cndp2	G	T	18: 84,689,002 (GRCm39)	P260Q	possibly damaging	Het
Cnnm3	A	G	1: 36,551,956 (GRCm39)	D322G	probably benign	Het
Crybg1	A	T	10: 43,851,054 (GRCm39)	S1606T	possibly damaging	Het
Crybg1	A	G	10: 43,879,596 (GRCm39)	S531P	probably damaging	Het
Espnl	A	T	1: 91,268,333 (GRCm39)	K320*	probably null	Het
Glt1d1	A	G	5: 127,709,384 (GRCm39)	T13A	possibly damaging	Het
Gpam	C	T	19: 55,066,764 (GRCm39)	A584T	possibly damaging	Het
Gpr19	A	G	6: 134,846,705 (GRCm39)	I289T	probably damaging	Het
Grm8	T	C	6: 27,363,800 (GRCm39)	I572V	probably damaging	Het
Gtpbp4	A	T	13: 9,027,308 (GRCm39)	N502K	probably benign	Het
Herpud2	T	C	9: 25,062,247 (GRCm39)	M6V	probably benign	Het
Igdcc3	T	C	9: 65,085,724 (GRCm39)	V263A	probably damaging	Het
Il33	G	A	19: 29,930,156 (GRCm39)	A65T	probably benign	Het
Itga9	T	A	9: 118,598,227 (GRCm39)	M1K	probably null	Het
Izumo3	T	C	4: 92,035,217 (GRCm39)		probably benign	Het
Kdr	G	A	5: 76,110,261 (GRCm39)	P909S	probably damaging	Het
Kirrel1	C	T	3: 86,997,182 (GRCm39)	E262K	probably benign	Het
Krt25	T	A	11: 99,208,996 (GRCm39)	Q278L	probably benign	Het
Lgi2	G	T	5: 52,711,807 (GRCm39)	P195Q	probably benign	Het
Lpcat3	T	C	6: 124,676,301 (GRCm39)	F120S	possibly damaging	Het
Nalcn	C	T	14: 123,554,661 (GRCm39)	R910Q	probably benign	Het
Nrxn1	A	G	17: 90,366,902 (GRCm39)		probably null	Het
Nuf2	A	T	1: 169,326,431 (GRCm39)	V440E	probably benign	Het
Or4f14	C	T	2: 111,742,652 (GRCm39)	V208M	probably benign	Het
Or51ah3	C	T	7: 103,210,008 (GRCm39)	S108F	probably benign	Het
Or6c205	T	C	10: 129,086,865 (GRCm39)	I154T	possibly damaging	Het
Pfpl	A	G	19: 12,405,974 (GRCm39)	D75G	probably damaging	Het
Pgm5	A	G	19: 24,812,130 (GRCm39)	V134A	possibly damaging	Het
Prkch	A	G	12: 73,805,787 (GRCm39)	I521V	possibly damaging	Het
Rps6kc1	T	A	1: 190,515,822 (GRCm39)	E968V	probably benign	Het
Slc25a30	T	C	14: 76,007,037 (GRCm39)	Y153C	probably damaging	Het
Smtnl2	T	A	11: 72,292,171 (GRCm39)		probably null	Het
Spmip4	C	A	6: 50,551,175 (GRCm39)	V425L	probably benign	Het
Tbc1d14	T	A	5: 36,700,544 (GRCm39)	K275*	probably null	Het
Tnc	T	C	4: 63,931,314 (GRCm39)	T799A	probably benign	Het
Trdn	A	T	10: 33,181,094 (GRCm39)		probably benign	Het
Ttn	T	C	2: 76,706,879 (GRCm39)		probably benign	Het
Uaca	T	C	9: 60,779,507 (GRCm39)	M1296T	probably benign	Het
Ubash3a	A	C	17: 31,434,116 (GRCm39)	I154L	probably benign	Het
Vmn2r4	T	A	3: 64,317,200 (GRCm39)		probably null	Het
Xpc	T	C	6: 91,467,089 (GRCm39)	K915E	probably benign	Het
Zfp318	T	C	17: 46,724,153 (GRCm39)	I2052T	possibly damaging	Het

Other mutations in Or10ag60

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01151:Or10ag60	APN	2	87,438,323 (GRCm39)	missense	probably damaging	1.00
IGL02558:Or10ag60	APN	2	87,437,903 (GRCm39)	missense	probably benign	0.00
R0323:Or10ag60	UTSW	2	87,437,841 (GRCm39)	missense	probably benign
R0590:Or10ag60	UTSW	2	87,438,338 (GRCm39)	missense	probably damaging	0.98
R0718:Or10ag60	UTSW	2	87,438,271 (GRCm39)	missense	probably benign	0.08
R2445:Or10ag60	UTSW	2	87,438,302 (GRCm39)	missense	probably damaging	0.99
R3408:Or10ag60	UTSW	2	87,438,220 (GRCm39)	missense	probably benign	0.03
R4280:Or10ag60	UTSW	2	87,438,595 (GRCm39)	missense	possibly damaging	0.90
R4491:Or10ag60	UTSW	2	87,437,736 (GRCm39)	start codon destroyed	probably null	0.84
R4928:Or10ag60	UTSW	2	87,438,487 (GRCm39)	missense	probably benign	0.06
R5033:Or10ag60	UTSW	2	87,438,055 (GRCm39)	missense	probably damaging	1.00
R5061:Or10ag60	UTSW	2	87,438,176 (GRCm39)	missense	probably benign	0.00
R5109:Or10ag60	UTSW	2	87,438,319 (GRCm39)	missense	possibly damaging	0.78
R5109:Or10ag60	UTSW	2	87,437,755 (GRCm39)	missense	possibly damaging	0.64
R5772:Or10ag60	UTSW	2	87,438,517 (GRCm39)	missense	probably benign	0.12
R6004:Or10ag60	UTSW	2	87,438,253 (GRCm39)	missense	probably damaging	1.00
R6005:Or10ag60	UTSW	2	87,438,424 (GRCm39)	missense	probably damaging	0.97
R6411:Or10ag60	UTSW	2	87,438,317 (GRCm39)	missense	probably damaging	1.00
R6964:Or10ag60	UTSW	2	87,437,957 (GRCm39)	missense	probably damaging	1.00
R7085:Or10ag60	UTSW	2	87,437,750 (GRCm39)	missense	probably benign	0.00
R7484:Or10ag60	UTSW	2	87,438,281 (GRCm39)	missense	probably damaging	1.00
R8429:Or10ag60	UTSW	2	87,437,868 (GRCm39)	missense	probably benign	0.06
R8471:Or10ag60	UTSW	2	87,437,989 (GRCm39)	missense	probably damaging	0.99
R8485:Or10ag60	UTSW	2	87,438,601 (GRCm39)	missense	probably benign	0.00
R8890:Or10ag60	UTSW	2	87,438,412 (GRCm39)	missense	probably damaging	1.00
R8935:Or10ag60	UTSW	2	87,438,421 (GRCm39)	missense	possibly damaging	0.72
X0060:Or10ag60	UTSW	2	87,438,386 (GRCm39)	missense	probably benign	0.11
Z1176:Or10ag60	UTSW	2	87,438,098 (GRCm39)	missense	probably benign	0.34

Posted On

2013-10-07