Incidental Mutation 'IGL01311:Slc25a34'
ID |
73683 |
Institutional Source |
Australian Phenomics Network
(link to record)
|
Gene Symbol |
Slc25a34
|
Ensembl Gene |
ENSMUSG00000040740 |
Gene Name |
solute carrier family 25, member 34 |
Synonyms |
LOC384071 |
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.071)
|
Stock # |
IGL01311
|
Quality Score |
|
Status
|
|
Chromosome |
4 |
Chromosomal Location |
141346135-141351132 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
G to A
at 141348747 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Threonine to Isoleucine
at position 239
(T239I)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000039188
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000030751]
[ENSMUST00000038661]
[ENSMUST00000053263]
[ENSMUST00000084203]
[ENSMUST00000143154]
|
AlphaFold |
A2ADF7 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000030751
|
SMART Domains |
Protein: ENSMUSP00000030751 Gene: ENSMUSG00000028917
Domain | Start | End | E-Value | Type |
RUN
|
93 |
156 |
3.18e-21 |
SMART |
low complexity region
|
230 |
246 |
N/A |
INTRINSIC |
low complexity region
|
295 |
307 |
N/A |
INTRINSIC |
low complexity region
|
459 |
469 |
N/A |
INTRINSIC |
low complexity region
|
485 |
495 |
N/A |
INTRINSIC |
low complexity region
|
505 |
538 |
N/A |
INTRINSIC |
Blast:PH
|
596 |
656 |
7e-31 |
BLAST |
PH
|
766 |
869 |
2.43e-12 |
SMART |
Blast:PH
|
879 |
960 |
6e-9 |
BLAST |
|
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000038661
AA Change: T239I
PolyPhen 2
Score 0.838 (Sensitivity: 0.84; Specificity: 0.93)
|
SMART Domains |
Protein: ENSMUSP00000039188 Gene: ENSMUSG00000040740 AA Change: T239I
Domain | Start | End | E-Value | Type |
Pfam:Mito_carr
|
16 |
111 |
2.2e-14 |
PFAM |
Pfam:Mito_carr
|
113 |
213 |
7.6e-18 |
PFAM |
Pfam:Mito_carr
|
217 |
314 |
9.3e-18 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000053263
|
SMART Domains |
Protein: ENSMUSP00000058412 Gene: ENSMUSG00000043085
Domain | Start | End | E-Value | Type |
Pfam:TMEM82
|
10 |
315 |
2.4e-137 |
PFAM |
low complexity region
|
342 |
356 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000084203
|
SMART Domains |
Protein: ENSMUSP00000081221 Gene: ENSMUSG00000028917
Domain | Start | End | E-Value | Type |
RUN
|
93 |
156 |
3.18e-21 |
SMART |
low complexity region
|
250 |
266 |
N/A |
INTRINSIC |
low complexity region
|
315 |
327 |
N/A |
INTRINSIC |
low complexity region
|
479 |
489 |
N/A |
INTRINSIC |
low complexity region
|
505 |
515 |
N/A |
INTRINSIC |
low complexity region
|
525 |
558 |
N/A |
INTRINSIC |
Blast:PH
|
616 |
676 |
7e-31 |
BLAST |
PH
|
786 |
889 |
2.43e-12 |
SMART |
Blast:PH
|
899 |
980 |
6e-9 |
BLAST |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000143154
|
SMART Domains |
Protein: ENSMUSP00000120973 Gene: ENSMUSG00000043085
Domain | Start | End | E-Value | Type |
low complexity region
|
3 |
16 |
N/A |
INTRINSIC |
transmembrane domain
|
31 |
53 |
N/A |
INTRINSIC |
transmembrane domain
|
74 |
96 |
N/A |
INTRINSIC |
low complexity region
|
126 |
142 |
N/A |
INTRINSIC |
transmembrane domain
|
144 |
166 |
N/A |
INTRINSIC |
transmembrane domain
|
203 |
222 |
N/A |
INTRINSIC |
transmembrane domain
|
232 |
249 |
N/A |
INTRINSIC |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000156246
|
Coding Region Coverage |
|
Validation Efficiency |
|
MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] SLC25A34 belongs to the SLC25 family of mitochondrial carrier proteins (Haitina et al., 2006 [PubMed 16949250]).[supplied by OMIM, Mar 2008]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 36 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Arap1 |
A |
T |
7: 101,037,343 (GRCm39) |
K457* |
probably null |
Het |
Arhgef10 |
C |
A |
8: 15,041,054 (GRCm39) |
|
probably null |
Het |
Becn1 |
C |
T |
11: 101,182,342 (GRCm39) |
G281S |
probably damaging |
Het |
Borcs8 |
A |
G |
8: 70,617,818 (GRCm39) |
S59G |
probably damaging |
Het |
Brd10 |
C |
T |
19: 29,731,420 (GRCm39) |
V531I |
probably benign |
Het |
Capn5 |
C |
A |
7: 97,811,130 (GRCm39) |
R53L |
probably damaging |
Het |
Cdk5 |
C |
T |
5: 24,624,593 (GRCm39) |
|
probably null |
Het |
Cnksr1 |
A |
G |
4: 133,957,777 (GRCm39) |
L434P |
probably damaging |
Het |
Col22a1 |
C |
T |
15: 71,845,486 (GRCm39) |
|
probably benign |
Het |
Fn1 |
T |
C |
1: 71,667,299 (GRCm39) |
D811G |
probably damaging |
Het |
Haus3 |
G |
A |
5: 34,324,988 (GRCm39) |
Q224* |
probably null |
Het |
Jakmip2 |
A |
G |
18: 43,690,389 (GRCm39) |
|
probably benign |
Het |
Jam3 |
T |
G |
9: 27,010,019 (GRCm39) |
T296P |
probably damaging |
Het |
Kcnrg |
T |
C |
14: 61,849,274 (GRCm39) |
L245P |
probably damaging |
Het |
Kif1b |
A |
G |
4: 149,305,059 (GRCm39) |
L909P |
probably damaging |
Het |
Klrc3 |
T |
C |
6: 129,618,375 (GRCm39) |
D136G |
probably damaging |
Het |
Lrrc37 |
T |
A |
11: 103,425,502 (GRCm39) |
R1450S |
unknown |
Het |
Ltf |
T |
C |
9: 110,860,080 (GRCm39) |
|
probably benign |
Het |
Meig1 |
A |
T |
2: 3,410,245 (GRCm39) |
V85D |
possibly damaging |
Het |
Mrgprb2 |
T |
A |
7: 48,201,746 (GRCm39) |
E326D |
probably benign |
Het |
Nlrp2 |
T |
A |
7: 5,322,238 (GRCm39) |
D65V |
possibly damaging |
Het |
Or4c100 |
T |
C |
2: 88,356,104 (GRCm39) |
F59S |
possibly damaging |
Het |
Or52h7 |
T |
C |
7: 104,214,036 (GRCm39) |
Y203H |
probably damaging |
Het |
Padi2 |
G |
A |
4: 140,644,948 (GRCm39) |
V61I |
probably benign |
Het |
Pkd1l1 |
T |
C |
11: 8,851,174 (GRCm39) |
S753G |
possibly damaging |
Het |
Ppp4r3b |
T |
C |
11: 29,144,591 (GRCm39) |
S314P |
probably benign |
Het |
Serpina3i |
T |
C |
12: 104,233,946 (GRCm39) |
S305P |
probably damaging |
Het |
Slc16a4 |
G |
T |
3: 107,199,821 (GRCm39) |
V23F |
possibly damaging |
Het |
Srebf2 |
T |
C |
15: 82,076,404 (GRCm39) |
|
probably benign |
Het |
Tasor2 |
A |
G |
13: 3,625,885 (GRCm39) |
V1355A |
possibly damaging |
Het |
Tcf12 |
A |
T |
9: 71,765,938 (GRCm39) |
|
probably benign |
Het |
Tnpo3 |
T |
C |
6: 29,586,077 (GRCm39) |
E171G |
possibly damaging |
Het |
Ubr4 |
A |
G |
4: 139,206,356 (GRCm39) |
H4864R |
possibly damaging |
Het |
Vmn2r108 |
A |
T |
17: 20,682,939 (GRCm39) |
L755* |
probably null |
Het |
Zfp292 |
C |
T |
4: 34,807,961 (GRCm39) |
M1699I |
probably benign |
Het |
Zmynd8 |
T |
C |
2: 165,647,129 (GRCm39) |
D880G |
probably damaging |
Het |
|
Other mutations in Slc25a34 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01578:Slc25a34
|
APN |
4 |
141,349,821 (GRCm39) |
splice site |
probably null |
|
IGL01694:Slc25a34
|
APN |
4 |
141,349,564 (GRCm39) |
missense |
probably benign |
0.03 |
IGL02421:Slc25a34
|
APN |
4 |
141,348,753 (GRCm39) |
missense |
probably benign |
0.00 |
R0139:Slc25a34
|
UTSW |
4 |
141,349,663 (GRCm39) |
missense |
possibly damaging |
0.51 |
R0415:Slc25a34
|
UTSW |
4 |
141,347,780 (GRCm39) |
missense |
possibly damaging |
0.48 |
R1851:Slc25a34
|
UTSW |
4 |
141,349,579 (GRCm39) |
missense |
probably benign |
0.06 |
R1852:Slc25a34
|
UTSW |
4 |
141,349,579 (GRCm39) |
missense |
probably benign |
0.06 |
R4776:Slc25a34
|
UTSW |
4 |
141,350,899 (GRCm39) |
missense |
possibly damaging |
0.83 |
R5112:Slc25a34
|
UTSW |
4 |
141,348,769 (GRCm39) |
missense |
probably benign |
0.01 |
R5426:Slc25a34
|
UTSW |
4 |
141,350,877 (GRCm39) |
missense |
probably damaging |
0.96 |
R5807:Slc25a34
|
UTSW |
4 |
141,350,973 (GRCm39) |
missense |
probably benign |
|
R6107:Slc25a34
|
UTSW |
4 |
141,350,806 (GRCm39) |
missense |
probably benign |
0.03 |
R6977:Slc25a34
|
UTSW |
4 |
141,347,809 (GRCm39) |
missense |
probably damaging |
1.00 |
R8191:Slc25a34
|
UTSW |
4 |
141,347,895 (GRCm39) |
missense |
probably damaging |
1.00 |
R9214:Slc25a34
|
UTSW |
4 |
141,350,641 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Posted On |
2013-10-07 |