Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01313:Or6c65'

73736

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or6c65

Ensembl Gene

ENSMUSG00000049894

Gene Name

olfactory receptor family 6 subfamily C member 65

Synonyms

GA_x6K02T2PULF-11446184-11447122, Olfr808, MOR112-2

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.063) question?

Stock #

IGL01313

Quality Score

Status

Chromosome

Chromosomal Location

129603367-129604305 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 129603464 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Cysteine at position 33 (Y33C)

Ref Sequence

ENSEMBL: ENSMUSP00000145315 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000060636] [ENSMUST00000203236]

AlphaFold

Q8VGI8

Predicted Effect

probably damaging
Transcript: ENSMUST00000060636
AA Change: Y33C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000059714
Gene: ENSMUSG00000049894
AA Change: Y33C

Domain	Start	End	E-Value	Type
Pfam:7tm_4	29	308	1.8e-53	PFAM
Pfam:7tm_1	39	288	7.7e-25	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000203236
AA Change: Y33C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000145315
Gene: ENSMUSG00000049894
AA Change: Y33C

Domain	Start	End	E-Value	Type
Pfam:7tm_4	29	308	1.8e-53	PFAM
Pfam:7tm_1	39	288	7.7e-25	PFAM

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 45 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A2m	T	C	6: 121,621,969 (GRCm39)		probably null	Het
Abca7	T	A	10: 79,838,957 (GRCm39)		probably benign	Het
Acvr1c	T	G	2: 58,205,986 (GRCm39)	Q41H	probably benign	Het
Apob	A	T	12: 8,050,898 (GRCm39)	N1041Y	probably damaging	Het
Asb5	A	T	8: 55,038,798 (GRCm39)		probably benign	Het
Asxl3	A	T	18: 22,650,516 (GRCm39)	E835V	probably benign	Het
Ccdc73	A	T	2: 104,737,972 (GRCm39)	M23L	probably benign	Het
Cep170b	G	A	12: 112,702,086 (GRCm39)	R293H	probably damaging	Het
Chd8	C	A	14: 52,448,032 (GRCm39)	L316F	probably damaging	Het
Cldn13	T	C	5: 134,944,114 (GRCm39)	S24G	possibly damaging	Het
Cnot10	A	T	9: 114,460,923 (GRCm39)	N82K	probably benign	Het
Colec10	G	A	15: 54,323,157 (GRCm39)	V127M	probably damaging	Het
Cyp2d40	T	C	15: 82,645,478 (GRCm39)	S130G	unknown	Het
Ddx60	T	A	8: 62,435,560 (GRCm39)	H904Q	probably damaging	Het
Dnaaf11	A	T	15: 66,252,362 (GRCm39)	S435T	probably benign	Het
Dnajc2	T	C	5: 21,979,974 (GRCm39)	N177S	possibly damaging	Het
F5	G	T	1: 164,021,181 (GRCm39)	V1219L	probably benign	Het
Fam47c	G	T	X: 77,781,454 (GRCm39)	R12L	probably damaging	Het
Fat4	T	C	3: 39,061,350 (GRCm39)	I4311T	possibly damaging	Het
Fbf1	A	G	11: 116,041,907 (GRCm39)	V545A	probably benign	Het
Fhod3	G	A	18: 25,153,777 (GRCm39)	E420K	probably damaging	Het
Ikzf2	T	C	1: 69,578,589 (GRCm39)	K162E	probably damaging	Het
Insl6	C	A	19: 29,298,953 (GRCm39)	S153I	possibly damaging	Het
Kcnh8	A	G	17: 53,141,708 (GRCm39)	Y317C	probably damaging	Het
Lzts1	C	A	8: 69,591,759 (GRCm39)	V130L	probably benign	Het
Mill1	T	C	7: 17,998,558 (GRCm39)	I256T	possibly damaging	Het
Mycbpap	A	C	11: 94,400,145 (GRCm39)		probably null	Het
Pdia6	T	A	12: 17,320,542 (GRCm39)		probably benign	Het
Pik3c2b	C	T	1: 132,999,369 (GRCm39)	Q406*	probably null	Het
Pkhd1	C	A	1: 20,271,248 (GRCm39)	G3102C	probably damaging	Het
Polr3b	T	A	10: 84,561,607 (GRCm39)	I1122N	probably damaging	Het
Ryr2	T	A	13: 11,653,371 (GRCm39)		probably null	Het
Samhd1	A	G	2: 156,958,321 (GRCm39)	I300T	probably damaging	Het
Skint5	T	A	4: 113,662,361 (GRCm39)	I609F	unknown	Het
Slc27a3	G	T	3: 90,293,861 (GRCm39)	T541K	probably damaging	Het
Stxbp4	A	G	11: 90,512,475 (GRCm39)		probably benign	Het
Sv2c	C	T	13: 96,224,797 (GRCm39)	V171M	probably damaging	Het
Tenm2	A	G	11: 35,915,075 (GRCm39)	V2154A	probably damaging	Het
Thoc1	A	T	18: 9,987,158 (GRCm39)	I433F	probably benign	Het
Thoc2	A	T	X: 40,916,223 (GRCm39)	V865D	probably benign	Het
Trdn	C	A	10: 33,076,216 (GRCm39)	P282Q	probably damaging	Het
Twsg1	C	A	17: 66,255,699 (GRCm39)	C25F	probably damaging	Het
Usp34	T	A	11: 23,423,206 (GRCm39)	I3155N	probably damaging	Het
Vmn2r106	T	A	17: 20,498,651 (GRCm39)	Q420L	probably damaging	Het
Vmn2r109	C	T	17: 20,770,419 (GRCm39)	R523K	probably damaging	Het

Other mutations in Or6c65

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00965:Or6c65	APN	10	129,603,455 (GRCm39)	missense	probably null	0.99
IGL01923:Or6c65	APN	10	129,603,973 (GRCm39)	missense	probably benign	0.01
IGL02010:Or6c65	APN	10	129,604,136 (GRCm39)	missense	probably benign	0.07
IGL02393:Or6c65	APN	10	129,603,662 (GRCm39)	missense	probably benign	0.06
IGL03026:Or6c65	APN	10	129,603,910 (GRCm39)	missense	probably benign	0.00
R1181:Or6c65	UTSW	10	129,604,033 (GRCm39)	missense	probably benign	0.09
R1760:Or6c65	UTSW	10	129,603,417 (GRCm39)	missense	probably benign	0.06
R1844:Or6c65	UTSW	10	129,603,725 (GRCm39)	missense	probably benign	0.03
R2697:Or6c65	UTSW	10	129,603,793 (GRCm39)	missense	probably benign	0.09
R3025:Or6c65	UTSW	10	129,603,542 (GRCm39)	missense	probably damaging	1.00
R3414:Or6c65	UTSW	10	129,604,301 (GRCm39)	missense	probably benign
R5824:Or6c65	UTSW	10	129,604,250 (GRCm39)	missense	probably damaging	1.00
R6260:Or6c65	UTSW	10	129,603,389 (GRCm39)	missense	probably benign	0.00
R6723:Or6c65	UTSW	10	129,604,284 (GRCm39)	missense	probably benign	0.38
R6758:Or6c65	UTSW	10	129,603,920 (GRCm39)	missense	probably damaging	0.97
R7305:Or6c65	UTSW	10	129,603,720 (GRCm39)	nonsense	probably null
R7422:Or6c65	UTSW	10	129,604,136 (GRCm39)	missense	possibly damaging	0.95
R8393:Or6c65	UTSW	10	129,604,304 (GRCm39)	makesense	probably null
R8444:Or6c65	UTSW	10	129,603,794 (GRCm39)	missense	probably damaging	1.00
R8702:Or6c65	UTSW	10	129,604,284 (GRCm39)	missense	probably benign	0.38
R8717:Or6c65	UTSW	10	129,604,127 (GRCm39)	missense	probably damaging	1.00
R8797:Or6c65	UTSW	10	129,603,674 (GRCm39)	missense	probably damaging	1.00
R9356:Or6c65	UTSW	10	129,604,035 (GRCm39)	missense	possibly damaging	0.87
R9596:Or6c65	UTSW	10	129,603,988 (GRCm39)	missense	probably damaging	1.00

Posted On

2013-10-07