Incidental Mutation 'IGL01320:Dcp1b'
ID74025
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Dcp1b
Ensembl Gene ENSMUSG00000041477
Gene Namedecapping mRNA 1B
SynonymsB930050E02Rik
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.114) question?
Stock #IGL01320
Quality Score
Status
Chromosome6
Chromosomal Location119175253-119221616 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 119215075 bp
ZygosityHeterozygous
Amino Acid Change Serine to Arginine at position 317 (S317R)
Ref Sequence ENSEMBL: ENSMUSP00000108397 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000073909] [ENSMUST00000112777]
Predicted Effect probably benign
Transcript: ENSMUST00000073909
AA Change: S317R

PolyPhen 2 Score 0.294 (Sensitivity: 0.91; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000073568
Gene: ENSMUSG00000041477
AA Change: S317R

DomainStartEndE-ValueType
low complexity region 2 8 N/A INTRINSIC
Pfam:DCP1 10 131 1.3e-53 PFAM
low complexity region 250 260 N/A INTRINSIC
low complexity region 451 462 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000112777
AA Change: S317R

PolyPhen 2 Score 0.294 (Sensitivity: 0.91; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000108397
Gene: ENSMUSG00000041477
AA Change: S317R

DomainStartEndE-ValueType
low complexity region 2 8 N/A INTRINSIC
Pfam:DCP1 13 129 3e-46 PFAM
low complexity region 250 260 N/A INTRINSIC
low complexity region 451 462 N/A INTRINSIC
low complexity region 515 526 N/A INTRINSIC
Pfam:mRNA_decap_C 536 578 2.1e-20 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000127059
Predicted Effect noncoding transcript
Transcript: ENSMUST00000136437
Predicted Effect noncoding transcript
Transcript: ENSMUST00000149651
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of a family of proteins that function in removing the 5' cap from mRNAs, which is a step in regulated mRNA decay. This protein localizes to cytoplasmic foci which are the site of mRNA breakdown and turnover. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A2ml1 T C 6: 128,575,588 E229G probably benign Het
Abca16 T A 7: 120,439,199 L368Q probably damaging Het
Ankrd17 A T 5: 90,260,129 S1410T probably damaging Het
Arntl T C 7: 113,303,407 I421T probably damaging Het
Asb8 A G 15: 98,141,278 probably benign Het
Chrdl2 A G 7: 100,017,041 Y56C probably damaging Het
Crnn T C 3: 93,148,212 S102P probably damaging Het
Cyb5a T C 18: 84,879,523 I115T probably damaging Het
Daw1 T C 1: 83,198,180 I213T possibly damaging Het
Dnah7a T C 1: 53,434,046 M3474V probably benign Het
E2f7 G A 10: 110,754,093 V36I probably benign Het
Esrp1 A G 4: 11,384,374 I103T possibly damaging Het
Hap1 G A 11: 100,349,380 T530I probably damaging Het
Hps3 T C 3: 20,030,469 N185S probably benign Het
Klra1 T A 6: 130,364,261 I250F probably benign Het
Lipn A G 19: 34,084,640 T332A probably benign Het
Ltbp4 A G 7: 27,328,359 probably benign Het
Ncor2 A G 5: 125,109,927 V11A probably benign Het
Nipsnap2 C T 5: 129,744,764 T108M probably damaging Het
Olfr153 T A 2: 87,532,285 M84K probably benign Het
Olfr479 A G 7: 108,054,981 probably benign Het
Ppid A G 3: 79,595,277 E46G probably damaging Het
Rrp12 A G 19: 41,877,936 L626P probably damaging Het
Slc6a15 A T 10: 103,404,745 I410F probably benign Het
Sorcs1 A G 19: 50,288,079 probably benign Het
Src G A 2: 157,469,503 G461R probably damaging Het
St8sia5 A T 18: 77,254,622 T307S probably damaging Het
Stac2 T C 11: 98,040,095 probably null Het
Tiam2 T C 17: 3,505,745 L77P probably damaging Het
Tmem87b G T 2: 128,831,216 G190V probably damaging Het
Trav7-6 T C 14: 53,717,108 S32P possibly damaging Het
Unc45b A G 11: 82,912,393 probably null Het
Wnt1 C A 15: 98,792,523 D244E possibly damaging Het
Other mutations in Dcp1b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01296:Dcp1b APN 6 119215358 missense probably damaging 0.96
IGL01348:Dcp1b APN 6 119183718 missense probably damaging 1.00
IGL01635:Dcp1b APN 6 119206537 missense probably damaging 1.00
IGL02888:Dcp1b APN 6 119220087 utr 3 prime probably benign
IGL03280:Dcp1b APN 6 119180058 intron probably benign
R1672:Dcp1b UTSW 6 119217911 missense probably benign
R2395:Dcp1b UTSW 6 119215064 missense probably benign
R2421:Dcp1b UTSW 6 119215266 missense probably benign 0.28
R2512:Dcp1b UTSW 6 119206512 missense possibly damaging 0.69
R2870:Dcp1b UTSW 6 119214774 missense probably benign
R2870:Dcp1b UTSW 6 119214774 missense probably benign
R4450:Dcp1b UTSW 6 119206476 missense probably benign 0.01
R5394:Dcp1b UTSW 6 119175367 missense probably damaging 1.00
R5688:Dcp1b UTSW 6 119217911 missense probably benign
Posted On2013-10-07