Incidental Mutation 'IGL01321:Lrrc59'
ID 74036
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Lrrc59
Ensembl Gene ENSMUSG00000020869
Gene Name leucine rich repeat containing 59
Synonyms C78668
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.266) question?
Stock # IGL01321
Quality Score
Status
Chromosome 11
Chromosomal Location 94520603-94536049 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) C to T at 94529426 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Stop codon at position 167 (R167*)
Ref Sequence ENSEMBL: ENSMUSP00000021239 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000021239]
AlphaFold Q922Q8
Predicted Effect probably null
Transcript: ENSMUST00000021239
AA Change: R167*
SMART Domains Protein: ENSMUSP00000021239
Gene: ENSMUSG00000020869
AA Change: R167*

DomainStartEndE-ValueType
LRR 38 60 6.22e0 SMART
LRR 61 83 1.33e-1 SMART
LRR 84 106 3.75e0 SMART
LRR 107 131 1.09e2 SMART
coiled coil region 148 216 N/A INTRINSIC
transmembrane domain 244 266 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000138782
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acnat2 A G 4: 49,380,269 (GRCm39) S370P probably damaging Het
Adamts5 T C 16: 85,696,363 (GRCm39) R265G probably benign Het
Cd2ap T C 17: 43,156,280 (GRCm39) S86G possibly damaging Het
Cers3 A C 7: 66,435,751 (GRCm39) probably benign Het
Dnaaf2 G T 12: 69,243,376 (GRCm39) P562T probably damaging Het
Dnajc21 A C 15: 10,447,188 (GRCm39) V520G probably benign Het
Dync1h1 A G 12: 110,592,041 (GRCm39) probably benign Het
Extl3 T C 14: 65,304,211 (GRCm39) N733D probably benign Het
Gm5499 T A 17: 87,385,928 (GRCm39) noncoding transcript Het
Gstm6 T C 3: 107,848,379 (GRCm39) Q180R probably benign Het
Hdlbp G A 1: 93,351,524 (GRCm39) R460W probably damaging Het
Ift81 T C 5: 122,749,031 (GRCm39) D40G probably damaging Het
Igsf3 T A 3: 101,334,338 (GRCm39) probably benign Het
Kcnb2 A G 1: 15,383,147 (GRCm39) T158A probably benign Het
Macf1 A G 4: 123,334,567 (GRCm39) C4397R probably damaging Het
Morc1 T C 16: 48,402,825 (GRCm39) S583P probably benign Het
Mucl3 A T 17: 35,947,758 (GRCm39) N490K probably damaging Het
Nipsnap2 T A 5: 129,834,205 (GRCm39) *282R probably null Het
Or2ag19 T C 7: 106,443,956 (GRCm39) L46P probably damaging Het
Or9m1b A T 2: 87,836,589 (GRCm39) C178S probably damaging Het
Parp14 T A 16: 35,676,929 (GRCm39) Q1013L probably benign Het
Pdzd8 A C 19: 59,289,961 (GRCm39) S480A probably benign Het
Piezo1 A T 8: 123,214,339 (GRCm39) S1609R probably damaging Het
Pkp4 G A 2: 59,180,971 (GRCm39) probably null Het
Plpp2 A T 10: 79,363,327 (GRCm39) V106D probably damaging Het
Rimbp2 T C 5: 128,863,816 (GRCm39) Y724C probably benign Het
Rpgrip1l A T 8: 91,987,501 (GRCm39) L852* probably null Het
Samd9l T A 6: 3,376,259 (GRCm39) D334V probably benign Het
Sipa1l2 G A 8: 126,218,257 (GRCm39) T360M probably damaging Het
Slc30a2 A T 4: 134,070,611 (GRCm39) D5V probably damaging Het
Spata31 T C 13: 65,069,568 (GRCm39) I572T probably benign Het
Tma16 G A 8: 66,929,512 (GRCm39) L161F probably benign Het
Trappc2b A T 11: 51,576,670 (GRCm39) V76D probably damaging Het
Trim69 A T 2: 122,003,765 (GRCm39) E238V possibly damaging Het
Zfhx4 A G 3: 5,307,388 (GRCm39) T205A probably benign Het
Other mutations in Lrrc59
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01525:Lrrc59 APN 11 94,525,522 (GRCm39) missense probably damaging 0.99
IGL01929:Lrrc59 APN 11 94,534,342 (GRCm39) missense possibly damaging 0.69
IGL01958:Lrrc59 APN 11 94,529,354 (GRCm39) splice site probably null
IGL02635:Lrrc59 APN 11 94,534,282 (GRCm39) missense probably damaging 1.00
R0277:Lrrc59 UTSW 11 94,534,248 (GRCm39) missense probably damaging 1.00
R0323:Lrrc59 UTSW 11 94,534,248 (GRCm39) missense probably damaging 1.00
R1794:Lrrc59 UTSW 11 94,529,421 (GRCm39) missense probably benign
R4833:Lrrc59 UTSW 11 94,525,498 (GRCm39) missense probably benign 0.00
R6242:Lrrc59 UTSW 11 94,525,809 (GRCm39) missense possibly damaging 0.65
R6817:Lrrc59 UTSW 11 94,520,891 (GRCm39) missense probably damaging 1.00
R7709:Lrrc59 UTSW 11 94,525,811 (GRCm39) missense probably damaging 1.00
R7724:Lrrc59 UTSW 11 94,534,170 (GRCm39) missense probably damaging 0.99
R8066:Lrrc59 UTSW 11 94,525,426 (GRCm39) missense possibly damaging 0.88
R9143:Lrrc59 UTSW 11 94,525,456 (GRCm39) missense probably damaging 1.00
R9166:Lrrc59 UTSW 11 94,522,959 (GRCm39) missense probably benign 0.00
R9266:Lrrc59 UTSW 11 94,532,044 (GRCm39) critical splice acceptor site probably null
Z1176:Lrrc59 UTSW 11 94,534,147 (GRCm39) missense probably benign 0.19
Posted On 2013-10-07