Incidental Mutation 'IGL01331:Dusp16'
ID 74523
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Dusp16
Ensembl Gene ENSMUSG00000030203
Gene Name dual specificity phosphatase 16
Synonyms MKP-7, MKP7, D6Ertd213e, 3830417M17Rik
Accession Numbers
Essential gene? Probably essential (E-score: 0.890) question?
Stock # IGL01331
Quality Score
Status
Chromosome 6
Chromosomal Location 134692431-134769588 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 134695067 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamine to Arginine at position 588 (Q588R)
Ref Sequence ENSEMBL: ENSMUSP00000098419 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000100857] [ENSMUST00000129433] [ENSMUST00000204083]
AlphaFold Q6PCP3
Predicted Effect possibly damaging
Transcript: ENSMUST00000100857
AA Change: Q588R

PolyPhen 2 Score 0.528 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000098419
Gene: ENSMUSG00000030203
AA Change: Q588R

DomainStartEndE-ValueType
RHOD 12 134 5.58e-16 SMART
DSPc 158 297 1.66e-68 SMART
Blast:DSPc 576 621 9e-11 BLAST
Predicted Effect probably benign
Transcript: ENSMUST00000129433
SMART Domains Protein: ENSMUSP00000115925
Gene: ENSMUSG00000030203

DomainStartEndE-ValueType
Blast:RHOD 1 67 8e-41 BLAST
PDB:2VSW|B 1 83 1e-52 PDB
DSPc 91 232 3.73e-44 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000148926
Predicted Effect noncoding transcript
Transcript: ENSMUST00000203452
Predicted Effect noncoding transcript
Transcript: ENSMUST00000203651
Predicted Effect probably benign
Transcript: ENSMUST00000204083
SMART Domains Protein: ENSMUSP00000144834
Gene: ENSMUSG00000030203

DomainStartEndE-ValueType
RHOD 12 124 1.5e-8 SMART
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a mitogen-activated protein kinase phosphatase that is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. The encoded protein specifically regulates the c-Jun amino-terminal kinase (JNK) and extracellular signal-regulated kinase (ERK) pathways.[provided by RefSeq, May 2010]
PHENOTYPE: Mice homozygous for a gene trap allele exhibit complete neonatal lethality and decreased birth weight. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Clca3a1 G A 3: 144,453,273 (GRCm39) T517M probably damaging Het
Clec4g T C 8: 3,767,190 (GRCm39) probably benign Het
Cmya5 C T 13: 93,233,454 (GRCm39) E545K possibly damaging Het
Cntn6 A T 6: 104,751,484 (GRCm39) D380V probably damaging Het
Col9a2 C T 4: 120,902,389 (GRCm39) P209S possibly damaging Het
Cyp2b9 T C 7: 25,887,140 (GRCm39) V183A probably damaging Het
Dpt T C 1: 164,624,379 (GRCm39) Y27H unknown Het
Emg1 A G 6: 124,682,033 (GRCm39) S164P probably benign Het
Foxk1 G A 5: 142,439,344 (GRCm39) R428Q probably damaging Het
Frmd4a T A 2: 4,607,036 (GRCm39) M667K probably benign Het
Gpr55 T A 1: 85,868,915 (GRCm39) probably benign Het
Gtpbp8 A G 16: 44,560,494 (GRCm39) I162T probably benign Het
Ighv1-59 C T 12: 115,298,992 (GRCm39) V21I possibly damaging Het
Ipo11 T A 13: 106,932,254 (GRCm39) Y938F possibly damaging Het
Map4 G T 9: 109,863,869 (GRCm39) V365L probably benign Het
Mboat1 C A 13: 30,403,684 (GRCm39) probably benign Het
Med12 A G X: 100,324,360 (GRCm39) E649G possibly damaging Het
Nfkbie T C 17: 45,869,495 (GRCm39) V150A probably benign Het
Or51ai2 A G 7: 103,586,782 (GRCm39) Y65C possibly damaging Het
Or8k22 A C 2: 86,163,048 (GRCm39) Y217* probably null Het
Prdm1 T A 10: 44,317,970 (GRCm39) K299N possibly damaging Het
Ribc1 T C X: 150,788,102 (GRCm39) T291A probably benign Het
Rps6kc1 G T 1: 190,532,549 (GRCm39) N484K possibly damaging Het
Serpina3k C A 12: 104,309,369 (GRCm39) A271D probably benign Het
Spata18 G T 5: 73,827,024 (GRCm39) R321L probably damaging Het
Styxl2 C A 1: 165,935,749 (GRCm39) V150L probably damaging Het
Syne2 C A 12: 75,976,027 (GRCm39) probably benign Het
Syt17 T A 7: 118,007,389 (GRCm39) I302F probably damaging Het
Tgm6 A G 2: 129,985,538 (GRCm39) probably null Het
Tmc2 A G 2: 130,074,276 (GRCm39) Y323C probably damaging Het
Tnc T C 4: 63,901,112 (GRCm39) D1452G probably damaging Het
Ttn A G 2: 76,620,022 (GRCm39) I7555T probably damaging Het
Ugt2b36 A T 5: 87,238,801 (GRCm39) W131R probably damaging Het
Vmn2r75 A T 7: 85,820,870 (GRCm39) C21* probably null Het
Zfp592 T A 7: 80,691,296 (GRCm39) C1158* probably null Het
Other mutations in Dusp16
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01090:Dusp16 APN 6 134,702,912 (GRCm39) missense probably benign 0.13
IGL01305:Dusp16 APN 6 134,695,824 (GRCm39) missense probably benign 0.03
IGL02535:Dusp16 APN 6 134,695,790 (GRCm39) missense probably benign
IGL02606:Dusp16 APN 6 134,737,999 (GRCm39) missense probably damaging 0.96
IGL02696:Dusp16 APN 6 134,695,398 (GRCm39) missense probably damaging 0.99
ANU22:Dusp16 UTSW 6 134,695,824 (GRCm39) missense probably benign 0.03
PIT4469001:Dusp16 UTSW 6 134,738,115 (GRCm39) unclassified probably benign
PIT4504001:Dusp16 UTSW 6 134,716,846 (GRCm39) missense possibly damaging 0.90
R0492:Dusp16 UTSW 6 134,695,365 (GRCm39) missense probably benign
R0578:Dusp16 UTSW 6 134,695,284 (GRCm39) missense probably damaging 1.00
R1630:Dusp16 UTSW 6 134,697,524 (GRCm39) missense probably damaging 1.00
R1962:Dusp16 UTSW 6 134,695,099 (GRCm39) nonsense probably null
R2004:Dusp16 UTSW 6 134,695,802 (GRCm39) missense probably benign
R3690:Dusp16 UTSW 6 134,738,082 (GRCm39) unclassified probably benign
R3730:Dusp16 UTSW 6 134,695,824 (GRCm39) missense probably benign
R5778:Dusp16 UTSW 6 134,695,277 (GRCm39) missense probably benign 0.01
R6267:Dusp16 UTSW 6 134,697,456 (GRCm39) critical splice donor site probably null
R6296:Dusp16 UTSW 6 134,697,456 (GRCm39) critical splice donor site probably null
R6860:Dusp16 UTSW 6 134,702,842 (GRCm39) nonsense probably null
R7248:Dusp16 UTSW 6 134,695,940 (GRCm39) missense probably benign 0.01
R7645:Dusp16 UTSW 6 134,702,888 (GRCm39) missense probably damaging 0.97
R8108:Dusp16 UTSW 6 134,716,836 (GRCm39) missense probably benign
R8743:Dusp16 UTSW 6 134,694,933 (GRCm39) missense probably benign 0.35
R8824:Dusp16 UTSW 6 134,716,732 (GRCm39) missense probably benign
R8934:Dusp16 UTSW 6 134,718,639 (GRCm39) intron probably benign
R9328:Dusp16 UTSW 6 134,716,902 (GRCm39) missense probably damaging 1.00
R9364:Dusp16 UTSW 6 134,695,982 (GRCm39) missense probably damaging 1.00
R9430:Dusp16 UTSW 6 134,737,829 (GRCm39) missense probably damaging 1.00
R9476:Dusp16 UTSW 6 134,695,226 (GRCm39) missense probably benign 0.07
R9510:Dusp16 UTSW 6 134,695,226 (GRCm39) missense probably benign 0.07
R9598:Dusp16 UTSW 6 134,695,185 (GRCm39) missense probably benign 0.01
Posted On 2013-10-07