Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01331:Styxl2'

74526

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Styxl2

Ensembl Gene

ENSMUSG00000026564

Gene Name

serine/threonine/tyrosine interacting like 2

Synonyms

C130085G02Rik, Dusp27

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL01331

Quality Score

Status

Chromosome

Chromosomal Location

165925717-165955467 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to A at 165935749 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Leucine at position 150 (V150L)

Ref Sequence

ENSEMBL: ENSMUSP00000141564 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000085992] [ENSMUST00000192369]

AlphaFold

Q148W8

Predicted Effect

probably damaging
Transcript: ENSMUST00000085992
AA Change: V150L

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000083155
Gene: ENSMUSG00000026564
AA Change: V150L

Domain	Start	End	E-Value	Type
low complexity region	6	20	N/A	INTRINSIC
DSPc	133	277	2.45e-30	SMART
low complexity region	339	348	N/A	INTRINSIC
low complexity region	404	425	N/A	INTRINSIC
low complexity region	429	439	N/A	INTRINSIC
low complexity region	618	635	N/A	INTRINSIC
low complexity region	655	666	N/A	INTRINSIC
low complexity region	773	788	N/A	INTRINSIC
coiled coil region	813	839	N/A	INTRINSIC
low complexity region	851	860	N/A	INTRINSIC
low complexity region	936	950	N/A	INTRINSIC
low complexity region	1001	1019	N/A	INTRINSIC
low complexity region	1026	1040	N/A	INTRINSIC
low complexity region	1074	1091	N/A	INTRINSIC
low complexity region	1108	1120	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000192369
AA Change: V150L

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000141564
Gene: ENSMUSG00000026564
AA Change: V150L

Domain	Start	End	E-Value	Type
low complexity region	6	20	N/A	INTRINSIC
DSPc	133	277	2.45e-30	SMART
low complexity region	339	348	N/A	INTRINSIC
low complexity region	404	425	N/A	INTRINSIC
low complexity region	429	439	N/A	INTRINSIC
low complexity region	618	635	N/A	INTRINSIC
low complexity region	655	666	N/A	INTRINSIC
low complexity region	773	788	N/A	INTRINSIC
coiled coil region	813	839	N/A	INTRINSIC
low complexity region	851	860	N/A	INTRINSIC
low complexity region	936	950	N/A	INTRINSIC
low complexity region	1001	1019	N/A	INTRINSIC
low complexity region	1026	1040	N/A	INTRINSIC
low complexity region	1074	1091	N/A	INTRINSIC
low complexity region	1108	1120	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 35 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Clca3a1	G	A	3: 144,453,273 (GRCm39)	T517M	probably damaging	Het
Clec4g	T	C	8: 3,767,190 (GRCm39)		probably benign	Het
Cmya5	C	T	13: 93,233,454 (GRCm39)	E545K	possibly damaging	Het
Cntn6	A	T	6: 104,751,484 (GRCm39)	D380V	probably damaging	Het
Col9a2	C	T	4: 120,902,389 (GRCm39)	P209S	possibly damaging	Het
Cyp2b9	T	C	7: 25,887,140 (GRCm39)	V183A	probably damaging	Het
Dpt	T	C	1: 164,624,379 (GRCm39)	Y27H	unknown	Het
Dusp16	T	C	6: 134,695,067 (GRCm39)	Q588R	possibly damaging	Het
Emg1	A	G	6: 124,682,033 (GRCm39)	S164P	probably benign	Het
Foxk1	G	A	5: 142,439,344 (GRCm39)	R428Q	probably damaging	Het
Frmd4a	T	A	2: 4,607,036 (GRCm39)	M667K	probably benign	Het
Gpr55	T	A	1: 85,868,915 (GRCm39)		probably benign	Het
Gtpbp8	A	G	16: 44,560,494 (GRCm39)	I162T	probably benign	Het
Ighv1-59	C	T	12: 115,298,992 (GRCm39)	V21I	possibly damaging	Het
Ipo11	T	A	13: 106,932,254 (GRCm39)	Y938F	possibly damaging	Het
Map4	G	T	9: 109,863,869 (GRCm39)	V365L	probably benign	Het
Mboat1	C	A	13: 30,403,684 (GRCm39)		probably benign	Het
Med12	A	G	X: 100,324,360 (GRCm39)	E649G	possibly damaging	Het
Nfkbie	T	C	17: 45,869,495 (GRCm39)	V150A	probably benign	Het
Or51ai2	A	G	7: 103,586,782 (GRCm39)	Y65C	possibly damaging	Het
Or8k22	A	C	2: 86,163,048 (GRCm39)	Y217*	probably null	Het
Prdm1	T	A	10: 44,317,970 (GRCm39)	K299N	possibly damaging	Het
Ribc1	T	C	X: 150,788,102 (GRCm39)	T291A	probably benign	Het
Rps6kc1	G	T	1: 190,532,549 (GRCm39)	N484K	possibly damaging	Het
Serpina3k	C	A	12: 104,309,369 (GRCm39)	A271D	probably benign	Het
Spata18	G	T	5: 73,827,024 (GRCm39)	R321L	probably damaging	Het
Syne2	C	A	12: 75,976,027 (GRCm39)		probably benign	Het
Syt17	T	A	7: 118,007,389 (GRCm39)	I302F	probably damaging	Het
Tgm6	A	G	2: 129,985,538 (GRCm39)		probably null	Het
Tmc2	A	G	2: 130,074,276 (GRCm39)	Y323C	probably damaging	Het
Tnc	T	C	4: 63,901,112 (GRCm39)	D1452G	probably damaging	Het
Ttn	A	G	2: 76,620,022 (GRCm39)	I7555T	probably damaging	Het
Ugt2b36	A	T	5: 87,238,801 (GRCm39)	W131R	probably damaging	Het
Vmn2r75	A	T	7: 85,820,870 (GRCm39)	C21*	probably null	Het
Zfp592	T	A	7: 80,691,296 (GRCm39)	C1158*	probably null	Het

Other mutations in Styxl2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00706:Styxl2	APN	1	165,928,121 (GRCm39)	missense	probably benign	0.00
IGL00973:Styxl2	APN	1	165,927,027 (GRCm39)	missense	probably benign
IGL01466:Styxl2	APN	1	165,928,073 (GRCm39)	missense	probably damaging	1.00
IGL01572:Styxl2	APN	1	165,927,941 (GRCm39)	missense	probably benign	0.18
IGL01906:Styxl2	APN	1	165,927,092 (GRCm39)	missense	probably damaging	1.00
IGL01974:Styxl2	APN	1	165,928,105 (GRCm39)	nonsense	probably null
IGL02112:Styxl2	APN	1	165,927,240 (GRCm39)	nonsense	probably null
IGL02805:Styxl2	APN	1	165,926,630 (GRCm39)	missense	probably damaging	1.00
IGL03343:Styxl2	APN	1	165,927,017 (GRCm39)	missense	probably benign	0.00
R0116:Styxl2	UTSW	1	165,927,270 (GRCm39)	missense	probably benign	0.19
R0367:Styxl2	UTSW	1	165,928,332 (GRCm39)	missense	probably benign	0.05
R0499:Styxl2	UTSW	1	165,926,670 (GRCm39)	missense	probably benign	0.00
R0542:Styxl2	UTSW	1	165,928,853 (GRCm39)	missense	possibly damaging	0.90
R1312:Styxl2	UTSW	1	165,926,860 (GRCm39)	missense	possibly damaging	0.46
R1572:Styxl2	UTSW	1	165,927,024 (GRCm39)	missense	possibly damaging	0.68
R1598:Styxl2	UTSW	1	165,937,828 (GRCm39)	missense	probably benign	0.10
R1858:Styxl2	UTSW	1	165,928,415 (GRCm39)	missense	possibly damaging	0.87
R2021:Styxl2	UTSW	1	165,928,392 (GRCm39)	missense	probably benign	0.00
R2970:Styxl2	UTSW	1	165,926,798 (GRCm39)	missense	probably benign	0.04
R3727:Styxl2	UTSW	1	165,927,075 (GRCm39)	missense	probably damaging	1.00
R4041:Styxl2	UTSW	1	165,927,680 (GRCm39)	missense	probably benign	0.01
R4245:Styxl2	UTSW	1	165,928,685 (GRCm39)	missense	probably damaging	1.00
R4955:Styxl2	UTSW	1	165,935,661 (GRCm39)	missense	probably damaging	1.00
R4967:Styxl2	UTSW	1	165,954,675 (GRCm39)	missense	probably damaging	1.00
R5040:Styxl2	UTSW	1	165,927,914 (GRCm39)	missense	probably benign	0.17
R5342:Styxl2	UTSW	1	165,937,819 (GRCm39)	missense	probably benign	0.01
R5467:Styxl2	UTSW	1	165,939,599 (GRCm39)	critical splice donor site	probably null
R5742:Styxl2	UTSW	1	165,927,023 (GRCm39)	missense	probably benign	0.00
R6222:Styxl2	UTSW	1	165,926,214 (GRCm39)	missense	probably benign	0.26
R6239:Styxl2	UTSW	1	165,926,388 (GRCm39)	missense	probably damaging	1.00
R6531:Styxl2	UTSW	1	165,937,615 (GRCm39)	splice site	probably null
R6586:Styxl2	UTSW	1	165,928,454 (GRCm39)	missense	possibly damaging	0.79
R6958:Styxl2	UTSW	1	165,935,565 (GRCm39)	missense	probably damaging	1.00
R7006:Styxl2	UTSW	1	165,926,663 (GRCm39)	missense	probably benign
R7111:Styxl2	UTSW	1	165,954,723 (GRCm39)	missense	possibly damaging	0.66
R7310:Styxl2	UTSW	1	165,926,300 (GRCm39)	missense	possibly damaging	0.46
R7312:Styxl2	UTSW	1	165,954,676 (GRCm39)	missense	probably damaging	0.99
R7378:Styxl2	UTSW	1	165,939,632 (GRCm39)	nonsense	probably null
R7398:Styxl2	UTSW	1	165,928,044 (GRCm39)	missense	probably damaging	1.00
R7442:Styxl2	UTSW	1	165,928,584 (GRCm39)	missense	probably benign	0.01
R7569:Styxl2	UTSW	1	165,935,604 (GRCm39)	missense	probably damaging	1.00
R7920:Styxl2	UTSW	1	165,927,465 (GRCm39)	missense	possibly damaging	0.72
R7954:Styxl2	UTSW	1	165,926,849 (GRCm39)	missense	probably benign	0.05
R7972:Styxl2	UTSW	1	165,926,708 (GRCm39)	missense	probably damaging	1.00
R8186:Styxl2	UTSW	1	165,927,648 (GRCm39)	missense	probably damaging	1.00
R8354:Styxl2	UTSW	1	165,935,702 (GRCm39)	missense	probably damaging	1.00
R8454:Styxl2	UTSW	1	165,935,702 (GRCm39)	missense	probably damaging	1.00
R8535:Styxl2	UTSW	1	165,928,730 (GRCm39)	missense	probably benign	0.01
R9419:Styxl2	UTSW	1	165,927,755 (GRCm39)	missense	probably damaging	1.00
R9493:Styxl2	UTSW	1	165,926,410 (GRCm39)	missense	probably damaging	1.00
R9694:Styxl2	UTSW	1	165,928,654 (GRCm39)	missense	probably damaging	1.00
Z1088:Styxl2	UTSW	1	165,926,852 (GRCm39)	missense	probably damaging	1.00

Posted On

2013-10-07