Incidental Mutation 'IGL01331:Tgm6'
| ID |
74531 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Tgm6
|
| Ensembl Gene |
ENSMUSG00000027403 |
| Gene Name |
transglutaminase 6 |
| Synonyms |
TGM3L |
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
IGL01331
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
2 |
| Chromosomal Location |
129954336-129996152 bp(+) (GRCm39) |
| Type of Mutation |
splice site (4 bp from exon) |
| DNA Base Change (assembly) |
A to G
at 129985538 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000028888
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000028888]
|
| AlphaFold |
Q8BM11 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000028888
|
| SMART Domains |
Protein: ENSMUSP00000028888
Gene: ENSMUSG00000027403
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Transglut_N
|
5 |
119 |
3e-31 |
PFAM |
|
TGc
|
266 |
359 |
3.48e-40 |
SMART |
|
low complexity region
|
466 |
483 |
N/A |
INTRINSIC |
|
Pfam:Transglut_C
|
495 |
600 |
2.4e-23 |
PFAM |
|
Pfam:Transglut_C
|
607 |
704 |
4.7e-21 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000140947
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000147616
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the transglutaminase superfamily. It catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Mutations in this gene are associated with spinocerebellar ataxia type 35 (SCA35). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 35 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Clca3a1 |
G |
A |
3: 144,453,273 (GRCm39) |
T517M |
probably damaging |
Het |
| Clec4g |
T |
C |
8: 3,767,190 (GRCm39) |
|
probably benign |
Het |
| Cmya5 |
C |
T |
13: 93,233,454 (GRCm39) |
E545K |
possibly damaging |
Het |
| Cntn6 |
A |
T |
6: 104,751,484 (GRCm39) |
D380V |
probably damaging |
Het |
| Col9a2 |
C |
T |
4: 120,902,389 (GRCm39) |
P209S |
possibly damaging |
Het |
| Cyp2b9 |
T |
C |
7: 25,887,140 (GRCm39) |
V183A |
probably damaging |
Het |
| Dpt |
T |
C |
1: 164,624,379 (GRCm39) |
Y27H |
unknown |
Het |
| Dusp16 |
T |
C |
6: 134,695,067 (GRCm39) |
Q588R |
possibly damaging |
Het |
| Emg1 |
A |
G |
6: 124,682,033 (GRCm39) |
S164P |
probably benign |
Het |
| Foxk1 |
G |
A |
5: 142,439,344 (GRCm39) |
R428Q |
probably damaging |
Het |
| Frmd4a |
T |
A |
2: 4,607,036 (GRCm39) |
M667K |
probably benign |
Het |
| Gpr55 |
T |
A |
1: 85,868,915 (GRCm39) |
|
probably benign |
Het |
| Gtpbp8 |
A |
G |
16: 44,560,494 (GRCm39) |
I162T |
probably benign |
Het |
| Ighv1-59 |
C |
T |
12: 115,298,992 (GRCm39) |
V21I |
possibly damaging |
Het |
| Ipo11 |
T |
A |
13: 106,932,254 (GRCm39) |
Y938F |
possibly damaging |
Het |
| Map4 |
G |
T |
9: 109,863,869 (GRCm39) |
V365L |
probably benign |
Het |
| Mboat1 |
C |
A |
13: 30,403,684 (GRCm39) |
|
probably benign |
Het |
| Med12 |
A |
G |
X: 100,324,360 (GRCm39) |
E649G |
possibly damaging |
Het |
| Nfkbie |
T |
C |
17: 45,869,495 (GRCm39) |
V150A |
probably benign |
Het |
| Or51ai2 |
A |
G |
7: 103,586,782 (GRCm39) |
Y65C |
possibly damaging |
Het |
| Or8k22 |
A |
C |
2: 86,163,048 (GRCm39) |
Y217* |
probably null |
Het |
| Prdm1 |
T |
A |
10: 44,317,970 (GRCm39) |
K299N |
possibly damaging |
Het |
| Ribc1 |
T |
C |
X: 150,788,102 (GRCm39) |
T291A |
probably benign |
Het |
| Rps6kc1 |
G |
T |
1: 190,532,549 (GRCm39) |
N484K |
possibly damaging |
Het |
| Serpina3k |
C |
A |
12: 104,309,369 (GRCm39) |
A271D |
probably benign |
Het |
| Spata18 |
G |
T |
5: 73,827,024 (GRCm39) |
R321L |
probably damaging |
Het |
| Styxl2 |
C |
A |
1: 165,935,749 (GRCm39) |
V150L |
probably damaging |
Het |
| Syne2 |
C |
A |
12: 75,976,027 (GRCm39) |
|
probably benign |
Het |
| Syt17 |
T |
A |
7: 118,007,389 (GRCm39) |
I302F |
probably damaging |
Het |
| Tmc2 |
A |
G |
2: 130,074,276 (GRCm39) |
Y323C |
probably damaging |
Het |
| Tnc |
T |
C |
4: 63,901,112 (GRCm39) |
D1452G |
probably damaging |
Het |
| Ttn |
A |
G |
2: 76,620,022 (GRCm39) |
I7555T |
probably damaging |
Het |
| Ugt2b36 |
A |
T |
5: 87,238,801 (GRCm39) |
W131R |
probably damaging |
Het |
| Vmn2r75 |
A |
T |
7: 85,820,870 (GRCm39) |
C21* |
probably null |
Het |
| Zfp592 |
T |
A |
7: 80,691,296 (GRCm39) |
C1158* |
probably null |
Het |
|
| Other mutations in Tgm6 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00567:Tgm6
|
APN |
2 |
129,978,415 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01348:Tgm6
|
APN |
2 |
129,979,299 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01787:Tgm6
|
APN |
2 |
129,993,354 (GRCm39) |
splice site |
probably benign |
|
|
IGL02208:Tgm6
|
APN |
2 |
129,977,790 (GRCm39) |
missense |
probably benign |
0.11 |
|
IGL02656:Tgm6
|
APN |
2 |
129,987,023 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03280:Tgm6
|
APN |
2 |
129,980,851 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0200:Tgm6
|
UTSW |
2 |
129,994,865 (GRCm39) |
splice site |
probably null |
|
|
R0507:Tgm6
|
UTSW |
2 |
129,980,751 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R0744:Tgm6
|
UTSW |
2 |
129,993,681 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0800:Tgm6
|
UTSW |
2 |
129,985,342 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R1530:Tgm6
|
UTSW |
2 |
129,993,202 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R1573:Tgm6
|
UTSW |
2 |
129,993,660 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1706:Tgm6
|
UTSW |
2 |
129,987,079 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R2330:Tgm6
|
UTSW |
2 |
129,985,162 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2881:Tgm6
|
UTSW |
2 |
129,979,359 (GRCm39) |
missense |
probably benign |
0.04 |
|
R2882:Tgm6
|
UTSW |
2 |
129,979,359 (GRCm39) |
missense |
probably benign |
0.04 |
|
R3622:Tgm6
|
UTSW |
2 |
129,993,681 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R3624:Tgm6
|
UTSW |
2 |
129,993,681 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R4370:Tgm6
|
UTSW |
2 |
129,985,525 (GRCm39) |
missense |
probably benign |
0.12 |
|
R4664:Tgm6
|
UTSW |
2 |
129,983,128 (GRCm39) |
missense |
probably benign |
0.34 |
|
R4664:Tgm6
|
UTSW |
2 |
129,979,314 (GRCm39) |
missense |
probably benign |
0.05 |
|
R4983:Tgm6
|
UTSW |
2 |
129,983,113 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5182:Tgm6
|
UTSW |
2 |
129,983,222 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5397:Tgm6
|
UTSW |
2 |
129,983,828 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R5411:Tgm6
|
UTSW |
2 |
129,987,116 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5683:Tgm6
|
UTSW |
2 |
129,980,875 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5933:Tgm6
|
UTSW |
2 |
129,983,176 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6016:Tgm6
|
UTSW |
2 |
129,983,148 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7252:Tgm6
|
UTSW |
2 |
129,986,884 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7290:Tgm6
|
UTSW |
2 |
129,983,110 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7581:Tgm6
|
UTSW |
2 |
129,983,205 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8143:Tgm6
|
UTSW |
2 |
129,983,763 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8153:Tgm6
|
UTSW |
2 |
129,986,975 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8219:Tgm6
|
UTSW |
2 |
129,993,200 (GRCm39) |
missense |
probably benign |
|
|
R8297:Tgm6
|
UTSW |
2 |
129,979,358 (GRCm39) |
missense |
probably benign |
|
|
R8743:Tgm6
|
UTSW |
2 |
129,985,418 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9312:Tgm6
|
UTSW |
2 |
129,977,701 (GRCm39) |
missense |
probably benign |
|
|
R9346:Tgm6
|
UTSW |
2 |
129,983,776 (GRCm39) |
nonsense |
probably null |
|
|
R9631:Tgm6
|
UTSW |
2 |
129,977,810 (GRCm39) |
missense |
probably benign |
0.32 |
|
| Posted On |
2013-10-07 |
Incidental Mutation