Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01335:Igsf5'

74610

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Igsf5

Ensembl Gene

ENSMUSG00000000159

Gene Name

immunoglobulin superfamily, member 5

Synonyms

Igsf5, Jam4, 2010003D20Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.054) question?

Stock #

IGL01335

Quality Score

Status

Chromosome

Chromosomal Location

96162868-96223321 bp(+) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

T to A at 96174353 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000109426 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000000163] [ENSMUST00000081093] [ENSMUST00000113794] [ENSMUST00000113795]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000000163

SMART Domains

Protein: ENSMUSP00000000163
Gene: ENSMUSG00000000159

Domain	Start	End	E-Value	Type
signal peptide	1	24	N/A	INTRINSIC
IG	31	127	9.63e-6	SMART
IG	134	221	2.64e0	SMART
transmembrane domain	239	261	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000081093

SMART Domains

Protein: ENSMUSP00000079874
Gene: ENSMUSG00000000159

Domain	Start	End	E-Value	Type
signal peptide	1	24	N/A	INTRINSIC
IG	31	125	4.74e-5	SMART
transmembrane domain	139	161	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000113794

SMART Domains

Protein: ENSMUSP00000109425
Gene: ENSMUSG00000000159

Domain	Start	End	E-Value	Type
signal peptide	1	24	N/A	INTRINSIC
IG	31	127	9.63e-6	SMART
IG	134	221	2.64e0	SMART
transmembrane domain	239	261	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000113795

SMART Domains

Protein: ENSMUSP00000109426
Gene: ENSMUSG00000000159

Domain	Start	End	E-Value	Type
signal peptide	1	24	N/A	INTRINSIC
IG	31	125	4.74e-5	SMART
transmembrane domain	139	161	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Homozygous mutation of this gene results in no obvious abnormalities. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 53 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
6820408C15Rik	T	A	2: 152,284,307 (GRCm39)	M300K	possibly damaging	Het
Adamts14	T	A	10: 61,034,460 (GRCm39)	R1143W	possibly damaging	Het
Ankrd28	T	C	14: 31,423,981 (GRCm39)	Y1083C	probably damaging	Het
Anxa8	T	C	14: 33,811,547 (GRCm39)	M34T	probably damaging	Het
Aox1	G	T	1: 58,121,312 (GRCm39)	E928*	probably null	Het
Atp8b5	T	A	4: 43,302,628 (GRCm39)	F50L	possibly damaging	Het
Brpf1	A	G	6: 113,296,298 (GRCm39)	S863G	probably damaging	Het
Cdc42bpb	A	G	12: 111,260,530 (GRCm39)		probably benign	Het
Cdh6	C	T	15: 13,051,395 (GRCm39)	A413T	probably benign	Het
Cfap96	A	T	8: 46,426,642 (GRCm39)		probably benign	Het
Cfap97	A	G	8: 46,623,492 (GRCm39)	Q294R	probably damaging	Het
Cit	C	T	5: 116,046,889 (GRCm39)		probably benign	Het
Dmbt1	A	G	7: 130,690,497 (GRCm39)	Y736C	possibly damaging	Het
Eno2	C	T	6: 124,743,618 (GRCm39)	G107E	probably damaging	Het
Gja8	T	C	3: 96,826,558 (GRCm39)	Q368R	probably benign	Het
Gm3633	T	A	14: 42,462,595 (GRCm39)		probably benign	Het
Gm4987	A	T	X: 45,544,755 (GRCm39)		noncoding transcript	Het
Gna13	G	A	11: 109,256,569 (GRCm39)	R164Q	probably damaging	Het
Grhl1	A	T	12: 24,658,057 (GRCm39)	E351D	probably damaging	Het
Idua	A	G	5: 108,828,737 (GRCm39)	Q280R	probably benign	Het
Mrpl52	T	C	14: 54,664,656 (GRCm39)	Y39H	probably damaging	Het
Naa16	A	T	14: 79,582,556 (GRCm39)		probably benign	Het
Naa35	T	A	13: 59,764,610 (GRCm39)	L338Q	probably damaging	Het
Nat8l	A	T	5: 34,155,791 (GRCm39)	Y149F	probably benign	Het
Nck1	A	T	9: 100,379,790 (GRCm39)	W154R	probably damaging	Het
Ncoa1	A	T	12: 4,347,520 (GRCm39)	S351R	probably benign	Het
Or10w1	A	T	19: 13,632,540 (GRCm39)	H249L	probably damaging	Het
Or12e10	A	T	2: 87,640,790 (GRCm39)	T209S	probably damaging	Het
Or6c8b	T	C	10: 128,882,380 (GRCm39)	K184R	probably benign	Het
Or8k1	A	T	2: 86,047,916 (GRCm39)	L46Q	probably damaging	Het
Pacs1	A	T	19: 5,192,660 (GRCm39)	V624E	probably damaging	Het
Pde6b	G	A	5: 108,571,379 (GRCm39)	R444H	probably benign	Het
Pigk	A	T	3: 152,448,173 (GRCm39)	T226S	probably benign	Het
Prkdc	T	C	16: 15,634,760 (GRCm39)		probably null	Het
Ptbp1	G	A	10: 79,698,708 (GRCm39)		probably null	Het
Pyroxd1	T	C	6: 142,307,484 (GRCm39)	V418A	probably damaging	Het
Rhot1	A	T	11: 80,141,055 (GRCm39)	D421V	probably damaging	Het
Rimkla	T	C	4: 119,335,156 (GRCm39)	T76A	possibly damaging	Het
Rtn1	A	G	12: 72,355,124 (GRCm39)	V274A	probably benign	Het
Tatdn2	T	A	6: 113,681,017 (GRCm39)	M289K	probably benign	Het
Trak1	A	G	9: 121,283,382 (GRCm39)	T476A	possibly damaging	Het
Ube2i	C	A	17: 25,488,410 (GRCm39)	Q11H	probably damaging	Het
Ugt2a3	A	T	5: 87,484,644 (GRCm39)	C127S	probably damaging	Het
Uimc1	T	A	13: 55,182,724 (GRCm39)	Q619L	probably benign	Het
Upk3a	T	A	15: 84,903,786 (GRCm39)	Y162N	probably damaging	Het
Usp33	T	C	3: 152,097,854 (GRCm39)	S849P	probably damaging	Het
Vmn2r120	G	A	17: 57,832,732 (GRCm39)	T149I	possibly damaging	Het
Vmn2r15	G	A	5: 109,434,602 (GRCm39)	P701S	possibly damaging	Het
Vmn2r28	T	C	7: 5,484,087 (GRCm39)	I704M	possibly damaging	Het
Wdhd1	T	C	14: 47,488,239 (GRCm39)	E756G	possibly damaging	Het
Xlr3c	C	A	X: 72,303,639 (GRCm39)	V102F	probably benign	Het
Zfp384	T	G	6: 125,002,016 (GRCm39)	D220E	probably benign	Het
Zfp521	A	T	18: 13,977,776 (GRCm39)	V879E	probably benign	Het

Other mutations in Igsf5

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00477:Igsf5	APN	16	96,192,220 (GRCm39)	missense	possibly damaging	0.72
IGL02576:Igsf5	APN	16	96,187,781 (GRCm39)	missense	probably benign	0.23
IGL02721:Igsf5	APN	16	96,192,222 (GRCm39)	missense	probably damaging	0.98
IGL03289:Igsf5	APN	16	96,326,632 (GRCm39)	missense	possibly damaging	0.94
R0630:Igsf5	UTSW	16	96,174,023 (GRCm39)	splice site	probably benign
R1858:Igsf5	UTSW	16	96,187,829 (GRCm39)	splice site	probably null
R1961:Igsf5	UTSW	16	96,179,551 (GRCm39)	missense	probably damaging	1.00
R2508:Igsf5	UTSW	16	96,165,247 (GRCm39)	missense	probably benign	0.01
R4491:Igsf5	UTSW	16	96,165,281 (GRCm39)	missense	probably benign	0.02
R5123:Igsf5	UTSW	16	96,174,279 (GRCm39)	missense	probably damaging	1.00
R5262:Igsf5	UTSW	16	96,192,237 (GRCm39)	nonsense	probably null
R5384:Igsf5	UTSW	16	96,192,226 (GRCm39)	missense	probably benign	0.21
R5558:Igsf5	UTSW	16	96,187,731 (GRCm39)	missense	possibly damaging	0.95
R5950:Igsf5	UTSW	16	96,174,072 (GRCm39)	missense	probably benign	0.07
R5957:Igsf5	UTSW	16	96,165,249 (GRCm39)	missense	probably benign	0.10
R6199:Igsf5	UTSW	16	96,222,939 (GRCm39)	missense	possibly damaging	0.66
R6298:Igsf5	UTSW	16	96,197,648 (GRCm39)	missense	possibly damaging	0.93
R7164:Igsf5	UTSW	16	96,174,048 (GRCm39)	missense	possibly damaging	0.85
R7197:Igsf5	UTSW	16	96,204,546 (GRCm39)	missense	probably damaging	1.00
R8213:Igsf5	UTSW	16	96,174,188 (GRCm39)	missense	probably damaging	1.00
R8353:Igsf5	UTSW	16	96,222,996 (GRCm39)	missense	probably benign	0.00
R8453:Igsf5	UTSW	16	96,222,996 (GRCm39)	missense	probably benign	0.00
R8823:Igsf5	UTSW	16	96,222,939 (GRCm39)	missense	possibly damaging	0.66
R9798:Igsf5	UTSW	16	96,174,075 (GRCm39)	missense	probably damaging	1.00
Z1176:Igsf5	UTSW	16	96,192,223 (GRCm39)	missense	probably damaging	1.00
Z1177:Igsf5	UTSW	16	96,179,533 (GRCm39)	missense	probably benign	0.06

Posted On

2013-10-07