Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01337:Sapcd2'

74660

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Sapcd2

Ensembl Gene

ENSMUSG00000026955

Gene Name

suppressor APC domain containing 2

Synonyms

2010317E24Rik, 6030458L21Rik, ang

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.343) question?

Stock #

IGL01337

Quality Score

Status

Chromosome

Chromosomal Location

25262333-25268225 bp(+) (GRCm39)

Type of Mutation

makesense

DNA Base Change (assembly)

A to G at 25266491 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Stop codon to Tryptophan at position 392 (*392W)

Ref Sequence

ENSEMBL: ENSMUSP00000109932 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000028329] [ENSMUST00000100323] [ENSMUST00000114293]

AlphaFold

Q9D818

Predicted Effect

probably null
Transcript: ENSMUST00000028329
AA Change: *426W

SMART Domains

Protein: ENSMUSP00000028329
Gene: ENSMUSG00000026955
AA Change: *426W

Domain	Start	End	E-Value	Type
low complexity region	197	212	N/A	INTRINSIC
low complexity region	236	250	N/A	INTRINSIC
Pfam:Suppressor_APC	257	340	1.6e-34	PFAM
low complexity region	348	362	N/A	INTRINSIC
coiled coil region	374	415	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000100323
AA Change: *447W

SMART Domains

Protein: ENSMUSP00000097898
Gene: ENSMUSG00000026955
AA Change: *447W

Domain	Start	End	E-Value	Type
low complexity region	202	216	N/A	INTRINSIC
Pfam:Suppressor_APC	224	305	2.2e-32	PFAM
low complexity region	385	392	N/A	INTRINSIC
coiled coil region	403	436	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000114293
AA Change: *392W

SMART Domains

Protein: ENSMUSP00000109932
Gene: ENSMUSG00000026955
AA Change: *392W

Domain	Start	End	E-Value	Type
low complexity region	202	216	N/A	INTRINSIC
Pfam:Suppressor_APC	223	306	1.4e-34	PFAM
low complexity region	314	328	N/A	INTRINSIC
coiled coil region	340	381	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000129214

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000132539

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000137171

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000155310

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Mice homozygous for disruptions in this gene display an apparently normal phenotype. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 34 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A2m	T	C	6: 121,645,529 (GRCm39)	Y1025H	probably damaging	Het
Adarb2	T	C	13: 8,620,282 (GRCm39)	L256P	probably benign	Het
Arsj	A	G	3: 126,158,763 (GRCm39)	Y114C	probably damaging	Het
Bdp1	G	A	13: 100,192,700 (GRCm39)	P1378L	probably benign	Het
Clca3a2	T	C	3: 144,800,939 (GRCm39)	Y138C	probably damaging	Het
Dsp	G	A	13: 38,376,663 (GRCm39)	D1483N	probably benign	Het
Etl4	T	C	2: 20,790,198 (GRCm39)	S617P	probably benign	Het
Fbxo34	T	C	14: 47,767,674 (GRCm39)	S345P	probably benign	Het
Gm5420	A	G	10: 21,567,514 (GRCm39)		noncoding transcript	Het
Gpr182	T	A	10: 127,586,655 (GRCm39)	I99F	possibly damaging	Het
Hectd1	A	G	12: 51,849,057 (GRCm39)	I349T	possibly damaging	Het
Kifc5b	A	G	17: 27,143,718 (GRCm39)	T497A	possibly damaging	Het
Mllt3	A	C	4: 87,759,057 (GRCm39)	D330E	probably damaging	Het
Mpp3	T	C	11: 101,891,411 (GRCm39)	T576A	probably benign	Het
Mroh2b	A	G	15: 4,934,506 (GRCm39)	M126V	probably benign	Het
Naalad2	T	G	9: 18,238,669 (GRCm39)	D644A	probably damaging	Het
Or4a74	A	G	2: 89,439,720 (GRCm39)	I242T	probably damaging	Het
Otof	C	A	5: 30,563,121 (GRCm39)	A242S	possibly damaging	Het
Otof	T	C	5: 30,576,856 (GRCm39)	D132G	probably benign	Het
Pdk4	T	A	6: 5,491,869 (GRCm39)	M68L	probably benign	Het
Ptprf	A	G	4: 118,093,488 (GRCm39)	Y385H	probably damaging	Het
Rxrb	A	G	17: 34,255,605 (GRCm39)	N254S	probably damaging	Het
Samd5	T	A	10: 9,504,768 (GRCm39)	Y162F	probably benign	Het
Senp6	T	C	9: 80,043,792 (GRCm39)	Y635H	probably damaging	Het
Serpine1	C	A	5: 137,098,185 (GRCm39)	V163L	probably damaging	Het
Slc15a1	T	C	14: 121,698,091 (GRCm39)	E678G	possibly damaging	Het
Slc22a16	T	C	10: 40,471,310 (GRCm39)	F494L	possibly damaging	Het
Slc5a12	T	A	2: 110,450,718 (GRCm39)	C304*	probably null	Het
Spink1	G	A	18: 43,870,216 (GRCm39)		probably benign	Het
Star	G	A	8: 26,299,892 (GRCm39)	G78E	probably damaging	Het
Stx1a	T	C	5: 135,074,518 (GRCm39)	I203T	probably damaging	Het
Tap2	A	G	17: 34,424,386 (GRCm39)		probably benign	Het
Trim75	T	C	8: 65,436,387 (GRCm39)	D21G	possibly damaging	Het
Vmn1r62	T	A	7: 5,679,144 (GRCm39)	I275N	probably damaging	Het

Other mutations in Sapcd2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R1596:Sapcd2	UTSW	2	25,266,422 (GRCm39)	missense	probably damaging	1.00
R3815:Sapcd2	UTSW	2	25,263,518 (GRCm39)	intron	probably benign
R4826:Sapcd2	UTSW	2	25,262,768 (GRCm39)	missense	probably benign	0.09
R4926:Sapcd2	UTSW	2	25,263,578 (GRCm39)	splice site	probably null
R6442:Sapcd2	UTSW	2	25,266,134 (GRCm39)	intron	probably benign
R6794:Sapcd2	UTSW	2	25,266,379 (GRCm39)	missense	probably damaging	1.00
R7090:Sapcd2	UTSW	2	25,266,091 (GRCm39)	missense	probably benign	0.00
R7659:Sapcd2	UTSW	2	25,265,978 (GRCm39)	critical splice acceptor site	probably null
R7744:Sapcd2	UTSW	2	25,263,508 (GRCm39)	missense	unknown
R9697:Sapcd2	UTSW	2	25,262,925 (GRCm39)	nonsense	probably null
R9728:Sapcd2	UTSW	2	25,262,669 (GRCm39)	missense	probably damaging	1.00

Posted On

2013-10-07