Incidental Mutation 'IGL00467:Wdr75'
ID 7494
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Wdr75
Ensembl Gene ENSMUSG00000025995
Gene Name WD repeat domain 75
Synonyms 1300003A18Rik, 2410118I19Rik
Accession Numbers
Essential gene? Probably essential (E-score: 0.944) question?
Stock # IGL00467
Quality Score
Status
Chromosome 1
Chromosomal Location 45834326-45862779 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 45841235 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Valine at position 106 (I106V)
Ref Sequence ENSEMBL: ENSMUSP00000117363 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027139] [ENSMUST00000147308]
AlphaFold Q3U821
Predicted Effect probably benign
Transcript: ENSMUST00000027139
AA Change: I106V

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000027139
Gene: ENSMUSG00000025995
AA Change: I106V

DomainStartEndE-ValueType
WD40 4 42 3.82e1 SMART
WD40 45 85 1.25e-9 SMART
WD40 185 230 1.61e-3 SMART
WD40 239 275 4.44e0 SMART
WD40 278 317 7.67e0 SMART
low complexity region 405 417 N/A INTRINSIC
WD40 431 473 7.67e0 SMART
WD40 486 524 3.08e0 SMART
WD40 527 568 3.96e1 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000142145
Predicted Effect noncoding transcript
Transcript: ENSMUST00000143737
Predicted Effect noncoding transcript
Transcript: ENSMUST00000146602
Predicted Effect probably benign
Transcript: ENSMUST00000147308
AA Change: I106V

PolyPhen 2 Score 0.016 (Sensitivity: 0.95; Specificity: 0.79)
SMART Domains Protein: ENSMUSP00000117363
Gene: ENSMUSG00000025995
AA Change: I106V

DomainStartEndE-ValueType
WD40 4 42 3.82e1 SMART
WD40 45 85 1.25e-9 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000154436
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 31 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca9 T C 11: 110,036,496 (GRCm39) probably benign Het
Acvrl1 C A 15: 101,041,221 (GRCm39) probably null Het
Ahnak T A 19: 8,984,587 (GRCm39) M1957K probably damaging Het
Brinp3 A G 1: 146,777,512 (GRCm39) D653G probably damaging Het
Dcstamp T A 15: 39,617,812 (GRCm39) C74S probably benign Het
Esrrg A G 1: 187,943,107 (GRCm39) E360G probably damaging Het
Fam13a C T 6: 58,917,098 (GRCm39) probably benign Het
Glipr1l1 A G 10: 111,914,286 (GRCm39) T216A probably benign Het
Lama2 T A 10: 27,343,193 (GRCm39) probably benign Het
Men1 G A 19: 6,387,237 (GRCm39) probably null Het
Mta3 T A 17: 84,063,113 (GRCm39) probably benign Het
Nfu1 A G 6: 86,997,755 (GRCm39) M213V possibly damaging Het
Pam A T 1: 97,852,152 (GRCm39) probably benign Het
Pcca A T 14: 122,820,041 (GRCm39) M62L probably benign Het
Phf6 A G X: 52,020,523 (GRCm39) Y25C probably damaging Het
Phlpp2 C T 8: 110,652,422 (GRCm39) H589Y probably benign Het
Ppp1r13b A G 12: 111,795,804 (GRCm39) I956T probably damaging Het
Prkcd G A 14: 30,324,379 (GRCm39) probably benign Het
Rapgef4 A T 2: 72,086,656 (GRCm39) N973I possibly damaging Het
Rnf20 G T 4: 49,655,480 (GRCm39) E905* probably null Het
Slc26a6 T A 9: 108,733,088 (GRCm39) D22E probably benign Het
Sp2 C T 11: 96,845,387 (GRCm39) R578H probably damaging Het
Taf6l A T 19: 8,760,752 (GRCm39) N57K probably benign Het
Tas2r109 C A 6: 132,956,986 (GRCm39) V315L probably benign Het
Tasor A G 14: 27,170,121 (GRCm39) N350S probably benign Het
Tex9 T C 9: 72,385,117 (GRCm39) T240A probably benign Het
Trank1 G A 9: 111,193,734 (GRCm39) probably benign Het
Trim30c A T 7: 104,031,389 (GRCm39) Y475* probably null Het
Trim60 T C 8: 65,453,371 (GRCm39) T293A possibly damaging Het
Ttc21b T C 2: 66,018,708 (GRCm39) Y1233C probably damaging Het
Zkscan16 T C 4: 58,957,709 (GRCm39) S664P possibly damaging Het
Other mutations in Wdr75
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00711:Wdr75 APN 1 45,862,541 (GRCm39) missense probably benign 0.00
IGL01350:Wdr75 APN 1 45,857,420 (GRCm39) nonsense probably null
IGL02135:Wdr75 APN 1 45,856,608 (GRCm39) splice site probably null
IGL02135:Wdr75 APN 1 45,853,723 (GRCm39) missense probably damaging 1.00
BB008:Wdr75 UTSW 1 45,858,795 (GRCm39) missense probably benign 0.00
BB018:Wdr75 UTSW 1 45,858,795 (GRCm39) missense probably benign 0.00
FR4976:Wdr75 UTSW 1 45,862,564 (GRCm39) utr 3 prime probably benign
PIT4378001:Wdr75 UTSW 1 45,859,333 (GRCm39) missense probably damaging 0.98
R0060:Wdr75 UTSW 1 45,855,777 (GRCm39) missense probably benign 0.16
R0463:Wdr75 UTSW 1 45,858,762 (GRCm39) missense probably damaging 1.00
R0963:Wdr75 UTSW 1 45,856,470 (GRCm39) missense probably benign 0.07
R1364:Wdr75 UTSW 1 45,838,222 (GRCm39) missense probably benign 0.01
R1382:Wdr75 UTSW 1 45,856,471 (GRCm39) missense probably damaging 1.00
R1562:Wdr75 UTSW 1 45,843,030 (GRCm39) splice site probably null
R1909:Wdr75 UTSW 1 45,862,563 (GRCm39) missense probably benign 0.00
R2968:Wdr75 UTSW 1 45,856,501 (GRCm39) missense probably damaging 1.00
R3972:Wdr75 UTSW 1 45,861,714 (GRCm39) missense probably benign 0.01
R4372:Wdr75 UTSW 1 45,845,833 (GRCm39) unclassified probably benign
R4720:Wdr75 UTSW 1 45,861,645 (GRCm39) missense probably benign 0.05
R4922:Wdr75 UTSW 1 45,855,638 (GRCm39) missense probably damaging 1.00
R5201:Wdr75 UTSW 1 45,862,519 (GRCm39) missense probably benign 0.00
R5242:Wdr75 UTSW 1 45,856,487 (GRCm39) nonsense probably null
R5255:Wdr75 UTSW 1 45,838,277 (GRCm39) missense probably damaging 1.00
R5320:Wdr75 UTSW 1 45,838,211 (GRCm39) missense probably damaging 0.96
R5450:Wdr75 UTSW 1 45,851,324 (GRCm39) missense probably benign 0.26
R6072:Wdr75 UTSW 1 45,838,211 (GRCm39) missense probably damaging 0.96
R6147:Wdr75 UTSW 1 45,858,698 (GRCm39) missense probably benign 0.00
R6341:Wdr75 UTSW 1 45,841,291 (GRCm39) critical splice donor site probably null
R6629:Wdr75 UTSW 1 45,851,216 (GRCm39) missense probably damaging 1.00
R6646:Wdr75 UTSW 1 45,838,247 (GRCm39) missense probably damaging 1.00
R6722:Wdr75 UTSW 1 45,844,512 (GRCm39) splice site probably null
R6750:Wdr75 UTSW 1 45,856,539 (GRCm39) missense probably damaging 1.00
R6850:Wdr75 UTSW 1 45,853,758 (GRCm39) missense probably benign 0.00
R6851:Wdr75 UTSW 1 45,862,587 (GRCm39) missense probably benign
R7172:Wdr75 UTSW 1 45,838,294 (GRCm39) missense probably damaging 1.00
R7248:Wdr75 UTSW 1 45,856,560 (GRCm39) missense probably damaging 1.00
R7809:Wdr75 UTSW 1 45,862,596 (GRCm39) missense probably benign 0.00
R7931:Wdr75 UTSW 1 45,858,795 (GRCm39) missense probably benign 0.00
R7937:Wdr75 UTSW 1 45,858,799 (GRCm39) missense probably benign 0.17
R8171:Wdr75 UTSW 1 45,861,706 (GRCm39) missense probably benign 0.00
R8218:Wdr75 UTSW 1 45,857,342 (GRCm39) missense probably damaging 1.00
R8724:Wdr75 UTSW 1 45,856,560 (GRCm39) missense probably damaging 1.00
R8900:Wdr75 UTSW 1 45,838,287 (GRCm39) missense probably damaging 0.99
R9400:Wdr75 UTSW 1 45,843,064 (GRCm39) missense probably damaging 1.00
R9665:Wdr75 UTSW 1 45,843,013 (GRCm39) missense unknown
Posted On 2012-04-20