Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01300:Vmn2r74'

75237

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r74

Ensembl Gene

ENSMUSG00000090774

Gene Name

vomeronasal 2, receptor 74

Synonyms

EG546980

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.110) question?

Stock #

IGL01300

Quality Score

Status

Chromosome

Chromosomal Location

85601075-85610690 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 85606414 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Histidine at position 311 (Y311H)

Ref Sequence

ENSEMBL: ENSMUSP00000126917 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000166355]

AlphaFold

E9PW21

Predicted Effect

probably benign
Transcript: ENSMUST00000166355
AA Change: Y311H

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)

SMART Domains

Protein: ENSMUSP00000126917
Gene: ENSMUSG00000090774
AA Change: Y311H

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	77	467	7.3e-28	PFAM
Pfam:NCD3G	510	562	4.7e-20	PFAM
Pfam:7tm_3	592	830	1.3e-52	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 33 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Anxa8	A	G	14: 33,821,700 (GRCm39)	D300G	probably benign	Het
Cacna1g	T	C	11: 94,324,738 (GRCm39)	H1161R	probably benign	Het
Col14a1	G	A	15: 55,331,372 (GRCm39)	R1471Q	unknown	Het
Gm14496	A	T	2: 181,642,753 (GRCm39)	E808V	probably damaging	Het
Gm1968	T	C	16: 29,781,038 (GRCm39)		noncoding transcript	Het
Gzmb	G	A	14: 56,497,653 (GRCm39)	R196C	probably benign	Het
Hkdc1	A	G	10: 62,231,040 (GRCm39)		probably benign	Het
Itgal	T	A	7: 126,913,290 (GRCm39)	V629E	probably damaging	Het
Jak2	T	A	19: 29,287,083 (GRCm39)	Y1050N	probably damaging	Het
Lrrc69	C	T	4: 14,773,663 (GRCm39)		probably benign	Het
Mmd	T	C	11: 90,140,537 (GRCm39)	M1T	probably null	Het
Myh6	A	G	14: 55,200,548 (GRCm39)	V191A	possibly damaging	Het
Mynn	A	G	3: 30,667,755 (GRCm39)	N485S	probably damaging	Het
Naa30	C	T	14: 49,410,714 (GRCm39)	T214M	probably damaging	Het
Ncoa3	A	T	2: 165,910,381 (GRCm39)	T1265S	probably benign	Het
Or10al2	C	A	17: 37,983,778 (GRCm39)	T288K	probably damaging	Het
Or1j10	T	C	2: 36,267,054 (GRCm39)	S89P	probably benign	Het
Prex1	A	G	2: 166,480,327 (GRCm39)	C138R	possibly damaging	Het
Prom2	A	T	2: 127,377,009 (GRCm39)	L535H	probably benign	Het
Pros1	T	C	16: 62,734,174 (GRCm39)	F327L	possibly damaging	Het
Ros1	A	G	10: 51,977,809 (GRCm39)	M1479T	probably benign	Het
Scn9a	G	A	2: 66,318,397 (GRCm39)	Q1465*	probably null	Het
Serpinb3b	A	G	1: 107,083,573 (GRCm39)		probably benign	Het
Sipa1l3	G	A	7: 29,099,253 (GRCm39)	Q339*	probably null	Het
Slc34a2	A	C	5: 53,225,469 (GRCm39)		probably null	Het
Smc3	T	A	19: 53,630,283 (GRCm39)		probably benign	Het
Tmem30a	A	G	9: 79,682,382 (GRCm39)		probably null	Het
Trappc11	A	T	8: 47,954,903 (GRCm39)	D878E	probably benign	Het
Trrap	C	T	5: 144,741,628 (GRCm39)	T1325M	probably damaging	Het
Ttc12	A	T	9: 49,359,222 (GRCm39)		probably benign	Het
Vmn1r237	T	A	17: 21,534,337 (GRCm39)	I20N	probably damaging	Het
Vmn2r115	T	A	17: 23,578,755 (GRCm39)	S743T	probably damaging	Het
Vnn3	T	A	10: 23,740,263 (GRCm39)	F189I	possibly damaging	Het

Other mutations in Vmn2r74

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00899:Vmn2r74	APN	7	85,606,338 (GRCm39)	missense	probably benign	0.03
IGL00904:Vmn2r74	APN	7	85,606,788 (GRCm39)	missense	probably benign	0.05
IGL01285:Vmn2r74	APN	7	85,606,692 (GRCm39)	missense	possibly damaging	0.54
IGL01410:Vmn2r74	APN	7	85,610,500 (GRCm39)	missense	possibly damaging	0.83
IGL01827:Vmn2r74	APN	7	85,606,800 (GRCm39)	missense	probably benign	0.00
IGL02094:Vmn2r74	APN	7	85,610,669 (GRCm39)	missense	probably benign	0.01
IGL02252:Vmn2r74	APN	7	85,606,531 (GRCm39)	missense	probably benign	0.41
IGL02349:Vmn2r74	APN	7	85,601,724 (GRCm39)	missense	probably damaging	0.99
IGL02438:Vmn2r74	APN	7	85,601,824 (GRCm39)	missense	probably damaging	0.98
IGL02554:Vmn2r74	APN	7	85,606,581 (GRCm39)	missense	probably benign	0.00
IGL03036:Vmn2r74	APN	7	85,601,900 (GRCm39)	nonsense	probably null
IGL03370:Vmn2r74	APN	7	85,607,265 (GRCm39)	missense	probably benign
R0115:Vmn2r74	UTSW	7	85,606,564 (GRCm39)	missense	probably benign	0.00
R0333:Vmn2r74	UTSW	7	85,601,491 (GRCm39)	missense	probably benign	0.06
R0415:Vmn2r74	UTSW	7	85,610,618 (GRCm39)	missense	probably damaging	1.00
R0571:Vmn2r74	UTSW	7	85,601,629 (GRCm39)	missense	probably damaging	1.00
R0626:Vmn2r74	UTSW	7	85,610,517 (GRCm39)	nonsense	probably null
R0659:Vmn2r74	UTSW	7	85,605,122 (GRCm39)	splice site	probably benign
R1202:Vmn2r74	UTSW	7	85,610,545 (GRCm39)	missense	possibly damaging	0.83
R1473:Vmn2r74	UTSW	7	85,610,618 (GRCm39)	missense	probably damaging	1.00
R1908:Vmn2r74	UTSW	7	85,601,650 (GRCm39)	missense	probably benign
R2079:Vmn2r74	UTSW	7	85,606,383 (GRCm39)	missense	probably benign	0.00
R2368:Vmn2r74	UTSW	7	85,610,522 (GRCm39)	missense	probably benign	0.39
R3782:Vmn2r74	UTSW	7	85,605,322 (GRCm39)	missense	probably benign	0.01
R3824:Vmn2r74	UTSW	7	85,607,466 (GRCm39)	missense	probably damaging	1.00
R3977:Vmn2r74	UTSW	7	85,607,345 (GRCm39)	missense	probably benign	0.01
R4182:Vmn2r74	UTSW	7	85,606,395 (GRCm39)	missense	possibly damaging	0.87
R4289:Vmn2r74	UTSW	7	85,606,562 (GRCm39)	missense	probably benign
R4294:Vmn2r74	UTSW	7	85,606,624 (GRCm39)	missense	probably benign	0.14
R4645:Vmn2r74	UTSW	7	85,606,317 (GRCm39)	missense	probably benign
R4646:Vmn2r74	UTSW	7	85,606,782 (GRCm39)	missense	probably benign	0.42
R4655:Vmn2r74	UTSW	7	85,610,555 (GRCm39)	missense	probably benign
R4901:Vmn2r74	UTSW	7	85,605,199 (GRCm39)	nonsense	probably null
R5532:Vmn2r74	UTSW	7	85,601,197 (GRCm39)	missense	probably benign	0.32
R5642:Vmn2r74	UTSW	7	85,606,588 (GRCm39)	missense	probably benign	0.00
R5913:Vmn2r74	UTSW	7	85,601,098 (GRCm39)	missense	probably damaging	0.98
R6035:Vmn2r74	UTSW	7	85,601,098 (GRCm39)	missense	probably damaging	0.98
R6035:Vmn2r74	UTSW	7	85,601,098 (GRCm39)	missense	probably damaging	0.98
R6039:Vmn2r74	UTSW	7	85,607,526 (GRCm39)	critical splice acceptor site	probably null
R6039:Vmn2r74	UTSW	7	85,607,526 (GRCm39)	critical splice acceptor site	probably null
R6170:Vmn2r74	UTSW	7	85,606,348 (GRCm39)	missense	probably benign	0.03
R6232:Vmn2r74	UTSW	7	85,607,498 (GRCm39)	missense	possibly damaging	0.82
R6238:Vmn2r74	UTSW	7	85,601,280 (GRCm39)	missense	probably damaging	1.00
R6255:Vmn2r74	UTSW	7	85,601,659 (GRCm39)	missense	possibly damaging	0.90
R6468:Vmn2r74	UTSW	7	85,610,599 (GRCm39)	missense	probably benign	0.34
R6732:Vmn2r74	UTSW	7	85,606,758 (GRCm39)	missense	probably damaging	1.00
R6816:Vmn2r74	UTSW	7	85,610,621 (GRCm39)	nonsense	probably null
R6836:Vmn2r74	UTSW	7	85,606,630 (GRCm39)	missense	probably benign	0.00
R6995:Vmn2r74	UTSW	7	85,606,860 (GRCm39)	critical splice acceptor site	probably null
R6995:Vmn2r74	UTSW	7	85,601,943 (GRCm39)	missense	probably benign	0.01
R7186:Vmn2r74	UTSW	7	85,601,150 (GRCm39)	nonsense	probably null
R7246:Vmn2r74	UTSW	7	85,605,173 (GRCm39)	missense	probably benign
R7374:Vmn2r74	UTSW	7	85,606,630 (GRCm39)	missense	probably benign	0.02
R7505:Vmn2r74	UTSW	7	85,606,279 (GRCm39)	nonsense	probably null
R7525:Vmn2r74	UTSW	7	85,610,510 (GRCm39)	missense	probably benign
R7569:Vmn2r74	UTSW	7	85,601,544 (GRCm39)	missense	probably damaging	0.99
R7644:Vmn2r74	UTSW	7	85,606,746 (GRCm39)	missense	probably benign	0.11
R7956:Vmn2r74	UTSW	7	85,605,166 (GRCm39)	missense	probably benign	0.09
R8119:Vmn2r74	UTSW	7	85,610,690 (GRCm39)	start codon destroyed	probably null	0.08
R8131:Vmn2r74	UTSW	7	85,601,943 (GRCm39)	missense	probably benign	0.01
R8147:Vmn2r74	UTSW	7	85,605,227 (GRCm39)	nonsense	probably null
R8181:Vmn2r74	UTSW	7	85,605,324 (GRCm39)	missense	probably damaging	1.00
R8184:Vmn2r74	UTSW	7	85,601,454 (GRCm39)	missense	probably benign	0.00
R8375:Vmn2r74	UTSW	7	85,601,914 (GRCm39)	missense	possibly damaging	0.64
R8948:Vmn2r74	UTSW	7	85,606,569 (GRCm39)	missense	probably damaging	1.00
R8950:Vmn2r74	UTSW	7	85,606,569 (GRCm39)	missense	probably damaging	1.00
R9033:Vmn2r74	UTSW	7	85,606,414 (GRCm39)	missense	probably benign
R9342:Vmn2r74	UTSW	7	85,606,624 (GRCm39)	missense	probably benign	0.14
R9578:Vmn2r74	UTSW	7	85,606,101 (GRCm39)	missense	probably benign	0.01
R9607:Vmn2r74	UTSW	7	85,610,619 (GRCm39)	missense	probably benign	0.02
R9776:Vmn2r74	UTSW	7	85,605,212 (GRCm39)	missense	possibly damaging	0.70
Z1176:Vmn2r74	UTSW	7	85,604,835 (GRCm39)	missense	probably damaging	1.00
Z31818:Vmn2r74	UTSW	7	85,604,729 (GRCm39)	splice site	probably null

Posted On

2013-10-07