Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01349:Vmn1r204'

75252

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn1r204

Ensembl Gene

ENSMUSG00000094637

Gene Name

vomeronasal 1 receptor 204

Synonyms

Gm11301

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.074) question?

Stock #

IGL01349

Quality Score

Status

Chromosome

Chromosomal Location

22740371-22741279 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 22740504 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Lysine at position 45 (I45K)

Ref Sequence

ENSEMBL: ENSMUSP00000154519 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000091728] [ENSMUST00000228195]

AlphaFold

I7HIK1

Predicted Effect

probably damaging
Transcript: ENSMUST00000091728
AA Change: I45K

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000089321
Gene: ENSMUSG00000094637
AA Change: I45K

Domain	Start	End	E-Value	Type
Pfam:TAS2R	3	293	8.4e-8	PFAM
Pfam:V1R	35	297	1.2e-40	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000228195
AA Change: I45K

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 46 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca13	C	T	11: 9,242,076 (GRCm39)	S1313L	probably benign	Het
Adam28	T	C	14: 68,848,455 (GRCm39)	H667R	probably benign	Het
Arap1	T	C	7: 101,036,359 (GRCm39)	V382A	possibly damaging	Het
Arih2	T	C	9: 108,482,609 (GRCm39)	Y444C	probably damaging	Het
Asxl3	T	G	18: 22,657,294 (GRCm39)	V1768G	probably benign	Het
Bbs9	T	A	9: 22,798,979 (GRCm39)	M869K	probably benign	Het
C4bp	A	G	1: 130,570,665 (GRCm39)		probably benign	Het
Cc2d2a	A	T	5: 43,881,126 (GRCm39)	Y1167F	probably benign	Het
Cgn	T	A	3: 94,674,486 (GRCm39)	K884*	probably null	Het
Chd1l	T	C	3: 97,498,550 (GRCm39)	Y283C	probably benign	Het
Cry1	A	G	10: 84,984,603 (GRCm39)	V157A	probably benign	Het
Dcc	T	A	18: 71,503,808 (GRCm39)	D950V	probably damaging	Het
Dlc1	A	G	8: 37,050,978 (GRCm39)	F918L	probably damaging	Het
Dnah2	T	C	11: 69,366,432 (GRCm39)	N1890S	probably damaging	Het
Dnah5	A	G	15: 28,295,059 (GRCm39)		probably benign	Het
Eif4b	C	T	15: 101,999,858 (GRCm39)	T412I	probably benign	Het
Eloa	A	C	4: 135,741,758 (GRCm39)	Y29D	probably benign	Het
Erbb4	A	G	1: 68,385,752 (GRCm39)	F279S	probably benign	Het
Etl4	A	G	2: 20,718,207 (GRCm39)	D316G	probably damaging	Het
Gm5114	T	C	7: 39,058,531 (GRCm39)	S363G	probably benign	Het
Gpam	A	G	19: 55,084,551 (GRCm39)		probably null	Het
Il17rd	T	A	14: 26,817,901 (GRCm39)	S197T	probably damaging	Het
Iqsec3	T	C	6: 121,450,083 (GRCm39)	E147G	possibly damaging	Het
Itk	T	A	11: 46,232,027 (GRCm39)	T303S	possibly damaging	Het
Kcnh6	A	G	11: 105,914,743 (GRCm39)	D716G	possibly damaging	Het
Lca5	A	G	9: 83,308,670 (GRCm39)	S59P	probably damaging	Het
Lrrc40	T	C	3: 157,764,302 (GRCm39)		probably benign	Het
Mmp7	T	C	9: 7,699,335 (GRCm39)		probably benign	Het
Mycbp2	T	C	14: 103,359,983 (GRCm39)	T4427A	probably damaging	Het
Nf2	T	C	11: 4,734,472 (GRCm39)	D513G	possibly damaging	Het
Or2y1b	T	A	11: 49,209,127 (GRCm39)	Y251*	probably null	Het
Pde7a	C	T	3: 19,283,843 (GRCm39)		probably benign	Het
Pira2	T	C	7: 3,847,138 (GRCm39)	T135A	probably damaging	Het
Rb1	T	C	14: 73,506,558 (GRCm39)	Y397C	probably damaging	Het
Ros1	A	T	10: 51,927,122 (GRCm39)	M2187K	probably damaging	Het
Ryr2	T	A	13: 11,602,125 (GRCm39)	I4586F	possibly damaging	Het
Serpinb3c	A	T	1: 107,200,513 (GRCm39)	M210K	probably damaging	Het
Slc22a19	C	A	19: 7,651,792 (GRCm39)	V472F	probably benign	Het
Slc4a11	A	G	2: 130,528,863 (GRCm39)	I462T	probably benign	Het
Spag11b	A	T	8: 19,191,492 (GRCm39)	H55L	probably damaging	Het
Trpv5	G	T	6: 41,652,309 (GRCm39)	N125K	possibly damaging	Het
Ubr4	G	T	4: 139,208,039 (GRCm39)	R4940L	unknown	Het
Vcan	T	A	13: 89,852,062 (GRCm39)	H966L	probably damaging	Het
Vnn3	A	T	10: 23,727,814 (GRCm39)	I75F	probably damaging	Het
Vps13b	A	T	15: 35,794,091 (GRCm39)	M2256L	probably benign	Het
Zfc3h1	T	A	10: 115,259,353 (GRCm39)	L1642M	probably damaging	Het

Other mutations in Vmn1r204

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00819:Vmn1r204	APN	13	22,741,117 (GRCm39)	nonsense	probably null
IGL02653:Vmn1r204	APN	13	22,740,800 (GRCm39)	missense	probably benign	0.34
R0029:Vmn1r204	UTSW	13	22,740,588 (GRCm39)	missense	probably benign	0.12
R0078:Vmn1r204	UTSW	13	22,740,379 (GRCm39)	missense	probably benign	0.01
R0562:Vmn1r204	UTSW	13	22,740,848 (GRCm39)	missense	probably benign	0.00
R1124:Vmn1r204	UTSW	13	22,741,209 (GRCm39)	missense	possibly damaging	0.76
R1521:Vmn1r204	UTSW	13	22,741,248 (GRCm39)	missense	probably benign	0.30
R1544:Vmn1r204	UTSW	13	22,740,465 (GRCm39)	missense	probably benign	0.13
R2238:Vmn1r204	UTSW	13	22,740,993 (GRCm39)	missense	probably benign	0.01
R2418:Vmn1r204	UTSW	13	22,740,420 (GRCm39)	missense	probably damaging	1.00
R2419:Vmn1r204	UTSW	13	22,740,420 (GRCm39)	missense	probably damaging	1.00
R3944:Vmn1r204	UTSW	13	22,741,014 (GRCm39)	missense	probably benign	0.02
R4675:Vmn1r204	UTSW	13	22,740,962 (GRCm39)	missense	probably damaging	1.00
R4782:Vmn1r204	UTSW	13	22,740,867 (GRCm39)	missense	probably benign	0.03
R4985:Vmn1r204	UTSW	13	22,741,230 (GRCm39)	missense	probably damaging	1.00
R5219:Vmn1r204	UTSW	13	22,741,069 (GRCm39)	missense	probably damaging	1.00
R5268:Vmn1r204	UTSW	13	22,740,912 (GRCm39)	missense	probably damaging	1.00
R6652:Vmn1r204	UTSW	13	22,740,573 (GRCm39)	missense	probably damaging	0.99
R6943:Vmn1r204	UTSW	13	22,740,474 (GRCm39)	missense	probably benign	0.00
R7264:Vmn1r204	UTSW	13	22,741,167 (GRCm39)	missense	probably benign	0.23
R7299:Vmn1r204	UTSW	13	22,740,975 (GRCm39)	missense	probably damaging	1.00
R7301:Vmn1r204	UTSW	13	22,740,975 (GRCm39)	missense	probably damaging	1.00
R7593:Vmn1r204	UTSW	13	22,740,754 (GRCm39)	nonsense	probably null
R7872:Vmn1r204	UTSW	13	22,740,404 (GRCm39)	missense	probably benign	0.00
R8495:Vmn1r204	UTSW	13	22,740,879 (GRCm39)	missense	probably damaging	1.00
R9110:Vmn1r204	UTSW	13	22,740,564 (GRCm39)	missense	possibly damaging	0.80

Posted On

2013-10-07