Incidental Mutation 'IGL01349:Vnn3'
| ID |
75273 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Vnn3
|
| Ensembl Gene |
ENSMUSG00000020010 |
| Gene Name |
vanin 3 |
| Synonyms |
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.055)
|
| Stock # |
IGL01349
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
10 |
| Chromosomal Location |
23727360-23745741 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 23727814 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Phenylalanine
at position 75
(I75F)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000020190
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000020190]
|
| AlphaFold |
Q9QZ25 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000020190
AA Change: I75F
PolyPhen 2
Score 0.988 (Sensitivity: 0.73; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000020190
Gene: ENSMUSG00000020010
AA Change: I75F
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
22 |
N/A |
INTRINSIC |
|
Pfam:CN_hydrolase
|
51 |
296 |
6.9e-19 |
PFAM |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 46 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca13 |
C |
T |
11: 9,242,076 (GRCm39) |
S1313L |
probably benign |
Het |
| Adam28 |
T |
C |
14: 68,848,455 (GRCm39) |
H667R |
probably benign |
Het |
| Arap1 |
T |
C |
7: 101,036,359 (GRCm39) |
V382A |
possibly damaging |
Het |
| Arih2 |
T |
C |
9: 108,482,609 (GRCm39) |
Y444C |
probably damaging |
Het |
| Asxl3 |
T |
G |
18: 22,657,294 (GRCm39) |
V1768G |
probably benign |
Het |
| Bbs9 |
T |
A |
9: 22,798,979 (GRCm39) |
M869K |
probably benign |
Het |
| C4bp |
A |
G |
1: 130,570,665 (GRCm39) |
|
probably benign |
Het |
| Cc2d2a |
A |
T |
5: 43,881,126 (GRCm39) |
Y1167F |
probably benign |
Het |
| Cgn |
T |
A |
3: 94,674,486 (GRCm39) |
K884* |
probably null |
Het |
| Chd1l |
T |
C |
3: 97,498,550 (GRCm39) |
Y283C |
probably benign |
Het |
| Cry1 |
A |
G |
10: 84,984,603 (GRCm39) |
V157A |
probably benign |
Het |
| Dcc |
T |
A |
18: 71,503,808 (GRCm39) |
D950V |
probably damaging |
Het |
| Dlc1 |
A |
G |
8: 37,050,978 (GRCm39) |
F918L |
probably damaging |
Het |
| Dnah2 |
T |
C |
11: 69,366,432 (GRCm39) |
N1890S |
probably damaging |
Het |
| Dnah5 |
A |
G |
15: 28,295,059 (GRCm39) |
|
probably benign |
Het |
| Eif4b |
C |
T |
15: 101,999,858 (GRCm39) |
T412I |
probably benign |
Het |
| Eloa |
A |
C |
4: 135,741,758 (GRCm39) |
Y29D |
probably benign |
Het |
| Erbb4 |
A |
G |
1: 68,385,752 (GRCm39) |
F279S |
probably benign |
Het |
| Etl4 |
A |
G |
2: 20,718,207 (GRCm39) |
D316G |
probably damaging |
Het |
| Gm5114 |
T |
C |
7: 39,058,531 (GRCm39) |
S363G |
probably benign |
Het |
| Gpam |
A |
G |
19: 55,084,551 (GRCm39) |
|
probably null |
Het |
| Il17rd |
T |
A |
14: 26,817,901 (GRCm39) |
S197T |
probably damaging |
Het |
| Iqsec3 |
T |
C |
6: 121,450,083 (GRCm39) |
E147G |
possibly damaging |
Het |
| Itk |
T |
A |
11: 46,232,027 (GRCm39) |
T303S |
possibly damaging |
Het |
| Kcnh6 |
A |
G |
11: 105,914,743 (GRCm39) |
D716G |
possibly damaging |
Het |
| Lca5 |
A |
G |
9: 83,308,670 (GRCm39) |
S59P |
probably damaging |
Het |
| Lrrc40 |
T |
C |
3: 157,764,302 (GRCm39) |
|
probably benign |
Het |
| Mmp7 |
T |
C |
9: 7,699,335 (GRCm39) |
|
probably benign |
Het |
| Mycbp2 |
T |
C |
14: 103,359,983 (GRCm39) |
T4427A |
probably damaging |
Het |
| Nf2 |
T |
C |
11: 4,734,472 (GRCm39) |
D513G |
possibly damaging |
Het |
| Or2y1b |
T |
A |
11: 49,209,127 (GRCm39) |
Y251* |
probably null |
Het |
| Pde7a |
C |
T |
3: 19,283,843 (GRCm39) |
|
probably benign |
Het |
| Pira2 |
T |
C |
7: 3,847,138 (GRCm39) |
T135A |
probably damaging |
Het |
| Rb1 |
T |
C |
14: 73,506,558 (GRCm39) |
Y397C |
probably damaging |
Het |
| Ros1 |
A |
T |
10: 51,927,122 (GRCm39) |
M2187K |
probably damaging |
Het |
| Ryr2 |
T |
A |
13: 11,602,125 (GRCm39) |
I4586F |
possibly damaging |
Het |
| Serpinb3c |
A |
T |
1: 107,200,513 (GRCm39) |
M210K |
probably damaging |
Het |
| Slc22a19 |
C |
A |
19: 7,651,792 (GRCm39) |
V472F |
probably benign |
Het |
| Slc4a11 |
A |
G |
2: 130,528,863 (GRCm39) |
I462T |
probably benign |
Het |
| Spag11b |
A |
T |
8: 19,191,492 (GRCm39) |
H55L |
probably damaging |
Het |
| Trpv5 |
G |
T |
6: 41,652,309 (GRCm39) |
N125K |
possibly damaging |
Het |
| Ubr4 |
G |
T |
4: 139,208,039 (GRCm39) |
R4940L |
unknown |
Het |
| Vcan |
T |
A |
13: 89,852,062 (GRCm39) |
H966L |
probably damaging |
Het |
| Vmn1r204 |
T |
A |
13: 22,740,504 (GRCm39) |
I45K |
probably damaging |
Het |
| Vps13b |
A |
T |
15: 35,794,091 (GRCm39) |
M2256L |
probably benign |
Het |
| Zfc3h1 |
T |
A |
10: 115,259,353 (GRCm39) |
L1642M |
probably damaging |
Het |
|
| Other mutations in Vnn3 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00675:Vnn3
|
APN |
10 |
23,743,066 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
IGL01300:Vnn3
|
APN |
10 |
23,740,263 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
IGL02491:Vnn3
|
APN |
10 |
23,741,816 (GRCm39) |
missense |
probably benign |
0.11 |
|
IGL03256:Vnn3
|
APN |
10 |
23,727,698 (GRCm39) |
splice site |
probably benign |
|
|
IGL03289:Vnn3
|
APN |
10 |
23,741,735 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
IGL02799:Vnn3
|
UTSW |
10 |
23,727,869 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R0599:Vnn3
|
UTSW |
10 |
23,741,603 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R1703:Vnn3
|
UTSW |
10 |
23,741,828 (GRCm39) |
missense |
probably benign |
|
|
R1753:Vnn3
|
UTSW |
10 |
23,741,718 (GRCm39) |
missense |
probably benign |
0.27 |
|
R2119:Vnn3
|
UTSW |
10 |
23,740,311 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2288:Vnn3
|
UTSW |
10 |
23,740,354 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4255:Vnn3
|
UTSW |
10 |
23,741,720 (GRCm39) |
missense |
probably benign |
0.18 |
|
R4458:Vnn3
|
UTSW |
10 |
23,741,567 (GRCm39) |
missense |
probably benign |
0.23 |
|
R4518:Vnn3
|
UTSW |
10 |
23,743,124 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R4545:Vnn3
|
UTSW |
10 |
23,732,224 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4723:Vnn3
|
UTSW |
10 |
23,727,589 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R4791:Vnn3
|
UTSW |
10 |
23,740,519 (GRCm39) |
missense |
probably benign |
|
|
R4921:Vnn3
|
UTSW |
10 |
23,740,473 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5152:Vnn3
|
UTSW |
10 |
23,740,237 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5390:Vnn3
|
UTSW |
10 |
23,727,483 (GRCm39) |
start codon destroyed |
probably null |
1.00 |
|
R5545:Vnn3
|
UTSW |
10 |
23,742,992 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6197:Vnn3
|
UTSW |
10 |
23,732,187 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6751:Vnn3
|
UTSW |
10 |
23,745,523 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6846:Vnn3
|
UTSW |
10 |
23,727,620 (GRCm39) |
missense |
probably benign |
|
|
R6917:Vnn3
|
UTSW |
10 |
23,741,832 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R7073:Vnn3
|
UTSW |
10 |
23,740,311 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7100:Vnn3
|
UTSW |
10 |
23,741,840 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7152:Vnn3
|
UTSW |
10 |
23,727,513 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R7336:Vnn3
|
UTSW |
10 |
23,727,806 (GRCm39) |
missense |
probably benign |
0.42 |
|
R7421:Vnn3
|
UTSW |
10 |
23,741,666 (GRCm39) |
missense |
probably benign |
0.06 |
|
R7875:Vnn3
|
UTSW |
10 |
23,743,146 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R8353:Vnn3
|
UTSW |
10 |
23,745,443 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8453:Vnn3
|
UTSW |
10 |
23,745,443 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8465:Vnn3
|
UTSW |
10 |
23,741,780 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R9105:Vnn3
|
UTSW |
10 |
23,740,461 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9261:Vnn3
|
UTSW |
10 |
23,741,607 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9441:Vnn3
|
UTSW |
10 |
23,740,498 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R9718:Vnn3
|
UTSW |
10 |
23,745,454 (GRCm39) |
nonsense |
probably null |
|
|
R9737:Vnn3
|
UTSW |
10 |
23,741,813 (GRCm39) |
missense |
probably benign |
0.02 |
|
| Posted On |
2013-10-07 |
Incidental Mutation