Incidental Mutation 'IGL01349:Cry1'
ID 75289
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Cry1
Ensembl Gene ENSMUSG00000020038
Gene Name cryptochrome circadian regulator 1
Synonyms Phll1
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL01349
Quality Score
Status
Chromosome 10
Chromosomal Location 84967564-85020918 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 84984603 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 157 (V157A)
Ref Sequence ENSEMBL: ENSMUSP00000020227 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000020227]
AlphaFold P97784
PDB Structure Crystal Structure of Mouse Cryptochrome1 in Complex with Period2 [X-RAY DIFFRACTION]
Crystal structure of mouse Cryptochrome 1 [X-RAY DIFFRACTION]
Predicted Effect probably benign
Transcript: ENSMUST00000020227
AA Change: V157A

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000020227
Gene: ENSMUSG00000020038
AA Change: V157A

DomainStartEndE-ValueType
Pfam:DNA_photolyase 5 168 1.4e-47 PFAM
Pfam:FAD_binding_7 213 486 6.9e-91 PFAM
internal_repeat_1 502 523 3.57e-8 PROSPERO
internal_repeat_1 521 543 3.57e-8 PROSPERO
low complexity region 544 555 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000214248
Predicted Effect unknown
Transcript: ENSMUST00000214675
AA Change: V47A
Predicted Effect noncoding transcript
Transcript: ENSMUST00000214805
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by Clock/Arntl heterodimers but then represses this upregulation in a feedback loop using Per/Cry heterodimers to interact with Clock/Arntl. Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely conserved across plants and animals. Loss of this gene results in a shortened circadian cycle in complete darkness. [provided by RefSeq, Feb 2014]
PHENOTYPE: Homozygotes for targeted null mutations exhibit a one-hour shorter circadian period under constant darkness and reduced expression of another circadian gene in the suprachiasmatic nucleus in response to acute light exposure. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca13 C T 11: 9,242,076 (GRCm39) S1313L probably benign Het
Adam28 T C 14: 68,848,455 (GRCm39) H667R probably benign Het
Arap1 T C 7: 101,036,359 (GRCm39) V382A possibly damaging Het
Arih2 T C 9: 108,482,609 (GRCm39) Y444C probably damaging Het
Asxl3 T G 18: 22,657,294 (GRCm39) V1768G probably benign Het
Bbs9 T A 9: 22,798,979 (GRCm39) M869K probably benign Het
C4bp A G 1: 130,570,665 (GRCm39) probably benign Het
Cc2d2a A T 5: 43,881,126 (GRCm39) Y1167F probably benign Het
Cgn T A 3: 94,674,486 (GRCm39) K884* probably null Het
Chd1l T C 3: 97,498,550 (GRCm39) Y283C probably benign Het
Dcc T A 18: 71,503,808 (GRCm39) D950V probably damaging Het
Dlc1 A G 8: 37,050,978 (GRCm39) F918L probably damaging Het
Dnah2 T C 11: 69,366,432 (GRCm39) N1890S probably damaging Het
Dnah5 A G 15: 28,295,059 (GRCm39) probably benign Het
Eif4b C T 15: 101,999,858 (GRCm39) T412I probably benign Het
Eloa A C 4: 135,741,758 (GRCm39) Y29D probably benign Het
Erbb4 A G 1: 68,385,752 (GRCm39) F279S probably benign Het
Etl4 A G 2: 20,718,207 (GRCm39) D316G probably damaging Het
Gm5114 T C 7: 39,058,531 (GRCm39) S363G probably benign Het
Gpam A G 19: 55,084,551 (GRCm39) probably null Het
Il17rd T A 14: 26,817,901 (GRCm39) S197T probably damaging Het
Iqsec3 T C 6: 121,450,083 (GRCm39) E147G possibly damaging Het
Itk T A 11: 46,232,027 (GRCm39) T303S possibly damaging Het
Kcnh6 A G 11: 105,914,743 (GRCm39) D716G possibly damaging Het
Lca5 A G 9: 83,308,670 (GRCm39) S59P probably damaging Het
Lrrc40 T C 3: 157,764,302 (GRCm39) probably benign Het
Mmp7 T C 9: 7,699,335 (GRCm39) probably benign Het
Mycbp2 T C 14: 103,359,983 (GRCm39) T4427A probably damaging Het
Nf2 T C 11: 4,734,472 (GRCm39) D513G possibly damaging Het
Or2y1b T A 11: 49,209,127 (GRCm39) Y251* probably null Het
Pde7a C T 3: 19,283,843 (GRCm39) probably benign Het
Pira2 T C 7: 3,847,138 (GRCm39) T135A probably damaging Het
Rb1 T C 14: 73,506,558 (GRCm39) Y397C probably damaging Het
Ros1 A T 10: 51,927,122 (GRCm39) M2187K probably damaging Het
Ryr2 T A 13: 11,602,125 (GRCm39) I4586F possibly damaging Het
Serpinb3c A T 1: 107,200,513 (GRCm39) M210K probably damaging Het
Slc22a19 C A 19: 7,651,792 (GRCm39) V472F probably benign Het
Slc4a11 A G 2: 130,528,863 (GRCm39) I462T probably benign Het
Spag11b A T 8: 19,191,492 (GRCm39) H55L probably damaging Het
Trpv5 G T 6: 41,652,309 (GRCm39) N125K possibly damaging Het
Ubr4 G T 4: 139,208,039 (GRCm39) R4940L unknown Het
Vcan T A 13: 89,852,062 (GRCm39) H966L probably damaging Het
Vmn1r204 T A 13: 22,740,504 (GRCm39) I45K probably damaging Het
Vnn3 A T 10: 23,727,814 (GRCm39) I75F probably damaging Het
Vps13b A T 15: 35,794,091 (GRCm39) M2256L probably benign Het
Zfc3h1 T A 10: 115,259,353 (GRCm39) L1642M probably damaging Het
Other mutations in Cry1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00234:Cry1 APN 10 84,982,698 (GRCm39) missense probably benign 0.11
IGL00737:Cry1 APN 10 84,978,904 (GRCm39) missense probably benign 0.02
IGL01544:Cry1 APN 10 84,982,360 (GRCm39) nonsense probably null
IGL01545:Cry1 APN 10 85,020,226 (GRCm39) missense possibly damaging 0.94
IGL01767:Cry1 APN 10 84,982,338 (GRCm39) missense probably damaging 1.00
IGL03392:Cry1 APN 10 84,992,993 (GRCm39) missense possibly damaging 0.88
R0119:Cry1 UTSW 10 84,969,104 (GRCm39) critical splice donor site probably null
R0605:Cry1 UTSW 10 85,020,223 (GRCm39) missense probably damaging 0.96
R1618:Cry1 UTSW 10 84,982,318 (GRCm39) missense probably damaging 1.00
R1955:Cry1 UTSW 10 84,980,042 (GRCm39) missense probably benign 0.00
R2209:Cry1 UTSW 10 84,982,619 (GRCm39) missense probably damaging 0.98
R2221:Cry1 UTSW 10 84,979,617 (GRCm39) missense probably damaging 1.00
R2223:Cry1 UTSW 10 84,979,617 (GRCm39) missense probably damaging 1.00
R2314:Cry1 UTSW 10 84,969,175 (GRCm39) missense probably benign 0.08
R3851:Cry1 UTSW 10 84,982,363 (GRCm39) missense probably benign 0.15
R3872:Cry1 UTSW 10 84,969,024 (GRCm39) critical splice acceptor site probably null
R3981:Cry1 UTSW 10 84,982,456 (GRCm39) missense probably damaging 0.99
R4856:Cry1 UTSW 10 84,984,634 (GRCm39) missense probably damaging 0.97
R5162:Cry1 UTSW 10 84,969,150 (GRCm39) missense probably benign
R5404:Cry1 UTSW 10 85,020,283 (GRCm39) missense probably damaging 1.00
R5449:Cry1 UTSW 10 84,968,999 (GRCm39) missense probably benign 0.17
R5484:Cry1 UTSW 10 84,982,588 (GRCm39) splice site probably null
R5599:Cry1 UTSW 10 84,980,114 (GRCm39) missense probably benign 0.14
R5717:Cry1 UTSW 10 84,982,280 (GRCm39) missense probably damaging 1.00
R7031:Cry1 UTSW 10 84,984,526 (GRCm39) missense probably benign 0.00
R7371:Cry1 UTSW 10 84,983,783 (GRCm39) missense probably benign 0.03
R7943:Cry1 UTSW 10 84,978,984 (GRCm39) missense probably benign 0.03
R8022:Cry1 UTSW 10 84,982,266 (GRCm39) missense probably damaging 0.97
R8290:Cry1 UTSW 10 84,978,977 (GRCm39) nonsense probably null
R8805:Cry1 UTSW 10 84,992,969 (GRCm39) missense probably benign 0.09
Z1176:Cry1 UTSW 10 84,980,061 (GRCm39) missense probably benign 0.00
Posted On 2013-10-07