Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01351:Tex19.1'

75352

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tex19.1

Ensembl Gene

ENSMUSG00000039329

Gene Name

testis expressed gene 19.1

Synonyms

Tex19.1, Tex19, 2410081M02Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.205) question?

Stock #

IGL01351

Quality Score

Status

Chromosome

Chromosomal Location

121036969-121039140 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 121038072 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Glutamic Acid at position 143 (D143E)

Ref Sequence

ENSEMBL: ENSMUSP00000048592 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000039088] [ENSMUST00000155694]

AlphaFold

Q99MV2

Predicted Effect

probably damaging
Transcript: ENSMUST00000039088
AA Change: D143E

PolyPhen 2 Score 0.983 (Sensitivity: 0.75; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000048592
Gene: ENSMUSG00000039329
AA Change: D143E

Domain	Start	End	E-Value	Type
Pfam:TEX19	1	164	2.3e-73	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000155694

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Mice homozygous for a knock-out allele exhibit decreased fertility, which in males is due to impaired spermatogenesis and increased male germ cell apoptosis. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 38 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca13	T	C	11: 9,217,565 (GRCm39)	S336P	probably benign	Het
Abca9	T	C	11: 110,039,729 (GRCm39)	Y428C	probably damaging	Het
Alpk1	T	C	3: 127,466,011 (GRCm39)	Q1165R	probably damaging	Het
Angel2	C	A	1: 190,665,310 (GRCm39)	N80K	probably benign	Het
Bmp6	T	C	13: 38,653,610 (GRCm39)	S226P	probably damaging	Het
Ccar2	T	C	14: 70,383,311 (GRCm39)	T229A	probably benign	Het
Cdh12	G	A	15: 21,237,989 (GRCm39)	V75M	probably damaging	Het
Cdh6	G	T	15: 13,034,326 (GRCm39)	A778E	possibly damaging	Het
Corin	A	T	5: 72,496,334 (GRCm39)	C540S	probably damaging	Het
Cyfip1	C	A	7: 55,547,991 (GRCm39)	Y530*	probably null	Het
Dock10	T	G	1: 80,570,876 (GRCm39)	K327N	probably damaging	Het
Dpy19l3	A	G	7: 35,426,840 (GRCm39)		probably benign	Het
E2f8	T	C	7: 48,516,899 (GRCm39)	T827A	probably benign	Het
Edem3	T	C	1: 151,668,136 (GRCm39)	V305A	possibly damaging	Het
Fam170a	T	C	18: 50,414,845 (GRCm39)	W164R	probably benign	Het
Fbxw14	T	C	9: 109,103,640 (GRCm39)	D24G	possibly damaging	Het
Gnmt	T	C	17: 47,037,606 (GRCm39)	D124G	probably benign	Het
Gpx5	T	C	13: 21,471,669 (GRCm39)	D178G	probably damaging	Het
Gsdmd	T	A	15: 75,736,186 (GRCm39)	I105N	probably damaging	Het
Hps5	C	T	7: 46,410,856 (GRCm39)	M1113I	probably damaging	Het
Hyal6	T	C	6: 24,734,178 (GRCm39)	F37S	probably damaging	Het
Il17c	C	T	8: 123,148,862 (GRCm39)	T2I	probably benign	Het
Lyz1	A	G	10: 117,127,093 (GRCm39)	C48R	probably damaging	Het
Or52e18	T	A	7: 104,609,946 (GRCm39)		probably benign	Het
Pafah1b3	G	A	7: 24,994,570 (GRCm39)	R215C	possibly damaging	Het
Psmb4	A	T	3: 94,793,538 (GRCm39)		probably null	Het
Rnf213	T	C	11: 119,373,944 (GRCm39)	V5009A	probably benign	Het
Sema6a	T	C	18: 47,414,369 (GRCm39)	K494E	possibly damaging	Het
Sfmbt1	T	C	14: 30,491,777 (GRCm39)	V17A	probably benign	Het
Speg	T	A	1: 75,387,920 (GRCm39)		probably benign	Het
Spint1	A	G	2: 119,076,936 (GRCm39)	D340G	probably damaging	Het
Tasor	A	G	14: 27,186,258 (GRCm39)	E819G	probably benign	Het
Tctn3	T	C	19: 40,596,081 (GRCm39)	I309V	probably benign	Het
Tktl2	A	G	8: 66,965,548 (GRCm39)	I369V	probably benign	Het
Tm2d2	A	G	8: 25,510,573 (GRCm39)		probably benign	Het
Traf4	C	A	11: 78,056,226 (GRCm39)	R14L	possibly damaging	Het
Zfhx4	A	G	3: 5,466,196 (GRCm39)	Y2118C	probably damaging	Het
Zmynd15	C	A	11: 70,354,416 (GRCm39)	N425K	probably benign	Het

Other mutations in Tex19.1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R1420:Tex19.1	UTSW	11	121,037,872 (GRCm39)	missense	probably damaging	0.97
R1593:Tex19.1	UTSW	11	121,038,079 (GRCm39)	missense	probably damaging	0.99
R5113:Tex19.1	UTSW	11	121,038,625 (GRCm39)	missense	probably benign	0.41
R6906:Tex19.1	UTSW	11	121,037,948 (GRCm39)	missense	probably benign	0.42
R7389:Tex19.1	UTSW	11	121,037,986 (GRCm39)	missense	possibly damaging	0.92
R7943:Tex19.1	UTSW	11	121,037,986 (GRCm39)	missense	possibly damaging	0.92
R8049:Tex19.1	UTSW	11	121,038,148 (GRCm39)	missense	probably benign
R9445:Tex19.1	UTSW	11	121,038,283 (GRCm39)	missense	probably benign	0.00
X0026:Tex19.1	UTSW	11	121,037,872 (GRCm39)	missense	possibly damaging	0.84
Z1176:Tex19.1	UTSW	11	121,038,389 (GRCm39)	missense	probably damaging	0.96

Posted On

2013-10-07