Incidental Mutation 'IGL01352:Zfp341'
| ID |
75398 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Zfp341
|
| Ensembl Gene |
ENSMUSG00000059842 |
| Gene Name |
zinc finger protein 341 |
| Synonyms |
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
IGL01352
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
2 |
| Chromosomal Location |
154455217-154488741 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to T
at 154470816 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Alanine to Serine
at position 278
(A278S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000105324
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000081926]
[ENSMUST00000109702]
[ENSMUST00000126421]
|
| AlphaFold |
Q6PGC9 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000081926
AA Change: A278S
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000080596
Gene: ENSMUSG00000059842
AA Change: A278S
| Domain | Start | End | E-Value | Type |
|---|
|
ZnF_C2H2
|
53 |
73 |
4.16e1 |
SMART |
|
low complexity region
|
96 |
110 |
N/A |
INTRINSIC |
|
low complexity region
|
154 |
161 |
N/A |
INTRINSIC |
|
low complexity region
|
177 |
200 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
320 |
342 |
3.69e-4 |
SMART |
|
ZnF_C2H2
|
348 |
370 |
1.04e-3 |
SMART |
|
ZnF_C2H2
|
442 |
464 |
1.45e-2 |
SMART |
|
ZnF_C2H2
|
470 |
494 |
2.17e-1 |
SMART |
|
ZnF_C2H2
|
500 |
522 |
2.91e-2 |
SMART |
|
ZnF_C2H2
|
537 |
561 |
1.23e0 |
SMART |
|
ZnF_C2H2
|
563 |
585 |
3.58e-2 |
SMART |
|
ZnF_C2H2
|
591 |
613 |
1.62e0 |
SMART |
|
ZnF_C2H2
|
619 |
641 |
2.27e-4 |
SMART |
|
ZnF_C2H2
|
647 |
674 |
7.29e0 |
SMART |
|
ZnF_C2H2
|
680 |
702 |
5.14e-3 |
SMART |
|
low complexity region
|
740 |
759 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000109702
AA Change: A278S
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000105324
Gene: ENSMUSG00000059842
AA Change: A278S
| Domain | Start | End | E-Value | Type |
|---|
|
ZnF_C2H2
|
53 |
73 |
4.16e1 |
SMART |
|
low complexity region
|
96 |
110 |
N/A |
INTRINSIC |
|
low complexity region
|
154 |
161 |
N/A |
INTRINSIC |
|
low complexity region
|
177 |
200 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
313 |
335 |
3.69e-4 |
SMART |
|
ZnF_C2H2
|
341 |
363 |
1.04e-3 |
SMART |
|
ZnF_C2H2
|
435 |
457 |
1.45e-2 |
SMART |
|
ZnF_C2H2
|
463 |
487 |
2.17e-1 |
SMART |
|
ZnF_C2H2
|
493 |
515 |
2.91e-2 |
SMART |
|
ZnF_C2H2
|
530 |
554 |
1.23e0 |
SMART |
|
ZnF_C2H2
|
556 |
578 |
3.58e-2 |
SMART |
|
ZnF_C2H2
|
584 |
606 |
1.62e0 |
SMART |
|
ZnF_C2H2
|
612 |
634 |
2.27e-4 |
SMART |
|
ZnF_C2H2
|
640 |
667 |
7.29e0 |
SMART |
|
ZnF_C2H2
|
673 |
695 |
5.14e-3 |
SMART |
|
low complexity region
|
733 |
752 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000126421
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000153208
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 39 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adamts9 |
T |
C |
6: 92,837,155 (GRCm39) |
I1169V |
probably benign |
Het |
| B3gnt5 |
T |
C |
16: 19,587,963 (GRCm39) |
S61P |
probably damaging |
Het |
| Bambi |
G |
A |
18: 3,512,071 (GRCm39) |
A152T |
probably damaging |
Het |
| Cacna1c |
G |
A |
6: 118,633,518 (GRCm39) |
Q930* |
probably null |
Het |
| Ccdc178 |
A |
G |
18: 22,152,031 (GRCm39) |
|
probably benign |
Het |
| Chit1 |
C |
T |
1: 134,076,228 (GRCm39) |
T295M |
probably damaging |
Het |
| Cntnap5c |
C |
A |
17: 58,600,896 (GRCm39) |
N746K |
probably benign |
Het |
| Cyfip2 |
A |
T |
11: 46,156,823 (GRCm39) |
F422I |
probably benign |
Het |
| Dsg3 |
A |
G |
18: 20,656,753 (GRCm39) |
M208V |
probably benign |
Het |
| Erich6 |
G |
A |
3: 58,529,781 (GRCm39) |
|
probably null |
Het |
| Gbf1 |
A |
G |
19: 46,253,654 (GRCm39) |
H574R |
probably damaging |
Het |
| Gm17654 |
T |
G |
14: 43,813,331 (GRCm39) |
E186D |
probably damaging |
Het |
| Gm8165 |
T |
C |
14: 43,913,573 (GRCm39) |
N97S |
unknown |
Het |
| Ilf3 |
C |
T |
9: 21,303,618 (GRCm39) |
L160F |
possibly damaging |
Het |
| Krt84 |
T |
A |
15: 101,437,209 (GRCm39) |
Q318L |
probably damaging |
Het |
| Lrp2 |
T |
A |
2: 69,333,870 (GRCm39) |
H1457L |
possibly damaging |
Het |
| Lrrc37a |
T |
A |
11: 103,390,181 (GRCm39) |
D1748V |
probably benign |
Het |
| Mybl1 |
T |
C |
1: 9,741,904 (GRCm39) |
E676G |
probably damaging |
Het |
| Myo10 |
C |
A |
15: 25,701,783 (GRCm39) |
R53S |
probably damaging |
Het |
| Myorg |
T |
A |
4: 41,499,469 (GRCm39) |
R54* |
probably null |
Het |
| Nrap |
A |
G |
19: 56,368,268 (GRCm39) |
S205P |
probably benign |
Het |
| Or4c52 |
A |
G |
2: 89,846,063 (GRCm39) |
D263G |
probably damaging |
Het |
| Or52z1 |
A |
T |
7: 103,437,285 (GRCm39) |
Y66* |
probably null |
Het |
| Or8b1b |
A |
G |
9: 38,376,030 (GRCm39) |
N231S |
probably benign |
Het |
| Pkhd1 |
T |
A |
1: 20,619,939 (GRCm39) |
M894L |
probably benign |
Het |
| Ptpn13 |
G |
A |
5: 103,634,641 (GRCm39) |
|
probably null |
Het |
| Pycard |
T |
C |
7: 127,592,674 (GRCm39) |
D9G |
probably damaging |
Het |
| Rbfox3 |
G |
A |
11: 118,396,439 (GRCm39) |
|
probably benign |
Het |
| Rnf122 |
C |
T |
8: 31,614,908 (GRCm39) |
R71* |
probably null |
Het |
| Scel |
T |
A |
14: 103,770,774 (GRCm39) |
D69E |
possibly damaging |
Het |
| Spag6 |
T |
G |
2: 18,715,284 (GRCm39) |
M21R |
possibly damaging |
Het |
| Stat5a |
A |
G |
11: 100,771,898 (GRCm39) |
D650G |
probably damaging |
Het |
| Tars3 |
T |
C |
7: 65,308,658 (GRCm39) |
I276T |
possibly damaging |
Het |
| Tnfaip2 |
G |
T |
12: 111,412,053 (GRCm39) |
E151D |
probably damaging |
Het |
| Trio |
G |
A |
15: 27,901,315 (GRCm39) |
T313I |
probably benign |
Het |
| Ubqln4 |
A |
C |
3: 88,471,775 (GRCm39) |
M404L |
probably benign |
Het |
| Vps33b |
T |
A |
7: 79,934,807 (GRCm39) |
|
probably null |
Het |
| Wdfy3 |
A |
T |
5: 102,091,986 (GRCm39) |
V451D |
probably damaging |
Het |
| Zp3r |
C |
T |
1: 130,547,093 (GRCm39) |
A28T |
possibly damaging |
Het |
|
| Other mutations in Zfp341 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00499:Zfp341
|
APN |
2 |
154,476,151 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01748:Zfp341
|
APN |
2 |
154,470,847 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02260:Zfp341
|
APN |
2 |
154,483,969 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
IGL02329:Zfp341
|
APN |
2 |
154,474,224 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
casanova_grimbacher
|
UTSW |
2 |
154,466,801 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Specious
|
UTSW |
2 |
154,488,054 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R0079:Zfp341
|
UTSW |
2 |
154,466,914 (GRCm39) |
nonsense |
probably null |
|
|
R0570:Zfp341
|
UTSW |
2 |
154,487,988 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0620:Zfp341
|
UTSW |
2 |
154,476,193 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R1018:Zfp341
|
UTSW |
2 |
154,487,972 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1611:Zfp341
|
UTSW |
2 |
154,487,623 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1733:Zfp341
|
UTSW |
2 |
154,483,298 (GRCm39) |
missense |
probably benign |
0.19 |
|
R1822:Zfp341
|
UTSW |
2 |
154,488,054 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R1956:Zfp341
|
UTSW |
2 |
154,480,132 (GRCm39) |
missense |
probably benign |
0.09 |
|
R2437:Zfp341
|
UTSW |
2 |
154,470,721 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3623:Zfp341
|
UTSW |
2 |
154,466,801 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4417:Zfp341
|
UTSW |
2 |
154,470,907 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R4806:Zfp341
|
UTSW |
2 |
154,487,786 (GRCm39) |
utr 3 prime |
probably benign |
|
|
R4807:Zfp341
|
UTSW |
2 |
154,487,786 (GRCm39) |
utr 3 prime |
probably benign |
|
|
R4863:Zfp341
|
UTSW |
2 |
154,487,786 (GRCm39) |
utr 3 prime |
probably benign |
|
|
R4955:Zfp341
|
UTSW |
2 |
154,479,950 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4962:Zfp341
|
UTSW |
2 |
154,468,734 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R5484:Zfp341
|
UTSW |
2 |
154,466,921 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5864:Zfp341
|
UTSW |
2 |
154,485,474 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5877:Zfp341
|
UTSW |
2 |
154,474,209 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5975:Zfp341
|
UTSW |
2 |
154,472,361 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5990:Zfp341
|
UTSW |
2 |
154,487,579 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6057:Zfp341
|
UTSW |
2 |
154,466,954 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6882:Zfp341
|
UTSW |
2 |
154,479,943 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7686:Zfp341
|
UTSW |
2 |
154,466,781 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7701:Zfp341
|
UTSW |
2 |
154,476,000 (GRCm39) |
splice site |
probably null |
|
|
R7847:Zfp341
|
UTSW |
2 |
154,476,114 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8109:Zfp341
|
UTSW |
2 |
154,469,820 (GRCm39) |
missense |
probably benign |
0.04 |
|
R9313:Zfp341
|
UTSW |
2 |
154,469,907 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9484:Zfp341
|
UTSW |
2 |
154,485,763 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Posted On |
2013-10-07 |
Incidental Mutation