Incidental Mutation 'IGL01354:Vstm4'
ID |
75462 |
Institutional Source |
Australian Phenomics Network
(link to record)
|
Gene Symbol |
Vstm4
|
Ensembl Gene |
ENSMUSG00000050666 |
Gene Name |
V-set and transmembrane domain containing 4 |
Synonyms |
E130203B14Rik |
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.057)
|
Stock # |
IGL01354
|
Quality Score |
|
Status
|
|
Chromosome |
14 |
Chromosomal Location |
32578713-32661448 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
A to T
at 32641202 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Threonine to Serine
at position 262
(T262S)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000055178
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000053175]
[ENSMUST00000100721]
|
AlphaFold |
T1NXB5 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000053175
AA Change: T262S
PolyPhen 2
Score 0.077 (Sensitivity: 0.93; Specificity: 0.85)
|
SMART Domains |
Protein: ENSMUSP00000055178 Gene: ENSMUSG00000050666 AA Change: T262S
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
22 |
N/A |
INTRINSIC |
IG
|
31 |
153 |
2.11e-2 |
SMART |
transmembrane domain
|
178 |
200 |
N/A |
INTRINSIC |
low complexity region
|
245 |
261 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000100721
AA Change: T113S
PolyPhen 2
Score 0.077 (Sensitivity: 0.93; Specificity: 0.85)
|
SMART Domains |
Protein: ENSMUSP00000098287 Gene: ENSMUSG00000050666 AA Change: T113S
Domain | Start | End | E-Value | Type |
transmembrane domain
|
29 |
51 |
N/A |
INTRINSIC |
low complexity region
|
96 |
112 |
N/A |
INTRINSIC |
|
Meta Mutation Damage Score |
0.0898 |
Coding Region Coverage |
|
Validation Efficiency |
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 27 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Aldh1l2 |
A |
G |
10: 83,363,240 (GRCm39) |
L41P |
probably damaging |
Het |
Baz2b |
T |
C |
2: 59,799,233 (GRCm39) |
Q297R |
probably benign |
Het |
Chl1 |
A |
T |
6: 103,642,814 (GRCm39) |
Q184L |
probably benign |
Het |
Cyp2a5 |
A |
G |
7: 26,536,528 (GRCm39) |
D169G |
possibly damaging |
Het |
Cyp2d34 |
G |
A |
15: 82,501,823 (GRCm39) |
T229M |
probably benign |
Het |
Fgd5 |
C |
T |
6: 92,038,824 (GRCm39) |
R995* |
probably null |
Het |
Gaa |
T |
C |
11: 119,161,394 (GRCm39) |
S146P |
probably benign |
Het |
Gm11437 |
T |
A |
11: 84,058,144 (GRCm39) |
|
probably benign |
Het |
Inpp5a |
T |
C |
7: 139,118,150 (GRCm39) |
F235L |
probably damaging |
Het |
Lpp |
T |
A |
16: 24,580,816 (GRCm39) |
Y177* |
probably null |
Het |
Malt1 |
A |
G |
18: 65,608,262 (GRCm39) |
Y654C |
probably damaging |
Het |
Or2y10 |
T |
C |
11: 49,455,024 (GRCm39) |
I92T |
probably damaging |
Het |
Or4k52 |
A |
C |
2: 111,611,246 (GRCm39) |
N194H |
possibly damaging |
Het |
Or8b4 |
G |
A |
9: 37,830,840 (GRCm39) |
V301I |
possibly damaging |
Het |
Otog |
A |
G |
7: 45,939,150 (GRCm39) |
N2060S |
probably damaging |
Het |
Phc1 |
G |
A |
6: 122,311,042 (GRCm39) |
T98I |
probably damaging |
Het |
Pik3cb |
A |
G |
9: 98,946,221 (GRCm39) |
I535T |
possibly damaging |
Het |
Plxna2 |
A |
G |
1: 194,444,743 (GRCm39) |
I712V |
probably benign |
Het |
Psmc2 |
A |
G |
5: 22,000,834 (GRCm39) |
E103G |
possibly damaging |
Het |
Ptprb |
A |
G |
10: 116,179,796 (GRCm39) |
I1405V |
probably benign |
Het |
Ralgapa1 |
T |
C |
12: 55,824,101 (GRCm39) |
N260D |
possibly damaging |
Het |
Reln |
G |
A |
5: 22,124,173 (GRCm39) |
Q2778* |
probably null |
Het |
Slco1a8 |
T |
C |
6: 141,936,134 (GRCm39) |
N317S |
probably benign |
Het |
Sptlc1 |
T |
A |
13: 53,487,987 (GRCm39) |
Q452L |
probably benign |
Het |
Traf4 |
C |
A |
11: 78,056,226 (GRCm39) |
R14L |
possibly damaging |
Het |
Ubap2 |
T |
C |
4: 41,207,005 (GRCm39) |
E191G |
probably damaging |
Het |
Zrsr2-ps1 |
T |
A |
11: 22,924,190 (GRCm39) |
H321Q |
probably damaging |
Het |
|
Other mutations in Vstm4 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL02720:Vstm4
|
APN |
14 |
32,585,574 (GRCm39) |
missense |
probably damaging |
0.99 |
IGL02927:Vstm4
|
APN |
14 |
32,659,745 (GRCm39) |
missense |
probably damaging |
0.99 |
R0122:Vstm4
|
UTSW |
14 |
32,585,768 (GRCm39) |
splice site |
probably null |
|
R0755:Vstm4
|
UTSW |
14 |
32,614,601 (GRCm39) |
missense |
probably damaging |
1.00 |
R1508:Vstm4
|
UTSW |
14 |
32,585,511 (GRCm39) |
missense |
probably damaging |
1.00 |
R2075:Vstm4
|
UTSW |
14 |
32,639,811 (GRCm39) |
missense |
probably damaging |
1.00 |
R2517:Vstm4
|
UTSW |
14 |
32,585,664 (GRCm39) |
missense |
probably benign |
0.02 |
R3087:Vstm4
|
UTSW |
14 |
32,614,592 (GRCm39) |
missense |
possibly damaging |
0.46 |
R3870:Vstm4
|
UTSW |
14 |
32,585,712 (GRCm39) |
missense |
probably benign |
0.43 |
R4463:Vstm4
|
UTSW |
14 |
32,639,833 (GRCm39) |
missense |
probably damaging |
1.00 |
R4731:Vstm4
|
UTSW |
14 |
32,639,859 (GRCm39) |
missense |
possibly damaging |
0.60 |
R4732:Vstm4
|
UTSW |
14 |
32,639,859 (GRCm39) |
missense |
possibly damaging |
0.60 |
R4733:Vstm4
|
UTSW |
14 |
32,639,859 (GRCm39) |
missense |
possibly damaging |
0.60 |
R4860:Vstm4
|
UTSW |
14 |
32,585,742 (GRCm39) |
missense |
possibly damaging |
0.84 |
R4860:Vstm4
|
UTSW |
14 |
32,585,742 (GRCm39) |
missense |
possibly damaging |
0.84 |
R4983:Vstm4
|
UTSW |
14 |
32,641,202 (GRCm39) |
missense |
probably benign |
0.08 |
R5059:Vstm4
|
UTSW |
14 |
32,585,687 (GRCm39) |
missense |
probably damaging |
0.98 |
R5455:Vstm4
|
UTSW |
14 |
32,585,835 (GRCm39) |
missense |
possibly damaging |
0.94 |
R5593:Vstm4
|
UTSW |
14 |
32,641,247 (GRCm39) |
missense |
probably benign |
0.08 |
R5771:Vstm4
|
UTSW |
14 |
32,626,526 (GRCm39) |
missense |
probably benign |
0.28 |
R6018:Vstm4
|
UTSW |
14 |
32,585,627 (GRCm39) |
missense |
probably benign |
0.25 |
R6927:Vstm4
|
UTSW |
14 |
32,585,959 (GRCm39) |
splice site |
probably null |
|
R8920:Vstm4
|
UTSW |
14 |
32,585,615 (GRCm39) |
missense |
probably damaging |
1.00 |
X0064:Vstm4
|
UTSW |
14 |
32,585,678 (GRCm39) |
missense |
probably benign |
0.01 |
Z1177:Vstm4
|
UTSW |
14 |
32,585,784 (GRCm39) |
missense |
probably benign |
0.01 |
|
Posted On |
2013-10-07 |