Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01357:Tas2r135'

75553

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tas2r135

Ensembl Gene

ENSMUSG00000056203

Gene Name

taste receptor, type 2, member 135

Synonyms

mt2r38, Tas2r35

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.051) question?

Stock #

IGL01357

Quality Score

Status

Chromosome

Chromosomal Location

42382463-42383428 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 42383078 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Leucine at position 206 (I206L)

Ref Sequence

ENSEMBL: ENSMUSP00000070247 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000070178]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000070178
AA Change: I206L

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000070247
Gene: ENSMUSG00000056203
AA Change: I206L

Domain	Start	End	E-Value	Type
Pfam:TAS2R	22	320	1.3e-63	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 42 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2310022B05Rik	C	A	8: 125,366,072 (GRCm39)	V224F	probably damaging	Het
Abca4	T	A	3: 121,897,232 (GRCm39)	M637K	probably damaging	Het
Abca8a	A	G	11: 109,922,398 (GRCm39)	V1395A	probably benign	Het
Adam20	A	C	8: 41,249,597 (GRCm39)	D569A	probably benign	Het
Axl	A	G	7: 25,473,594 (GRCm39)	L344P	probably benign	Het
B3gat1	T	C	9: 26,668,283 (GRCm39)	L291P	probably damaging	Het
Cdc25c	A	T	18: 34,867,910 (GRCm39)		probably null	Het
Crat	A	T	2: 30,297,736 (GRCm39)	Y263N	probably damaging	Het
Crb2	A	G	2: 37,685,523 (GRCm39)		probably benign	Het
Dhx33	G	A	11: 70,884,687 (GRCm39)	Q40*	probably null	Het
Dnah7a	A	T	1: 53,701,540 (GRCm39)	V205D	probably benign	Het
Emsy	A	T	7: 98,240,077 (GRCm39)	Y1011*	probably null	Het
Fbln5	C	T	12: 101,717,146 (GRCm39)	S414N	probably damaging	Het
Fev	T	C	1: 74,921,683 (GRCm39)	E89G	possibly damaging	Het
Fgg	A	G	3: 82,921,535 (GRCm39)	E406G	possibly damaging	Het
Glra1	A	T	11: 55,405,715 (GRCm39)	M425K	possibly damaging	Het
Gm8214	C	T	1: 183,414,129 (GRCm39)		noncoding transcript	Het
Kdm3b	A	G	18: 34,926,067 (GRCm39)	E69G	probably damaging	Het
Kntc1	T	A	5: 123,895,877 (GRCm39)	V89E	probably damaging	Het
L3mbtl3	T	A	10: 26,206,083 (GRCm39)	N361I	unknown	Het
Macrod2	A	G	2: 142,226,250 (GRCm39)	N457S	probably damaging	Het
Mal	C	A	2: 127,482,234 (GRCm39)	M56I	probably damaging	Het
Mfsd5	C	T	15: 102,189,882 (GRCm39)	T418M	probably benign	Het
Mmaa	C	A	8: 79,994,600 (GRCm39)	R402L	probably benign	Het
Myo15a	T	C	11: 60,393,115 (GRCm39)		probably benign	Het
Nme1	A	G	11: 93,850,317 (GRCm39)	S122P	possibly damaging	Het
Nxt1	A	G	2: 148,517,316 (GRCm39)	E19G	probably damaging	Het
Nynrin	A	T	14: 56,107,874 (GRCm39)	T994S	probably benign	Het
Orc2	T	G	1: 58,536,551 (GRCm39)	E56D	probably benign	Het
Orc2	T	C	1: 58,536,552 (GRCm39)	E56G	probably benign	Het
Pid1	G	A	1: 84,016,026 (GRCm39)	T113I	probably damaging	Het
Plcg2	G	A	8: 118,340,900 (GRCm39)		probably benign	Het
Rad50	A	G	11: 53,597,848 (GRCm39)	V12A	probably damaging	Het
Serpinb9c	C	T	13: 33,335,862 (GRCm39)	V197I	probably benign	Het
Sfxn2	A	T	19: 46,574,212 (GRCm39)	N134I	probably damaging	Het
Spen	T	C	4: 141,244,424 (GRCm39)	R204G	unknown	Het
Strip2	A	G	6: 29,939,166 (GRCm39)		probably benign	Het
Tmem243	A	G	5: 9,151,348 (GRCm39)	T11A	probably damaging	Het
Tmprss11c	A	G	5: 86,379,666 (GRCm39)	V401A	probably damaging	Het
Trim50	T	A	5: 135,392,808 (GRCm39)	I241N	probably damaging	Het
Ttn	A	C	2: 76,781,864 (GRCm39)	S1015A	possibly damaging	Het
Wee1	T	C	7: 109,741,242 (GRCm39)	S622P	probably benign	Het

Other mutations in Tas2r135

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01395:Tas2r135	APN	6	42,382,846 (GRCm39)	nonsense	probably null
IGL02479:Tas2r135	APN	6	42,382,685 (GRCm39)	nonsense	probably null
IGL02526:Tas2r135	APN	6	42,383,214 (GRCm39)	missense	probably damaging	1.00
IGL02806:Tas2r135	APN	6	42,383,382 (GRCm39)	missense	probably benign	0.00
IGL02982:Tas2r135	APN	6	42,383,187 (GRCm39)	missense	probably benign
IGL03057:Tas2r135	APN	6	42,378,061 (GRCm39)	unclassified	probably benign
R0057:Tas2r135	UTSW	6	42,383,354 (GRCm39)	missense	probably benign	0.07
R0104:Tas2r135	UTSW	6	42,383,258 (GRCm39)	missense	possibly damaging	0.79
R1412:Tas2r135	UTSW	6	42,382,768 (GRCm39)	missense	probably benign	0.00
R4517:Tas2r135	UTSW	6	42,383,013 (GRCm39)	missense	probably benign
R4629:Tas2r135	UTSW	6	42,383,160 (GRCm39)	missense	probably benign	0.03
R5788:Tas2r135	UTSW	6	42,382,531 (GRCm39)	missense	probably damaging	1.00
R6021:Tas2r135	UTSW	6	42,383,321 (GRCm39)	missense	probably damaging	1.00
R6586:Tas2r135	UTSW	6	42,382,952 (GRCm39)	missense	probably benign	0.18
R7180:Tas2r135	UTSW	6	42,382,685 (GRCm39)	nonsense	probably null
R7458:Tas2r135	UTSW	6	42,382,881 (GRCm39)	missense	possibly damaging	0.95
R7850:Tas2r135	UTSW	6	42,383,072 (GRCm39)	missense	probably benign
R9113:Tas2r135	UTSW	6	42,383,315 (GRCm39)	missense	probably benign	0.00
Z1176:Tas2r135	UTSW	6	42,383,168 (GRCm39)	missense	probably benign	0.03

Posted On

2013-10-07