Incidental Mutation 'IGL01357:Cdc25c'
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Cdc25c
Ensembl Gene ENSMUSG00000044201
Gene Namecell division cycle 25C
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL01357
Quality Score
Chromosomal Location34732997-34751533 bp(-) (GRCm38)
Type of Mutationsplice site
DNA Base Change (assembly) A to T at 34734857 bp
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000055427 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000060710] [ENSMUST00000105038]
Predicted Effect probably null
Transcript: ENSMUST00000060710
SMART Domains Protein: ENSMUSP00000055427
Gene: ENSMUSG00000044201

low complexity region 246 257 N/A INTRINSIC
RHOD 284 398 3.71e-21 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000105038
SMART Domains Protein: ENSMUSP00000100655
Gene: ENSMUSG00000078240

Pfam:Ribosomal_L29e 3 42 1.4e-31 PFAM
low complexity region 124 160 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: This gene encodes a dual specificity phosphatase that dephosphorylates cyclin B-bound Cdk1 to trigger entry into mitosis. [provided by RefSeq, Dec 2014]
PHENOTYPE: Mice homozygous for a targeted null mutation exhibit no discernable phenotype; mice are viable and fertile with normal T and B lymphocyte development and proliferative responses. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2310022B05Rik C A 8: 124,639,333 V224F probably damaging Het
Abca4 T A 3: 122,103,583 M637K probably damaging Het
Abca8a A G 11: 110,031,572 V1395A probably benign Het
Adam20 A C 8: 40,796,560 D569A probably benign Het
Axl A G 7: 25,774,169 L344P probably benign Het
B3gat1 T C 9: 26,756,987 L291P probably damaging Het
Crat A T 2: 30,407,724 Y263N probably damaging Het
Crb2 A G 2: 37,795,511 probably benign Het
Dhx33 G A 11: 70,993,861 Q40* probably null Het
Dnah7a A T 1: 53,662,381 V205D probably benign Het
Emsy A T 7: 98,590,870 Y1011* probably null Het
Fbln5 C T 12: 101,750,887 S414N probably damaging Het
Fev T C 1: 74,882,524 E89G possibly damaging Het
Fgg A G 3: 83,014,228 E406G possibly damaging Het
Glra1 A T 11: 55,514,889 M425K possibly damaging Het
Gm8214 C T 1: 183,681,932 noncoding transcript Het
Kdm3b A G 18: 34,793,014 E69G probably damaging Het
Kntc1 T A 5: 123,757,814 V89E probably damaging Het
L3mbtl3 T A 10: 26,330,185 N361I unknown Het
Macrod2 A G 2: 142,384,330 N457S probably damaging Het
Mal C A 2: 127,640,314 M56I probably damaging Het
Mfsd5 C T 15: 102,281,447 T418M probably benign Het
Mmaa C A 8: 79,267,971 R402L probably benign Het
Myo15 T C 11: 60,502,289 probably benign Het
Nme1 A G 11: 93,959,491 S122P possibly damaging Het
Nxt1 A G 2: 148,675,396 E19G probably damaging Het
Nynrin A T 14: 55,870,417 T994S probably benign Het
Orc2 T G 1: 58,497,392 E56D probably benign Het
Orc2 T C 1: 58,497,393 E56G probably benign Het
Pid1 G A 1: 84,038,305 T113I probably damaging Het
Plcg2 G A 8: 117,614,161 probably benign Het
Rad50 A G 11: 53,707,021 V12A probably damaging Het
Serpinb9c C T 13: 33,151,879 V197I probably benign Het
Sfxn2 A T 19: 46,585,773 N134I probably damaging Het
Spen T C 4: 141,517,113 R204G unknown Het
Strip2 A G 6: 29,939,167 probably benign Het
Tas2r135 A T 6: 42,406,144 I206L probably benign Het
Tmem243 A G 5: 9,101,348 T11A probably damaging Het
Tmprss11c A G 5: 86,231,807 V401A probably damaging Het
Trim50 T A 5: 135,363,954 I241N probably damaging Het
Ttn A C 2: 76,951,520 S1015A possibly damaging Het
Wee1 T C 7: 110,142,035 S622P probably benign Het
Other mutations in Cdc25c
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00773:Cdc25c APN 18 34747241 missense probably benign 0.45
IGL02122:Cdc25c APN 18 34743985 missense probably benign 0.03
R0053:Cdc25c UTSW 18 34735435 missense probably benign 0.16
R0053:Cdc25c UTSW 18 34735435 missense probably benign 0.16
R1077:Cdc25c UTSW 18 34748973 splice site probably benign
R1679:Cdc25c UTSW 18 34747295 missense probably damaging 1.00
R2036:Cdc25c UTSW 18 34738239 missense probably damaging 1.00
R2051:Cdc25c UTSW 18 34738239 missense probably damaging 1.00
R2077:Cdc25c UTSW 18 34738239 missense probably damaging 1.00
R2511:Cdc25c UTSW 18 34738239 missense probably damaging 1.00
R5304:Cdc25c UTSW 18 34750811 missense possibly damaging 0.71
R5604:Cdc25c UTSW 18 34733648 missense probably damaging 1.00
Posted On2013-10-07