Incidental Mutation 'IGL01357:Cdc25c'
ID75589
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Cdc25c
Ensembl Gene ENSMUSG00000044201
Gene Namecell division cycle 25C
SynonymsCdc25
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL01357
Quality Score
Status
Chromosome18
Chromosomal Location34732997-34751533 bp(-) (GRCm38)
Type of Mutationsplice site
DNA Base Change (assembly) A to T at 34734857 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000055427 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000060710] [ENSMUST00000105038]
Predicted Effect probably null
Transcript: ENSMUST00000060710
SMART Domains Protein: ENSMUSP00000055427
Gene: ENSMUSG00000044201

DomainStartEndE-ValueType
low complexity region 246 257 N/A INTRINSIC
RHOD 284 398 3.71e-21 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000105038
SMART Domains Protein: ENSMUSP00000100655
Gene: ENSMUSG00000078240

DomainStartEndE-ValueType
Pfam:Ribosomal_L29e 3 42 1.4e-31 PFAM
low complexity region 124 160 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: This gene encodes a dual specificity phosphatase that dephosphorylates cyclin B-bound Cdk1 to trigger entry into mitosis. [provided by RefSeq, Dec 2014]
PHENOTYPE: Mice homozygous for a targeted null mutation exhibit no discernable phenotype; mice are viable and fertile with normal T and B lymphocyte development and proliferative responses. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2310022B05Rik C A 8: 124,639,333 V224F probably damaging Het
Abca4 T A 3: 122,103,583 M637K probably damaging Het
Abca8a A G 11: 110,031,572 V1395A probably benign Het
Adam20 A C 8: 40,796,560 D569A probably benign Het
Axl A G 7: 25,774,169 L344P probably benign Het
B3gat1 T C 9: 26,756,987 L291P probably damaging Het
Crat A T 2: 30,407,724 Y263N probably damaging Het
Crb2 A G 2: 37,795,511 probably benign Het
Dhx33 G A 11: 70,993,861 Q40* probably null Het
Dnah7a A T 1: 53,662,381 V205D probably benign Het
Emsy A T 7: 98,590,870 Y1011* probably null Het
Fbln5 C T 12: 101,750,887 S414N probably damaging Het
Fev T C 1: 74,882,524 E89G possibly damaging Het
Fgg A G 3: 83,014,228 E406G possibly damaging Het
Glra1 A T 11: 55,514,889 M425K possibly damaging Het
Gm8214 C T 1: 183,681,932 noncoding transcript Het
Kdm3b A G 18: 34,793,014 E69G probably damaging Het
Kntc1 T A 5: 123,757,814 V89E probably damaging Het
L3mbtl3 T A 10: 26,330,185 N361I unknown Het
Macrod2 A G 2: 142,384,330 N457S probably damaging Het
Mal C A 2: 127,640,314 M56I probably damaging Het
Mfsd5 C T 15: 102,281,447 T418M probably benign Het
Mmaa C A 8: 79,267,971 R402L probably benign Het
Myo15 T C 11: 60,502,289 probably benign Het
Nme1 A G 11: 93,959,491 S122P possibly damaging Het
Nxt1 A G 2: 148,675,396 E19G probably damaging Het
Nynrin A T 14: 55,870,417 T994S probably benign Het
Orc2 T G 1: 58,497,392 E56D probably benign Het
Orc2 T C 1: 58,497,393 E56G probably benign Het
Pid1 G A 1: 84,038,305 T113I probably damaging Het
Plcg2 G A 8: 117,614,161 probably benign Het
Rad50 A G 11: 53,707,021 V12A probably damaging Het
Serpinb9c C T 13: 33,151,879 V197I probably benign Het
Sfxn2 A T 19: 46,585,773 N134I probably damaging Het
Spen T C 4: 141,517,113 R204G unknown Het
Strip2 A G 6: 29,939,167 probably benign Het
Tas2r135 A T 6: 42,406,144 I206L probably benign Het
Tmem243 A G 5: 9,101,348 T11A probably damaging Het
Tmprss11c A G 5: 86,231,807 V401A probably damaging Het
Trim50 T A 5: 135,363,954 I241N probably damaging Het
Ttn A C 2: 76,951,520 S1015A possibly damaging Het
Wee1 T C 7: 110,142,035 S622P probably benign Het
Other mutations in Cdc25c
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00773:Cdc25c APN 18 34747241 missense probably benign 0.45
IGL02122:Cdc25c APN 18 34743985 missense probably benign 0.03
R0053:Cdc25c UTSW 18 34735435 missense probably benign 0.16
R0053:Cdc25c UTSW 18 34735435 missense probably benign 0.16
R1077:Cdc25c UTSW 18 34748973 splice site probably benign
R1679:Cdc25c UTSW 18 34747295 missense probably damaging 1.00
R2036:Cdc25c UTSW 18 34738239 missense probably damaging 1.00
R2051:Cdc25c UTSW 18 34738239 missense probably damaging 1.00
R2077:Cdc25c UTSW 18 34738239 missense probably damaging 1.00
R2511:Cdc25c UTSW 18 34738239 missense probably damaging 1.00
R5304:Cdc25c UTSW 18 34750811 missense possibly damaging 0.71
R5604:Cdc25c UTSW 18 34733648 missense probably damaging 1.00
Posted On2013-10-07