Mutagenetix > Incidental Mutation

Incidental Mutation 'P0012:Tas2r124'

7559

Institutional Source

Beutler Lab

Gene Symbol

Tas2r124

Ensembl Gene

ENSMUSG00000060412

Gene Name

taste receptor, type 2, member 124

Synonyms

mt2r50, mGR24, Tas2r24, T2R24

MMRRC Submission

038266-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.056) question?

Stock #

P0012 (G1)

Quality Score

Status

Validated

Chromosome

Chromosomal Location

132731693-132732622 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 132732503 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Histidine at position 271 (Y271H)

Ref Sequence

ENSEMBL: ENSMUSP00000075509 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000076150]

AlphaFold

Q7M718

Predicted Effect

possibly damaging
Transcript: ENSMUST00000076150
AA Change: Y271H

PolyPhen 2 Score 0.697 (Sensitivity: 0.86; Specificity: 0.92)

SMART Domains

Protein: ENSMUSP00000075509
Gene: ENSMUSG00000060412
AA Change: Y271H

Domain	Start	End	E-Value	Type
Pfam:TAS2R	1	298	2.3e-92	PFAM

Meta Mutation Damage Score

0.1795

Coding Region Coverage

1x: 85.5%
3x: 81.0%
10x: 67.7%
20x: 52.2%

Validation Efficiency

85% (579/685)

Allele List at MGI

Other mutations in this stock

Total: 9 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adamtsl3	A	C	7: 82,223,465 (GRCm39)	N156T	probably benign	Het
Akap3	T	C	6: 126,841,564 (GRCm39)	F61S	possibly damaging	Het
Arhgap1	T	C	2: 91,500,608 (GRCm39)	V379A	probably benign	Het
Ces1h	T	C	8: 94,080,138 (GRCm39)	K459E	unknown	Het
Fbn1	T	C	2: 125,211,241 (GRCm39)		probably benign	Het
Hrh2	T	C	13: 54,368,447 (GRCm39)	F141S	probably benign	Het
Igkv3-4	A	T	6: 70,649,231 (GRCm39)	N77Y	probably benign	Het
Nup205	T	C	6: 35,173,478 (GRCm39)	M496T	possibly damaging	Het
Tnfrsf11b	A	G	15: 54,123,194 (GRCm39)		probably benign	Het

Other mutations in Tas2r124

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00985:Tas2r124	APN	6	132,732,492 (GRCm39)	missense	probably benign	0.02
IGL01343:Tas2r124	APN	6	132,732,378 (GRCm39)	missense	probably damaging	1.00
IGL01646:Tas2r124	APN	6	132,732,332 (GRCm39)	missense	probably damaging	0.98
IGL01743:Tas2r124	APN	6	132,731,798 (GRCm39)	missense	probably benign	0.01
IGL02251:Tas2r124	APN	6	132,732,524 (GRCm39)	missense	probably benign	0.02
IGL03081:Tas2r124	APN	6	132,732,497 (GRCm39)	missense	possibly damaging	0.61
IGL03309:Tas2r124	APN	6	132,731,898 (GRCm39)	missense	probably benign	0.01
IGL03374:Tas2r124	APN	6	132,732,081 (GRCm39)	missense	probably benign	0.00
R1450:Tas2r124	UTSW	6	132,732,019 (GRCm39)	missense	probably damaging	1.00
R1804:Tas2r124	UTSW	6	132,732,488 (GRCm39)	missense	probably benign	0.11
R2048:Tas2r124	UTSW	6	132,731,858 (GRCm39)	missense	possibly damaging	0.94
R2846:Tas2r124	UTSW	6	132,732,230 (GRCm39)	missense	possibly damaging	0.73
R3415:Tas2r124	UTSW	6	132,732,601 (GRCm39)	missense	probably benign	0.00
R3416:Tas2r124	UTSW	6	132,732,601 (GRCm39)	missense	probably benign	0.00
R3417:Tas2r124	UTSW	6	132,732,601 (GRCm39)	missense	probably benign	0.00
R4306:Tas2r124	UTSW	6	132,731,954 (GRCm39)	missense	probably benign	0.03
R4308:Tas2r124	UTSW	6	132,731,954 (GRCm39)	missense	probably benign	0.03
R4823:Tas2r124	UTSW	6	132,732,509 (GRCm39)	missense	probably damaging	0.98
R4867:Tas2r124	UTSW	6	132,732,156 (GRCm39)	missense	probably damaging	0.98
R4949:Tas2r124	UTSW	6	132,731,858 (GRCm39)	missense	possibly damaging	0.94
R5242:Tas2r124	UTSW	6	132,732,503 (GRCm39)	missense	possibly damaging	0.70
R6001:Tas2r124	UTSW	6	132,732,416 (GRCm39)	missense	probably damaging	0.99
R6263:Tas2r124	UTSW	6	132,731,867 (GRCm39)	missense	probably benign	0.45
R6313:Tas2r124	UTSW	6	132,732,410 (GRCm39)	missense	probably benign	0.00
R6394:Tas2r124	UTSW	6	132,732,039 (GRCm39)	missense	probably damaging	1.00
R7685:Tas2r124	UTSW	6	132,732,056 (GRCm39)	missense	probably damaging	0.97
R8354:Tas2r124	UTSW	6	132,732,410 (GRCm39)	missense	probably benign	0.10
R9045:Tas2r124	UTSW	6	132,732,034 (GRCm39)	missense	probably damaging	0.99
R9615:Tas2r124	UTSW	6	132,732,492 (GRCm39)	missense	probably benign	0.02

Posted On

2012-10-04