Incidental Mutation 'IGL01366:Vmn1r21'
| ID |
75923 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Vmn1r21
|
| Ensembl Gene |
ENSMUSG00000115343 |
| Gene Name |
vomeronasal 1 receptor 21 |
| Synonyms |
V1rc28 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.118)
|
| Stock # |
IGL01366
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
6 |
| Chromosomal Location |
57820549-57821442 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 57820799 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Threonine
at position 215
(I215T)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000154295
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000081186]
[ENSMUST00000203310]
[ENSMUST00000203488]
[ENSMUST00000226191]
|
| AlphaFold |
Q8R2C6 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000081186
AA Change: I215T
PolyPhen 2
Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
|
| SMART Domains |
Protein: ENSMUSP00000079950
Gene: ENSMUSG00000058588
AA Change: I215T
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:V1R
|
28 |
293 |
5.9e-52 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000203270
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000203310
AA Change: I215T
PolyPhen 2
Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
|
| SMART Domains |
Protein: ENSMUSP00000145398
Gene: ENSMUSG00000115343
AA Change: I215T
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:V1R
|
27 |
107 |
1.8e-14 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000203488
AA Change: I215T
PolyPhen 2
Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
|
| SMART Domains |
Protein: ENSMUSP00000144978
Gene: ENSMUSG00000115343
AA Change: I215T
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:V1R
|
28 |
105 |
2e-13 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000226191
AA Change: I215T
PolyPhen 2
Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 36 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2310002L09Rik |
A |
T |
4: 73,868,937 (GRCm39) |
|
probably benign |
Het |
| Adamts2 |
T |
C |
11: 50,687,295 (GRCm39) |
Y1041H |
probably damaging |
Het |
| Adck5 |
A |
C |
15: 76,479,816 (GRCm39) |
*568C |
probably null |
Het |
| AK157302 |
T |
A |
13: 21,679,471 (GRCm39) |
|
probably benign |
Het |
| Bmpr2 |
G |
T |
1: 59,852,836 (GRCm39) |
G56W |
probably damaging |
Het |
| Capn11 |
A |
C |
17: 45,964,126 (GRCm39) |
I146S |
probably damaging |
Het |
| Ccdc162 |
A |
T |
10: 41,456,302 (GRCm39) |
D1613E |
possibly damaging |
Het |
| Ccdc167 |
T |
C |
17: 29,924,286 (GRCm39) |
E50G |
probably damaging |
Het |
| Col5a2 |
G |
T |
1: 45,431,048 (GRCm39) |
P864Q |
possibly damaging |
Het |
| Col7a1 |
C |
T |
9: 108,806,187 (GRCm39) |
|
probably benign |
Het |
| Crebbp |
T |
A |
16: 3,944,370 (GRCm39) |
H556L |
probably damaging |
Het |
| Dcpp1 |
T |
A |
17: 24,101,710 (GRCm39) |
I153N |
possibly damaging |
Het |
| Dgke |
C |
T |
11: 88,946,212 (GRCm39) |
R196H |
probably benign |
Het |
| Efr3a |
T |
A |
15: 65,722,999 (GRCm39) |
I459K |
probably benign |
Het |
| Espl1 |
T |
A |
15: 102,228,271 (GRCm39) |
C1682S |
probably benign |
Het |
| Exosc3 |
C |
T |
4: 45,317,747 (GRCm39) |
R185H |
probably damaging |
Het |
| Fgd6 |
T |
C |
10: 93,879,338 (GRCm39) |
V64A |
possibly damaging |
Het |
| Fhip2b |
G |
A |
14: 70,822,813 (GRCm39) |
R688C |
probably damaging |
Het |
| Gata3 |
A |
G |
2: 9,882,276 (GRCm39) |
L42P |
probably damaging |
Het |
| Ggta1 |
C |
A |
2: 35,292,462 (GRCm39) |
E282* |
probably null |
Het |
| Ghr |
T |
C |
15: 3,349,669 (GRCm39) |
D503G |
probably damaging |
Het |
| Gls |
C |
T |
1: 52,207,558 (GRCm39) |
G602D |
probably damaging |
Het |
| Gm2058 |
A |
G |
7: 39,238,658 (GRCm39) |
|
noncoding transcript |
Het |
| Grb7 |
T |
C |
11: 98,343,100 (GRCm39) |
|
probably benign |
Het |
| Ifngr1 |
A |
T |
10: 19,485,348 (GRCm39) |
H449L |
probably damaging |
Het |
| Ighg2b |
T |
G |
12: 113,270,656 (GRCm39) |
D158A |
possibly damaging |
Het |
| Nphs2 |
T |
C |
1: 156,138,605 (GRCm39) |
V83A |
probably benign |
Het |
| Parp6 |
T |
A |
9: 59,543,996 (GRCm39) |
M390K |
possibly damaging |
Het |
| Pask |
T |
C |
1: 93,238,574 (GRCm39) |
K1304E |
probably benign |
Het |
| Scai |
A |
G |
2: 38,996,973 (GRCm39) |
S274P |
probably benign |
Het |
| Sik2 |
A |
G |
9: 50,818,763 (GRCm39) |
S404P |
probably damaging |
Het |
| Slc7a8 |
A |
T |
14: 55,018,645 (GRCm39) |
I47N |
probably damaging |
Het |
| Tas2r113 |
A |
T |
6: 132,870,760 (GRCm39) |
I263F |
probably benign |
Het |
| Tdrd1 |
T |
A |
19: 56,843,734 (GRCm39) |
D737E |
probably benign |
Het |
| Trio |
T |
C |
15: 27,732,954 (GRCm39) |
T2976A |
possibly damaging |
Het |
| Ttc28 |
T |
C |
5: 111,233,037 (GRCm39) |
|
probably null |
Het |
|
| Other mutations in Vmn1r21 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00329:Vmn1r21
|
APN |
6 |
57,821,049 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL01660:Vmn1r21
|
APN |
6 |
57,821,222 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02864:Vmn1r21
|
APN |
6 |
57,820,661 (GRCm39) |
missense |
probably benign |
0.13 |
|
IGL02961:Vmn1r21
|
APN |
6 |
57,820,974 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL03170:Vmn1r21
|
APN |
6 |
57,820,847 (GRCm39) |
missense |
probably damaging |
0.99 |
|
PIT4453001:Vmn1r21
|
UTSW |
6 |
57,821,307 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1800:Vmn1r21
|
UTSW |
6 |
57,820,799 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1928:Vmn1r21
|
UTSW |
6 |
57,821,077 (GRCm39) |
nonsense |
probably null |
|
|
R3407:Vmn1r21
|
UTSW |
6 |
57,820,877 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5566:Vmn1r21
|
UTSW |
6 |
57,821,079 (GRCm39) |
missense |
probably benign |
0.06 |
|
R6012:Vmn1r21
|
UTSW |
6 |
57,820,891 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6293:Vmn1r21
|
UTSW |
6 |
57,821,255 (GRCm39) |
missense |
probably benign |
0.19 |
|
R6473:Vmn1r21
|
UTSW |
6 |
57,820,583 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7128:Vmn1r21
|
UTSW |
6 |
57,820,936 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7489:Vmn1r21
|
UTSW |
6 |
57,820,877 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7559:Vmn1r21
|
UTSW |
6 |
57,821,227 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8002:Vmn1r21
|
UTSW |
6 |
57,821,199 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8218:Vmn1r21
|
UTSW |
6 |
57,820,910 (GRCm39) |
missense |
noncoding transcript |
|
|
R8467:Vmn1r21
|
UTSW |
6 |
57,821,441 (GRCm39) |
start codon destroyed |
probably null |
1.00 |
|
R8922:Vmn1r21
|
UTSW |
6 |
57,820,829 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8930:Vmn1r21
|
UTSW |
6 |
57,820,998 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8932:Vmn1r21
|
UTSW |
6 |
57,820,998 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8961:Vmn1r21
|
UTSW |
6 |
57,820,829 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9154:Vmn1r21
|
UTSW |
6 |
57,821,348 (GRCm39) |
missense |
probably benign |
0.36 |
|
Z1176:Vmn1r21
|
UTSW |
6 |
57,820,563 (GRCm39) |
missense |
probably benign |
0.01 |
|
| Posted On |
2013-10-07 |
Incidental Mutation