Incidental Mutation 'IGL01369:Myg1'
ID |
76040 |
Institutional Source |
Australian Phenomics Network
(link to record)
|
Gene Symbol |
Myg1
|
Ensembl Gene |
ENSMUSG00000001285 |
Gene Name |
melanocyte proliferating gene 1 |
Synonyms |
Gamm1 |
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.200)
|
Stock # |
IGL01369
|
Quality Score |
|
Status
|
|
Chromosome |
15 |
Chromosomal Location |
102240144-102246574 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
G to A
at 102242773 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Valine to Methionine
at position 155
(V155M)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000109312
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000001331]
[ENSMUST00000001335]
[ENSMUST00000041208]
[ENSMUST00000062492]
[ENSMUST00000113682]
[ENSMUST00000165671]
[ENSMUST00000165717]
[ENSMUST00000166658]
[ENSMUST00000170627]
[ENSMUST00000228959]
|
AlphaFold |
Q9JK81 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000001331
AA Change: V152M
PolyPhen 2
Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
|
SMART Domains |
Protein: ENSMUSP00000001331 Gene: ENSMUSG00000001285 AA Change: V152M
Domain | Start | End | E-Value | Type |
Pfam:UPF0160
|
41 |
161 |
4.8e-54 |
PFAM |
Pfam:UPF0160
|
158 |
312 |
1.3e-59 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000001335
|
SMART Domains |
Protein: ENSMUSP00000001335 Gene: ENSMUSG00000001289
Domain | Start | End | E-Value | Type |
SCOP:d1fxkc_
|
12 |
58 |
4e-3 |
SMART |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000041208
|
SMART Domains |
Protein: ENSMUSP00000044604 Gene: ENSMUSG00000036678
Domain | Start | End | E-Value | Type |
WD40
|
136 |
179 |
3.7e0 |
SMART |
WD40
|
181 |
221 |
4.75e1 |
SMART |
WD40
|
232 |
273 |
1.17e-5 |
SMART |
WD40
|
278 |
315 |
2.66e0 |
SMART |
Blast:WD40
|
319 |
357 |
2e-15 |
BLAST |
low complexity region
|
534 |
545 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000062492
|
SMART Domains |
Protein: ENSMUSP00000126970 Gene: ENSMUSG00000001289
Domain | Start | End | E-Value | Type |
Pfam:Prefoldin
|
1 |
75 |
2.2e-20 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000113682
AA Change: V155M
PolyPhen 2
Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
|
SMART Domains |
Protein: ENSMUSP00000109312 Gene: ENSMUSG00000001285 AA Change: V155M
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
Pfam:UPF0160
|
45 |
365 |
1.5e-143 |
PFAM |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000164019
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000164961
|
Predicted Effect |
unknown
Transcript: ENSMUST00000171244
AA Change: V150M
|
SMART Domains |
Protein: ENSMUSP00000129494 Gene: ENSMUSG00000001285 AA Change: V150M
Domain | Start | End | E-Value | Type |
Pfam:UPF0160
|
41 |
209 |
1.7e-76 |
PFAM |
Pfam:UPF0160
|
204 |
306 |
3.3e-43 |
PFAM |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000171733
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000170281
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000170713
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000168805
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000170078
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000168547
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000165671
|
SMART Domains |
Protein: ENSMUSP00000128526 Gene: ENSMUSG00000001289
Domain | Start | End | E-Value | Type |
Pfam:Prefoldin
|
1 |
75 |
2.2e-20 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000165717
|
SMART Domains |
Protein: ENSMUSP00000132441 Gene: ENSMUSG00000001289
Domain | Start | End | E-Value | Type |
Pfam:Prefoldin
|
1 |
72 |
1.4e-20 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000166658
|
SMART Domains |
Protein: ENSMUSP00000129178 Gene: ENSMUSG00000001289
Domain | Start | End | E-Value | Type |
Pfam:Prefoldin
|
22 |
143 |
8.6e-32 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000170627
|
SMART Domains |
Protein: ENSMUSP00000131245 Gene: ENSMUSG00000001289
Domain | Start | End | E-Value | Type |
Pfam:Prefoldin
|
7 |
99 |
4.6e-22 |
PFAM |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000229589
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000228959
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000230239
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000230812
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000231099
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000230406
|
Coding Region Coverage |
|
Validation Efficiency |
|
MGI Phenotype |
PHENOTYPE: Mice homozygous for a null mutation display no gross abnormalities but altered sex-dependent anxiety-like behaviors in different tests. [provided by MGI curators]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 49 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Aadacl4fm4 |
T |
C |
4: 144,401,215 (GRCm39) |
T90A |
possibly damaging |
Het |
Abi2 |
A |
G |
1: 60,476,215 (GRCm39) |
T96A |
probably damaging |
Het |
Adam34 |
T |
A |
8: 44,104,094 (GRCm39) |
K517M |
probably benign |
Het |
Atm |
A |
T |
9: 53,426,617 (GRCm39) |
I547N |
probably benign |
Het |
Cadm4 |
A |
T |
7: 24,198,947 (GRCm39) |
D74V |
possibly damaging |
Het |
Caprin1 |
G |
A |
2: 103,599,210 (GRCm39) |
P46S |
probably damaging |
Het |
Cbl |
A |
T |
9: 44,112,358 (GRCm39) |
Y112* |
probably null |
Het |
Ccdc180 |
T |
C |
4: 45,900,256 (GRCm39) |
V246A |
probably benign |
Het |
Chd1 |
A |
T |
17: 15,975,259 (GRCm39) |
E1103V |
probably damaging |
Het |
Clock |
G |
A |
5: 76,384,933 (GRCm39) |
P428L |
probably benign |
Het |
Cntn2 |
T |
A |
1: 132,443,843 (GRCm39) |
I979F |
probably benign |
Het |
Col2a1 |
A |
G |
15: 97,875,707 (GRCm39) |
S1193P |
unknown |
Het |
Fga |
A |
T |
3: 82,937,507 (GRCm39) |
Y128F |
probably benign |
Het |
Glyr1 |
A |
T |
16: 4,838,152 (GRCm39) |
D365E |
probably benign |
Het |
Gmppb |
G |
A |
9: 107,928,446 (GRCm39) |
|
probably null |
Het |
Gmps |
A |
T |
3: 63,909,013 (GRCm39) |
H505L |
probably benign |
Het |
Hexim2 |
A |
G |
11: 103,029,464 (GRCm39) |
N172S |
probably benign |
Het |
Hmgcr |
T |
C |
13: 96,803,030 (GRCm39) |
E65G |
probably null |
Het |
Hsd17b4 |
T |
C |
18: 50,305,100 (GRCm39) |
S446P |
possibly damaging |
Het |
Kirrel3 |
C |
T |
9: 34,927,737 (GRCm39) |
T382I |
probably benign |
Het |
Klra7 |
A |
T |
6: 130,203,498 (GRCm39) |
Y169* |
probably null |
Het |
Lmbrd1 |
T |
C |
1: 24,745,055 (GRCm39) |
|
probably benign |
Het |
Loxhd1 |
A |
G |
18: 77,416,897 (GRCm39) |
E211G |
possibly damaging |
Het |
Maf1 |
T |
A |
15: 76,236,892 (GRCm39) |
F44I |
probably damaging |
Het |
Mmd2 |
A |
G |
5: 142,560,984 (GRCm39) |
S84P |
probably damaging |
Het |
Morc2b |
T |
C |
17: 33,357,139 (GRCm39) |
E211G |
probably benign |
Het |
Mov10l1 |
T |
C |
15: 88,909,040 (GRCm39) |
|
probably benign |
Het |
Mycbp2 |
C |
A |
14: 103,392,946 (GRCm39) |
C3205F |
possibly damaging |
Het |
Ncam2 |
A |
G |
16: 81,258,459 (GRCm39) |
N247S |
probably benign |
Het |
Nek11 |
A |
G |
9: 105,177,259 (GRCm39) |
|
probably null |
Het |
Nt5dc3 |
T |
A |
10: 86,656,139 (GRCm39) |
|
probably benign |
Het |
Nudcd3 |
A |
G |
11: 6,100,551 (GRCm39) |
Y134H |
probably damaging |
Het |
Ogfod1 |
T |
C |
8: 94,789,719 (GRCm39) |
|
probably null |
Het |
Or5b99 |
A |
T |
19: 12,977,125 (GRCm39) |
L258F |
possibly damaging |
Het |
Orm2 |
T |
C |
4: 63,281,215 (GRCm39) |
V51A |
probably benign |
Het |
P2ry14 |
T |
C |
3: 59,022,756 (GRCm39) |
I244V |
probably damaging |
Het |
Poll |
A |
G |
19: 45,542,115 (GRCm39) |
V397A |
probably damaging |
Het |
Ppdpf |
C |
A |
2: 180,829,687 (GRCm39) |
|
probably benign |
Het |
Ptch1 |
T |
C |
13: 63,659,495 (GRCm39) |
E1249G |
probably benign |
Het |
Rdh16f1 |
C |
A |
10: 127,595,844 (GRCm39) |
T13K |
probably benign |
Het |
Rrp1 |
G |
A |
10: 78,240,905 (GRCm39) |
|
probably benign |
Het |
Sec14l2 |
A |
G |
11: 4,053,432 (GRCm39) |
M346T |
probably benign |
Het |
Sh2d2a |
A |
T |
3: 87,759,136 (GRCm39) |
Q246L |
probably benign |
Het |
Slc44a1 |
G |
A |
4: 53,491,448 (GRCm39) |
D62N |
probably damaging |
Het |
Snx22 |
A |
G |
9: 65,976,060 (GRCm39) |
Y58H |
probably damaging |
Het |
Spata31f1a |
T |
C |
4: 42,852,548 (GRCm39) |
|
probably null |
Het |
Ttn |
T |
A |
2: 76,599,779 (GRCm39) |
D19104V |
probably damaging |
Het |
Ugt2a3 |
T |
C |
5: 87,474,979 (GRCm39) |
S422G |
probably damaging |
Het |
Zfyve19 |
G |
T |
2: 119,041,094 (GRCm39) |
|
probably benign |
Het |
|
Other mutations in Myg1 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL02188:Myg1
|
APN |
15 |
102,245,876 (GRCm39) |
missense |
probably benign |
0.08 |
IGL02373:Myg1
|
APN |
15 |
102,245,268 (GRCm39) |
missense |
probably damaging |
0.99 |
IGL02885:Myg1
|
APN |
15 |
102,240,594 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL03066:Myg1
|
APN |
15 |
102,242,801 (GRCm39) |
unclassified |
probably benign |
|
R0583:Myg1
|
UTSW |
15 |
102,246,225 (GRCm39) |
nonsense |
probably null |
|
R0631:Myg1
|
UTSW |
15 |
102,240,284 (GRCm39) |
missense |
probably benign |
0.00 |
R0835:Myg1
|
UTSW |
15 |
102,240,537 (GRCm39) |
missense |
probably damaging |
1.00 |
R1016:Myg1
|
UTSW |
15 |
102,242,786 (GRCm39) |
missense |
possibly damaging |
0.50 |
R1466:Myg1
|
UTSW |
15 |
102,245,825 (GRCm39) |
missense |
probably damaging |
1.00 |
R1466:Myg1
|
UTSW |
15 |
102,245,825 (GRCm39) |
missense |
probably damaging |
1.00 |
R1757:Myg1
|
UTSW |
15 |
102,240,264 (GRCm39) |
missense |
probably benign |
|
R2400:Myg1
|
UTSW |
15 |
102,246,171 (GRCm39) |
missense |
probably damaging |
1.00 |
R2428:Myg1
|
UTSW |
15 |
102,246,171 (GRCm39) |
missense |
probably damaging |
1.00 |
R2429:Myg1
|
UTSW |
15 |
102,246,171 (GRCm39) |
missense |
probably damaging |
1.00 |
R2431:Myg1
|
UTSW |
15 |
102,246,171 (GRCm39) |
missense |
probably damaging |
1.00 |
R2997:Myg1
|
UTSW |
15 |
102,245,945 (GRCm39) |
missense |
probably null |
1.00 |
R3683:Myg1
|
UTSW |
15 |
102,246,171 (GRCm39) |
missense |
probably damaging |
1.00 |
R3826:Myg1
|
UTSW |
15 |
102,246,171 (GRCm39) |
missense |
probably damaging |
1.00 |
R3827:Myg1
|
UTSW |
15 |
102,246,171 (GRCm39) |
missense |
probably damaging |
1.00 |
R3829:Myg1
|
UTSW |
15 |
102,246,171 (GRCm39) |
missense |
probably damaging |
1.00 |
R4923:Myg1
|
UTSW |
15 |
102,240,288 (GRCm39) |
missense |
probably benign |
|
R5363:Myg1
|
UTSW |
15 |
102,246,259 (GRCm39) |
missense |
probably benign |
0.00 |
R5419:Myg1
|
UTSW |
15 |
102,245,397 (GRCm39) |
missense |
probably damaging |
0.99 |
R9389:Myg1
|
UTSW |
15 |
102,245,372 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Posted On |
2013-10-07 |