Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01369:Zfyve19'

76083

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfyve19

Ensembl Gene

ENSMUSG00000068580

Gene Name

zinc finger, FYVE domain containing 19

Synonyms

1500041L05Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.173) question?

Stock #

IGL01369

Quality Score

Status

Chromosome

Chromosomal Location

119039098-119047530 bp(+) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

G to T at 119041094 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000099577 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000038439] [ENSMUST00000090174] [ENSMUST00000102519]

AlphaFold

Q9DAZ9

Predicted Effect

probably benign
Transcript: ENSMUST00000038439

SMART Domains

Protein: ENSMUSP00000041841
Gene: ENSMUSG00000034278

Domain	Start	End	E-Value	Type
DnaJ	10	68	3.66e-21	SMART
coiled coil region	112	151	N/A	INTRINSIC
low complexity region	172	181	N/A	INTRINSIC
Pfam:RRM_1	187	243	1.8e-6	PFAM
Pfam:RRM_5	194	246	1.7e-7	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000090174

SMART Domains

Protein: ENSMUSP00000087636
Gene: ENSMUSG00000068580

Domain	Start	End	E-Value	Type
FYVE	2	59	4.32e-6	SMART
RING	8	53	5.56e-1	SMART
low complexity region	167	187	N/A	INTRINSIC
coiled coil region	226	260	N/A	INTRINSIC
low complexity region	325	335	N/A	INTRINSIC
PDB:2D8V\|A	336	389	2e-35	PDB
Blast:RING	339	380	7e-21	BLAST

Predicted Effect

probably benign
Transcript: ENSMUST00000102519

SMART Domains

Protein: ENSMUSP00000099577
Gene: ENSMUSG00000068580

Domain	Start	End	E-Value	Type
FYVE	2	59	4.32e-6	SMART
RING	8	53	5.56e-1	SMART
low complexity region	167	187	N/A	INTRINSIC
coiled coil region	226	260	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000123323

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000123776

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000125731

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000141514

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000154185

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000142644

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000149036

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000154057

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000153349

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 49 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aadacl4fm4	T	C	4: 144,401,215 (GRCm39)	T90A	possibly damaging	Het
Abi2	A	G	1: 60,476,215 (GRCm39)	T96A	probably damaging	Het
Adam34	T	A	8: 44,104,094 (GRCm39)	K517M	probably benign	Het
Atm	A	T	9: 53,426,617 (GRCm39)	I547N	probably benign	Het
Cadm4	A	T	7: 24,198,947 (GRCm39)	D74V	possibly damaging	Het
Caprin1	G	A	2: 103,599,210 (GRCm39)	P46S	probably damaging	Het
Cbl	A	T	9: 44,112,358 (GRCm39)	Y112*	probably null	Het
Ccdc180	T	C	4: 45,900,256 (GRCm39)	V246A	probably benign	Het
Chd1	A	T	17: 15,975,259 (GRCm39)	E1103V	probably damaging	Het
Clock	G	A	5: 76,384,933 (GRCm39)	P428L	probably benign	Het
Cntn2	T	A	1: 132,443,843 (GRCm39)	I979F	probably benign	Het
Col2a1	A	G	15: 97,875,707 (GRCm39)	S1193P	unknown	Het
Fga	A	T	3: 82,937,507 (GRCm39)	Y128F	probably benign	Het
Glyr1	A	T	16: 4,838,152 (GRCm39)	D365E	probably benign	Het
Gmppb	G	A	9: 107,928,446 (GRCm39)		probably null	Het
Gmps	A	T	3: 63,909,013 (GRCm39)	H505L	probably benign	Het
Hexim2	A	G	11: 103,029,464 (GRCm39)	N172S	probably benign	Het
Hmgcr	T	C	13: 96,803,030 (GRCm39)	E65G	probably null	Het
Hsd17b4	T	C	18: 50,305,100 (GRCm39)	S446P	possibly damaging	Het
Kirrel3	C	T	9: 34,927,737 (GRCm39)	T382I	probably benign	Het
Klra7	A	T	6: 130,203,498 (GRCm39)	Y169*	probably null	Het
Lmbrd1	T	C	1: 24,745,055 (GRCm39)		probably benign	Het
Loxhd1	A	G	18: 77,416,897 (GRCm39)	E211G	possibly damaging	Het
Maf1	T	A	15: 76,236,892 (GRCm39)	F44I	probably damaging	Het
Mmd2	A	G	5: 142,560,984 (GRCm39)	S84P	probably damaging	Het
Morc2b	T	C	17: 33,357,139 (GRCm39)	E211G	probably benign	Het
Mov10l1	T	C	15: 88,909,040 (GRCm39)		probably benign	Het
Mycbp2	C	A	14: 103,392,946 (GRCm39)	C3205F	possibly damaging	Het
Myg1	G	A	15: 102,242,773 (GRCm39)	V155M	probably benign	Het
Ncam2	A	G	16: 81,258,459 (GRCm39)	N247S	probably benign	Het
Nek11	A	G	9: 105,177,259 (GRCm39)		probably null	Het
Nt5dc3	T	A	10: 86,656,139 (GRCm39)		probably benign	Het
Nudcd3	A	G	11: 6,100,551 (GRCm39)	Y134H	probably damaging	Het
Ogfod1	T	C	8: 94,789,719 (GRCm39)		probably null	Het
Or5b99	A	T	19: 12,977,125 (GRCm39)	L258F	possibly damaging	Het
Orm2	T	C	4: 63,281,215 (GRCm39)	V51A	probably benign	Het
P2ry14	T	C	3: 59,022,756 (GRCm39)	I244V	probably damaging	Het
Poll	A	G	19: 45,542,115 (GRCm39)	V397A	probably damaging	Het
Ppdpf	C	A	2: 180,829,687 (GRCm39)		probably benign	Het
Ptch1	T	C	13: 63,659,495 (GRCm39)	E1249G	probably benign	Het
Rdh16f1	C	A	10: 127,595,844 (GRCm39)	T13K	probably benign	Het
Rrp1	G	A	10: 78,240,905 (GRCm39)		probably benign	Het
Sec14l2	A	G	11: 4,053,432 (GRCm39)	M346T	probably benign	Het
Sh2d2a	A	T	3: 87,759,136 (GRCm39)	Q246L	probably benign	Het
Slc44a1	G	A	4: 53,491,448 (GRCm39)	D62N	probably damaging	Het
Snx22	A	G	9: 65,976,060 (GRCm39)	Y58H	probably damaging	Het
Spata31f1a	T	C	4: 42,852,548 (GRCm39)		probably null	Het
Ttn	T	A	2: 76,599,779 (GRCm39)	D19104V	probably damaging	Het
Ugt2a3	T	C	5: 87,474,979 (GRCm39)	S422G	probably damaging	Het

Other mutations in Zfyve19

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01078:Zfyve19	APN	2	119,046,981 (GRCm39)	nonsense	probably null
IGL02387:Zfyve19	APN	2	119,046,907 (GRCm39)	unclassified	probably benign
IGL02623:Zfyve19	APN	2	119,042,496 (GRCm39)	critical splice donor site	probably null
IGL02904:Zfyve19	APN	2	119,040,953 (GRCm39)	splice site	probably benign
IGL02938:Zfyve19	APN	2	119,041,999 (GRCm39)	missense	probably benign
IGL03190:Zfyve19	APN	2	119,046,717 (GRCm39)	missense	probably damaging	0.98
R0653:Zfyve19	UTSW	2	119,041,696 (GRCm39)	missense	probably benign	0.00
R0835:Zfyve19	UTSW	2	119,041,266 (GRCm39)	missense	probably benign	0.41
R1709:Zfyve19	UTSW	2	119,041,300 (GRCm39)	missense	probably damaging	0.96
R1824:Zfyve19	UTSW	2	119,042,016 (GRCm39)	missense	probably benign	0.00
R1938:Zfyve19	UTSW	2	119,041,693 (GRCm39)	missense	probably benign
R3699:Zfyve19	UTSW	2	119,041,720 (GRCm39)	missense	probably benign	0.03
R4177:Zfyve19	UTSW	2	119,046,693 (GRCm39)	missense	possibly damaging	0.48
R4191:Zfyve19	UTSW	2	119,041,312 (GRCm39)	missense	possibly damaging	0.84
R5492:Zfyve19	UTSW	2	119,039,595 (GRCm39)	start gained	probably benign
R5531:Zfyve19	UTSW	2	119,042,427 (GRCm39)	missense	probably damaging	0.99
R6349:Zfyve19	UTSW	2	119,041,078 (GRCm39)	missense	probably damaging	1.00
R7199:Zfyve19	UTSW	2	119,047,118 (GRCm39)	missense	probably damaging	1.00
R8947:Zfyve19	UTSW	2	119,041,290 (GRCm39)	missense	probably damaging	1.00
R9100:Zfyve19	UTSW	2	119,041,718 (GRCm39)	missense	probably benign	0.27
R9130:Zfyve19	UTSW	2	119,045,330 (GRCm39)	missense	probably damaging	0.96

Posted On

2013-10-07