Incidental Mutation 'IGL01370:Or1o11'
ID 76085
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or1o11
Ensembl Gene ENSMUSG00000059687
Gene Name olfactory receptor family 1 subfamily O member 11
Synonyms MOR156-5, GA_x6K02T2PSCP-1893605-1894534, Olfr108
Accession Numbers
Essential gene? Probably non essential (E-score: 0.049) question?
Stock # IGL01370
Quality Score
Status
Chromosome 17
Chromosomal Location 37756371-37757408 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 37756605 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Glutamine at position 64 (H64Q)
Ref Sequence ENSEMBL: ENSMUSP00000151360 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000078207] [ENSMUST00000207414] [ENSMUST00000218675]
AlphaFold Q8VFA1
Predicted Effect probably benign
Transcript: ENSMUST00000078207
AA Change: H53Q

PolyPhen 2 Score 0.445 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000077337
Gene: ENSMUSG00000059687
AA Change: H53Q

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srv 33 315 8.8e-9 PFAM
Pfam:7tm_4 39 316 9.5e-54 PFAM
Pfam:7tm_1 49 298 1.8e-19 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000207414
AA Change: H64Q
Predicted Effect probably benign
Transcript: ENSMUST00000218675
AA Change: H64Q

PolyPhen 2 Score 0.445 (Sensitivity: 0.89; Specificity: 0.90)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adck1 A T 12: 88,423,503 (GRCm39) probably benign Het
Add1 C T 5: 34,787,859 (GRCm39) T210I probably damaging Het
Ajm1 T C 2: 25,468,969 (GRCm39) E314G possibly damaging Het
Alpk2 A T 18: 65,483,662 (GRCm39) D115E possibly damaging Het
Ankrd36 C T 11: 5,534,019 (GRCm39) T290I probably benign Het
Bltp1 T A 3: 37,001,904 (GRCm39) I1283N probably benign Het
Castor2 T C 5: 134,167,111 (GRCm39) V323A probably benign Het
Ccnt2 T C 1: 127,731,250 (GRCm39) F709S possibly damaging Het
Erc1 T C 6: 119,801,426 (GRCm39) E197G probably damaging Het
Ftsj3 G T 11: 106,143,145 (GRCm39) R390S possibly damaging Het
Gabrb3 G A 7: 57,466,226 (GRCm39) A347T probably benign Het
Gde1 A G 7: 118,288,383 (GRCm39) probably benign Het
Jhy A T 9: 40,828,438 (GRCm39) N489K probably benign Het
Kiss1r A G 10: 79,754,658 (GRCm39) T51A probably benign Het
Lama5 T C 2: 179,839,193 (GRCm39) S772G possibly damaging Het
Lamb2 G T 9: 108,364,932 (GRCm39) probably null Het
Loxl3 A G 6: 83,026,468 (GRCm39) T475A probably damaging Het
Lpl A T 8: 69,340,220 (GRCm39) S72C possibly damaging Het
Lrrc74a A T 12: 86,801,204 (GRCm39) I352F probably damaging Het
Mcoln2 T C 3: 145,887,585 (GRCm39) I334T possibly damaging Het
Mettl8 T G 2: 70,812,383 (GRCm39) D49A probably damaging Het
Ms4a3 T A 19: 11,610,245 (GRCm39) T106S probably benign Het
Obscn T A 11: 58,886,389 (GRCm39) probably null Het
Or14j2 T C 17: 37,885,412 (GRCm39) I301V probably null Het
Or1p1c G A 11: 74,160,325 (GRCm39) V37I probably benign Het
Or4n4 G T 14: 50,519,689 (GRCm39) T7K probably damaging Het
Or5b107 A T 19: 13,142,663 (GRCm39) Y95F possibly damaging Het
Pcnx2 T C 8: 126,528,222 (GRCm39) K1333E probably damaging Het
Pias3 T C 3: 96,610,891 (GRCm39) F364L probably damaging Het
Piezo2 T A 18: 63,155,531 (GRCm39) I2438F probably damaging Het
Plcb3 A C 19: 6,940,192 (GRCm39) V465G probably damaging Het
Plekho2 G T 9: 65,465,912 (GRCm39) H159N probably damaging Het
Polr2e A G 10: 79,872,681 (GRCm39) probably benign Het
Rab6b G T 9: 103,041,094 (GRCm39) V163L probably benign Het
Rabep1 A G 11: 70,816,607 (GRCm39) M597V probably benign Het
Rbm15 A G 3: 107,238,326 (GRCm39) S691P probably damaging Het
Sec24b G A 3: 129,801,253 (GRCm39) probably benign Het
Slc6a18 A G 13: 73,815,150 (GRCm39) I386T probably damaging Het
Stxbp3 A C 3: 108,704,741 (GRCm39) Y497* probably null Het
Styk1 T C 6: 131,278,615 (GRCm39) K353R probably damaging Het
Tbc1d10b A T 7: 126,798,253 (GRCm39) H629Q probably damaging Het
Tbc1d5 T A 17: 51,273,755 (GRCm39) I119F probably benign Het
Tcp11l1 G T 2: 104,536,831 (GRCm39) D11E probably benign Het
Tfap2d A G 1: 19,175,009 (GRCm39) Y154C probably damaging Het
Tgm5 T C 2: 120,884,018 (GRCm39) N325S probably benign Het
Thbs2 T C 17: 14,910,327 (GRCm39) K91E possibly damaging Het
Vmn2r26 T A 6: 124,038,715 (GRCm39) F763L probably benign Het
Washc4 A G 10: 83,394,694 (GRCm39) E308G probably damaging Het
Xpot C A 10: 121,440,399 (GRCm39) A611S probably benign Het
Other mutations in Or1o11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01469:Or1o11 APN 17 37,756,426 (GRCm39) missense probably benign 0.00
IGL02291:Or1o11 APN 17 37,757,176 (GRCm39) missense possibly damaging 0.62
IGL02892:Or1o11 APN 17 37,756,925 (GRCm39) missense probably damaging 1.00
IGL03390:Or1o11 APN 17 37,757,255 (GRCm39) missense probably benign 0.02
R0115:Or1o11 UTSW 17 37,756,670 (GRCm39) missense probably benign 0.00
R0395:Or1o11 UTSW 17 37,756,757 (GRCm39) missense probably damaging 1.00
R0427:Or1o11 UTSW 17 37,756,593 (GRCm39) missense probably damaging 0.99
R0557:Or1o11 UTSW 17 37,756,712 (GRCm39) missense probably damaging 1.00
R1709:Or1o11 UTSW 17 37,757,091 (GRCm39) nonsense probably null
R3076:Or1o11 UTSW 17 37,756,375 (GRCm39) start gained probably benign
R5467:Or1o11 UTSW 17 37,756,973 (GRCm39) missense probably damaging 1.00
R5642:Or1o11 UTSW 17 37,756,663 (GRCm39) missense probably damaging 1.00
R5916:Or1o11 UTSW 17 37,756,570 (GRCm39) missense probably benign 0.16
R7451:Or1o11 UTSW 17 37,757,196 (GRCm39) missense probably damaging 1.00
R8205:Or1o11 UTSW 17 37,757,180 (GRCm39) missense probably damaging 1.00
R8280:Or1o11 UTSW 17 37,756,744 (GRCm39) missense probably benign 0.11
R9748:Or1o11 UTSW 17 37,756,595 (GRCm39) missense probably benign 0.00
Posted On 2013-10-07