Incidental Mutation 'IGL01370:Olfr108'
ID76085
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr108
Ensembl Gene ENSMUSG00000059687
Gene Nameolfactory receptor 108
SynonymsMOR156-5, GA_x6K02T2PSCP-1893605-1894534
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.122) question?
Stock #IGL01370
Quality Score
Status
Chromosome17
Chromosomal Location37445480-37446517 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) C to A at 37445714 bp
ZygosityHeterozygous
Amino Acid Change Histidine to Glutamine at position 64 (H64Q)
Ref Sequence ENSEMBL: ENSMUSP00000151360 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000078207] [ENSMUST00000207414] [ENSMUST00000218675]
Predicted Effect probably benign
Transcript: ENSMUST00000078207
AA Change: H53Q

PolyPhen 2 Score 0.445 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000077337
Gene: ENSMUSG00000059687
AA Change: H53Q

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srv 33 315 8.8e-9 PFAM
Pfam:7tm_4 39 316 9.5e-54 PFAM
Pfam:7tm_1 49 298 1.8e-19 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000207414
AA Change: H64Q
Predicted Effect probably benign
Transcript: ENSMUST00000218675
AA Change: H64Q

PolyPhen 2 Score 0.445 (Sensitivity: 0.89; Specificity: 0.90)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4932438A13Rik T A 3: 36,947,755 I1283N probably benign Het
Adck1 A T 12: 88,456,733 probably benign Het
Add1 C T 5: 34,630,515 T210I probably damaging Het
Alpk2 A T 18: 65,350,591 D115E possibly damaging Het
Ankrd36 C T 11: 5,584,019 T290I probably benign Het
Ccnt2 T C 1: 127,803,513 F709S possibly damaging Het
Erc1 T C 6: 119,824,465 E197G probably damaging Het
Ftsj3 G T 11: 106,252,319 R390S possibly damaging Het
Gabrb3 G A 7: 57,816,478 A347T probably benign Het
Gatsl2 T C 5: 134,138,272 V323A probably benign Het
Gde1 A G 7: 118,689,160 probably benign Het
Gm996 T C 2: 25,578,957 E314G possibly damaging Het
Jhy A T 9: 40,917,142 N489K probably benign Het
Kiss1r A G 10: 79,918,824 T51A probably benign Het
Lama5 T C 2: 180,197,400 S772G possibly damaging Het
Lamb2 G T 9: 108,487,733 probably null Het
Loxl3 A G 6: 83,049,487 T475A probably damaging Het
Lpl A T 8: 68,887,568 S72C possibly damaging Het
Lrrc74a A T 12: 86,754,430 I352F probably damaging Het
Mcoln2 T C 3: 146,181,830 I334T possibly damaging Het
Mettl8 T G 2: 70,982,039 D49A probably damaging Het
Ms4a3 T A 19: 11,632,881 T106S probably benign Het
Obscn T A 11: 58,995,563 probably null Het
Olfr113 T C 17: 37,574,521 I301V probably null Het
Olfr1461 A T 19: 13,165,299 Y95F possibly damaging Het
Olfr406 G A 11: 74,269,499 V37I probably benign Het
Olfr732 G T 14: 50,282,232 T7K probably damaging Het
Pcnx2 T C 8: 125,801,483 K1333E probably damaging Het
Pias3 T C 3: 96,703,575 F364L probably damaging Het
Piezo2 T A 18: 63,022,460 I2438F probably damaging Het
Plcb3 A C 19: 6,962,824 V465G probably damaging Het
Plekho2 G T 9: 65,558,630 H159N probably damaging Het
Polr2e A G 10: 80,036,847 probably benign Het
Rab6b G T 9: 103,163,895 V163L probably benign Het
Rabep1 A G 11: 70,925,781 M597V probably benign Het
Rbm15 A G 3: 107,331,010 S691P probably damaging Het
Sec24b G A 3: 130,007,604 probably benign Het
Slc6a18 A G 13: 73,667,031 I386T probably damaging Het
Stxbp3 A C 3: 108,797,425 Y497* probably null Het
Styk1 T C 6: 131,301,652 K353R probably damaging Het
Tbc1d10b A T 7: 127,199,081 H629Q probably damaging Het
Tbc1d5 T A 17: 50,966,727 I119F probably benign Het
Tcp11l1 G T 2: 104,706,486 D11E probably benign Het
Tfap2d A G 1: 19,104,785 Y154C probably damaging Het
Tgm5 T C 2: 121,053,537 N325S probably benign Het
Thbs2 T C 17: 14,690,065 K91E possibly damaging Het
Vmn2r26 T A 6: 124,061,756 F763L probably benign Het
Washc4 A G 10: 83,558,830 E308G probably damaging Het
Xpot C A 10: 121,604,494 A611S probably benign Het
Other mutations in Olfr108
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01469:Olfr108 APN 17 37445535 missense probably benign 0.00
IGL02291:Olfr108 APN 17 37446285 missense possibly damaging 0.62
IGL02892:Olfr108 APN 17 37446034 missense probably damaging 1.00
IGL03390:Olfr108 APN 17 37446364 missense probably benign 0.02
R0115:Olfr108 UTSW 17 37445779 missense probably benign 0.00
R0395:Olfr108 UTSW 17 37445866 missense probably damaging 1.00
R0427:Olfr108 UTSW 17 37445702 missense probably damaging 0.99
R0557:Olfr108 UTSW 17 37445821 missense probably damaging 1.00
R1709:Olfr108 UTSW 17 37446200 nonsense probably null
R3076:Olfr108 UTSW 17 37445484 start gained probably benign
R5467:Olfr108 UTSW 17 37446082 missense probably damaging 1.00
R5642:Olfr108 UTSW 17 37445772 missense probably damaging 1.00
R5916:Olfr108 UTSW 17 37445679 missense probably benign 0.16
Posted On2013-10-07