Incidental Mutation 'IGL01370:Olfr113'
ID76087
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr113
Ensembl Gene ENSMUSG00000092292
Gene Nameolfactory receptor 113
SynonymsGA_x6K02T2PSCP-2034880-2033942, MOR218-9
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.131) question?
Stock #IGL01370
Quality Score
Status
Chromosome17
Chromosomal Location37573877-37577663 bp(-) (GRCm38)
Type of Mutationunclassified
DNA Base Change (assembly) T to C at 37574521 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Valine at position 301 (I301V)
Ref Sequence ENSEMBL: ENSMUSP00000134080 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000174139] [ENSMUST00000216181]
Predicted Effect probably null
Transcript: ENSMUST00000174139
AA Change: I301V

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000134080
Gene: ENSMUSG00000109212
AA Change: I301V

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 3.7e-46 PFAM
Pfam:7TM_GPCR_Srx 32 307 3.4e-7 PFAM
Pfam:7TM_GPCR_Srsx 35 305 4.2e-6 PFAM
Pfam:7tm_1 41 290 2.9e-20 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000216181
AA Change: I301V

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4932438A13Rik T A 3: 36,947,755 I1283N probably benign Het
Adck1 A T 12: 88,456,733 probably benign Het
Add1 C T 5: 34,630,515 T210I probably damaging Het
Alpk2 A T 18: 65,350,591 D115E possibly damaging Het
Ankrd36 C T 11: 5,584,019 T290I probably benign Het
Ccnt2 T C 1: 127,803,513 F709S possibly damaging Het
Erc1 T C 6: 119,824,465 E197G probably damaging Het
Ftsj3 G T 11: 106,252,319 R390S possibly damaging Het
Gabrb3 G A 7: 57,816,478 A347T probably benign Het
Gatsl2 T C 5: 134,138,272 V323A probably benign Het
Gde1 A G 7: 118,689,160 probably benign Het
Gm996 T C 2: 25,578,957 E314G possibly damaging Het
Jhy A T 9: 40,917,142 N489K probably benign Het
Kiss1r A G 10: 79,918,824 T51A probably benign Het
Lama5 T C 2: 180,197,400 S772G possibly damaging Het
Lamb2 G T 9: 108,487,733 probably null Het
Loxl3 A G 6: 83,049,487 T475A probably damaging Het
Lpl A T 8: 68,887,568 S72C possibly damaging Het
Lrrc74a A T 12: 86,754,430 I352F probably damaging Het
Mcoln2 T C 3: 146,181,830 I334T possibly damaging Het
Mettl8 T G 2: 70,982,039 D49A probably damaging Het
Ms4a3 T A 19: 11,632,881 T106S probably benign Het
Obscn T A 11: 58,995,563 probably null Het
Olfr108 C A 17: 37,445,714 H64Q probably benign Het
Olfr1461 A T 19: 13,165,299 Y95F possibly damaging Het
Olfr406 G A 11: 74,269,499 V37I probably benign Het
Olfr732 G T 14: 50,282,232 T7K probably damaging Het
Pcnx2 T C 8: 125,801,483 K1333E probably damaging Het
Pias3 T C 3: 96,703,575 F364L probably damaging Het
Piezo2 T A 18: 63,022,460 I2438F probably damaging Het
Plcb3 A C 19: 6,962,824 V465G probably damaging Het
Plekho2 G T 9: 65,558,630 H159N probably damaging Het
Polr2e A G 10: 80,036,847 probably benign Het
Rab6b G T 9: 103,163,895 V163L probably benign Het
Rabep1 A G 11: 70,925,781 M597V probably benign Het
Rbm15 A G 3: 107,331,010 S691P probably damaging Het
Sec24b G A 3: 130,007,604 probably benign Het
Slc6a18 A G 13: 73,667,031 I386T probably damaging Het
Stxbp3 A C 3: 108,797,425 Y497* probably null Het
Styk1 T C 6: 131,301,652 K353R probably damaging Het
Tbc1d10b A T 7: 127,199,081 H629Q probably damaging Het
Tbc1d5 T A 17: 50,966,727 I119F probably benign Het
Tcp11l1 G T 2: 104,706,486 D11E probably benign Het
Tfap2d A G 1: 19,104,785 Y154C probably damaging Het
Tgm5 T C 2: 121,053,537 N325S probably benign Het
Thbs2 T C 17: 14,690,065 K91E possibly damaging Het
Vmn2r26 T A 6: 124,061,756 F763L probably benign Het
Washc4 A G 10: 83,558,830 E308G probably damaging Het
Xpot C A 10: 121,604,494 A611S probably benign Het
Other mutations in Olfr113
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00088:Olfr113 APN 17 37574917 missense probably damaging 0.98
IGL01061:Olfr113 APN 17 37574904 missense possibly damaging 0.47
IGL01293:Olfr113 APN 17 37575417 missense probably benign
IGL01535:Olfr113 APN 17 37574788 missense possibly damaging 0.90
IGL02134:Olfr113 APN 17 37575358 missense probably benign 0.01
IGL02536:Olfr113 APN 17 37574926 missense probably damaging 1.00
IGL02640:Olfr113 APN 17 37575021 missense possibly damaging 0.73
IGL02652:Olfr113 APN 17 37574945 nonsense probably null
IGL02963:Olfr113 APN 17 37574854 missense probably benign 0.09
R0104:Olfr113 UTSW 17 37574926 missense probably damaging 1.00
R1662:Olfr113 UTSW 17 37575273 missense probably damaging 1.00
R2904:Olfr113 UTSW 17 37574814 missense possibly damaging 0.95
R5129:Olfr113 UTSW 17 37575180 missense probably damaging 1.00
R5197:Olfr113 UTSW 17 37575220 missense probably benign 0.00
R5347:Olfr113 UTSW 17 37574727 missense probably damaging 0.97
R6044:Olfr113 UTSW 17 37574535 missense probably damaging 0.96
R7048:Olfr113 UTSW 17 37575223 missense probably damaging 1.00
R7064:Olfr113 UTSW 17 37574743 missense probably damaging 1.00
X0062:Olfr113 UTSW 17 37574497 missense probably benign 0.01
Posted On2013-10-07