Incidental Mutation 'IGL01372:Fam91a1'
ID 76168
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Fam91a1
Ensembl Gene ENSMUSG00000037119
Gene Name family with sequence similarity 91, member A1
Synonyms D15Ertd621e
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL01372
Quality Score
Status
Chromosome 15
Chromosomal Location 58287317-58329589 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 58301911 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Methionine at position 258 (I258M)
Ref Sequence ENSEMBL: ENSMUSP00000036524 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000037270]
AlphaFold Q3UVG3
Predicted Effect probably damaging
Transcript: ENSMUST00000037270
AA Change: I258M

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000036524
Gene: ENSMUSG00000037119
AA Change: I258M

DomainStartEndE-ValueType
Pfam:FAM91_N 8 312 2.8e-149 PFAM
Pfam:FAM91_C 374 821 3.8e-182 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000227770
Predicted Effect noncoding transcript
Transcript: ENSMUST00000227796
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a transgenic gene disruption exhibit male infertility. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca7 G A 10: 79,842,089 (GRCm39) D1049N probably benign Het
Ankdd1a A T 9: 65,411,421 (GRCm39) L362Q probably damaging Het
Ankib1 A T 5: 3,822,594 (GRCm39) N37K probably damaging Het
Ankrd55 T A 13: 112,459,677 (GRCm39) D90E probably damaging Het
Atp1a2 T C 1: 172,106,510 (GRCm39) R831G probably damaging Het
Bcar3 A G 3: 122,316,943 (GRCm39) D638G probably damaging Het
Cabp4 T A 19: 4,189,322 (GRCm39) E78D probably benign Het
Cmtm8 A G 9: 114,619,755 (GRCm39) V130A possibly damaging Het
Cyth3 A G 5: 143,678,393 (GRCm39) T66A possibly damaging Het
Dmbt1 A T 7: 130,705,409 (GRCm39) I1171F possibly damaging Het
Dnah10 G A 5: 124,856,218 (GRCm39) G2060D probably damaging Het
Dnah11 T C 12: 118,156,134 (GRCm39) H172R probably damaging Het
Dnah5 C T 15: 28,230,636 (GRCm39) A178V probably benign Het
Efcab6 T G 15: 83,928,505 (GRCm39) M30L possibly damaging Het
Ehbp1l1 T C 19: 5,765,817 (GRCm39) probably benign Het
Eps15 G A 4: 109,179,303 (GRCm39) E230K probably damaging Het
Gm5581 G A 6: 131,145,366 (GRCm39) noncoding transcript Het
Hrh1 G A 6: 114,456,958 (GRCm39) V80I probably damaging Het
Ldhd G A 8: 112,355,032 (GRCm39) H290Y probably benign Het
Lepr G A 4: 101,592,774 (GRCm39) E130K possibly damaging Het
Mycbpap T C 11: 94,397,282 (GRCm39) I40V possibly damaging Het
Nrap T A 19: 56,317,534 (GRCm39) probably null Het
Opn5 T A 17: 42,891,435 (GRCm39) probably null Het
Or1j14 T A 2: 36,417,463 (GRCm39) I13N probably benign Het
Or5ac24 A G 16: 59,165,524 (GRCm39) I180T probably damaging Het
Otop3 A T 11: 115,235,930 (GRCm39) T521S possibly damaging Het
Pcsk5 T G 19: 17,595,108 (GRCm39) T409P probably damaging Het
Pde9a T A 17: 31,680,685 (GRCm39) F322Y probably benign Het
Pgm5 T A 19: 24,710,985 (GRCm39) I406F probably damaging Het
Prrc2b T C 2: 32,113,942 (GRCm39) S1998P probably damaging Het
Prune2 T C 19: 17,102,433 (GRCm39) Y2531H probably damaging Het
Ptprk T C 10: 28,445,923 (GRCm39) V932A probably benign Het
Rapgef6 T A 11: 54,559,437 (GRCm39) probably benign Het
Rgsl1 T A 1: 153,701,887 (GRCm39) Y224F probably damaging Het
Rps6kl1 A T 12: 85,193,663 (GRCm39) C143S probably damaging Het
S100a7l2 A G 3: 90,995,616 (GRCm39) probably benign Het
Slc5a5 G A 8: 71,343,020 (GRCm39) probably benign Het
Tfb2m A G 1: 179,369,878 (GRCm39) S182P probably damaging Het
Tmc3 A G 7: 83,261,746 (GRCm39) H608R probably damaging Het
Trim37 T A 11: 87,075,772 (GRCm39) H459Q probably benign Het
Vmn2r71 A T 7: 85,270,022 (GRCm39) probably benign Het
Xirp2 T C 2: 67,344,334 (GRCm39) S2192P possibly damaging Het
Other mutations in Fam91a1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00090:Fam91a1 APN 15 58,302,584 (GRCm39) missense probably damaging 0.99
IGL00590:Fam91a1 APN 15 58,287,565 (GRCm39) missense possibly damaging 0.66
IGL01301:Fam91a1 APN 15 58,314,720 (GRCm39) missense probably damaging 0.99
IGL01979:Fam91a1 APN 15 58,304,433 (GRCm39) missense probably damaging 1.00
IGL02085:Fam91a1 APN 15 58,313,505 (GRCm39) missense possibly damaging 0.95
IGL02553:Fam91a1 APN 15 58,304,831 (GRCm39) critical splice donor site probably null
IGL02605:Fam91a1 APN 15 58,303,045 (GRCm39) splice site probably benign
IGL02882:Fam91a1 APN 15 58,324,910 (GRCm39) splice site probably benign
IGL02894:Fam91a1 APN 15 58,315,080 (GRCm39) missense probably benign 0.09
ANU18:Fam91a1 UTSW 15 58,314,720 (GRCm39) missense probably damaging 0.99
H8562:Fam91a1 UTSW 15 58,298,970 (GRCm39) splice site probably null
R0395:Fam91a1 UTSW 15 58,326,641 (GRCm39) missense probably benign
R1165:Fam91a1 UTSW 15 58,302,518 (GRCm39) missense possibly damaging 0.90
R1699:Fam91a1 UTSW 15 58,304,797 (GRCm39) missense probably benign 0.04
R1749:Fam91a1 UTSW 15 58,298,443 (GRCm39) missense probably benign 0.02
R1997:Fam91a1 UTSW 15 58,296,044 (GRCm39) critical splice acceptor site probably null
R2042:Fam91a1 UTSW 15 58,298,443 (GRCm39) missense probably benign 0.02
R2188:Fam91a1 UTSW 15 58,302,512 (GRCm39) missense probably damaging 0.98
R2518:Fam91a1 UTSW 15 58,322,449 (GRCm39) missense possibly damaging 0.92
R3124:Fam91a1 UTSW 15 58,293,738 (GRCm39) missense probably benign 0.34
R3916:Fam91a1 UTSW 15 58,302,583 (GRCm39) missense probably damaging 1.00
R4810:Fam91a1 UTSW 15 58,306,589 (GRCm39) missense probably damaging 1.00
R4959:Fam91a1 UTSW 15 58,303,059 (GRCm39) missense probably benign 0.16
R4973:Fam91a1 UTSW 15 58,303,059 (GRCm39) missense probably benign 0.16
R5288:Fam91a1 UTSW 15 58,320,243 (GRCm39) missense probably benign
R5385:Fam91a1 UTSW 15 58,320,243 (GRCm39) missense probably benign
R5386:Fam91a1 UTSW 15 58,320,243 (GRCm39) missense probably benign
R5941:Fam91a1 UTSW 15 58,303,166 (GRCm39) missense probably benign 0.01
R6415:Fam91a1 UTSW 15 58,314,766 (GRCm39) missense probably damaging 1.00
R6869:Fam91a1 UTSW 15 58,303,117 (GRCm39) missense probably benign 0.00
R7175:Fam91a1 UTSW 15 58,302,527 (GRCm39) missense probably benign 0.06
R7872:Fam91a1 UTSW 15 58,320,209 (GRCm39) missense probably benign 0.01
X0024:Fam91a1 UTSW 15 58,302,038 (GRCm39) missense probably damaging 0.98
Z1177:Fam91a1 UTSW 15 58,304,397 (GRCm39) missense possibly damaging 0.68
Posted On 2013-10-07